Mohamed M Sayed-Ahmed

Summary

Publications

  1. ncbi request reprint Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model
    Abdulhakeem A Al-Majed
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Pharmacol Res 53:278-86. 2006
  2. ncbi request reprint L-carnitine prevents the progression of atherosclerotic lesions in hypercholesterolaemic rabbits
    M M Sayed-Ahmed
    Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo, Egypt
    Pharmacol Res 44:235-42. 2001
  3. ncbi request reprint Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia
    Clin Exp Pharmacol Physiol 34:399-405. 2007
  4. doi request reprint Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Eur J Pharmacol 640:143-9. 2010
  5. ncbi request reprint Progression of cisplatin-induced nephrotoxicity in a carnitine-depleted rat model
    Mohamed M Sayed-Ahmed
    Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Fum El Khalig, Kasr El Aini Street, Cairo, Egypt
    Chemotherapy 50:162-70. 2004
  6. ncbi request reprint Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues
    Abdulaziz M Aleisa
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Clin Exp Pharmacol Physiol 34:1252-9. 2007
  7. pmc Downregulation of oxidative and nitrosative apoptotic signaling by L-carnitine in Ifosfamide-induced Fanconi syndrome rat model
    Mohamed M Sayed-Ahmed
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Oxid Med Cell Longev 2012:696704. 2012
  8. doi request reprint Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats
    Mahmoud N Nagi
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 25:135-42. 2011
  9. doi request reprint Increased urinary losses of carnitine and decreased intramitochondrial coenzyme A in gentamicin-induced acute renal failure in rats
    Othman A Al-Shabanah
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Kingdom of Saudi Arabia
    Nephrol Dial Transplant 25:69-76. 2010
  10. ncbi request reprint Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus
    Abdulhakeem A Al-Majed
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Clin Exp Pharmacol Physiol 33:725-33. 2006

