Shahab Uddin

Summary

Affiliation: King Faisal Specialist Hospital and Research Centre
Country: Saudi Arabia

Publications

  1. ncbi request reprint Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis
    Amit Verma
    Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Affairs Medical Center, Chicago, Illinois 60607, USA
    J Biol Chem 277:7726-35. 2002
  2. ncbi request reprint Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, Riyadh, Saudi Arabia
    Oncogene 24:7022-30. 2005
  3. ncbi request reprint Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis
    Khawla S Al-Kuraya
    Research Research Centre, King Faisal Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    Saudi Med J 27:323-8. 2006
  4. doi request reprint Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis
    Shahab Uddin
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, MBC 98 16, P O Box 3354, Riyadh, 11211, Saudi Arabia
    Tumour Biol 35:871-9. 2014
  5. pmc Role of leptin and its receptors in the pathogenesis of thyroid cancer
    Shahab Uddin
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia
    Int J Clin Exp Pathol 4:637-43. 2011
  6. ncbi request reprint Mechanisms of type-I interferon signal transduction
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Biochem Mol Biol 37:635-41. 2004
  7. ncbi request reprint Inhibition of phosphatidylinositol 3'-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, Riyadh, Saudi Arabia
    Clin Cancer Res 11:3102-8. 2005
  8. ncbi request reprint Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Blood 108:4178-86. 2006
  9. ncbi request reprint Developing curcumin into a viable therapeutic for lymphoma
    Shahab Uddin
    Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, MBC 98 16, PO Box 3354, Riyadh 11211, Saudi Arabia
    Expert Opin Investig Drugs 18:57-67. 2009
  10. doi request reprint Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer
    Shahab Uddin
    King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Int J Cancer 126:382-94. 2010

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type I interferons and transforming growth factor-beta on normal hematopoiesis
    Amit Verma
    Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Affairs Medical Center, Chicago, Illinois 60607, USA
    J Biol Chem 277:7726-35. 2002
    ....
  2. ncbi request reprint Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, Riyadh, Saudi Arabia
    Oncogene 24:7022-30. 2005
    ..Therefore, curcumin may have a future therapeutic role in PEL and possibly other malignancies with constitutive activation of STAT3...
  3. ncbi request reprint Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis
    Khawla S Al-Kuraya
    Research Research Centre, King Faisal Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
    Saudi Med J 27:323-8. 2006
    ..To document the incidence and role of p53 and DNA mismatch repair proteins in colorectal carcinomas, and to evaluate the relative frequency of major molecular pathways in colorectal cancers from Saudi Arabia...
  4. doi request reprint Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis
    Shahab Uddin
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, MBC 98 16, P O Box 3354, Riyadh, 11211, Saudi Arabia
    Tumour Biol 35:871-9. 2014
    ..In this review, current understanding of leptin and its receptor's roles in the pathogenesis of colonogenic cancer has been described. ..
  5. pmc Role of leptin and its receptors in the pathogenesis of thyroid cancer
    Shahab Uddin
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia
    Int J Clin Exp Pathol 4:637-43. 2011
    ..In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described...
  6. ncbi request reprint Mechanisms of type-I interferon signal transduction
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Biochem Mol Biol 37:635-41. 2004
    ..Recent developments in this research area are emphasized and the implications of these new discoveries on our understanding of interferon actions are discussed...
  7. ncbi request reprint Inhibition of phosphatidylinositol 3'-kinase/AKT signaling promotes apoptosis of primary effusion lymphoma cells
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, Riyadh, Saudi Arabia
    Clin Cancer Res 11:3102-8. 2005
    ..However, the role of PI3'-kinase in KSHV-associated primary effusion lymphoma (PEL) is not known. To assess this, we studied survival and apoptosis in PEL cell lines following inhibition of PI3'-kinase...
  8. ncbi request reprint Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Blood 108:4178-86. 2006
    ..In multivariate analysis, this correlation was no longer significant. Altogether, these results suggest that the PI3K/AKT pathway may be a potential target for therapeutic intervention in DLBCL...
  9. ncbi request reprint Developing curcumin into a viable therapeutic for lymphoma
    Shahab Uddin
    Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, MBC 98 16, PO Box 3354, Riyadh 11211, Saudi Arabia
    Expert Opin Investig Drugs 18:57-67. 2009
    ..Curcumin has been shown to have cancer chemopreventive potential against a variety of tumors via targeting key survival pathways that are aberrantly activated in cancer cells...
