Afaf K El-Ansary

Summary

Affiliation: King Saud University
Country: Saudi Arabia

Publications

  1. pmc Plasma fatty acids as diagnostic markers in autistic patients from Saudi Arabia
    Afaf K El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    Lipids Health Dis 10:62. 2011
  2. ncbi request reprint Relative abundance of short chain and polyunsaturated fatty acids in propionic acid-induced autistic features in rat pups as potential markers in autism
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    Lipids Health Dis 13:140. 2014
  3. ncbi request reprint Protective and restorative potency of Vitamin D on persistent biochemical autistic features induced in propionic acid-intoxicated rat pups
    Hanan A Alfawaz
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    BMC Complement Altern Med 14:416. 2014
  4. pmc A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders
    Altaf Alabdali
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    Behav Brain Funct 10:14. 2014
  5. pmc On the toxicity of therapeutically used nanoparticles: an overview
    A El-Ansary
    Biochemistry Department, Science College, King Saud University, P O Box 22452, Riyadh 11451, Saudi Arabia
    J Toxicol 2009:754810. 2009
  6. pmc Selected biomarkers as predictive tools in testing efficacy of melatonin and coenzyme Q on propionic acid - induced neurotoxicity in rodent model of autism
    Mashael Al-Ghamdi
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    BMC Neurosci 15:34. 2014
  7. pmc Association of social and cognitive impairment and biomarkers in autism spectrum disorders
    Altaf Alabdali
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    J Neuroinflammation 11:4. 2014
  8. pmc The neurotoxic effect of clindamycin - induced gut bacterial imbalance and orally administered propionic acid on DNA damage assessed by the comet assay: protective potency of carnosine and carnitine
    Afaf El-Ansary
    Department of Biochemistry, College of Science, King Saud University, P, O Box 22452, Riyadh 11495, Saudi Arabia
    Gut Pathog 5:9. 2013
  9. pmc Neuroinflammation in autism spectrum disorders
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O, Box 22452, 11495, Riyadh, Saudi Arabia
    J Neuroinflammation 9:265. 2012
  10. pmc Lipid mediators in plasma of autism spectrum disorders
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia
    Lipids Health Dis 11:160. 2012

