Maria Sasvari-Szekely

Summary

Publications

  1. ncbi request reprint [Genetic aspects of the Stroop test]
    Tibor Nánási
    Semmelweis Egyetem, Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézete, Budapest, Hungary
    Neuropsychopharmacol Hung 14:252-8. 2012
  2. doi request reprint Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 gene
    Omar Abdul Rahman
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Electrophoresis 31:1790-5. 2010
  3. ncbi request reprint Dopaminergic candidate genes in Tourette syndrome: association between tic severity and 3' UTR polymorphism of the dopamine transporter gene
    Zsanett Tarnok
    Vadaskert Child and Adolescent Psychiatric Clinic, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 144:900-5. 2007
  4. ncbi request reprint Association between the 120-bp duplication of the dopamine D4 receptor gene and attention deficit hyperactivity disorder: genetic and molecular analyses
    Eva Kereszturi
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 144:231-6. 2007
  5. doi request reprint Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity
    Gabor Varga
    Institute of Psychology, Eotvos Lorand University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 159:281-8. 2012
  6. doi request reprint Association between hypnotizability and the catechol-O-methyltransferase (COMT) polymorphism
    Anna Szekely
    Institute of Psychology, Eotvos Lorand University, Budapest, Hungary
    Int J Clin Exp Hypn 58:301-15. 2010
  7. ncbi request reprint Combined effect of promoter polymorphisms in the dopamine D4 receptor and the serotonin transporter genes in heroin dependence
    Agnes Szilagyi
    Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    Neuropsychopharmacol Hung 7:28-33. 2005
  8. pmc Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs
    Eniko Kubinyi
    Department of Ethology, Eotvos Lorand University, Budapest, Hungary
    PLoS ONE 7:e30271. 2012
  9. ncbi request reprint [Analysis of the dopamine D4 receptor gene variants in attention deficit hyperactivity disorder]
    Eva Kereszturi
    Semmelweis Egyetem, Orvosi Vegytani, Molekuláris Biológiai és Pathobiokémiai Intézet, Budapest
    Neuropsychopharmacol Hung 9:11-8. 2007
  10. doi request reprint P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients
    Geza Nagy
    Semmelweis University, 2nd Department of Internal Medicine, Budapest, 1088, Szentkiralyi u 46, Hungary
    Prog Neuropsychopharmacol Biol Psychiatry 32:1884-8. 2008

