Mouhab Ayas

Summary

Affiliation: King Faisal Specialist Hospital and Research Centre
Country: Saudi Arabia

Publications

  1. pmc Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia
    Mouhab Ayas
    King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Clin Oncol 31:1669-76. 2013
  2. doi The Saudi experience in fludarabine-based conditioning regimens in patients with Fanconi anemia undergoing stem cell transplantation: excellent outcome in recipients of matched related stem cells but not in recipients of unrelated cord blood stem cells
    Mouhab Ayas
    Section of Pediatric Stem Cell Transplantation, Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Biol Blood Marrow Transplant 18:627-32. 2012
  3. doi Outcome of second allogenic stem cell transplantation in pediatric patients with non-malignant hematological and immune deficiency disorders
    Mouhab Ayas
    Section of Pediatric Stem Cell Transplantation, Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Pediatr Blood Cancer 56:289-93. 2011
  4. doi Unrelated cord blood transplantation in pediatric patients: a report from Saudi Arabia
    M Ayas
    Section of Pediatric Stem Cell Transplantation, Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Bone Marrow Transplant 45:1281-6. 2010
  5. ncbi Congenital sideroblastic anaemia successfully treated using allogeneic stem cell transplantation
    M Ayas
    Department of Oncology, King Faisal Specialist Hospital and Research Centre KFSH and RC, Riyadh, Saudi Arabia
    Br J Haematol 113:938-9. 2001
  6. ncbi Matched-related allogeneic stem cell transplantation in Saudi patients with Fanconi anemia: 10 year's experience
    M Ayas
    The Section of Pediatric Stem Cell Transplant, Department of Pediatric Hematology Oncology, Riyadh, Saudi Arabia
    Bone Marrow Transplant 42:S45-S48. 2008
  7. doi Second stem cell transplantation in patients with Fanconi anemia using antithymocyte globulin alone for conditioning
    Mouhab Ayas
    Section of Pediatric Stem Cell Transplant, Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Biol Blood Marrow Transplant 14:445-8. 2008
  8. ncbi Allogeneic stem cell transplantation in Fanconi anemia patients presenting with myelodysplasia and/or clonal abnormality: update on the Saudi experience
    M Ayas
    Section of Pediatric Stem Cell Transplant, Department of Pediatric Hematology Oncology, Riyadh, Saudi Arabia
    Bone Marrow Transplant 41:261-5. 2008
  9. ncbi The outcome of children with acute myeloid leukemia (AML) post-allogeneic stem cell transplantation (SCT) is not improved by the addition of etoposide to the conditioning regimen
    Mouhab Ayas
    Department of Pediatric Hematology Oncology, Section of Stem Cell Transplant, KFSHRC, Riyadh, Saudi Arabia
    Pediatr Blood Cancer 47:926-30. 2006
  10. ncbi Allogeneic stem cell transplantation in a patient with dyskeratosis congenita after conditioning with low-dose cyclophosphamide and anti-thymocyte globulin
    M Ayas
    Section of Stem Cell Transplant, Department of Pediatric Hematology Oncology, KFSHRC, Riyadh, Saudi Arabia
    Pediatr Blood Cancer 49:103-4. 2007