Collaborators

Detail Information

Publications20

  1. pmc Plasma fatty acids as diagnostic markers in autistic patients from Saudi Arabia
    Afaf K El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    Lipids Health Dis 10:62. 2011
    ..The aim of this study is to compare plasma fatty acid profiles of Saudi autistic patients with those of age-matching control subjects in an attempt to clarify the role of FA in the etiology of autism...
  2. ncbi request reprint Relative abundance of short chain and polyunsaturated fatty acids in propionic acid-induced autistic features in rat pups as potential markers in autism
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    Lipids Health Dis 13:140. 2014
    ..Omega-3 PUFAs mediate some of these effects by antagonizing Omega-6 PUFA (arachidonic acid, AA)-induced proinflammatory prostaglandin E₂ (PGE₂) formation...
  3. ncbi request reprint Protective and restorative potency of Vitamin D on persistent biochemical autistic features induced in propionic acid-intoxicated rat pups
    Hanan A Alfawaz
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    BMC Complement Altern Med 14:416. 2014
    ..The present study investigated the protective and/or therapeutic effects of vitamin D against brain intoxication induced by propionic acid (PPA) in rats...
  4. pmc A key role for an impaired detoxification mechanism in the etiology and severity of autism spectrum disorders
    Altaf Alabdali
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    Behav Brain Funct 10:14. 2014
    ..e., mild, moderate and severe) will give greater insight into the pathogenesis of this disease and will enable effective early diagnostic strategies and treatments for this disorder...
  5. pmc On the toxicity of therapeutically used nanoparticles: an overview
    A El-Ansary
    Biochemistry Department, Science College, King Saud University, P O Box 22452, Riyadh 11451, Saudi Arabia
    J Toxicol 2009:754810. 2009
    ..This paper highlights the need for caution during the use and disposal of such manufactured nanomaterials to prevent unintended environmental impacts...
  6. pmc Selected biomarkers as predictive tools in testing efficacy of melatonin and coenzyme Q on propionic acid - induced neurotoxicity in rodent model of autism
    Mashael Al-Ghamdi
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    BMC Neurosci 15:34. 2014
    ..Heat shock protein70 (Hsp70), Gamma amino-butyric acid (GABA), serotonin, dopamine, oxytocin and interferon γ-inducible protein 16 together with Comet DNA assay were measured in brain tissues of the six studied groups...
  7. pmc Association of social and cognitive impairment and biomarkers in autism spectrum disorders
    Altaf Alabdali
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495 Riyadh, Saudi Arabia
    J Neuroinflammation 11:4. 2014
    ....
  8. pmc The neurotoxic effect of clindamycin - induced gut bacterial imbalance and orally administered propionic acid on DNA damage assessed by the comet assay: protective potency of carnosine and carnitine
    Afaf El-Ansary
    Department of Biochemistry, College of Science, King Saud University, P, O Box 22452, Riyadh 11495, Saudi Arabia
    Gut Pathog 5:9. 2013
    ..Additionally, the protective effect of carnosine and carnitine as natural dietary supplements is assessed...
  9. pmc Neuroinflammation in autism spectrum disorders
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O, Box 22452, 11495, Riyadh, Saudi Arabia
    J Neuroinflammation 9:265. 2012
    ..This study aims to test the role that might be played by heat shock protein (HSP)70, transforming growth factor (TGF)-β2, Caspase 7 and interferon-γ (IFN-γ)in the pathophysiology of autism...
  10. pmc Lipid mediators in plasma of autism spectrum disorders
    Afaf El-Ansary
    Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia
    Lipids Health Dis 11:160. 2012
    ..The genesis of this disorder is still not understood but inflammation in utero or early in childhood is an environmental risk factor...
  11. pmc Mechanism of nitrogen metabolism-related parameters and enzyme activities in the pathophysiology of autism
    Ghada A Abu Shmais
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    J Neurodev Disord 4:4. 2012
    ..abstract:..
  12. pmc On the protective effect of omega-3 against propionic acid-induced neurotoxicity in rat pups
    Afaf K El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495, Riydh, Saudi Arabia
    Lipids Health Dis 10:142. 2011
    ..Results from animal studies may guide investigations of human populations toward identifying environmental contaminants and drugs that produce or protect from neurotoxicity and may help in the treatment of neurodevelopmental disorders...
  13. ncbi request reprint Relationship between chronic lead toxicity and plasma neurotransmitters in autistic patients from Saudi Arabia
    Afaf K El-Ansary
    Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia
    Clin Biochem 44:1116-20. 2011
    ..This study aims to clarify the relationship between blood Pb(2+) concentration as a ubiquitous environmental pollutant and plasma neurotransmitters as biochemical parameters that reflect brain function in Saudi autistic patients...
  14. pmc Impaired plasma phospholipids and relative amounts of essential polyunsaturated fatty acids in autistic patients from Saudi Arabia
    Afaf K El-Ansary
    Biochemistry Department, Science College, King Saud University, PO Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    Lipids Health Dis 10:63. 2011
    ....
  15. pmc Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia
    Afaf K El-Ansary
    Biochemistry Department, Science College, King Saud University, P, O Box 22452, Zip code 11495, Riyadh, Saudi Arabia
    J Neuroinflammation 8:142. 2011
    ..This study aims to clarify the relationship amongst absolute and relative concentrations of K+, Na+, Ca2+, Mg2+ and/or proinflammatory and proapoptotic biomarkers...
  16. pmc A novel study on amyloid β peptide 40, 42 and 40/42 ratio in Saudi autistics
    Laila Y Al-Ayadhi
    Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
    Behav Brain Funct 8:4. 2012
    ..We examined whether plasma concentrations of amyloid beta (Aβ) as protein derivatives play a central role in the etiology of autistic features...
  17. pmc Etiology of autistic features: the persisting neurotoxic effects of propionic acid
    Afaf K El-Ansary
    Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia
    J Neuroinflammation 9:74. 2012
    ..Propionic acid (PA) is a short chain fatty acid and an important intermediate of cellular metabolism. Although PA has several beneficial biological effects, its accumulation is neurotoxic...
  18. pmc Identification of potential biomarkers of gold nanoparticle toxicity in rat brains
    Nikhat J Siddiqi
    Department of Biochemistry, College of Science, King Saud University, PO Box 22452, Riyadh 11495, Saudi Arabia
    J Neuroinflammation 9:123. 2012
    ..However, their toxic effects still remain to be elucidated. Therefore this study was undertaken to study the biochemical effects of AuNPs on rat brain and identify potential biomarkers of AuNP toxicity...
  19. pmc Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi Arabia
    Yusra A Al-Yafee
    Biochemistry Department, Science College, King Saud University, Riyadh, Saudi Arabia
    BMC Neurol 11:139. 2011
    ....