Collaborators

Detail Information

Publications41

  1. ncbi request reprint [Genetic aspects of the Stroop test]
    Tibor Nánási
    Semmelweis Egyetem, Orvosi Vegytani, Molekuláris Biológiai és Patobiokémiai Intézete, Budapest, Hungary
    Neuropsychopharmacol Hung 14:252-8. 2012
    ..In conclusion, further studies are needed for clarifying the genetic background of Stroop performance, characterizing attentional functions...
  2. doi request reprint Analysis of a polymorphic microRNA target site in the purinergic receptor P2RX7 gene
    Omar Abdul Rahman
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Electrophoresis 31:1790-5. 2010
    ..The developed genotyping method was applied in our depression-related association study...
  3. ncbi request reprint Dopaminergic candidate genes in Tourette syndrome: association between tic severity and 3' UTR polymorphism of the dopamine transporter gene
    Zsanett Tarnok
    Vadaskert Child and Adolescent Psychiatric Clinic, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 144:900-5. 2007
    ..002). In summary, allele frequencies did not differ between cases and controls, but DAT1 genotype accounted for variations of tic severity within the TS group...
  4. ncbi request reprint Association between the 120-bp duplication of the dopamine D4 receptor gene and attention deficit hyperactivity disorder: genetic and molecular analyses
    Eva Kereszturi
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 144:231-6. 2007
    ..These results suggest that the 1-repeat form of the 120-bp dup might be a risk factor of ADHD, especially in the homozygous form and/or in the context of certain haplotypes...
  5. doi request reprint Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity
    Gabor Varga
    Institute of Psychology, Eotvos Lorand University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 159:281-8. 2012
    ..These results clearly suggest an additive effect of dopaminergic and serotonergic polymorphisms on trait impulsivity...
  6. doi request reprint Association between hypnotizability and the catechol-O-methyltransferase (COMT) polymorphism
    Anna Szekely
    Institute of Psychology, Eotvos Lorand University, Budapest, Hungary
    Int J Clin Exp Hypn 58:301-15. 2010
    ..The present study replicates association of COMT Val(158)Met SNP and hypnotizability and stresses the importance of mediating factors, such as group vs. individual inductions...
  7. ncbi request reprint Combined effect of promoter polymorphisms in the dopamine D4 receptor and the serotonin transporter genes in heroin dependence
    Agnes Szilagyi
    Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary
    Neuropsychopharmacol Hung 7:28-33. 2005
    ..However, due to the limited size of our sample these results should be interpreted with caution...
  8. pmc Polymorphism in the tyrosine hydroxylase (TH) gene is associated with activity-impulsivity in German Shepherd Dogs
    Eniko Kubinyi
    Department of Ethology, Eotvos Lorand University, Budapest, Hungary
    PLoS ONE 7:e30271. 2012
    ..007; AIBS: p = 0.023). The results have some potential to support human studies; however, further research should reveal the molecular function of the TH gene variants, and look for the effect in more breeds...
  9. ncbi request reprint [Analysis of the dopamine D4 receptor gene variants in attention deficit hyperactivity disorder]
    Eva Kereszturi
    Semmelweis Egyetem, Orvosi Vegytani, Molekuláris Biológiai és Pathobiokémiai Intézet, Budapest
    Neuropsychopharmacol Hung 9:11-8. 2007
    ..01). These results of association and functional analyses suggest that the 1-repeat form of the 120 bp duplication might be a risk factor of ADHD...
  10. doi request reprint P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients
    Geza Nagy
    Semmelweis University, 2nd Department of Internal Medicine, Budapest, 1088, Szentkiralyi u 46, Hungary
    Prog Neuropsychopharmacol Biol Psychiatry 32:1884-8. 2008
    ..We assumed that genetic influence would be stronger on depressive symptoms in the "poor glycemic control" group (PC: HbA1C>7%) compared to the "good glycemic control" group (GC: HbA1C<or=7%)...
  11. doi request reprint Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children
    Eva Kereszturi
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 147:1431-5. 2008
    ..015). This interaction might reflect the regulatory effect of COMT dominated prefrontal dopamine transmission on subcortical dopamine systems, which are the actual site of methylphenidate action...
  12. doi request reprint Associations between depression severity and purinergic receptor P2RX7 gene polymorphisms
    Zsuzsa Halmai
    Department of Clinical and Theoretical Mental Health, Kutvolgyi Clinical Center, Semmelweis University, Budapest, Hungary
    J Affect Disord 150:104-9. 2013
    ..In the current study the genetic effects of rs2230912 (Gln460Arg) and rs1653625 (located in the 3' untranslated region of the P2RX7 gene) were explored in mood disorders...
  13. doi request reprint Haplotyping of putative microRNA-binding sites in the SNAP-25 gene
    Reka Kovacs-Nagy
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Electrophoresis 32:2013-20. 2011
    ..Results of the study of the two SNPs might shed light on the association of SNAP-25 variants and pathological phenotypes at the molecular level...
  14. ncbi request reprint Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction
    Bernadett Blasko
    Research Group of Inflammation Biology and Immunogenomics, Semmelweis University and Hungarian Academy of Sciences, Budapest, Hungary
