Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disordersGiovanni Scapagnini
Department of Health Sciences, University of Molise, Campobasso, Italy
Mol Neurobiol 44:192-201. 2011
..These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against cognitive decline...
Pleiotropic protective effects of phytochemicals in Alzheimer's diseaseSergio Davinelli
Clinical Biochemistry and Clinical Molecular Biology Laboratory, Department of Health Sciences, University of Molise, 86100 Campobasso, Italy
Oxid Med Cell Longev 2012:386527. 2012
..We will focus on specific molecular targets of these selected phytochemical compounds highlighting the correlations between their neuroprotective functions and their potential therapeutic value in AD...
Therapeutic potential of dietary polyphenols against brain ageing and neurodegenerative disordersGiovanni Scapagnini
Department of Health Sciences, University of Molise, Campobasso, Italy
Adv Exp Med Biol 698:27-35. 2010
..These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against the acute neurodegenerative conditions that affect many in the world's increasingly ageing population...
- The major green tea polyphenol, (-)-epigallocatechin-3-gallate, induces heme oxygenase in rat neurons and acts as an effective neuroprotective agent against oxidative stress
Loriana Romeo
SPES Dipartimento di Scienze per la Salute, Facolta di Medicina, Universita del Molise, via DeSanctis, Campobasso, Italy
J Am Coll Nutr 28:492S-499S. 2009
..Recently, green tea catechins have received much attention, as they can facilitate a number of antioxidative mechanisms and improve glycemic control...
- Antioxidants as antidepressants: fact or fiction?
Giovanni Scapagnini
Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy
CNS Drugs 26:477-90. 2012
..There is an urgent need to develop better tolerated and more effective treatments for depressive disorders and several antioxidant treatments appear promising and deserve further study...
- The "Alzheimer's disease signature": potential perspectives for novel biomarkers
Sergio Davinelli
Department of Health Sciences, University of Molise, Campobasso, Italy
Immun Ageing 8:7. 2011
..We also discuss the latest and most significant results that will help to define a specific disease signature whose validity might be clinically relevant for future AD diagnosis...
- Therapeutic Potential of Dietary Polyphenols against Brain Ageing and Neurodegenerative Disorders
Giovanni Scapagnini
Department of Health Sciences, University of Molise, Campobasso, Italy
Adv Exp Med Biol 698:27-35. 2011
..These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against the acute neurodegenerative conditions that affect many in the world's increasingly ageing population...
- Role of sirtuins, calorie restriction and physical activity in aging
Graziamaria Corbi
Department of Health Sciences, Faculty of Medicine and Surgery, University of Molise, via Giovanni Paolo II Localita Tappino, 86100 Campobasso, Italy
Front Biosci (Elite Ed) 4:768-78. 2012
..However, in aged rats a moderate prolonged exercise training is able to induce increase in SIRT1 activity, suggesting that this tool could counteract age-related dysfunctions...
- Extending healthy ageing: nutrient sensitive pathway and centenarian population
Sergio Davinelli
Department of Health Sciences, University of Molise, Campobasso, Italy
Immun Ageing 9:9. 2012
..Finally, we also discuss the potential role of Nrf2 system in the pro-ageing signaling emphasizing its phytohormetic activation...
- Genetic risk factors and candidate biomarkers for Alzheimer's disease
Giovanni Scapagnini
Department of Health Sciences, University of Molise, Campobasso, Italy
Front Biosci (Schol Ed) 2:616-22. 2010
..This review will elaborate on the available selection of genetic and biochemical biomarkers for AD, with a particular reference to those linked to inflammation and oxidative stress...