  10. doi request reprint Cyclooxygenase-2 inhibition inhibits PI3K/AKT kinase activity in epithelial ovarian cancer
    Shahab Uddin
    King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Int J Cancer 126:382-94. 2010
    ..These data identify COX-2 as a potential biomarker and therapeutic target in distinct molecular subtypes of ovarian cancer...
  11. ncbi request reprint Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway
    Shahab Uddin
    King Fahad National Center for Children s Cancer and Research, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    Biochem Biophys Res Commun 320:932-8. 2004
    ....
  12. doi request reprint Bortezomib-mediated expression of p27Kip1 through S-phase kinase protein 2 degradation in epithelial ovarian cancer
    Shahab Uddin
    Department of Human Cancer Genomic Research, King Fahad National Centre for Children s Cancer and Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Lab Invest 89:1115-27. 2009
    ..Altogether, our results suggest that SKP2 and ubiquitin-proteasome pathway may be a potential target for therapeutic intervention for treatment of EOC...
  13. doi request reprint Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling
    Azhar R Hussain
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Pathol 222:180-90. 2010
    ..In summary, our data suggest that XIAP expression is a poor prognostic factor in DLBCL and the XIAP-AKT relationship should be explored further as a potential therapeutic target in DLBCL...
  14. pmc Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population
    Abdul K Siraj
    Cancer Genomics, Research Centre, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    BMC Med Genet 9:61. 2008
    ..To evaluate the role of genetic polymorphisms of xenobiotic genes in thyroid cancer, we conducted a hospital-based case-control study in Saudi population...
  15. doi request reprint Leptin receptor expression in Middle Eastern colorectal cancer and its potential clinical implication
    Shahab Uddin
    Human Cancer Genomic Research, Research Centre, Saudi Arabia
    Carcinogenesis 30:1832-40. 2009
    ..0098). Ob plays a critical role in CRC carcinogenesis through PI3K/AKT pathway via Ob-R. Ob-R is a prognostic marker associated with better survival...
  16. doi request reprint Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma
    Jehad Abubaker
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    J Pathol 219:435-45. 2009
    ..Our results highlight the differential role of KRAS isoforms in CRC, their utility as a prognostic biomarker, and underline the importance of KRAS alterations as a potential therapeutic target for CRC...
  17. pmc Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma
    Prashant Bavi
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Am J Pathol 178:2109-20. 2011
    ..Altogether, our results suggest that UBE2C and the ubiquitin-proteasome pathway may be potential targets for therapeutic intervention in CRC...
  18. doi request reprint High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target
    Shahab Uddin
    Department of Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, Research Center, Riyadh, Saudi Arabia
    Am J Gastroenterol 104:1790-801. 2009
    ..However, the role of FASN in colorectal cancer (CRC) has not been fully elucidated. We investigated the expression of FASN and determined its functional association with the PI3/AKT pathway in CRC...
  19. doi request reprint Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma
    Shahab Uddin
    Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Endocr Relat Cancer 17:191-202. 2010
    ..Altogether, these data show that leptin plays an important role in PTC pathogenesis through PI3K/AKT pathway via Ob-R and is a potential prognostic marker associated with an aggressive phenotype and poor disease-free survival...
  20. doi request reprint Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers
    Shahab Uddin
    Department of Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Cancer, Riyadh 11211, Saudi Arabia
    J Clin Endocrinol Metab 93:4088-97. 2008
    ..Fatty acid synthase (FASN) is an enzyme that plays a critical role in de novo synthesis of fatty acids. FASN is overexpressed in variety of human cancers, but its role has not been elucidated in papillary thyroid carcinoma (PTC)...
  21. pmc Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis
    Azhar R Hussain
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    PLoS ONE 7:e39945. 2012
    ..NFkBis constitutively activated in a number of malignancies, including multiple myeloma, Burkitt's lymphoma and diffuse large cell B-cell lymphoma. However, its role in primary effusion lymphoma has not been fully explored...
  22. pmc Coexpression of activated c-Met and death receptor 5 predicts better survival in colorectal carcinoma
    Shahab Uddin
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Am J Pathol 179:3032-44. 2011
    ....
