K M Alkharfy

Summary

Affiliation: King Saud University
Country: Saudi Arabia

Publications

  1. ncbi request reprint Community pharmacists' knowledge, attitudes and practices towards herbal remedies in Riyadh, Saudi Arabia
    K M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    East Mediterr Health J 16:988-93. 2010
  2. pmc Selected dietary nutrients and the prevalence of metabolic syndrome in adult males and females in Saudi Arabia: a pilot study
    Nasser M Al-Daghri
    Center of Excellence in Biotechnology Research, King Saud University, Riyadh 11451, Saudi Arabia
    Nutrients 5:4587-604. 2013
  3. pmc Quantitative determination of imatinib stability under various stress conditions
    Khalid Mohammed Alkharfy
    Department of Clinical Pharmacy, Pharmacokinetic Research Laboratory, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    J Pharm Bioallied Sci 5:49-52. 2013
  4. ncbi request reprint Lepidium sativum but not Nigella sativa affects carbamazepine disposition in an animal model
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
    Drug Metab Lett 7:47-51. 2013
  5. ncbi request reprint Influence of vitamin D treatment on transcriptional regulation of insulin-sensitive genes
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Metab Syndr Relat Disord 11:283-8. 2013
  6. pmc Effects of probiotics in patients with diabetes mellitus type 2: study protocol for a randomized, double-blind, placebo-controlled trial
    Majed S Alokail
    Biomarkers Research Program, King Saud University, Riyadh 11451, Saudi Arabia
    Trials 14:195. 2013
  7. pmc Tea and coffee consumption in relation to vitamin D and calcium levels in Saudi adolescents
    Abdulaziz Al-Othman
    Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA
    Nutr J 11:56. 2012
  8. pmc Vitamin D supplementation as an adjuvant therapy for patients with T2DM: an 18-month prospective interventional study
    Nasser M Al-Daghri
    Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, PO Box, 2455, Riyadh, 11451, Kingdom of Saudi Arabia
    Cardiovasc Diabetol 11:85. 2012
  9. pmc Association of body mass index, sagittal abdominal diameter and waist-hip ratio with cardiometabolic risk factors and adipocytokines in Arab children and adolescents
    Omar S Al-Attas
    Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
    BMC Pediatr 12:119. 2012
  10. pmc Effect of physical activity and sun exposure on vitamin D status of Saudi children and adolescents
    Abdulaziz Al-Othman
    Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, Kingdom of Saudi Arabia
    BMC Pediatr 12:92. 2012

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Community pharmacists' knowledge, attitudes and practices towards herbal remedies in Riyadh, Saudi Arabia
    K M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    East Mediterr Health J 16:988-93. 2010
    ..While 56% of participating pharmacists expressed concerns about the safety of herbal remedies, 30% considered them to be harmless. Community pharmacists need to be better informed about herbal products...
  2. pmc Selected dietary nutrients and the prevalence of metabolic syndrome in adult males and females in Saudi Arabia: a pilot study
    Nasser M Al-Daghri
    Center of Excellence in Biotechnology Research, King Saud University, Riyadh 11451, Saudi Arabia
    Nutrients 5:4587-604. 2013
    ..The pattern of daily dietary intake of selected nutrients among the general population of Saudi Arabia raises concern, and this dietary imbalance could increase the risk of metabolic syndrome, particularly in adult Saudi females. ..
  3. pmc Quantitative determination of imatinib stability under various stress conditions
    Khalid Mohammed Alkharfy
    Department of Clinical Pharmacy, Pharmacokinetic Research Laboratory, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    J Pharm Bioallied Sci 5:49-52. 2013
    ..A simple, rapid, reverse phase and stability-indicating high-performance liquid chromatography (HPLC) method for the estimation of imatinib in solution and in plasma under forced degradation conditions was developed...
  4. ncbi request reprint Lepidium sativum but not Nigella sativa affects carbamazepine disposition in an animal model
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
    Drug Metab Lett 7:47-51. 2013
    ..Further confirmation of these results in humans will warrant changes in CBZ dose and/or frequency before co-administration with these herbal medicines. ..
