Research Topics

Igor A Schepetkin

Summary

Publications

  1. Khlebnikov A, Schepetkin I, Kishkentaeva A, Shaimerdenova Z, Atazhanova G, Adekenov S, et al. Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70. Molecules. 2019;24: pubmed publisher
    ..We suggest that natural and/or semi-synthetic SLs with an α -methylene- γ -lactone moiety can specifically target GSH and the kinase site of ZAP-70 and inhibit the initial phases of TCR activation. ..
  2. Zykova M, Schepetkin I, Belousov M, Krivoshchekov S, Logvinova L, Bratishko K, et al. Physicochemical Characterization and Antioxidant Activity of Humic Acids Isolated from Peat of Various Origins. Molecules. 2018;23: pubmed publisher
    ..Overall, these data provide a molecular basis to explain at least part of the beneficial therapeutic properties of peat-derived HAs. ..
  3. Kouakou K, Schepetkin I, Jun S, Kirpotina L, Yapi A, Khramova D, et al. Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis. BMC Complement Altern Med. 2013;13:149 pubmed publisher
    ..However, little is known about the high-molecular weight active components conferring therapeutic properties to these extracts...