Abdelilah Aboussekhra

Summary

Affiliation: King Faisal Specialist Hospital and Research Centre
Country: Saudi Arabia

Publications

  1. pmc Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7-H1 as an anti-apoptotic molecule
    Hazem Ghebeh
    Tumor Immunology Section, King Faisal Specialist Hospital and Research Center PO Box 3354, Riyadh 11211, Saudi Arabia
    Breast Cancer Res 12:R48. 2010
  2. doi request reprint Role of cancer-associated fibroblasts in breast cancer development and prognosis
    Abdelilah Aboussekhra
    King Faisal Specialist Hospital and Research Center, Riyadh, KSA
    Int J Dev Biol 55:841-9. 2011
  3. doi request reprint Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation
    Ibtehaj Al-Sharif
    Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, MBC 03 66, PO Box 3354, Riyadh 11211, Saudi Arabia
    BMC Cancer 13:600. 2013
  4. pmc Homologous recombination is involved in transcription-coupled repair of UV damage in Saccharomyces cerevisiae
    Abdelilah Aboussekhra
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    EMBO J 24:1999-2010. 2005
  5. ncbi request reprint Response of medulloblastoma cells to vincristine and lomustine: role of TRKC, CTNNB1 and STK15
    Zakia Shinwari
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, K S A
    Anticancer Res 31:1721-33. 2011
  6. ncbi request reprint Expression of survivin and p16(INK4a)/Cdk6/pRB proteins and induction of apoptosis in response to radiation and cisplatin in meningioma cells
    Huda H Al-Khalaf
    Department of Biological and Medical Research, MBC 03, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Brain Res 1188:25-34. 2008
  7. doi request reprint The RAD9-dependent gene trans-activation is required for excision repair of active genes but not for repair of non-transcribed DNA
    Nisreen M Al-Moghrabi
    King Faisal Specialist Hospital and Research Center, Department of Biological and Medical Research, Riyadh, Saudi Arabia
    Mutat Res 663:60-8. 2009
  8. pmc Curcumin triggers p16-dependent senescence in active breast cancer-associated fibroblasts and suppresses their paracrine procarcinogenic effects
    Siti Fauziah Hendrayani
    Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Neoplasia 15:631-40. 2013
  9. ncbi request reprint Vincristine and lomustine induce apoptosis and p21(WAF1) up-regulation in medulloblastoma and normal human epithelial and fibroblast cells
    Zakia Shinwari
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Neurooncol 87:123-32. 2008
  10. doi request reprint Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
    Maha H Elamin
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Carcinog 49:302-14. 2010

Collaborators

  • Said Dermime
  • Taher Al-Tweigeri
  • Namik Kaya
  • Dilek Colak
  • Hazem Ghebeh
  • Monther Al-Alwan
  • Nisreen Al-Moghrabi
  • Ali Hellani
  • Ayodele Alaiya
  • Huda H Al-Khalaf
  • Siti Faujiah Hendrayani
  • Zakia Shinwari
  • Mysoon M Al-Ansari
  • Nujoud Al-Yousef
  • Siti Fauziah Hendrayani
  • Ibtehaj Al-Sharif
  • Mai A Al-Mohanna
  • Pulicat S Manogaran
  • Salman A Alrokayan
  • Ayman Allam
  • Boleslaw Lach
  • Maher Hassounah
  • Maha A Al-Rakan
  • Albandary Al-Bakheet
  • Khaled Al-Hussein
  • Ibrahim Al-Jammaz
  • Basem Al-Otaibi
  • Ensaf M Al-Hujaily
  • Essam Al-Shail
  • Yasser Khafaga
  • Amani Al-Kofide
  • Hindi Al-Hindi
  • Maha H Elamin
  • Asma Tulbah
  • Nahed M Hawsawi
  • Ahmed Alkhani
  • Khaled A Al-Hussein
  • Mohammed N Al-Ahdal
  • Nancy Pangue-Cruz
  • Mohammed A Hannan
  • Falah H Al-Mohanna
  • Osama Al-Malik
  • Adnane Remmal
  • Ameera Gaafar
  • Afaf I Shehata
  • Maher Al-Saif
  • Ameera Gaafar Mohamed
  • Nasser El-Kum
  • Khalid S Khabar
  • Khairia M Youssef
  • Amal Al-Haza'a
  • Maha Al-Eid
  • Nasser Elkum
  • Dahish Ajarim
  • Huda Al-Khalaf
  • Abeer Al-Omeir
  • Yunus Siddiqui
  • Zuha Al-Mukhalafi
  • Mohammed Kunhi
  • Yunis Siddiqui
  • Monica Siewertsen
  • Noujud Al-Yussef
  • Fahad M Al-Khodairy

