Giovanni Scapagnini

Summary

Publications

  1. doi request reprint Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Mol Neurobiol 44:192-201. 2011
  2. pmc Pleiotropic protective effects of phytochemicals in Alzheimer's disease
    Sergio Davinelli
    Clinical Biochemistry and Clinical Molecular Biology Laboratory, Department of Health Sciences, University of Molise, 86100 Campobasso, Italy
    Oxid Med Cell Longev 2012:386527. 2012
  3. ncbi request reprint Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Adv Exp Med Biol 698:27-35. 2010
  4. ncbi request reprint Synergistic effect of L-Carnosine and EGCG in the prevention of physiological brain aging
    Sergio Davinelli
    Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy
    Curr Pharm Des 19:2722-7. 2013
  5. ncbi request reprint The major green tea polyphenol, (-)-epigallocatechin-3-gallate, induces heme oxygenase in rat neurons and acts as an effective neuroprotective agent against oxidative stress
    Loriana Romeo
    SPES Dipartimento di Scienze per la Salute, Facolta di Medicina, Universita del Molise, via DeSanctis, Campobasso, Italy
    J Am Coll Nutr 28:492S-499S. 2009
  6. doi request reprint Antioxidants as antidepressants: fact or fiction?
    Giovanni Scapagnini
    Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
    CNS Drugs 26:477-90. 2012
  7. pmc Muscle uncoupling protein 3 expression is unchanged by chronic ephedrine/caffeine treatment: results of a double blind, randomised clinical trial in morbidly obese females
    Renata Bracale
    Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
    PLoS ONE 9:e98244. 2014
  8. ncbi request reprint Therapeutic Potential of Dietary Polyphenols against Brain Ageing and Neurodegenerative Disorders
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Adv Exp Med Biol 698:27-35. 2011
  9. pmc The "Alzheimer's disease signature": potential perspectives for novel biomarkers
    Sergio Davinelli
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Immun Ageing 8:7. 2011
  10. pmc Extending healthy ageing: nutrient sensitive pathway and centenarian population
    Sergio Davinelli
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Immun Ageing 9:9. 2012

Collaborators

Detail Information

Publications12

  1. doi request reprint Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Mol Neurobiol 44:192-201. 2011
    ..These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against cognitive decline...
  2. pmc Pleiotropic protective effects of phytochemicals in Alzheimer's disease
    Sergio Davinelli
    Clinical Biochemistry and Clinical Molecular Biology Laboratory, Department of Health Sciences, University of Molise, 86100 Campobasso, Italy
    Oxid Med Cell Longev 2012:386527. 2012
    ..We will focus on specific molecular targets of these selected phytochemical compounds highlighting the correlations between their neuroprotective functions and their potential therapeutic value in AD...
  3. ncbi request reprint Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disorders
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Adv Exp Med Biol 698:27-35. 2010
    ..These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against the acute neurodegenerative conditions that affect many in the world's increasingly ageing population...
  4. ncbi request reprint Synergistic effect of L-Carnosine and EGCG in the prevention of physiological brain aging
    Sergio Davinelli
    Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy
    Curr Pharm Des 19:2722-7. 2013
    ..Our results indicate that the combined administration of EGCG and L-Carnosine would benefit the treatment and prevention of neurodegenerative diseases by reducing the neuronal damage caused by oxidative stress...
  5. ncbi request reprint The major green tea polyphenol, (-)-epigallocatechin-3-gallate, induces heme oxygenase in rat neurons and acts as an effective neuroprotective agent against oxidative stress
    Loriana Romeo
    SPES Dipartimento di Scienze per la Salute, Facolta di Medicina, Universita del Molise, via DeSanctis, Campobasso, Italy
    J Am Coll Nutr 28:492S-499S. 2009
    ..Recently, green tea catechins have received much attention, as they can facilitate a number of antioxidative mechanisms and improve glycemic control...
  6. doi request reprint Antioxidants as antidepressants: fact or fiction?
    Giovanni Scapagnini
    Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
    CNS Drugs 26:477-90. 2012
    ..There is an urgent need to develop better tolerated and more effective treatments for depressive disorders and several antioxidant treatments appear promising and deserve further study...
  7. pmc Muscle uncoupling protein 3 expression is unchanged by chronic ephedrine/caffeine treatment: results of a double blind, randomised clinical trial in morbidly obese females
    Renata Bracale
    Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
    PLoS ONE 9:e98244. 2014
    ..Our study provides evidence that 4-week EC administration resulted in a pronounced thermogenic effect not related to muscle UCP3 gene expression and weight loss in morbidly obese females under controlled conditions...
  8. ncbi request reprint Therapeutic Potential of Dietary Polyphenols against Brain Ageing and Neurodegenerative Disorders
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Adv Exp Med Biol 698:27-35. 2011
    ..These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against the acute neurodegenerative conditions that affect many in the world's increasingly ageing population...
  9. pmc The "Alzheimer's disease signature": potential perspectives for novel biomarkers
    Sergio Davinelli
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Immun Ageing 8:7. 2011
    ..We also discuss the latest and most significant results that will help to define a specific disease signature whose validity might be clinically relevant for future AD diagnosis...
  10. pmc Extending healthy ageing: nutrient sensitive pathway and centenarian population
    Sergio Davinelli
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Immun Ageing 9:9. 2012
    ..Finally, we also discuss the potential role of Nrf2 system in the pro-ageing signaling emphasizing its phytohormetic activation...
  11. ncbi request reprint Role of sirtuins, calorie restriction and physical activity in aging
    Graziamaria Corbi
    Department of Health Sciences, Faculty of Medicine and Surgery, University of Molise, via Giovanni Paolo II Localita Tappino, 86100 Campobasso, Italy
    Front Biosci (Elite Ed) 4:768-78. 2012
    ..However, in aged rats a moderate prolonged exercise training is able to induce increase in SIRT1 activity, suggesting that this tool could counteract age-related dysfunctions...
  12. ncbi request reprint Genetic risk factors and candidate biomarkers for Alzheimer's disease
    Giovanni Scapagnini
    Department of Health Sciences, University of Molise, Campobasso, Italy
    Front Biosci (Schol Ed) 2:616-22. 2010
    ..This review will elaborate on the available selection of genetic and biochemical biomarkers for AD, with a particular reference to those linked to inflammation and oxidative stress...