    Int Immunol 20:31-7. 2008
    ..The +252 G allele of the lymphotoxin-alpha (LTA) gene encoded close to the C4B gene was also reported to be related to CVD-related mortality in an Oriental population...
  15. pmc No direct effect of the -521 C/T polymorphism in the human dopamine D4 receptor gene promoter on transcriptional activity
    Eva Kereszturi
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    BMC Mol Biol 7:18. 2006
    ..Previously, the -521C/T SNP was shown to influence promoter activity. The aim of this study is to perform an in-depth analysis of this effect in the context of various neural cell lines...
  16. doi request reprint Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD
    Zsofia Nemoda
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Neuropharmacology 57:731-3. 2009
    ..410 +/- 0.127 vs 0.572 +/- 0.153 mg/kg, t(1,88) = 2.33, p = 0.022). This result warrants for further investigations of the CES1 gene in larger ADHD samples...
  17. pmc Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence
    Andrea Vereczkei
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    PLoS ONE 8:e66592. 2013
    ..Since the dopaminergic system has a key role in rewarding mechanism of the brain, which is directly or indirectly targeted by most drugs of abuse, we focus on the effects and interactions among dopaminergic gene variants...
  18. doi request reprint Peripheral vascular endothelial growth factor level is associated with antidepressant treatment response: results of a preliminary study
    Zsuzsa Halmai
    Department of Clinical and Theoretical Mental Health, Kutvolgyi Clinical Center, Semmelweis University, Faculty of Medicine, Budapest, Hungary
    J Affect Disord 144:269-73. 2013
    ..In this study we were interested in investigating a possible association between VEGF levels and treatment response in patients with a current episode of major depression (MDE)...
  19. pmc Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients
    Zsofia Nemoda
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Behav Brain Funct 6:4. 2010
    ..However, the efficacy of dopamine D2 receptor (DRD2) blocking antipsychotic drugs in BPD treatment also suggests involvement of the dopamine system in the neurobiology of BPD...
  20. pmc Real-time PCR quantification of human complement C4A and C4B genes
    Agnes Szilagyi
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    BMC Genet 7:1. 2006
    ..Despite of this major clinical relevance, only low throughput, time and labor intensive methods have been used so far for the quantification of C4A and C4B genes...
  21. doi request reprint Interaction of 5-HTTLPR genotype and unipolar major depression in the emergence of aggressive/hostile traits
    Xenia Gonda
    Department of Clinical and Theoretical Mental Health, Kutvolgyi Clinical Center, Semmelweis University, Budapest, Hungary
    J Affect Disord 132:432-7. 2011
    ..Our aim was to investigate the association between 5-HTTLPR and aggressive/hostile traits in depressed patients and controls...
  22. pmc Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood
    Zsofia Nemoda
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Neurosci Biobehav Rev 35:1665-86. 2011
    ..The dopamine catabolizing enzyme genes, such as monoamine oxidase (MAO) A and catechol-O-methyltransferase (COMT) genes, have been linked to aggressive behaviors...
  23. doi request reprint Association of extracellular superoxide dismutase (SOD3) Ala40Thr gene polymorphism with pre-eclampsia complicated by severe fetal growth restriction
    Klara Rosta
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Eur J Obstet Gynecol Reprod Biol 142:134-8. 2009
    ..The aim of our study was to examine whether two missense polymorphisms of the extracellular superoxide dismutase (SOD3) gene (Arg213Gly and Ala40Thr) are associated with pre-eclampsia in a Caucasian population from Hungary...
  24. pmc Altered gene expression profiles in the hippocampus and prefrontal cortex of type 2 diabetic rats
    Omar Abdul-Rahman
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    BMC Genomics 13:81. 2012
    ....
  25. pmc Infant genotype may moderate sensitivity to maternal affective communications: attachment disorganization, quality of care, and the DRD4 polymorphism
    Judit Gervai
    Institute for Psychology, Hungarian Academy of Sciences, Budapest, Hungary
    Soc Neurosci 2:307-19. 2007
    ..Among carriers of the 7-repeat DRD4 allele, there was no relation between quality of maternal communication and infant disorganization. This interaction effect was independent of degree of social risk and maternal DRD4 genotype...
  26. ncbi request reprint [The potential role of childhood ADHD in the development of heroin dependence at a young age]
    Agnes Szilagyi
    Farmakológai es Farmakoterápiás Intézet, Semmelweis Egyetem, Budapest
    Neuropsychopharmacol Hung 9:69-75. 2007
    ..These results support the hypothesis that untreated childhood ADHD could be a risk factor for developing substance use disorder...
  27. ncbi request reprint Novel repeat polymorphisms of the dopaminergic neurotransmitter genes among dogs and wolves
    Krisztina Hejjas
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Mamm Genome 18:871-9. 2007
    ..Preliminary findings are presented that polymorphisms of the DRD4, DBH, and DAT genes can be associated with attention deficit among Belgian Tervuerens...
  28. ncbi request reprint Contribution of serotonin transporter gene polymorphisms to pediatric migraine
