Dilek Colak

Summary

Affiliation: King Faisal Specialist Hospital and Research Centre
Country: Saudi Arabia

Publications

  1. pmc Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women
    Dilek Colak
    Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    PLoS ONE 8:e63204. 2013
  2. pmc Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old
    Dilek Colak
    Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Mol Cancer 9:146. 2010
  3. doi request reprint A novel X-linked disorder with developmental delay and autistic features
    Namik Kaya
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Ann Neurol 71:498-508. 2012
  4. doi request reprint Breast stromal fibroblasts from histologically normal surgical margins are pro-carcinogenic
    Maha A Al-Rakan
    Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Pathol 231:457-65. 2013
  5. doi request reprint Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism
    Anas M Alazami
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Hum Mutat 33:1429-34. 2012
  6. ncbi request reprint Clinical and biochemical features associated with BCS1L mutation
    Mohammed Al-Owain
    Department of Medical Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Inherit Metab Dis 36:813-20. 2013
  7. pmc Induction of cell proliferation in old rat liver can reset certain gene expression levels characteristic of old liver to those associated with young liver
    Muhammad A Chishti
    Department of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia, 11211
    Age (Dordr) 35:719-32. 2013
  8. doi request reprint Phenotypical spectrum of cerebellar ataxia associated with a novel mutation in the CA8 gene, encoding carbonic anhydrase (CA) VIII
    Namik Kaya
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Am J Med Genet B Neuropsychiatr Genet 156:826-34. 2011
  9. doi request reprint Identification of a novel IVD mutation in a consanguineous family with isovaleric acidemia
    Namik Kaya
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Saudi Arabia
    Gene 513:297-300. 2013
  10. doi request reprint GM2 gangliosidosis in Saudi Arabia: multiple mutations and considerations for future carrier screening
    Namik Kaya
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Am J Med Genet A 155:1281-4. 2011

