Koneni V Sashidhara

Summary

Publications

  1. doi request reprint Synthesis of novel benzocoumarin derivatives as lipid lowering agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India
    Bioorg Med Chem Lett 20:3065-9. 2010
  2. ncbi request reprint Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, BS 10 1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, Uttar Pradesh 226031, India Electronic address
    Eur J Med Chem 81:499-509. 2014
  3. ncbi request reprint Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, BS 10 1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, Uttar Pradesh 226031, India Electronic address
    Eur J Med Chem 81:473-80. 2014
  4. doi request reprint Synthesis and evaluation of new coumarin-pyridine hybrids with promising anti-osteoporotic activities
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, CSIR CDRI, BS 10 1, Sector 10, Jankipuram Extension, Sitapur Road, P O Box 173, Lucknow 226031, India Electronic address
    Eur J Med Chem 70:802-10. 2013
  5. doi request reprint Hybrid benzofuran-bisindole derivatives: new prototypes with promising anti-hyperlipidemic activities
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India Electronic address
    Eur J Med Chem 68:38-46. 2013
  6. doi request reprint Main extracts and hypolipidemic effects of the Bauhinia racemosa Lam. leaf extract in HFD-fed hamsters
    Koneni V Sashidhara
    Division of Medicinal and Process Chemistry, CSIR Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India
    Nat Prod Res 27:1127-31. 2013
  7. doi request reprint Coumarin chalcone fibrates: a new structural class of lipid lowering agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
    Eur J Med Chem 64:422-31. 2013
  8. doi request reprint Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent
    Koneni V Sashidhara
    Department of Medicinal and Process Chemistry, CSIR Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India
    Eur J Med Chem 60:120-7. 2013
  9. doi request reprint Isolation and identification of β-hematin inhibitors from Flacourtia indica as promising antiplasmodial agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Lucknow 226001, India
    Eur J Med Chem 60:497-502. 2013
  10. doi request reprint In vitro and in vivo antifilarial activity evaluation of 3,6-epoxy [1,5]dioxocines: a new class of antifilarial agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Lucknow, India
    Bioorg Med Chem Lett 22:1527-32. 2012