  23. pmc Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer
    Shahab Uddin
    Department of Human Cancer Genomic Research, Research Center, Department of Pathology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Cancer 8:74. 2009
    ..This study was design to investigate the prevalence of leptin and Ob-R in Middle Eastern epithelial ovarian cancer (EOC) and to analyze the role of leptin and the mechanisms under its action in EOC tissue sample and cell lines...
  24. pmc PIK3CA alterations in Middle Eastern ovarian cancers
    Jehad Abubaker
    Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Cancer 8:51. 2009
    ..Therefore, we investigated PI3K/AKT genetic alterations such as PIK3CA amplification, PIK3CA mutation, PTEN protein loss and their relationships with various clinicopathological characteristics in 156 EOCs...
  25. doi request reprint Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer
    Zeenath Jehan
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Pathol 219:337-46. 2009
    ..Furthermore, PIK3CA amplification is an independent prognostic marker for better survival and may be one of the promising markers to define CRC subsets that may maximally benefit from adjuvant therapy...
  26. doi request reprint Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines
    Azhar R Hussain
    Department of Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    Mol Cancer Ther 7:3318-29. 2008
    ..These findings also raise the possibility that incorporation of curcumin in treatment regimens may provide a novel approach for the treatment of Burkitt's lymphomas and provide the molecular basis for such future translational efforts...
  27. doi request reprint FoxM1 and its association with matrix metalloproteinases (MMP) signaling pathway in papillary thyroid carcinoma
    Maqbool Ahmed
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Centre, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    J Clin Endocrinol Metab 97:E1-E13. 2012
    ..FoxM1 has also been shown to be associated with matrix metalloproteinases (MMP) in various cancers. However, little is known about its function in papillary thyroid carcinoma (PTC)...
  28. pmc Overexpression of fatty acid synthase in Middle Eastern epithelial ovarian carcinoma activates AKT and Its inhibition potentiates cisplatin-induced apoptosis
    Shahab Uddin
    Human Cancer Genomic Research, Research Center, Riyadh, Saudi Arabia
    Mol Med 17:635-45. 2011
    ..Altogether, our results show overexpression of FASN in Middle Eastern EOC, suggesting that FASN may be a potential therapeutic target in a subset of EOC, alone or in combination with other conventional chemotherapeutic agents...
  29. doi request reprint HGF/c-Met pathway has a prominent role in mediating antiapoptotic signals through AKT in epithelial ovarian carcinoma
    Rong Bu
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Lab Invest 91:124-37. 2011
    ..These results indicate that c-Met/HGF pathway may be a potential target for therapeutic intervention for treatment of EOC...
  30. doi request reprint Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma
    Rong Bu
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Leuk Lymphoma 53:1971-7. 2012
    ....
  31. pmc c-Met inhibitor synergizes with tumor necrosis factor-related apoptosis-induced ligand to induce papillary thyroid carcinoma cell death
    Rong Bu
    Human Cancer Genomic Research, Research Center, Riyadh, Saudi Arabia
    Mol Med 18:167-77. 2012
    ..Our data suggest that the c-Met/AKT pathway may be a potential target for therapeutic intervention for treatment of PTC refractory to conventionally therapeutic modalities...
  32. doi request reprint Proteasome inhibitor MG-132 mediated expression of p27Kip1 via S-phase kinase protein 2 degradation induces cell cycle coupled apoptosis in primary effusion lymphoma cells
    Azhar R Hussain
    Human Cancer Genomic Research, King Fahad National Children s Cancer Center, Riyadh, Saudi Arabia
    Leuk Lymphoma 50:1204-13. 2009
    ....
  33. doi request reprint Leptin receptor expression and its association with PI3K/AKT signaling pathway in diffuse large B-cell lymphoma
    Shahab Uddin
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Leuk Lymphoma 51:1305-14. 2010
    ..Altogether, these data suggest that leptin plays a critical role in DLBCL pathogesis through the P13K/AKT pathway via Ob-R...
  34. pmc Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy
    Shahab Uddin
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Am J Pathol 178:537-47. 2011
    ..Altogether, our data indicate that FoxM1 signaling contributes to aggressiveness in a subset of CRC and that the FOXM1 gene may serve as a useful molecular biomarker and potential therapeutic target...