Detail Information

Publications28

  1. pmc Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7-H1 as an anti-apoptotic molecule
    Hazem Ghebeh
    Tumor Immunology Section, King Faisal Specialist Hospital and Research Center PO Box 3354, Riyadh 11211, Saudi Arabia
    Breast Cancer Res 12:R48. 2010
    ..Indeed, in previous reports we have shown an association of B7-H1 expression with high-risk breast cancer patients...
  2. doi request reprint Role of cancer-associated fibroblasts in breast cancer development and prognosis
    Abdelilah Aboussekhra
    King Faisal Specialist Hospital and Research Center, Riyadh, KSA
    Int J Dev Biol 55:841-9. 2011
    ..Additionally, I summarize our current understanding of the procarcinogenic actions of these cells and their potential prognostic value for breast cancer patients...
  3. doi request reprint Eugenol triggers apoptosis in breast cancer cells through E2F1/survivin down-regulation
    Ibtehaj Al-Sharif
    Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, MBC 03 66, PO Box 3354, Riyadh 11211, Saudi Arabia
    BMC Cancer 13:600. 2013
    ..Therefore, novel generation of anti-cancer drugs with higher efficiency and specificity are urgently needed...
  4. pmc Homologous recombination is involved in transcription-coupled repair of UV damage in Saccharomyces cerevisiae
    Abdelilah Aboussekhra
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    EMBO J 24:1999-2010. 2005
    ..These results show the existence of functional cross-talk between transcription, homologous recombination and NER...
  5. ncbi request reprint Response of medulloblastoma cells to vincristine and lomustine: role of TRKC, CTNNB1 and STK15
    Zakia Shinwari
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, K S A
    Anticancer Res 31:1721-33. 2011
    ..Vincristine and lomustine are two important chemotherapeutic drugs used for the treatment of different types of neoplasms, including medulloblastomas...
  6. ncbi request reprint Expression of survivin and p16(INK4a)/Cdk6/pRB proteins and induction of apoptosis in response to radiation and cisplatin in meningioma cells
    Huda H Al-Khalaf
    Department of Biological and Medical Research, MBC 03, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Brain Res 1188:25-34. 2008
    ..These data shed more light on the molecular biology of meningioma cells and suggest that survivin and proteins of the RB pathway could play a determinant role in the development and the treatment of meningiomas...
  7. doi request reprint The RAD9-dependent gene trans-activation is required for excision repair of active genes but not for repair of non-transcribed DNA
    Nisreen M Al-Moghrabi
    King Faisal Specialist Hospital and Research Center, Department of Biological and Medical Research, Riyadh, Saudi Arabia
    Mutat Res 663:60-8. 2009
    ..Furthermore, de novo protein synthesis was not required for NER in the absence of transcription-coupled NER. This implies that RAD9-dependent gene up-regulation is required for NER only when this process is coupled to transcription...
  8. pmc Curcumin triggers p16-dependent senescence in active breast cancer-associated fibroblasts and suppresses their paracrine procarcinogenic effects
    Siti Fauziah Hendrayani
    Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Neoplasia 15:631-40. 2013
    ..These results indicate the possible inactivation of cancer-associated myofibroblasts and present the first indication that curcumin can trigger DNA damage-independent and safe senescence in stromal fibroblasts...
  9. ncbi request reprint Vincristine and lomustine induce apoptosis and p21(WAF1) up-regulation in medulloblastoma and normal human epithelial and fibroblast cells
    Zakia Shinwari
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    J Neurooncol 87:123-32. 2008
    ..These results shed more light on the biological effects of vincristine and lomustine and show that lomustine is a more specific and potent anti-medulloblastoma agent...
  10. doi request reprint Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells
    Maha H Elamin
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Mol Carcinog 49:302-14. 2010
    ..This effect was mediated through strong downregulation of Bcl-2. These results indicate that curcumin, a natural nontoxic compound, represents great promise as Shh-targeted therapy for medulloblastomas...
  11. ncbi request reprint UV-induced de novo protein synthesis enhances nucleotide excision repair efficiency in a transcription-dependent manner in S. cerevisiae
    Nisreen M Al-Moghrabi
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, MBC 03, PO Box 3354, Riyadh 11211, Saudi Arabia
    DNA Repair (Amst) 2:1185-97. 2003
    ....
  12. pmc Survivin expression increases during aging and enhances the resistance of aged human fibroblasts to genotoxic stress
    Huda H Al-Khalaf
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, MBC 03 66, P O Box 3354, Riyadh, 11211, Saudi Arabia
    Age (Dordr) 35:549-62. 2013
    ..These results show the role of survivin in the age-dependent resistance of human fibroblasts, and provide new insights into the molecular mechanisms that underlie the complex relationship between aging, apoptosis, and cancer...
  13. doi request reprint Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes
    Nahed M Hawsawi
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Cancer Res 68:2717-25. 2008
    ..Taken together these results indicate that different genetic alterations can occur in breast CAFs and their corresponding adjacent counterparts, showing the important role that stroma could play in breast carcinogenesis and treatment...
  14. doi request reprint The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation
