Jennifer M Sasser

Summary

Publications

  1. pmc Sexual dimorphism in development of kidney damage in aging Fischer-344 rats
    Jennifer M Sasser
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA
    Gend Med 9:219-31. 2012
  2. pmc Nebivolol does not protect against 5/6 ablation/infarction induced chronic kidney disease in rats - comparison with angiotensin II receptor blockade
    Jennifer M Sasser
    Departments of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA
    Life Sci 91:54-63. 2012
  3. pmc Protective actions of nebivolol on chronic nitric oxide synthase inhibition-induced hypertension and chronic kidney disease in the rat: a comparison with angiotensin II receptor blockade
    Natasha C Moningka
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA
    Nephrol Dial Transplant 27:913-20. 2012
  4. pmc Chronic vasodilation increases renal medullary PDE5A and α-ENaC through independent renin-angiotensin-aldosterone system pathways
    Crystal A West
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida
    Am J Physiol Regul Integr Comp Physiol 305:R1133-40. 2013
  5. pmc Protection against age-dependent renal injury in the F344xBrown Norway male rat is associated with maintained nitric oxide synthase
    Natasha C Moningka
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610, USA
    Mech Ageing Dev 132:1-7. 2011
  6. pmc Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species
    Annet Kirabo
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Cardiovasc Res 91:171-9. 2011
  7. pmc Arginine and asymmetric dimethylarginine in puromycin aminonucleoside-induced chronic kidney disease in the rat
    Gin Fu Chen
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, USA
    Am J Nephrol 35:40-8. 2012
  8. pmc Renal redox response to normal pregnancy in the rat
    Mark W Cunningham
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Am J Physiol Regul Integr Comp Physiol 304:R443-9. 2013
  9. pmc Renal nitric oxide synthase and antioxidant preservation in Cyp1a1-Ren-2 transgenic rats with inducible malignant hypertension
    Mark W Cunningham
    Departments of Physiology and Medicine, University of Florida, Gainesville, Florida
    Am J Hypertens 26:1242-9. 2013
  10. pmc Effects of angiotensin type 1 receptor blockade on arginine and ADMA synthesis and metabolic pathways in fawn-hooded hypertensive rats
    Gin Fu Chen
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA
    Nephrol Dial Transplant 25:3518-25. 2010