  35. doi request reprint The biological and clinical impact of inhibition of NF-κB-initiated apoptosis in diffuse large B cell lymphoma (DLBCL)
    Prashant Bavi
    Human Cancer Genomic Research, Research Center, King Fahad National Center for Children s Cancer, Riyadh, Saudi Arabia
    J Pathol 224:355-66. 2011
    ..Altogether, these results suggest that NF-κB may be a useful prognostic biomarker and a potential target for therapeutic intervention in DLBCL...
  36. doi request reprint Inhibition of fatty acid synthase suppresses c-Met receptor kinase and induces apoptosis in diffuse large B-cell lymphoma
    Shahab Uddin
    Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, Research Center, Riyadh, Saudi Arabia
    Mol Cancer Ther 9:1244-55. 2010
    ..These findings provide evidence that FASN, via c-Met tyrosine kinase, plays a critical role in the carcinogenesis of DLBCL and strongly suggest that targeting FASN may have therapeutic value in treatment of DLBCL...
  37. ncbi request reprint Sanguinarine-dependent induction of apoptosis in primary effusion lymphoma cells
    Azhar R Hussain
    Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, Biological and Medical Research, Riyadh 11211, Saudi Arabia
    Cancer Res 67:3888-97. 2007
    ....
  38. pmc Resveratrol suppresses constitutive activation of AKT via generation of ROS and induces apoptosis in diffuse large B cell lymphoma cell lines
    Azhar R Hussain
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    PLoS ONE 6:e24703. 2011
    ....
  39. doi request reprint Demethylation of TMS1 gene sensitizes thyroid cancer cells to TRAIL-induced apoptosis
    Abdul K Siraj
    Department of Human Cancer Genomics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Clin Endocrinol Metab 96:E215-24. 2011
    ..However, its methylation status has not been investigated in thyroid cancer. Therefore, we studied the methylation of TMS1 and its functional consequence in thyroid cancer...
  40. doi request reprint Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma
    Prashant Bavi
    Human Cancer Genomics Research Centre, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    Hum Pathol 39:885-94. 2008
    ..0286) and multivariate analysis with International Prognostic Index (P = .0180). Our study demonstrates the independent prognostic value of cyclin H expression in DLBCL and proposes its use as a prognostic marker...
  41. doi request reprint Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population
    Fouad Al-Dayel
    Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Leuk Lymphoma 49:122-9. 2008
    ..Our findings suggest that polymorphisms of xenobiotic metabolizing enzyme genes may modify the individual susceptibility to develop DLBCL in Saudi Arabian population...
  42. doi request reprint Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer
    Shahab Uddin
    Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital, Riyadh, Saudi Arabia
    Cancer Res 68:3379-88. 2008
    ..Altogether, our results suggest that SKP2 and the ubiquitin-proteasome pathway may be potential targets for therapeutic intervention for treatment of CRC...
  43. pmc Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations
    Prashant Bavi
    Department of Human Cancer Genomic Research, MBC 98 16, Research Centre at KFNCCC, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia
    Mol Cancer 9:203. 2010
    ..Expression of TRAIL receptors is higher in colorectal carcinoma (CRC) as compared to normal colorectal mucosa and targeted therapy with TRAIL leads to preferential killing of tumor cells sparing normal cells...
  44. doi request reprint Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma
    Azhar R Hussain
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    Free Radic Biol Med 50:978-87. 2011
    ....
  45. doi request reprint Inhibition of c-MET is a potential therapeutic strategy for treatment of diffuse large B-cell lymphoma
    Shahab Uddin
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Lab Invest 90:1346-56. 2010
    ..This data also enlightens the fact that c-Met through AKT kinase has a critical role in carcinogenesis of DLBCL, and strongly suggest that targeting c-Met may have therapeutic value in treatment of DLBCL...
  46. doi request reprint Distinct gene expression profiles: nodal versus extranodal diffuse large B-cell lymphoma
    Zeenath Jehan
    Human Cancer Genomic Research, King Fahad National Centre for Children s Cancer and Research, Riyadh, Saudi Arabia
    Oncology 75:71-80. 2008
    ..Perceived differences in outcome between extranodal and nodal DLBCL raise the possibility that these subgroups may represent different biological and clinical entities...