    Agnes Szilagyi
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Headache 46:478-85. 2006
    ..The serotonin transporter gene is a promising candidate locus for the genetic susceptibility of migraine...
  29. doi request reprint Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approach
    Krisztina Hejjas
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 150:295-9. 2009
    ..In conclusion, case-control analysis did not reveal significant results, but using a symptom severity scale we could support the association between depressive disorder and the G-allele of the Gln460Arg polymorphism in the P2RX7 gene...
  30. doi request reprint Association of aggression with a novel microRNA binding site polymorphism in the wolframin gene
    Reka Kovacs-Nagy
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Am J Med Genet B Neuropsychiatr Genet 162:404-12. 2013
    ..To our knowledge, this is the first report describing a microRNA binding site polymorphism of the WFS1 gene and its association with human aggression based on a large, non-clinical sample...
  31. ncbi request reprint [Analysis of the genetic variability of complement component C4 by real-time PCR]
    Szilágyi Agnes
    Semmelweis Egyetem, Orvosi Vegytani, Molekuláris Biológiai és Pathobiokémiai Intézet, Budapest
    Neuropsychopharmacol Hung 9:5-10. 2007
    ..The novel method was demonstrated to be a simple, fast and reliable choice for studies of the complement C4 system, especially in large-scale populations screening...
  32. ncbi request reprint [Association between mood characteristics and polymorphisms of glial cell line-derived neurotrophic factor (GNDF) in patients with depression]
    Eszter Kótyuk
    Eotvos Lorand Tudomanyegyetem, Pszichologiai Intezet, Budapest, Hungary
    Neuropsychopharmacol Hung 15:63-72. 2013
    ....
  33. ncbi request reprint SNAP-25: a novel candidate gene in psychiatric genetics
    Reka Kovacs-Nagy
    Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Neuropsychopharmacol Hung 11:89-94. 2009
    ..If the putative miR SNPs are shown to have a function in vivo their implication in further psychogenetic association studies will have a higher impact...
  34. ncbi request reprint [Dopamine D4 receptor hypoxia sensitivity and child psychiatric disorders]
    Viktor Mozes
    Semmelweis Egyetem, Orvosi Vegytani, Molekuláris Biológiai és Pathobiokémiai Intézet, Budapest, Hungary
    Neuropsychopharmacol Hung 12:289-93. 2010
    ..These observations suggest that the effect of hypoxia on the dopaminergic neurotransmission might be an important factor in the pathomechanism of ADHD...
  35. doi request reprint Linkage analysis of the C4A/C4B copy number variation and polymorphisms of the adjacent steroid 21-hydroxylase gene in a healthy population
    Bernadett Blasko
    Semmelweis University Hungarian Academy of Sciences, Budapest, Hungary
    Mol Immunol 46:2623-9. 2009
    ..These results suggest that variations of CYP21A2 gene can be involved in disease associations of the 8.1 haplotype and the C4B*Q0 genotype...
  36. ncbi request reprint Candidate gene studies of dopaminergic and serotonergic polymorphisms
    Gabor Varga
    Institute of Psychology, Eotvos Lorand University, Budapest, Hungary
    Neuropsychopharmacol Hung 13:93-101. 2011
    ..On the whole, however, it can be declared that psychogenetic research plays an important role in the development of personalized pharmacotherapy...
  37. ncbi request reprint [Genetic variability of the oxytocine receptor: an in silico study]
    Peter Marx
    Budapesti Muszaki és Gazdaságtudományi Egyetem, Méréstechnika és Információs Rendszerek Tanszék, Budapest, Hungary
    Neuropsychopharmacol Hung 13:139-44. 2011
    ..One of the sources of inconsistency could originate from the fact that the OXTR gene contains more than 270 SNPs (single nucleotide polymorphisms) without clarified molecular effect...
  38. pmc Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample
    Geza Nagy
    2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
    BMC Med Genet 10:79. 2009
    ..Our aim was to replicate these findings on a Caucasian (Hungarian) population, as well as to study whether this genetic effect is restricted to T2DM or can be expanded to diabetes in general...
  39. ncbi request reprint [The role of genetic variants of the dopaminergic system in heroin dependence]
    Andrea Vereczkei
    Semmelweis Egyetem, Orvosi Vegytani, Molekuláris Biológiai es Patobiokémiai Intézet, Budapest
    Neuropsychopharmacol Hung 11:95-101. 2009
    ..To unravel the contradictions and better understand the pathogenesis of the disease more research needs to be conducted...
  40. doi request reprint Candidate gene copy number analysis by PCR and multicapillary electrophoresis
    Eszter Szantai
    Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest, Hungary
    Electrophoresis 30:1098-101. 2009
    ..This method can be readily implemented for the analysis of candidate gene CNVs in high throughput clinical laboratories and also in personalized medicine care of depression-related risk factors...
  41. ncbi request reprint [Effect of dopaminergic and serotonergic gene variants on cognitive performance]
    Rozsa Eniko Katonai
    Eotvos Lorand Tudomanyegyetem, Pszichologiai Intezet, Budapest, Hungary
    Neuropsychopharmacol Hung 13:81-6. 2011
    ..Results of candidate gene studies implicate an important role of the dopaminergic system in coding individual differences in reaction time performance, and the possible role of the function of the serotonergic system has also emerged...