Collaborators

Detail Information

Publications15

  1. pmc Sexual dimorphism in development of kidney damage in aging Fischer-344 rats
    Jennifer M Sasser
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA
    Gend Med 9:219-31. 2012
    ..Aging kidneys exhibit slowly developing injury and women are usually protected compared with men, in association with maintained renal nitric oxide...
  2. pmc Nebivolol does not protect against 5/6 ablation/infarction induced chronic kidney disease in rats - comparison with angiotensin II receptor blockade
    Jennifer M Sasser
    Departments of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA
    Life Sci 91:54-63. 2012
    ..Here, we investigated whether Nebivolol attenuates hypertension and renal injury after 5/6 ablation/infarction (A/I). Efficacy was compared to the AT1 receptor antagonist Olmesartan...
  3. pmc Protective actions of nebivolol on chronic nitric oxide synthase inhibition-induced hypertension and chronic kidney disease in the rat: a comparison with angiotensin II receptor blockade
    Natasha C Moningka
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA
    Nephrol Dial Transplant 27:913-20. 2012
    ..The β-blocker, nebivolol (N), also enhances NO production, and we studied whether N attenuates CKD and hypertension caused by chronic NO synthase inhibition (CNOSI)...
  4. pmc Chronic vasodilation increases renal medullary PDE5A and α-ENaC through independent renin-angiotensin-aldosterone system pathways
    Crystal A West
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida
    Am J Physiol Regul Integr Comp Physiol 305:R1133-40. 2013
    ..These data indicate that the PVE and renal medullary adaptations in response to chronic vasodilation result from RAAS signaling, with increases in PDE5A mediated through AT1 receptor and α-ENaC through the MR...
  5. pmc Protection against age-dependent renal injury in the F344xBrown Norway male rat is associated with maintained nitric oxide synthase
    Natasha C Moningka
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610, USA
    Mech Ageing Dev 132:1-7. 2011
    ..The tubulointerstitial injury seen with aging is reversed with 6 months of ARB but not ACEI and is not associated with renal NOS...
  6. pmc Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species
    Annet Kirabo
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Cardiovasc Res 91:171-9. 2011
    ..However, the importance of this tissue-specific coupling is poorly understood. The purpose of this investigation was to determine the importance of VSMC-derived Jak2 in angiotensin II-mediated hypertension...
  7. pmc Arginine and asymmetric dimethylarginine in puromycin aminonucleoside-induced chronic kidney disease in the rat
    Gin Fu Chen
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, USA
    Am J Nephrol 35:40-8. 2012
    ..This study investigated pathways of L-Arg synthesis/uptake/utilization, ADMA degradation and oxidant/antioxidants in puromycin aminonucleoside (PAN) chronic kidney disease (CKD)...
  8. pmc Renal redox response to normal pregnancy in the rat
    Mark W Cunningham
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Am J Physiol Regul Integr Comp Physiol 304:R443-9. 2013
    ..Aortic CuZn SOD deceased at PP, while the other aortic SODs and aortic TAC did not change. Data from this study suggest that the kidney cortex is protected from OS during normal rat pregnancy via an increase in antioxidant activity...
  9. pmc Renal nitric oxide synthase and antioxidant preservation in Cyp1a1-Ren-2 transgenic rats with inducible malignant hypertension
    Mark W Cunningham
    Departments of Physiology and Medicine, University of Florida, Gainesville, Florida
    Am J Hypertens 26:1242-9. 2013
    ..We tested the hypothesis that maintenance of renal function in hypertensive Cyp1a1-Ren2 TGRs is due to preservation of the intrarenal nitric oxide (NO) and antioxidant systems...
  10. pmc Effects of angiotensin type 1 receptor blockade on arginine and ADMA synthesis and metabolic pathways in fawn-hooded hypertensive rats
    Gin Fu Chen
    Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, USA
    Nephrol Dial Transplant 25:3518-25. 2010
    ..L-Arg is then taken up from plasma into cells where it can be utilized by NOS and other pathways. The competitive inhibitor of NOS, ADMA, is degraded by dimethylarginine dimethylaminohydrolase (DDAH)...
  11. pmc Relaxin ameliorates hypertension and increases nitric oxide metabolite excretion in angiotensin II but not N(ω)-nitro-L-arginine methyl ester hypertensive rats
    Jennifer M Sasser
    Department of Physiology and Functional Genomics, University of Florida, PO Box 100274, Gainesville, FL 32610, USA
    Hypertension 58:197-204. 2011
    ..These data suggest that the vasodilatory effects of relaxin are dependent on a functional NO synthase system and increased NO bioavailability possibly because of a reduction in oxidative stress...
  12. pmc Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to a nitric oxide donor in the pregnant rat
    Jennifer M Sasser
    Dept of Physiology and Functional Genomics, Univ of Florida, PO Box 100274, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 299:F810-4. 2010
    ..Therefore, increased intrarenal PDE5 mediates the blunted natriuretic response to NO, and loss of responsiveness to the cGMP-dependent, natriuretic agents may contribute to volume expansion during pregnancy...
  13. pmc Chronic vasodilation produces plasma volume expansion and hemodilution in rats: consequences of decreased effective arterial blood volume
    Andrea Fekete
    Department of Physiology and Functional Genomics, University of Florida, PO Box 100274, Gainesville, FL 32610, USA
    Am J Physiol Renal Physiol 300:F113-8. 2011
    ..We suggest that a primary, persistent vasodilation drives increased inner medullary PDE5 expression which facilitates continual renal Na retention causing "refilling" of the vasculature and volume expansion...
  14. pmc Asymmetric dimethylarginine in angiotensin II-induced hypertension
    Jennifer M Sasser
    Dept of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610, USA
    Am J Physiol Regul Integr Comp Physiol 298:R740-6. 2010
    ..However, the presence of renal injury and sustained hypertension for 6 wk increases ADMA levels and contributes to nitric oxide deficiency and cardiovascular disease...
  15. pmc Effects of sildenafil on maternal hemodynamics and fetal growth in normal rat pregnancy
    Jennifer M Sasser
    Department of Physiology and Functional Genomics, University of Florida, P O Box 100274, Gainesville, FL 32610, USA
    Am J Physiol Regul Integr Comp Physiol 298:R433-8. 2010
    ..The effects of systemic sildenafil on blood pressure and sodium retention during hypertension in human pregnancy remain to be examined...