  5. ncbi request reprint Influence of vitamin D treatment on transcriptional regulation of insulin-sensitive genes
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Metab Syndr Relat Disord 11:283-8. 2013
    ..Vitamin D, besides being a transcriptional regulator, is an inflammation suppressor. However, the role of vitamin D in alleviating obesity-induced insulin resistance is still not well understood...
  6. pmc Effects of probiotics in patients with diabetes mellitus type 2: study protocol for a randomized, double-blind, placebo-controlled trial
    Majed S Alokail
    Biomarkers Research Program, King Saud University, Riyadh 11451, Saudi Arabia
    Trials 14:195. 2013
    ..Therefore, the aim of this study is to characterize the beneficial effects of probiotics on circulating endotoxin levels and other biomarkers related to systemic low-grade inflammation in patients with T2DM...
  7. pmc Tea and coffee consumption in relation to vitamin D and calcium levels in Saudi adolescents
    Abdulaziz Al-Othman
    Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA
    Nutr J 11:56. 2012
    ..Here we determine for the first time whether increased coffee and tea consumption affects circulating levels of 25-hydroxyvitamin D in a cohort of Saudi adolescents...
  8. pmc Vitamin D supplementation as an adjuvant therapy for patients with T2DM: an 18-month prospective interventional study
    Nasser M Al-Daghri
    Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, PO Box, 2455, Riyadh, 11451, Kingdom of Saudi Arabia
    Cardiovasc Diabetol 11:85. 2012
    ..In this prospective interventional study we investigated the effects of vitamin D3 supplementation on the metabolic profiles of Saudi T2DM subjects pre- and post-vitamin D supplementation over an 18-month period...
  9. pmc Association of body mass index, sagittal abdominal diameter and waist-hip ratio with cardiometabolic risk factors and adipocytokines in Arab children and adolescents
    Omar S Al-Attas
    Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
    BMC Pediatr 12:119. 2012
    ....
  10. pmc Effect of physical activity and sun exposure on vitamin D status of Saudi children and adolescents
    Abdulaziz Al-Othman
    Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, Kingdom of Saudi Arabia
    BMC Pediatr 12:92. 2012
    ..In this context, we aimed to determine whether the prevalence of vitamin D deficiency is related to degree of physical activity and sun exposure among apparently healthy Saudi children and adolescents, a little studied population...
  11. pmc Circulating leukocyte telomere length is highly heritable among families of Arab descent
    Omar S Al-Attas
    Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, Kingdom of Saudi Arabia
    BMC Med Genet 13:38. 2012
    ..As such, the aim of this study was to address the inheritability of telomere length in Saudi families and the impact of cardiometabolic disease biomarkers on telomere length...
  12. pmc Mammalian NPC1 genes may undergo positive selection and human polymorphisms associate with type 2 diabetes
    Nasser M Al-Daghri
    Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, King Abdullah road, Riyadh 11451, Kingdom of Saudi Arabia
    BMC Med 10:140. 2012
    ....
  13. pmc Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells
    Nasser M Al-Daghri
    Biomarkers Research Program, Department of Biochemistry, College of Science King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia
    BMC Complement Altern Med 12:202. 2012
    ..The current study focuses on the anticancer properties of fenugreek, a herb with proven anti-diabetic, antitumor and immune-stimulating functions...
  14. doi request reprint Calcitriol attenuates weight-related systemic inflammation and ultrastructural changes in the liver in a rodent model
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Basic Clin Pharmacol Toxicol 112:42-9. 2013
    ..Overall, our data signify an important effect of calcitriol on inflammation under HFD conditions and a protective effect on the liver structure...
  15. pmc Serum retinol-binding protein 4 as a marker for cardiovascular disease in women
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    PLoS ONE 7:e48612. 2012
    ..Elevated serum level of retinol-binding protein 4 (RBP4) has been associated with obesity-related co-morbidities including insulin resistance, dyslipidemia and hypertension...
