M DeNiro

Summary

Publications:
1- Dual Targeting of Retinal Vasculature in the Mouse Model of Oxygen Induced Retinopathy. The Open Diabetes Journal, 2011, 4, 60-74.

2- Reversal of Retinal Vascular Changes Associated with Ocular
Neovascularization by Small Molecules: Progress toward Identifying Molecular Targets for Therapeutic Intervention. The Open Diabetes Journal, 2011, 4, 75-95.

Publications

  1. DeNiro M, Al Halafi A, Al Mohanna F, Alsmadi O, Al Mohanna F. Pleiotropic effects of YC-1 selectively inhibit pathological retinal neovascularization and promote physiological revascularization in a mouse model of oxygen-induced retinopathy. Mol Pharmacol. 2010;77:348-67 pubmed publisher
    ..The pleiotropic effects of YC-1 allude to its possible use as a promising therapeutic iNOS inhibitor candidate for the treatment of retinal neovascularization. ..
  2. Deniro M, Al Mohanna F, Alsmadi O, Al Mohanna F. The nexus between VEGF and NF?B orchestrates a hypoxia-independent neovasculogenesis. PLoS ONE. 2013;8:e59021 pubmed publisher
    ..Our data may suggest the potential use of YC-1 to attenuate the deleterious effects that are associated with hypoxia/ischemia-independent retinal vasculopathies. ..
  3. DeNiro M, Alsmadi O, Al Mohanna F. Modulating the hypoxia-inducible factor signaling pathway as a therapeutic modality to regulate retinal angiogenesis. Exp Eye Res. 2009;89:700-17 pubmed publisher
  4. Deniro M, Al Mohanna F. Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: a potential therapeutic target to prevent ischemic retinopathy. PLoS ONE. 2012;7:e50360 pubmed publisher
    ..Therefore, targeting ZnT8 provides a therapeutic strategy to combat neovascular eye diseases. ..
  5. Deniro M, Al Mohanna F, Al Mohanna F. Inhibition of reactive gliosis prevents neovascular growth in the mouse model of oxygen-induced retinopathy. PLoS ONE. 2011;6:e22244 pubmed publisher
    ..In addition, the study reveals that YC-1 may exert promising therapeutic effects in the treatment of retinal and neuronal pathologies...