Joseph Schacherer

Summary

Publications

  1. Reisser C, Dick C, Kruglyak L, Botstein D, Schacherer J, Hess D. Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case. G3 (Bethesda). 2013;3:733-740 pubmed publisher
    ..These findings further refine our understanding of ammonium toxicity in yeast and provide an example of using natural variation to understand cellular processes. ..
  2. Jung P, Sigwalt A, Ohnuki S, De Montigny J, Ohya Y, Schacherer J. Large-Scale Survey of Intraspecific Fitness and Cell Morphology Variation in a Protoploid Yeast Species. G3 (Bethesda). 2016;6:1063-71 pubmed publisher
    ..kluyveri might be useful in further linkage mapping analyses of complex traits, and could ultimately provide a better insight into the evolution of the genotype-phenotype relationship across yeast species. ..
  3. Hou J, Schacherer J. Negative epistasis: a route to intraspecific reproductive isolation in yeast?. Curr Genet. 2016;62:25-9 pubmed publisher
    ..These advances deepened our current understandings and opened further perspectives regarding the complete picture of molecular and evolutionary origins driving the onset of intraspecific reproductive isolation in yeasts. ..
  4. Peter J, De Chiara M, Friedrich A, Yue J, Pflieger D, Bergström A, et al. Genome evolution across 1,011 Saccharomyces cerevisiae isolates. Nature. 2018;556:339-344 pubmed publisher
    ..This resource will guide future population genomics and genotype-phenotype studies in this classic model system. ..
  5. Freel K, Friedrich A, Hou J, Schacherer J. Population genomic analysis reveals highly conserved mitochondrial genomes in the yeast species Lachancea thermotolerans. Genome Biol Evol. 2014;6:2586-94 pubmed publisher
    ..kluyveri, demonstrating that the factors driving mt genome evolution are different even between closely related species. ..
  6. Brion C, Pflieger D, Friedrich A, Schacherer J. Evolution of intraspecific transcriptomic landscapes in yeasts. Nucleic Acids Res. 2015;43:4558-68 pubmed publisher
    ..Our data set sheds an important light on the evolution of intraspecific transcriptomic variation across distant species. ..
  7. Freel K, Friedrich A, Schacherer J. Mitochondrial genome evolution in yeasts: an all-encompassing view. FEMS Yeast Res. 2015;15:fov023 pubmed publisher
    ..Here, we summarize the present state of yeast mitogenomics, including the currently available data and what it reveals concerning the diversity of content, organization, structure and evolution of mt genomes. ..
  8. Freel K, Friedrich A, Sarilar V, Devillers H, Neuvéglise C, Schacherer J. Whole-Genome Sequencing and Intraspecific Analysis of the Yeast Species Lachancea quebecensis. Genome Biol Evol. 2016;8:733-41 pubmed publisher
    ..However, even with relatively similar ranges of genome divergence, L. quebecensis has an extremely low global phenotypic variance of 0.062 compared with 0.59 previously determined in S. cerevisiae. ..
  9. Hou J, Schacherer J. On the Mapping of Epistatic Genetic Interactions in Natural Isolates: Combining Classical Genetics and Genomics. Methods Mol Biol. 2016;1361:345-60 pubmed publisher

More Information

Publications16

  1. Hou J, Fournier T, Schacherer J. Species-wide survey reveals the various flavors of intraspecific reproductive isolation in yeast. FEMS Yeast Res. 2016;16: pubmed publisher
  2. Schacherer J. Beyond the simplicity of Mendelian inheritance. C R Biol. 2016;339:284-8 pubmed publisher
    ..Our study also demonstrated that combining the elegancy of both classical genetics and high-throughput genomics is more than valuable to dissect the genotype-phenotype relationship in natural populations. ..
  3. Sigwalt A, Caradec C, Brion C, Hou J, De Montigny J, Jung P, et al. Dissection of quantitative traits by bulk segregant mapping in a protoploid yeast species. FEMS Yeast Res. 2016;16: pubmed publisher
    ..kluyveri Overall, this study demonstrates that bulk segregant mapping is a powerful way for investigating the genetic basis of natural variations in non-model yeast organisms and more precisely in L. kluyveri. ..
  4. Brion C, Pflieger D, Souali Crespo S, Friedrich A, Schacherer J. Differences in environmental stress response among yeasts is consistent with species-specific lifestyles. Mol Biol Cell. 2016;27:1694-705 pubmed publisher
    ..This large data set allowed for the characterization of the evolution of gene regulation and provides an efficient tool for assessing gene function. ..
  5. Hou J, Sigwalt A, Fournier T, Pflieger D, Peter J, De Montigny J, et al. The Hidden Complexity of Mendelian Traits across Natural Yeast Populations. Cell Rep. 2016;16:1106-1114 pubmed publisher
    ..In fact, when taking into account the natural population diversity, the hidden complexity of traits could be substantial, confounding phenotypic predictability even for simple Mendelian traits. ..
  6. Hou J, Schacherer J. Fitness Trade-Offs Lead to Suppressor Tolerance in Yeast. Mol Biol Evol. 2017;34:110-118 pubmed publisher
    ..Our results present a detailed dissection of suppressor tolerance in yeast and provide insights into the molecular basis of trade-offs between fitness and evolutionary potential. ..
  7. Fournier T, Schacherer J. Genetic backgrounds and hidden trait complexity in natural populations. Curr Opin Genet Dev. 2017;47:48-53 pubmed publisher