  47. ncbi request reprint Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East
    Abdul K Siraj
    Department of Human Cancer Genomic Research Centre, King Fahad National Center for Children s Cancer and Research, Riyadh, Saudi Arabia
    Ann Hematol 86:887-95. 2007
    ..Additionally, the results indicated that MTHFR variants were not related to MGMT or FHIT hypermethylation in DLBCL...
  48. ncbi request reprint Prevalence of fragile histidine triad expression in tumors from saudi arabia: a tissue microarray analysis
    Prashant Bavi
    Research Centre at KFNCCC and R, King Faisal Specialist Hospital and Research Centre, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    Cancer Epidemiol Biomarkers Prev 15:1708-18. 2006
    ..It encodes the most active common human chromosomal fragile region, FRA3B. We studied the prevalence of loss of FHIT expression in various tumors and correlated its loss with various clinicopathologic features...
  49. pmc Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release
    Azhar R Hussain
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    PLoS ONE 8:e60540. 2013
    ..These data show that p-IκBα can be used as a prognostic marker and target for therapy in this aggressive sub-type of DLBCL and TQ may play an important role in the management of DLBCL in the future...
  50. ncbi request reprint Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population
    Jehad Abubaker
    Department of Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Cancer, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    J Clin Endocrinol Metab 93:611-8. 2008
    ..Mutations in the PIK3CA have also been identified in thyroid cancers and, although relatively common in anaplastic thyroid carcinoma, are uncommon in PTC...
  51. doi request reprint Bortezomib inhibits proteasomal degradation of IκBα and induces mitochondrial dependent apoptosis in activated B-cell diffuse large B-cell lymphoma
    Rong Bu
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Leuk Lymphoma 55:415-24. 2014
    ..Altogether, these results suggest that NFκB may be a potential target for therapeutic intervention in DLBCL using proteasomal inhibitors such as bortezomib. ..
  52. pmc HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer
    Khawla Al-Kuraya
    Department of Human Cancer Genomic Research, Research Centre at King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Clin Pathol 60:768-72. 2007
    ..Fluorescence in situ hybridisation (FISH) was used to estimate frequencies of copy number changes of known oncogenes, including HER2, TOPO2A, CCND1, EGFR and C-MYC...
  53. doi request reprint Sphingosine kinase is an attractive target for novel pharmacological interventions in non-Hodgkin lymphomas
    Shahab Uddin
    Department of Human Cancer Genomic Research, KFNCCC and R, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Leuk Lymphoma 49:850-1. 2008
  54. ncbi request reprint The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1
    Fatima Lekmine
    Section of Hematology Oncology, University of Illinois at Chicago and West Side Veterans Administration Medical Center, Chicago, Illinois 60607, USA
    Biochem Biophys Res Commun 291:744-50. 2002
    ..Taken altogether, these findings indicate that CrkL provides an important link between Jak-kinases and downstream cascades that play critical roles in IFN-dependent transcriptional regulation and induction of growth inhibitory responses...
  55. ncbi request reprint Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells
    Dolores L Mahmud
    The University of Illinois Medical Center, Chicago, Illinois, USA
    Oncogene 21:1556-62. 2002
    ..Thus mammalian forkhead transcription factors are involved in Epo and SCF signaling in primary erythroid progenitors and may play a role in the induction of apoptotic and mitogenic signals...
  56. ncbi request reprint Cutting edge: activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia
    Amit Verma
    Section of Hematology Oncology, Department of Medicine, University of Illinois and West Side Veterans Administration Medical Center, Chicago, IL 60607, USA
    J Immunol 168:5984-8. 2002
    ....
  57. ncbi request reprint Regulation of myeloma cell growth through Akt/Gsk3/forkhead signaling pathway
    Maaza G-Amlak
    Hematology Oncology Section, University of Illinois Medical Center and West Side VA Medical Center, Chicago, IL 60607, USA
    Biochem Biophys Res Commun 297:760-4. 2002
    ..Finally, we show that inhibition of Gsk3 activity is sufficient to suppress cell growth and induce apoptosis thus overriding the effects of IL-6 in myeloma cells...
  58. ncbi request reprint Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons
    Fatima Lekmine
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 278:27772-80. 2003
    ..Altogether, our data establish that the Type I IFN receptor-activated PI 3'-kinase pathway mediates activation of the p70 S6 kinase and inactivation of 4E-BP1, to regulate mRNA translation and induction of Type I IFN responses...