Collaborators

Detail Information

Publications21

  1. pmc Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women
    Dilek Colak
    Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    PLoS ONE 8:e63204. 2013
    ..Moreover, our integrative genomic and cross-species analysis may provide robust biomarkers for the detection of disease progression in young women, and lead to more effective treatment strategies...
  2. pmc Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old
    Dilek Colak
    Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Mol Cancer 9:146. 2010
    ....
  3. doi request reprint A novel X-linked disorder with developmental delay and autistic features
    Namik Kaya
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Ann Neurol 71:498-508. 2012
    ..We aim to understand a novel genomic disorder with profound phenotypic consequences, most notably global developmental delay, autism, psychosis, and anorexia nervosa...
  4. doi request reprint Breast stromal fibroblasts from histologically normal surgical margins are pro-carcinogenic
    Maha A Al-Rakan
    Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Pathol 231:457-65. 2013
    ..Together, these results indicate that stromal fibroblasts located in non-cancerous tissues exhibit a tumour-promoting phenotype, indicating that their presence post-surgery may play important roles in cancer recurrence...
  5. doi request reprint Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism
    Anas M Alazami
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Hum Mutat 33:1429-34. 2012
    ..This study documents a critical role played by ncRNA in human development and adds to the growing list of molecular mechanisms that, when perturbed, converge on the PD phenotype...
  6. ncbi request reprint Clinical and biochemical features associated with BCS1L mutation
    Mohammed Al-Owain
    Department of Medical Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Inherit Metab Dis 36:813-20. 2013
    ....
  7. pmc Induction of cell proliferation in old rat liver can reset certain gene expression levels characteristic of old liver to those associated with young liver
    Muhammad A Chishti
    Department of Comparative Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia, 11211
    Age (Dordr) 35:719-32. 2013
    ....
  8. doi request reprint Phenotypical spectrum of cerebellar ataxia associated with a novel mutation in the CA8 gene, encoding carbonic anhydrase (CA) VIII
    Namik Kaya
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Am J Med Genet B Neuropsychiatr Genet 156:826-34. 2011
    ..This report expands the neurological and radiological phenotype associated with CA8 mutations. CA8 involvement should be considered in the differential diagnosis of other genetically unresolved autosomal recessive cerebellar ataxias...
  9. doi request reprint Identification of a novel IVD mutation in a consanguineous family with isovaleric acidemia
    Namik Kaya
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Saudi Arabia
    Gene 513:297-300. 2013
    ..We explored the functional consequences of the mutation by using various bioinformatics prediction algorithms and discussed the likely mechanism of the disease caused by the mutation...
  10. doi request reprint GM2 gangliosidosis in Saudi Arabia: multiple mutations and considerations for future carrier screening
    Namik Kaya
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Am J Med Genet A 155:1281-4. 2011
    ..Alternative solutions are proposed which can also be implemented for other autosomal recessive diseases in our population...
  11. doi request reprint ICF syndrome in Saudi Arabia: immunological, cytogenetic and molecular analysis
    Namik Kaya
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Clin Immunol 31:245-52. 2011
    ....
  12. doi request reprint Genome-wide expression profiling of patients with primary open angle glaucoma
    Dilek Colak
    Department of Biostatistics Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Invest Ophthalmol Vis Sci 53:5899-904. 2012
    ..To identify differentially expressed genes and to elucidate gene interaction networks and molecular pathways possibly contributing to the development of POAG...
  13. doi request reprint Novel V97G ASAH1 mutation found in Farber disease patients: unique appearance of the disease with an intermediate severity, and marked early involvement of central and peripheral nervous system
    Aziza K Chedrawi
    Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Brain Dev 34:400-4. 2012
    ..This is the first report of a detailed clinical and molecular analysis of cases with Farber disease from Saudi Arabia...
  14. pmc Chromosome 12q24.31-q24.33 deletion causes multiple dysmorphic features and developmental delay: First mosaic patient and overview of the phenotype related to 12q24qter defects
    Jawaher Al-Zahrani
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia
    Mol Cytogenet 4:9. 2011
    ..abstract:..
  15. doi request reprint Genomic and transcriptomic analyses distinguish classic Rett and Rett-like syndrome and reveals shared altered pathways
    Dilek Colak
    Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Genomics 97:19-28. 2011
    ..To our knowledge, this is the first report on investigating common regulatory mechanisms/signaling pathways that may be relevant to the pathobiology of the "common RTT" phenotype...
  16. doi request reprint Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy
    Dilek Colak
    Department of Biostatistics, Epidemiology and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Genomics 94:20-31. 2009
    ..Our data demonstrate an association of DCM with alterations in various cellular events and multiple yet undeciphered genes that may contribute to heart muscle disease pathways...
  17. doi request reprint Array comparative genomic hybridization (aCGH) reveals the largest novel deletion in PCCA found in a Saudi family with propionic acidemia
    Namik Kaya
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    Eur J Med Genet 51:558-65. 2008
    ..The deletion so far is the largest gross change reported in the literature for the PCCA gene...
  18. pmc Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms
    Leen Abu-Safieh
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Am J Hum Genet 89:313-9. 2011
    ..The retinal phenotype appears to be mediated by a role in vascular endothelium, where IGFBP7 is highly expressed...
  19. pmc p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1
    Huda H Al-Khalaf
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    PLoS ONE 6:e21111. 2011
    ..However, the precise function of the different members of this pathway and their functional interplay are still not well defined...
  20. ncbi request reprint Novel homozygous DEAF1 variant suspected in causing white matter disease, intellectual disability, and microcephaly
    Eissa A Faqeih
    Section of Medical Genetic, Pediatric Department, Children s Hospital, King Fahad Medical City, Riyadh, Saudi Arabia
    Am J Med Genet A 164:1565-70. 2014
    ..This study indicates, for the first time to our knowledge, a hereditary role of DEAF1 in white matter abnormalities, microcephaly and syndromic intellectual disability...
  21. pmc Mutations in C2orf37, encoding a nucleolar protein, cause hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome
    Anas M Alazami
    Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Am J Hum Genet 83:684-91. 2008
    ..Our findings expand the list of human disorders linked to the nucleolus and further highlight the developmental and/or maintenance functions of this organelle...