Collaborators

Detail Information

Publications25

  1. pmc Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia
    Mouhab Ayas
    King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Clin Oncol 31:1669-76. 2013
    ..Data on outcomes in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome (MDS), or acute leukemia have not been separately analyzed...
  2. doi The Saudi experience in fludarabine-based conditioning regimens in patients with Fanconi anemia undergoing stem cell transplantation: excellent outcome in recipients of matched related stem cells but not in recipients of unrelated cord blood stem cells
    Mouhab Ayas
    Section of Pediatric Stem Cell Transplantation, Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Biol Blood Marrow Transplant 18:627-32. 2012
    ..Its value in unrelated cord blood transplantation probably depends on other factors, such as the degree of HLA matching and the cell dose...
  3. doi Outcome of second allogenic stem cell transplantation in pediatric patients with non-malignant hematological and immune deficiency disorders
    Mouhab Ayas
    Section of Pediatric Stem Cell Transplantation, Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Pediatr Blood Cancer 56:289-93. 2011
    ..Second stem cell transplantation (SCT) is usually associated with high morbidity and mortality and the data on its outcome in pediatric patients with non-malignant disorders are scarce...
  4. doi Unrelated cord blood transplantation in pediatric patients: a report from Saudi Arabia
    M Ayas
    Section of Pediatric Stem Cell Transplantation, Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Bone Marrow Transplant 45:1281-6. 2010
    ..Our data are encouraging for UCB transplant programs in countries in which there are no national UCB transplantation banks...
  5. ncbi Congenital sideroblastic anaemia successfully treated using allogeneic stem cell transplantation
    M Ayas
    Department of Oncology, King Faisal Specialist Hospital and Research Centre KFSH and RC, Riyadh, Saudi Arabia
    Br J Haematol 113:938-9. 2001
    ..Graft-versus-host disease (GVHD) prophylaxis was with cyclosporin A and methotrexate. All patients engrafted, and are alive and transfusion independent. SCT can be curative for patients with SA...
  6. ncbi Matched-related allogeneic stem cell transplantation in Saudi patients with Fanconi anemia: 10 year's experience
    M Ayas
    The Section of Pediatric Stem Cell Transplant, Department of Pediatric Hematology Oncology, Riyadh, Saudi Arabia
    Bone Marrow Transplant 42:S45-S48. 2008
    ..5 and 96.9% (P=0.013); and event-free survival was 72.5 and 82.3% (P=0.3). The use of the nonradiation Cy/ATG regimen in matched related SCT for FA patients offers better overall and event-free survival...
  7. doi Second stem cell transplantation in patients with Fanconi anemia using antithymocyte globulin alone for conditioning
    Mouhab Ayas
    Section of Pediatric Stem Cell Transplant, Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Biol Blood Marrow Transplant 14:445-8. 2008
    ..We conclude, therefore, that the use of ATG alone for conditioning before a second SCT may offer a chance of long-term disease-free survival for FA patients who fail their first transplant...
  8. ncbi Allogeneic stem cell transplantation in Fanconi anemia patients presenting with myelodysplasia and/or clonal abnormality: update on the Saudi experience
    M Ayas
    Section of Pediatric Stem Cell Transplant, Department of Pediatric Hematology Oncology, Riyadh, Saudi Arabia
    Bone Marrow Transplant 41:261-5. 2008
    ..Ten patients remain currently alive, well and with no evidence of disease, with a median follow-up of almost 4 years...
  9. ncbi The outcome of children with acute myeloid leukemia (AML) post-allogeneic stem cell transplantation (SCT) is not improved by the addition of etoposide to the conditioning regimen
    Mouhab Ayas
    Department of Pediatric Hematology Oncology, Section of Stem Cell Transplant, KFSHRC, Riyadh, Saudi Arabia
    Pediatr Blood Cancer 47:926-30. 2006
    ....
  10. ncbi Allogeneic stem cell transplantation in a patient with dyskeratosis congenita after conditioning with low-dose cyclophosphamide and anti-thymocyte globulin
    M Ayas
    Section of Stem Cell Transplant, Department of Pediatric Hematology Oncology, KFSHRC, Riyadh, Saudi Arabia
    Pediatr Blood Cancer 49:103-4. 2007
    ..The regimen was well tolerated and associated with no significant short-term toxicity...
  11. ncbi Stem cell transplantation for patients with Fanconi anemia with low-dose cyclophosphamide and antithymocyte globulins without the use of radiation therapy
    M Ayas
    Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Center KFSHRC, Riyadh, Saudi Arabia
    Bone Marrow Transplant 35:463-6. 2005
    ..We conclude that low-dose CY without radiation therapy can be used satisfactorily in the conditioning of patients with FA undergoing related SCT...
  12. ncbi Allogeneic stem cell transplantation in patients with Fanconi's anemia and myelodysplasia or leukemia utilizing low-dose cyclophosphamide and total body irradiation
    M Ayas
    Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Center KFSHRC, Riyadh, Saudi Arabia
    Bone Marrow Transplant 33:15-7. 2004
    ..We conclude that the use of low-dose CY plus TBI in patients with FA and MDS/AML undergoing SCT is adequate; the regimen is well tolerated and may be curative for such patients...
