Igor A Schepetkin
Khlebnikov A, Schepetkin I, Kishkentaeva A, Shaimerdenova Z, Atazhanova G, Adekenov S, et al
. Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70. Molecules. 2019;24: pubmed publisher
..We suggest that natural and/or semi-synthetic SLs with an α -methylene- γ -lactone moiety can specifically target GSH and the kinase site of ZAP-70 and inhibit the initial phases of TCR activation. ..
Zykova M, Schepetkin I, Belousov M, Krivoshchekov S, Logvinova L, Bratishko K, et al
. Physicochemical Characterization and Antioxidant Activity of Humic Acids Isolated from Peat of Various Origins. Molecules. 2018;23: pubmed publisher
..Overall, these data provide a molecular basis to explain at least part of the beneficial therapeutic properties of peat-derived HAs. ..
Kouakou K, Schepetkin I, Jun S, Kirpotina L, Yapi A, Khramova D, et al
. Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: beneficial effects in experimental autoimmune encephalomyelitis. BMC Complement Altern Med. 2013;13:149 pubmed publisher
..However, little is known about the high-molecular weight active components conferring therapeutic properties to these extracts...