  59. ncbi request reprint Activation of protein kinase C delta by IFN-gamma
    Dilip K Deb
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Immunol 171:267-73. 2003
    ..Thus, PKCdelta is activated during engagement of the IFN-gamma receptor and plays an important role in IFN-gamma signaling by mediating serine phosphorylation of Stat1 and facilitating transcription of IFN-gamma-stimulated genes...
  60. ncbi request reprint Activation of protein kinase C delta by all-trans-retinoic acid
    Suman Kambhampati
    Robert H Lurie Comprehensive Cancer Center and the Division of Hematology Oncology, Northwestern University Feinberg School of Medicine and Lakeside Veterans Affairs Medical Center, Chicago, Illinois 60611, USA
    J Biol Chem 278:32544-51. 2003
    ..Altogether, our data provide strong evidence that PKC delta is activated in an RA-dependent manner and plays a critical role in the generation of the biological effects of RA in malignant cells...
  61. ncbi request reprint Role of Stat5 in type I interferon-signaling and transcriptional regulation
    Shahab Uddin
    Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
    Biochem Biophys Res Commun 308:325-30. 2003
    ..Furthermore, our results strongly suggest that, in addition to phosphorylation on tyrosine residues, phosphorylation on serine residues exhibits regulatory effects on the transcriptional capacity of Stat5...
  62. pmc Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells
    Shahab Uddin
    Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 101:147-52. 2004
    ....
  63. ncbi request reprint Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways
    Prashant P Bavi
    Department of Human Cancer Genomic Research, Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia
    Saudi Med J 29:75-80. 2008
    ..To evaluate the overall incidence of microsatellite instability (MSI), hereditary non polyposis colorectal cancer, and tumor supressor gene (TP53) mutations in Saudi colorectal carcinomas...
  64. ncbi request reprint p38 MAPK activation coupled to endocytosis is a determinant of endothelial monolayer integrity
    Shahid S Siddiqui
    Department of Pharmacology, University of Illinois College of Medicine, 835 South Wolcott Ave M C 868, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 292:L114-24. 2007
    ..Thus caveolae-mediated endocytosis and concomitant activation of p38 MAPK may help to maintain endothelial monolayer integrity by signaling proliferation and survival of endothelial cells...
  65. ncbi request reprint The PI3' kinase pathway in interferon signaling
    Surinder Kaur
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, 303 East Superior Street, Chicago, IL 60611, USA
    J Interferon Cytokine Res 25:780-7. 2005
    ..This pathway is activated distinctively from the Stat pathway but plays important roles in the regulation of IFN-dependent gene transcription and initiation of mRNA translation...
  66. ncbi request reprint Role of protein kinase C-delta (PKC-delta) in the generation of the effects of IFN-alpha in chronic myelogenous leukemia cells
    Surinder Kaur
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Affairs Medical Center, Chicago, Ill 60611, USA
    Exp Hematol 33:550-7. 2005
    ..We examined whether a member of the protein kinase C (PKC) family of proteins, PKC-delta, is activated during treatment of BCR-ABL cells with IFN-alpha and participates in the induction of interferon responses...
  67. pmc Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells
    Simrit Parmar
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Lakeside Veterans Administration Medical Center, Section of Hematology Oncology, University of Chicago, IL, USA
    Blood 106:2436-43. 2005
    ..They also support the concept that combined use of imatinib mesylate with mTOR inhibitors may be an appropriate future therapeutic strategy for the treatment of CML...
  68. ncbi request reprint Activation of the p70 S6 kinase by all-trans-retinoic acid in acute promyelocytic leukemia cells
    Lakhvir Lal
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 105:1669-77. 2005
    ....
  69. ncbi request reprint Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein
    Fatima Lekmine
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School and Lakeside Veterans Administration Medical Center, Chicago, IL 60611, USA
    Exp Cell Res 295:173-82. 2004
    ....
  70. ncbi request reprint Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727
    Shahab Uddin
    Section of Hematology Oncology, Department of Medicine, University of Illinois at Chicago and West Side Veterans Administration Medical Center, Chicago, Illinois 60607, USA
    J Biol Chem 277:14408-16. 2002
    ..Altogether, these findings indicate that PKC-delta functions as a serine kinase for Stat1 and an upstream regulator of the p38 MAP kinase and plays an important role in the induction of Type I IFN-biological responses...