K W Saupe

Summary

Publications

  1. ncbi request reprint Impaired cardiac energetics in mice lacking muscle-specific isoenzymes of creatine kinase
    K W Saupe
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circ Res 82:898-907. 1998
  2. ncbi request reprint Comparison of hearts with 2 types of pressure-overload left ventricular hypertrophy
    K W Saupe
    Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
    Hypertension 35:1167-72. 2000
  3. ncbi request reprint Metabolic support as an adjunct to inotropic support in the hypoperfused heart
    K W Saupe
    Cardiac Muscle Research Laboratory, Boston University School of Medicine, 650 Albany St, X720, Boston, MA 02118, USA
    J Mol Cell Cardiol 33:261-9. 2001
  4. ncbi request reprint Kinetic, thermodynamic, and developmental consequences of deleting creatine kinase isoenzymes from the heart. Reaction kinetics of the creatine kinase isoenzymes in the intact heart
    K W Saupe
    Cardiac Muscle Research Laboratory, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 275:19742-6. 2000
  5. pmc Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy
    M Spindler
    NMR Laboratory for Physiological Chemistry, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 101:1775-83. 1998
  6. ncbi request reprint Endogenous nitric oxide enhances coupling between O2 consumption and ATP synthesis in guinea pig hearts
    W Shen
    NMR Laboratory for Physiological Chemistry, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Heart Circ Physiol 281:H838-46. 2001
  7. ncbi request reprint Exercise training attenuates age-associated diastolic dysfunction in rats
    D A Brenner
    Cardiac Muscle Research Laboratory, Boston University School of Medicine, Boston, MA 02118, USA
    Circulation 104:221-6. 2001
  8. ncbi request reprint Exercise intolerance in rats with hypertensive heart disease is associated with impaired diastolic relaxation
    M Guazzi
    Institute of Cardiology, University of Milan, Milan, Italy
    Hypertension 37:204-8. 2001

Detail Information

Publications8

  1. ncbi request reprint Impaired cardiac energetics in mice lacking muscle-specific isoenzymes of creatine kinase
    K W Saupe
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
    Circ Res 82:898-907. 1998
    ....
  2. ncbi request reprint Comparison of hearts with 2 types of pressure-overload left ventricular hypertrophy
    K W Saupe
    Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
    Hypertension 35:1167-72. 2000
    ..65 to 0.80) with the degree of LV stiffening. We conclude that in Dahl rats, LVH secondary to hypertension protects against ischemia-induced diastolic dysfunction by minimizing the size of the region of severe acidosis...
  3. ncbi request reprint Metabolic support as an adjunct to inotropic support in the hypoperfused heart
    K W Saupe
    Cardiac Muscle Research Laboratory, Boston University School of Medicine, 650 Albany St, X720, Boston, MA 02118, USA
    J Mol Cell Cardiol 33:261-9. 2001
    ..We conclude that inotropic support of the hypoperfused heart can cause new diastolic dysfunction, but that this diastolic dysfunction can be eliminated by preserving myocardial high-energy phosphates with increased glucose and insulin...
  4. ncbi request reprint Kinetic, thermodynamic, and developmental consequences of deleting creatine kinase isoenzymes from the heart. Reaction kinetics of the creatine kinase isoenzymes in the intact heart
    K W Saupe
    Cardiac Muscle Research Laboratory, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 275:19742-6. 2000
    ..Finally, combined loss of M- and Mt-CK (but not loss of only M-CK) prevented the amount of free energy released from ATP hydrolysis from increasing when pyruvate was provided as a substrate for oxidative phosphorylation...
  5. pmc Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy
    M Spindler
    NMR Laboratory for Physiological Chemistry, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 101:1775-83. 1998
    ..Changes in high-energy phosphate content suggest that an energy-requiring process may contribute to the observed diastolic dysfunction...
  6. ncbi request reprint Endogenous nitric oxide enhances coupling between O2 consumption and ATP synthesis in guinea pig hearts
    W Shen
    NMR Laboratory for Physiological Chemistry, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Heart Circ Physiol 281:H838-46. 2001
    ..Thus, because inhibition of eNO production by L-NNA increased MVO2 without a change in the ATP synthesis rate, these data suggest that eNO increases myocardial metabolic efficiency by reducing MVO2 in the heart...
  7. ncbi request reprint Exercise training attenuates age-associated diastolic dysfunction in rats
    D A Brenner
    Cardiac Muscle Research Laboratory, Boston University School of Medicine, Boston, MA 02118, USA
    Circulation 104:221-6. 2001
    ..CONCLUSIONS: Our findings indicate that in rats, some age-associated changes in diastolic function are reversible and thus may not be intrinsic to aging but instead secondary to other processes, such as deconditioning...
  8. ncbi request reprint Exercise intolerance in rats with hypertensive heart disease is associated with impaired diastolic relaxation
    M Guazzi
    Institute of Cardiology, University of Milan, Milan, Italy
    Hypertension 37:204-8. 2001
    ..However, studies in which LV function is assessed during exercise are needed to conclusively define the roles of systolic and diastolic dysfunction in causing exercise intolerance...