- Impaired cardiac energetics in mice lacking muscle-specific isoenzymes of creatine kinase
K W Saupe
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
Circ Res 82:898-907. 1998
- Comparison of hearts with 2 types of pressure-overload left ventricular hypertrophy
K W Saupe
Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute, Boston University School of Medicine, MA 02118, USA
Hypertension 35:1167-72. 2000
..65 to 0.80) with the degree of LV stiffening. We conclude that in Dahl rats, LVH secondary to hypertension protects against ischemia-induced diastolic dysfunction by minimizing the size of the region of severe acidosis...
- Metabolic support as an adjunct to inotropic support in the hypoperfused heart
K W Saupe
Cardiac Muscle Research Laboratory, Boston University School of Medicine, 650 Albany St, X720, Boston, MA 02118, USA
J Mol Cell Cardiol 33:261-9. 2001
..We conclude that inotropic support of the hypoperfused heart can cause new diastolic dysfunction, but that this diastolic dysfunction can be eliminated by preserving myocardial high-energy phosphates with increased glucose and insulin...
- Kinetic, thermodynamic, and developmental consequences of deleting creatine kinase isoenzymes from the heart. Reaction kinetics of the creatine kinase isoenzymes in the intact heart
K W Saupe
Cardiac Muscle Research Laboratory, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 275:19742-6. 2000
..Finally, combined loss of M- and Mt-CK (but not loss of only M-CK) prevented the amount of free energy released from ATP hydrolysis from increasing when pyruvate was provided as a substrate for oxidative phosphorylation...
- Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy
NMR Laboratory for Physiological Chemistry, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 101:1775-83. 1998
..Changes in high-energy phosphate content suggest that an energy-requiring process may contribute to the observed diastolic dysfunction...
- Endogenous nitric oxide enhances coupling between O2 consumption and ATP synthesis in guinea pig hearts
NMR Laboratory for Physiological Chemistry, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Heart Circ Physiol 281:H838-46. 2001
..Thus, because inhibition of eNO production by L-NNA increased MVO2 without a change in the ATP synthesis rate, these data suggest that eNO increases myocardial metabolic efficiency by reducing MVO2 in the heart...
- Exercise training attenuates age-associated diastolic dysfunction in rats
D A Brenner
Cardiac Muscle Research Laboratory, Boston University School of Medicine, Boston, MA 02118, USA
Circulation 104:221-6. 2001
..CONCLUSIONS: Our findings indicate that in rats, some age-associated changes in diastolic function are reversible and thus may not be intrinsic to aging but instead secondary to other processes, such as deconditioning...
- Exercise intolerance in rats with hypertensive heart disease is associated with impaired diastolic relaxation
Institute of Cardiology, University of Milan, Milan, Italy
Hypertension 37:204-8. 2001
..However, studies in which LV function is assessed during exercise are needed to conclusively define the roles of systolic and diastolic dysfunction in causing exercise intolerance...