  16. doi request reprint Effects of vitamin D treatment on skeletal muscle histology and ultrastructural changes in a rodent model
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Molecules 17:9081-9. 2012
    ..The current findings indicate an important effect of vitamin D on skeletal muscle histology under HFD conditions...
  17. ncbi request reprint Variants of endothelial nitric oxide synthase gene are associated with components of metabolic syndrome in an Arab population
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Endocr J 59:253-63. 2012
    ..A genetic predisposition to develop abnormal metabolic phenotypes, consistent with an increased prevalence of metabolic phenotypes can be detected in this ethnic group...
  18. pmc Diabetes mellitus type 2 and other chronic non-communicable diseases in the central region, Saudi Arabia (Riyadh cohort 2): a decade of an epidemic
    Nasser M Al-Daghri
    Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Kingdom of Saudi Arabia
    BMC Med 9:76. 2011
    ..This study aims to fill this gap...
  19. doi request reprint Endothelial nitric oxide synthase gene polymorphisms (894G > T and -786T > C) and risk of coronary artery disease in a Saudi population
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Arch Med Res 41:134-41. 2010
    ..We studied the associations of 894G>T and -786T>C polymorphisms of endothelial nitric oxide synthase gene with coronary artery disease in Saudi population...
  20. ncbi request reprint Liquid chromatographic assay of abouthiouzine in plasma and its application to pharmacokinetic studies
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    J Chromatogr B Analyt Technol Biomed Life Sci 817:183-6. 2005
    ..The within- and between-day coefficients of variation were less than 7%. Our method has been successfully used to measure abouthiouzine plasma concentrations in a rabbit model following an intravenous administration of the drug...
  21. ncbi request reprint Pharmacokinetics of diclofenac in sheep following intravenous and intramuscular administration
    Abdulla Y Altaher
    Department of Pharmacology, College of Veterinary Medicine and Animal Resources, King Faisal University, Houfof, Saudi Arabia
    Vet Anaesth Analg 33:241-5. 2006
    ..The aim of this work was to examine the pharmacokinetics of diclofenac (DCLF) in sheep after intravenous (IV) and intramuscular (IM) dosing...
  22. ncbi request reprint Disposition of abouthiouzine: a novel antihyperthyroid drug
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Biopharm Drug Dispos 28:105-11. 2007
    ..Further studies are needed to evaluate the route of elimination of abouthiouzine in these animal models including any metabolite formation and the role of enterohepatic recycling in this process...
  23. ncbi request reprint Effect of valerian, valerian/hops extracts, and valerenic acid on glucuronidation in vitro
    K M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Xenobiotica 37:113-23. 2007
    ..Overall, these findings suggest that valerian-containing products may interfere with the glucuronidation of endo- and xenobiotics...
  24. ncbi request reprint Effect of the acute phase response induced by endotoxin administration on the expression and activity of UGT isoforms in rats
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Drug Metab Lett 2:248-55. 2008
    ..These findings demonstrate that both mRNA and activity of UGT isoforms in rats are decreased following endotoxin treatment, although tissue specific effects do also exist...
  25. pmc Influence of overt diabetes mellitus on cyclosporine pharmacokinetics in a canine model
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Exp Diabetes Res 2009:363787. 2009
    ..Diabetic patients usually require more medications than their nondiabetic counterparts. This work examined the effect of hyperglycemia on the pharmacokinetic properties of cyclosporine in a diabetic dog model...
  26. doi request reprint Simple and sensitive LC-ESI-MS method for the quantitation of sildenafil in plasma samples
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    J Sep Sci 32:3866-70. 2009
    ..99). Within- and between-day coefficients of variation were less than 7%. This method has been successfully used to measure sildenafil plasma concentrations in a beagle dog model following an oral administration of the drug...