  13. ncbi Allogeneic stem cell transplantation using myeloablative and reduced-intensity conditioning in patients with major histocompatibility complex class II deficiency
    Hamoud Al-Mousa
    Section of Pediatric Allergy and Immunology, Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Biol Blood Marrow Transplant 16:818-23. 2010
    ..Further studies and long-term follow-up are needed to determine the appropriate conditioning regimen...
  14. doi Allogeneic hematopoietic stem cell transplantation in leukocyte adhesion deficiency type 1: a single center experience
    Hasan Al-Dhekri
    Section of Pediatric Allergy Immunology, Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Biol Blood Marrow Transplant 17:1245-9. 2011
    ..HSCT from a matched related donor or unrelated cord blood provided excellent outcome, and mixed chimerism appeared satisfactory to prevent recurrent infections...
  15. ncbi Outcome of allogeneic stem cell transplantation with a conditioning regimen of busulfan, cyclophosphamide and low-dose etoposide for children with myelodysplastic syndrome
    Amal Al-Seraihy
    Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Hematol Oncol Stem Cell Ther 4:121-5. 2011
    ..Allogeneic stem cell transplantation (SCT) offers the best chance of cure and long-term survival for children with myelodysplastic syndromes (MDS)...
  16. doi Outcome of risk adapted therapy for relapsed/refractory acute lymphoblastic leukemia in children
    Asim F Belgaumi
    Department of Pediatric Hematology Oncology, King Fahd National Center for Children s Cancer, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Leuk Lymphoma 54:547-54. 2013
    ..7%), identifying a particularly good-risk cohort. Patients not in this category continue with poor outcome even following hematopoietic stem cell transplant...
  17. pmc Trends of hematopoietic stem cell transplantation in the Eastern Mediterranean region, 1984-2007
    Syed O A Ahmed
    King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Biol Blood Marrow Transplant 17:1352-61. 2011
    ..Notable differences in transplantation practices as reported to the European Group for Blood and Marrow Transplantation over recent years are highlighted...
  18. pmc Clinical characteristics and outcome of children with biphenotypic acute leukemia
    Amal S Al-Seraihy
    Deprtment of Pediatric, Hematology Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Haematologica 94:1682-90. 2009
    ..Knowledge concerning the clinical and biological presentation, as well as the outcome of treatment, of biphenotypic acute leukemia in children is limited...
  19. pmc Clinical characteristics and treatment outcome of pediatric patients with chronic myeloid leukemia
    Asim F Belgaumi
    Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Center, PO Box 3354, MBC 53 Riyadh 11211, Saudi Arabia
    Haematologica 95:1211-5. 2010
    ..Pediatric patients with chronic myeloid leukemia should undergo stem cell transplantation when appropriate related donors are available...
  20. ncbi Cytomegalovirus infections in unrelated cord blood transplantation in pediatric patients: incidence, risk factors, and outcomes
    Sami Al-Hajjar
    Department of Pediatric, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Hematol Oncol Stem Cell Ther 4:67-72. 2011
    ..Cytomegalovirus (CMV) is thought to contribute significantly to HSCT morbidity and mortality...
  21. ncbi Ocular findings after allogeneic hematopoietic stem cell transplantation
    Khalid F Tabbara
    The Eye Center and The Eye Foundation for Research in Ophthalmology, Riyadh, Saudi Arabia
    Ophthalmology 116:1624-9. 2009
    ..To study the incidence, causes, and outcome of major ocular complications in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT)...
  22. ncbi Localised Ewing sarcoma/PNET of bone--prognostic factors and international data comparison
    R Derek Jenkin
    Department of Oncology, Section of Radiation Oncology, King Faisal Specialist Hospital and Research Centre, PO Box 3354, Riyadh, Saudi Arabia 11211
    Med Pediatr Oncol 39:586-93. 2002
    ..To determine if the distribution of prognostic factors accounted for the differences when the outcome for localised Ewing Sarcoma/PNET bone in Saudi Arabia was compared with results from countries with well developed health care systems...
  23. doi Status of hematopoietic stem cell transplantation in the WHO Eastern Mediterranean Region (EMRO)
    Mahmoud Aljurf
    King Faisal Cancer Center, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Transfus Apher Sci 42:169-75. 2010
    ..8% of total population has access to such a program in EM region. GNI/capita had no clear association with low HSCT activity; however improvement in infrastructure and establishment of EM regional HSCT registry need prioritization...
  24. ncbi A prospective study of G-CSF primed bone marrow as a stem-cell source for allogeneic bone marrow transplantation in children: a Pediatric Blood and Marrow Transplant Consortium (PBMTC) study
    Haydar Frangoul
    Department of Pediatrics, Vanderbilt University, Nashville, TN 37232 2573, USA
    Blood 110:4584-7. 2007
    ..Collection of G-BM from pediatric donors is safe, and can result in high NC and CD34 cell doses that facilitate engraftment after myeloablative BMT without a discernable increase in the risk of GVHD...
  25. ncbi In cyclosporine induced neurotoxicity, is tacrolimus an appropriate substitute or is it out of the frying pan and into the fire?
    Mouhab Ayas
    Pediatr Blood Cancer 50:426; author reply 427. 2008