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Propionyl-L-carnitine prevents the progression of cisplatin-induced cardiomyopathy in a carnitine-depleted rat model
    Abdulhakeem A Al-Majed
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Pharmacol Res 53:278-86. 2006
    ....
  2. ncbi request reprint L-carnitine prevents the progression of atherosclerotic lesions in hypercholesterolaemic rabbits
    M M Sayed-Ahmed
    Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Cairo, Egypt
    Pharmacol Res 44:235-42. 2001
    ....
  3. ncbi request reprint Thymoquinone supplementation prevents the development of gentamicin-induced acute renal toxicity in rats
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Kingdom of Saudi Arabia
    Clin Exp Pharmacol Physiol 34:399-405. 2007
    ....
  4. doi request reprint Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Eur J Pharmacol 640:143-9. 2010
    ..The progressive increase in cardiotoxicity enzymatic indices and the decrease in H-FABP and OCTN2 expression may point to the possible contribution of H-FABP and OCTN2 as a mechanism during development of doxorubicin cardiotoxicity...
  5. ncbi request reprint Progression of cisplatin-induced nephrotoxicity in a carnitine-depleted rat model
    Mohamed M Sayed-Ahmed
    Pharmacology Unit, Cancer Biology Department, National Cancer Institute, Fum El Khalig, Kasr El Aini Street, Cairo, Egypt
    Chemotherapy 50:162-70. 2004
    ....
  6. ncbi request reprint Reversal of cisplatin-induced carnitine deficiency and energy starvation by propionyl-L-carnitine in rat kidney tissues
    Abdulaziz M Aleisa
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Clin Exp Pharmacol Physiol 34:1252-9. 2007
    ..This will open new perspectives for the use of PLC in the treatment of renal diseases associated with or secondary to carnitine deficiency...
  7. pmc Downregulation of oxidative and nitrosative apoptotic signaling by L-carnitine in Ifosfamide-induced Fanconi syndrome rat model
    Mohamed M Sayed-Ahmed
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Oxid Med Cell Longev 2012:696704. 2012
    ..Data from this study suggest that L-carnitine prevents the development of IFO-induced nephrotoxicity via downregulation of oxidative and nitrosative apoptotic signaling in kidney tissues...
  8. doi request reprint Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats
    Mahmoud N Nagi
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    J Biochem Mol Toxicol 25:135-42. 2011
    ....
  9. doi request reprint Increased urinary losses of carnitine and decreased intramitochondrial coenzyme A in gentamicin-induced acute renal failure in rats
    Othman A Al-Shabanah
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Kingdom of Saudi Arabia
    Nephrol Dial Transplant 25:69-76. 2010
    ....
  10. ncbi request reprint Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus
    Abdulhakeem A Al-Majed
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Clin Exp Pharmacol Physiol 33:725-33. 2006
    ..The results of the present study will open up new perspectives for the use of PLC in the treatment of neurodegenerative diseases associated with, or secondary to, myocardial ischaemia-reperfusion injury and chronic circulatory failure...
  11. pmc Progression of diethylnitrosamine-induced hepatic carcinogenesis in carnitine-depleted rats
    Salim S Al-Rejaie
    Department of Pharmacology, College of Pharmacy, King Saud University, PO Box 2457, Kingdom of Saudi Arabia
    World J Gastroenterol 15:1373-80. 2009
    ..To investigate whether carnitine deficiency is a risk factor during the development of diethylnitrosamine (DENA)-induced hepatic carcinogenesis...
  12. pmc Metformin rescues the myocardium from doxorubicin-induced energy starvation and mitochondrial damage in rats
    Abdelkader E Ashour
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Oxid Med Cell Longev 2012:434195. 2012
    ..These findings demonstrate that MET successfully prevents DOX-induced cardiotoxicity in vivo by inhibiting DOX-induced oxidative stress, energy starvation, and depletion of intramitochondrial CoA-SH...
  13. doi request reprint Thymoquinone supplementation reverses acetaminophen-induced oxidative stress, nitric oxide production and energy decline in mice liver
    Mahmoud N Nagi
    Department of Pharmacology, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
    Food Chem Toxicol 48:2361-5. 2010
    ..In conclusion, TQ is effective in protecting mice against acetaminophen-induced hepatotoxicity possibly via increased resistance to oxidative and nitrosative stress as well as its ability to improve the mitochondrial energy production...
  14. pmc Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through TFG-β/Smad p53 pathway in rat model
    Othman A Al-Shabanah
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Oxid Med Cell Longev 2012:619185. 2012
    ..2) DOX increases apoptosis through upregulation of CDKN2A and p53 and downregulation of Mdm2 gene expression. (3) The preventive effect of DFX against DOX-induced cardiotoxicity is mediated via the TGF-β1/Smad pathway...
  15. doi request reprint L-Carnitine attenuates ifosfamide-induced carnitine deficiency and decreased intramitochondrial CoA-SH in rat kidney tissues
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    J Nephrol 24:490-8. 2011
    ..This study aimed to investigate, on a mechanism basis, whether L-carnitine could prevent the development of IFO-induced Fanconi syndrome in rats...
  16. pmc Inhibition of gene expression of organic cation/carnitine transporter and antioxidant enzymes in oxazaphosphorines-induced acute cardiomyopathic rat models
    Mohamed M Sayed-Ahmed
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Oxid Med Cell Longev 2012:452902. 2012
    ..3) Carnitine supplementation attenuates CP but not IFO-induced inhibition of OCTN2 mRNA and protein expression in heart and kidney tissues...
  17. doi request reprint Carnitine deficiency aggravates cyclophosphamide-induced cardiotoxicity in rats
    Amal G Fatani
    Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Chemotherapy 56:71-81. 2010
    ....
  18. doi request reprint Nitric oxide pros and cons: The role of L-arginine, a nitric oxide precursor, and idebenone, a coenzyme-Q analogue in ameliorating cerebral hypoxia in rat
    Nayira A Abdel Baky
    Pharmacology Department, Faculty of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Brain Res Bull 83:49-56. 2010
    ..This study showed that ID and l-arg were capable of reducing neurological injury following HP in rat, and support the idea of the usefulness of l-arg and ID as prophylaxis from hypoxic brain injury...
  19. doi request reprint Progression of cyclophosphamide-induced acute renal metabolic damage in carnitine-depleted rat model
    Mohamed M Sayed-Ahmed
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh, 11451, Kingdom of Saudi Arabia
    Clin Exp Nephrol 14:418-26. 2010
    ....
  20. pmc Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat
    Salem S Al-Rejaie
    Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia
    BMC Complement Altern Med 13:136. 2013
    ..Rutin (RT) is a natural flavonoid (vitamin p), which possesses an antioxidant activity with protective potential. The present study aimed to examine the potential effects of rutin on hypercholesterolemia-induced hepatotoxicity in rat...
  21. ncbi request reprint Probucol attenuates oxidative stress and energy decline in isoproterenol-induced heart failure in rat
    Ebtehal El-Demerdash
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Abasia, Cairo, Egypt
    Pharmacol Res 51:311-8. 2005
    ....
  22. ncbi request reprint Protective role of carnitine esters against alcohol-induced gastric lesions in rats
    Hossam M M Arafa
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
    Pharmacol Res 48:285-90. 2003
    ....
  23. doi request reprint Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression
    Abdulqader A Alhaider
    Department of Pharmacology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Chem Biol Interact 192:233-42. 2011
    ..Our data lend further credence for the contribution of metformin in the nephroprotective effect in addition to its well known hypoglycemic action...
  24. ncbi request reprint New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity
    Ebtehal El-Demerdash
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt
    Cancer Chemother Pharmacol 52:411-6. 2003
    ....
  25. doi request reprint Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: molecular docking study
    Adel S El-Azab
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University Riyadh 11451, Saudi Arabia
    Eur J Med Chem 45:4188-98. 2010
    ..59 microg/ml. Virtual screening was carried out through docking the designed compounds into the ATP binding site of epidermal growth factor receptor (EGFR) to predict if these compounds have analogous binding mode to the EGFR inhibitors...
  26. ncbi request reprint MicroRNAs and metastasis-related gene expression in Egyptian breast cancer patients
    Mohamed M Hafez
    Collage of Pharmacy, Pharmacology Department, King Saud University, Riyadh, Saudi Arabia
    Asian Pac J Cancer Prev 13:591-8. 2012
    ..The present study was conducted to study miRNAs in Egyptian breast cancer (BC) and their relation to metastasis, tumor invasion and apoptosis in addition to their association with the ER and PR statuses...