    Huda H Al-Khalaf
    King Faisal Specialist Hospital and Research Center, Department of Biological and Medical Research, Riyadh, KSA
    Mol Cancer Res 9:311-9. 2011
    ..Together, these results indicate that p16(INK4A) and p27(Kip1) are key targets in the Atr-dependent signaling pathway in response to UV damage...
  15. doi request reprint PAC, a novel curcumin analogue, has anti-breast cancer properties with higher efficiency on ER-negative cells
    Ensaf M Al-Hujaily
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, KSA
    Breast Cancer Res Treat 128:97-107. 2011
    ..These results indicate that PAC could constitute a powerful, yet not toxic, new chemotherapeutic agent against ER-negative breast tumours...
  16. pmc p16INK4A represses breast stromal fibroblasts migration/invasion and their VEGF-A-dependent promotion of angiogenesis through Akt inhibition
    Mysoon M Al-Ansari
    Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Neoplasia 14:1269-77. 2012
    ....
  17. doi request reprint ATR controls the p21(WAF1/Cip1) protein up-regulation and apoptosis in response to low UV fluences
    Huda H Al-Khalaf
    King Faisal Specialist Hospital and Research Center, Department of Biological and Medical Research, Riyadh, KSA
    Mol Carcinog 51:930-8. 2012
    ..Together, these results indicate that during the cellular response to low UVC fluences the ATR protein kinase up-regulates p21(WAF1/Cip1) and inhibits apoptosis. © 2011 Wiley Periodicals, Inc...
  18. pmc p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1
    Huda H Al-Khalaf
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    PLoS ONE 6:e21111. 2011
    ..However, the precise function of the different members of this pathway and their functional interplay are still not well defined...
  19. doi request reprint Camel urine components display anti-cancer properties in vitro
    Nujoud Al-Yousef
    Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, MBC 03, PO Box 3354, Riyadh 11211, Saudi Arabia
    J Ethnopharmacol 143:819-25. 2012
    ..The objective of the present study is to investigate whether camel urine has anti-cancer effect on human cells in vitro...
  20. doi request reprint Breast stromal fibroblasts from histologically normal surgical margins are pro-carcinogenic
    Maha A Al-Rakan
    Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Pathol 231:457-65. 2013
    ..2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. ..
  21. ncbi request reprint The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells
    Huda H Al-Khalaf
    Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Center, MBC 03 66, 3354, Riyadh 11211, KSA
    J Neurooncol 83:9-15. 2007
    ..These results suggest that the tumor suppressors p53/p21 signaling pathway and PTEN play important roles in the development of benign meningiomas...
  22. ncbi request reprint Deficiency in the repair of UV-induced DNA damage in human skin fibroblasts compromised for the ATM gene
    Mohammed A Hannan
    King Faisal Specialist Hospital and Research Center, Biological and Medical Research Department, MBC 03 66, Riyadh 11211, Saudi Arabia
    Carcinogenesis 23:1617-24. 2002
    ..These results constitute the first clear evidence showing the deficiency of A-T cells in the repair of UV-induced DNA damage, and provide further information on the relationship between cell cycle control and DNA repair in human cells...
  23. ncbi request reprint The tumor suppressor p16(INK4a) gene is a regulator of apoptosis induced by ultraviolet light and cisplatin
    Mai A Al-Mohanna
    King Faisal Specialist Hospital and Research Center, BMR, MBC 03, PO Box 3354, Riyadh 11211, Saudi Arabia
    Oncogene 23:201-12. 2004
    ..These novel findings provide further insight into the role of p16 in carcinogenesis, and has potential implications for future therapy strategies...
  24. pmc The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light
    Mai A Al-Mohanna
    King Faisal Specialist Hospital and Research Center, Department of Biological and Medical Research, MBC 03 66, PO Box 3354, Riyadh 11211, KSA
    Nucleic Acids Res 35:223-33. 2007
    ..These results indicate that, in addition to its role in cell proliferation, p16INK4a is also an important regulator of the cellular response to UV damage...
  25. doi request reprint Caffeine Mediates Sustained Inactivation of Breast Cancer-Associated Myofibroblasts via Up-Regulation of Tumor Suppressor Genes
    Mysoon M Al-Ansari
    Department of Microbiology, Faculty of Science and Medical Studies, King Saud University, Riyadh, Saudi Arabia
    PLoS ONE 9:e90907. 2014
    ..To this end, we investigated the effect of the natural and pharmacologically safe molecule, caffeine, on CAF cells and their various procarcinogenic effects...
  26. pmc p16(INK4A) positively regulates p21(WAF1) expression by suppressing AUF1-dependent mRNA decay
    Huda H Al-Khalaf
    Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    PLoS ONE 8:e70133. 2013
    ..Therefore, we sought to elucidate the molecular mechanisms underlying the link between these two important tumor suppressor proteins...
  27. doi request reprint Methylation-related mutations in the BRCA1 promoter in peripheral blood cells from cancer-free women
    Nisreen Al-Moghrabi
    DNA Repair and Apoptosis Section, Department of Biological and Medical Research, King Faisal Specialist Hospital and Research Centre, MBC 03, PO Box 3354, Riyadh 11211, Saudi Arabia
    Int J Oncol 39:129-35. 2011
    ....
  28. ncbi request reprint Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis
    Maher Hassounah
    Department of Neurosciences, MBC 76, Riadh, KSA
    J Neurooncol 72:203-8. 2005
    ....