Jehad Abubaker

Summary

Affiliation: King Faisal Specialist Hospital and Research Centre
Country: Saudi Arabia

Publications

  1. pmc PIK3CA alterations in Middle Eastern ovarian cancers
    Jehad Abubaker
    Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Cancer 8:51. 2009
  2. pmc Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population
    Abdul K Siraj
    Cancer Genomics, Research Centre, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    BMC Med Genet 9:61. 2008
  3. doi request reprint Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma
    Jehad Abubaker
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    J Pathol 219:435-45. 2009
  4. pmc Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer
    Shahab Uddin
    Department of Human Cancer Genomic Research, Research Center, Department of Pathology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Cancer 8:74. 2009
  5. pmc Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma
    Prashant Bavi
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Am J Pathol 178:2109-20. 2011
  6. ncbi request reprint Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer
    Zeenath Jehan
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Pathol 219:337-46. 2009
  7. pmc Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy
    Shahab Uddin
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Am J Pathol 178:537-47. 2011
  8. ncbi request reprint Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma
    Rong Bu
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Leuk Lymphoma 53:1971-7. 2012
  9. doi request reprint Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma
    Shahab Uddin
    Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Endocr Relat Cancer 17:191-202. 2010
  10. doi request reprint Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling
    Azhar R Hussain
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Pathol 222:180-90. 2010