  27. doi request reprint The protective effect of thymoquinone against sepsis syndrome morbidity and mortality in mice
    Khalid M Alkharfy
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Int Immunopharmacol 11:250-4. 2011
    ..1817 and 0.0851, respectively). This study gives strength to the potential clinical relevance of thymoquinone in sepsis-related morbidity and mortality reduction and suggests that human studies should be performed...
  28. doi request reprint Hypovitaminosis D associations with adverse metabolic parameters are accentuated in patients with Type 2 diabetes mellitus: a body mass index-independent role of adiponectin?
    N M Al-Daghri
    Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA
    J Endocrinol Invest 36:1-6. 2013
    ..The purpose of this study was to examine the association between 25-hydroxy-vitamin D (25-OH-VitD) levels and indices of insulin resistance (IR), including adipocytokines, in a Saudi population with or without DMT2...
  29. doi request reprint Gender-specific associations between insulin resistance, hypertension, and markers of inflammation among adult Saudis with and without diabetes mellitus type 2
    N M Al-Daghri
    Department of Biochemistry, King Saud University, Riyadh, Kingdom of Saudi Arabia
    Adv Med Sci 55:179-85. 2010
    ....
  30. doi request reprint Urinary iodine is associated with insulin resistance in subjects with diabetes mellitus type 2
    O S al-Attas
    Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Saudi Arabia
    Exp Clin Endocrinol Diabetes 120:618-22. 2012
    ..The purpose of this study was to examine the urinary excretion of iodine in type 2 DM (T2DM) patients, and to assess the clinical implication of iodine status on T2DM...
  31. doi request reprint Normal circulating PTH in Saudi healthy individuals with hypovitaminosis D
    Y Al-Saleh
    Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA
    Horm Metab Res 45:43-6. 2013
    ..This study suggests that local cutoffs should be set that will be of clinical significance in the identification of those at true risk for harder end-points, such as secondary hyperparathyroidism and bone-related diseases...
  32. ncbi request reprint Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects
    F I al-Jenoobi
    Departments of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Drug Metab Lett 4:51-5. 2010
    ..To investigate the effects of black seed on the metabolic activities of CYP3A4 and CYP2D6 in human liver microsomes and in human subjects using dextromethorphan as a probe drug...
  33. ncbi request reprint Bioequivalence of Jusline following subcutaneous administration in healthy subjects
    K A Al-Rubeaan
    Department of Medicine, College of Medicine, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    Int J Clin Pharmacol Ther 46:382-8. 2008
    ....
  34. ncbi request reprint Cardiotoxic effects of arsenic trioxide/imatinib mesilate combination in rats
    Sherif Y Saad
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    J Pharm Pharmacol 58:567-73. 2006
    ....
  35. ncbi request reprint Severe hypovitaminosis D is widespread and more common in non-diabetics than diabetics in Saudi adults
    Nasser M Al-Daghri
    Biochemistry Department, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Kingdom of Saudi Arabia
    Saudi Med J 31:775-80. 2010
    ..To compare the incidence of hypovitaminosis D in subjects, with and without type 2 diabetes mellitus (T2DM), and determine its association to various risk factors...
  36. doi request reprint Mechanism and implication of cephalosporin penetration into oropharyngeal mucosa
    Tawfeeg A Najjar
    Department of Clinical Pharmacy, College of Pharmacy, King Saud University, PO Box 2457, Riyadh, 11451, Saudi Arabia
    J Infect Chemother 15:70-4. 2009
    ..Our findings indicate that an active transport mechanism exists for cefixime excretion into human oropharyngeal mucosa, whereas cephalexin is passively diffused, although to a limited extent, as measured by its salivary concentrations...
  37. ncbi request reprint Sensitive liquid chromatographic method using fluorescence detection for the determination of estradiol 3- and 17-glucuronides in rat and human liver microsomal incubations: formation kinetics
    Khalid M Alkharfy
    Department of Pharmaceutical Sciences, University of Pittsburgh, 807 Salk Hall, Pittsburgh, PA 15261, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 774:33-8. 2002
    ..Overall, the assay described is a sensitive and reproducible method for the determination of estradiol glucuronides in liver microsomal preparations...