Collaborators

Detail Information

Publications18

  1. pmc PIK3CA alterations in Middle Eastern ovarian cancers
    Jehad Abubaker
    Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Cancer 8:51. 2009
    ..Therefore, we investigated PI3K/AKT genetic alterations such as PIK3CA amplification, PIK3CA mutation, PTEN protein loss and their relationships with various clinicopathological characteristics in 156 EOCs...
  2. pmc Polymorphisms of selected xenobiotic genes contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population
    Abdul K Siraj
    Cancer Genomics, Research Centre, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    BMC Med Genet 9:61. 2008
    ..To evaluate the role of genetic polymorphisms of xenobiotic genes in thyroid cancer, we conducted a hospital-based case-control study in Saudi population...
  3. doi request reprint Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma
    Jehad Abubaker
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    J Pathol 219:435-45. 2009
    ..Our results highlight the differential role of KRAS isoforms in CRC, their utility as a prognostic biomarker, and underline the importance of KRAS alterations as a potential therapeutic target for CRC...
  4. pmc Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer
    Shahab Uddin
    Department of Human Cancer Genomic Research, Research Center, Department of Pathology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Cancer 8:74. 2009
    ..This study was design to investigate the prevalence of leptin and Ob-R in Middle Eastern epithelial ovarian cancer (EOC) and to analyze the role of leptin and the mechanisms under its action in EOC tissue sample and cell lines...
  5. pmc Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma
    Prashant Bavi
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Am J Pathol 178:2109-20. 2011
    ..Altogether, our results suggest that UBE2C and the ubiquitin-proteasome pathway may be potential targets for therapeutic intervention in CRC...
  6. ncbi request reprint Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer
    Zeenath Jehan
    Human Cancer Genomic Research, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Pathol 219:337-46. 2009
    ..Furthermore, PIK3CA amplification is an independent prognostic marker for better survival and may be one of the promising markers to define CRC subsets that may maximally benefit from adjuvant therapy...
  7. pmc Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy
    Shahab Uddin
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Am J Pathol 178:537-47. 2011
    ..Altogether, our data indicate that FoxM1 signaling contributes to aggressiveness in a subset of CRC and that the FOXM1 gene may serve as a useful molecular biomarker and potential therapeutic target...
  8. ncbi request reprint Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma
    Rong Bu
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Leuk Lymphoma 53:1971-7. 2012
    ....
  9. doi request reprint Leptin-R and its association with PI3K/AKT signaling pathway in papillary thyroid carcinoma
    Shahab Uddin
    Department of Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Endocr Relat Cancer 17:191-202. 2010
    ..Altogether, these data show that leptin plays an important role in PTC pathogenesis through PI3K/AKT pathway via Ob-R and is a potential prognostic marker associated with an aggressive phenotype and poor disease-free survival...
  10. doi request reprint Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling
    Azhar R Hussain
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Pathol 222:180-90. 2010
    ..In summary, our data suggest that XIAP expression is a poor prognostic factor in DLBCL and the XIAP-AKT relationship should be explored further as a potential therapeutic target in DLBCL...
  11. doi request reprint The biological and clinical impact of inhibition of NF-κB-initiated apoptosis in diffuse large B cell lymphoma (DLBCL)
    Prashant Bavi
    Human Cancer Genomic Research, Research Center, King Fahad National Center for Children s Cancer, Riyadh, Saudi Arabia
    J Pathol 224:355-66. 2011
    ..Altogether, these results suggest that NF-κB may be a useful prognostic biomarker and a potential target for therapeutic intervention in DLBCL...
  12. pmc c-Met inhibitor synergizes with tumor necrosis factor-related apoptosis-induced ligand to induce papillary thyroid carcinoma cell death
    Rong Bu
    Human Cancer Genomic Research, Research Center, Riyadh, Saudi Arabia
    Mol Med 18:167-77. 2012
    ..Our data suggest that the c-Met/AKT pathway may be a potential target for therapeutic intervention for treatment of PTC refractory to conventionally therapeutic modalities...
  13. doi request reprint Polymorphisms of drug-metabolizing enzymes CYP1A1, GSTT and GSTP contribute to the development of diffuse large B-cell lymphoma risk in the Saudi Arabian population
    Fouad Al-Dayel
    Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    Leuk Lymphoma 49:122-9. 2008
    ..Our findings suggest that polymorphisms of xenobiotic metabolizing enzyme genes may modify the individual susceptibility to develop DLBCL in Saudi Arabian population...
  14. ncbi request reprint Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population
    Jehad Abubaker
    Department of Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Cancer, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    J Clin Endocrinol Metab 93:611-8. 2008
    ..Mutations in the PIK3CA have also been identified in thyroid cancers and, although relatively common in anaplastic thyroid carcinoma, are uncommon in PTC...
  15. ncbi request reprint High prevalence of fatty acid synthase expression in colorectal cancers in Middle Eastern patients and its potential role as a therapeutic target
    Shahab Uddin
    Department of Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, Research Center, Riyadh, Saudi Arabia
    Am J Gastroenterol 104:1790-801. 2009
    ..However, the role of FASN in colorectal cancer (CRC) has not been fully elucidated. We investigated the expression of FASN and determined its functional association with the PI3/AKT pathway in CRC...
  16. doi request reprint Distinct gene expression profiles: nodal versus extranodal diffuse large B-cell lymphoma
    Zeenath Jehan
    Human Cancer Genomic Research, King Fahad National Centre for Children s Cancer and Research, Riyadh, Saudi Arabia
    Oncology 75:71-80. 2008
    ..Perceived differences in outcome between extranodal and nodal DLBCL raise the possibility that these subgroups may represent different biological and clinical entities...
  17. doi request reprint Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines
    Azhar R Hussain
    Department of Human Cancer Genomic Research, King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, MBC 98 16, P O Box 3354, Riyadh 11211, Saudi Arabia
    Mol Cancer Ther 7:3318-29. 2008
    ..These findings also raise the possibility that incorporation of curcumin in treatment regimens may provide a novel approach for the treatment of Burkitt's lymphomas and provide the molecular basis for such future translational efforts...
  18. ncbi request reprint Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East
    Abdul K Siraj
    Department of Human Cancer Genomic Research Centre, King Fahad National Center for Children s Cancer and Research, Riyadh, Saudi Arabia
    Ann Hematol 86:887-95. 2007
    ..Additionally, the results indicated that MTHFR variants were not related to MGMT or FHIT hypermethylation in DLBCL...