Detail Information

Publications38

  1. doi request reprint Synthesis of novel benzocoumarin derivatives as lipid lowering agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India
    Bioorg Med Chem Lett 20:3065-9. 2010
    ..The study revealed that such attempts on benzocoumarin-based pharmacophores which is a biologically important scaffold might result in identification of new lead for anti-dyslipidemia...
  2. ncbi request reprint Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, BS 10 1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, Uttar Pradesh 226031, India Electronic address
    Eur J Med Chem 81:499-509. 2014
    ..Our results suggest that these new hybrid architectures may serve as promising leads for the development of next generation lipid lowering agents. ..
  3. ncbi request reprint Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, BS 10 1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, Uttar Pradesh 226031, India Electronic address
    Eur J Med Chem 81:473-80. 2014
    ..Compound 4n showed 100% embryostatic effect and 49% macrofilaricidal in jirds and M. coucha models, respectively. This study provides a new structural clue for the development of novel antifilarial lead molecules. ..
  4. doi request reprint Synthesis and evaluation of new coumarin-pyridine hybrids with promising anti-osteoporotic activities
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, CSIR CDRI, BS 10 1, Sector 10, Jankipuram Extension, Sitapur Road, P O Box 173, Lucknow 226031, India Electronic address
    Eur J Med Chem 70:802-10. 2013
    ..In this context, compound 6j was selected as a potential lead for further structural optimization in the development of new anti-osteoporotic agents...
  5. doi request reprint Hybrid benzofuran-bisindole derivatives: new prototypes with promising anti-hyperlipidemic activities
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India Electronic address
    Eur J Med Chem 68:38-46. 2013
    ..These results indicate that these hybrids constitute novel prototypes for the management of dyslipidemia. ..
  6. doi request reprint Main extracts and hypolipidemic effects of the Bauhinia racemosa Lam. leaf extract in HFD-fed hamsters
    Koneni V Sashidhara
    Division of Medicinal and Process Chemistry, CSIR Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India
    Nat Prod Res 27:1127-31. 2013
    ..The results of activity profile of the plant were found to be better than the standard drug lovastatin...
  7. doi request reprint Coumarin chalcone fibrates: a new structural class of lipid lowering agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
    Eur J Med Chem 64:422-31. 2013
    ..Altogether, our data suggests that these novel hybrids would be a potential new class of therapeutic agents against dyslipidemia...
  8. doi request reprint Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent
    Koneni V Sashidhara
    Department of Medicinal and Process Chemistry, CSIR Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India
    Eur J Med Chem 60:120-7. 2013
    ..The concept of molecular hybridization led us to discover a novel class of coumarin-monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines...
  9. doi request reprint Isolation and identification of β-hematin inhibitors from Flacourtia indica as promising antiplasmodial agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Lucknow 226001, India
    Eur J Med Chem 60:497-502. 2013
    ..It forms a complex with hematin and inhibits β-hematin formation, suggesting that this compound act on a heme polymerization target...
  10. doi request reprint In vitro and in vivo antifilarial activity evaluation of 3,6-epoxy [1,5]dioxocines: a new class of antifilarial agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Lucknow, India
    Bioorg Med Chem Lett 22:1527-32. 2012
    ..These results demonstrate that 3,6-epoxy [1,5]dioxocines exhibits potent antifilarial activity and might be developed into a new class of antifilarial drug...
  11. doi request reprint Synthesis of novel 3-carboxamide-benzocoumarin derivatives as orally active antithrombotic agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute CDRI CSIR, Lucknow, India
    Bioorg Med Chem Lett 21:7034-40. 2011
    ....
  12. doi request reprint Coumarin-trioxane hybrids: synthesis and evaluation as a new class of antimalarial scaffolds
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute CSIR CDRI, Lucknow 226 001, India
    Bioorg Med Chem Lett 22:3926-30. 2012
    ....
  13. doi request reprint Synthesis and evaluation of anti-thrombotic activity of benzocoumarin amide derivatives
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR CDRI, Lucknow 226 001, India
    Bioorg Med Chem Lett 22:3115-21. 2012
    ..05). Thus, in the present study, these benzocoumarin amide derivatives exhibited anti-thrombotic profile via both anti-platelet as well as anti-coagulant action...
  14. doi request reprint Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India
    Eur J Med Chem 50:230-5. 2012
    ..It was found to be better than the standard drug ivermectin and diethylcarbamazine (DEC) in terms of dose and efficacy...
  15. doi request reprint Indole-based fibrates as potential hypolipidemic and antiobesity agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute CSIR CDRI, Lucknow 226 001, India
    J Med Chem 55:2769-79. 2012
    ....
  16. ncbi request reprint Antimicrobial evaluation of clerodane diterpenes from Polyalthia longifolia var. pendula
    Koneni V Sashidhara
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, U P 226001, India
    Nat Prod Commun 4:327-30. 2009
    ..Clerodane derivatives 1-7 were evaluated for their antimicrobial activity. Diterpene 3 was found to be most potent agent with MIC value of 6.25 microg/mL against Staphylococcus aureus and Sporothrix schenckii...
  17. ncbi request reprint Antidyslipidemic and antioxidative activities of 8-hydroxyquinoline derived novel keto-enamine Schiffs bases
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, Uttar Pradesh, India
    Eur J Med Chem 44:1813-8. 2009
    ..Compound 6 was found to be most active antidyslipidemic and antioxidative agent in this series, respectively, and thus represent a new class of promising lead...
  18. doi request reprint Rare dipeptide and urea derivatives from roots of Moringa oleifera as potential anti-inflammatory and antinociceptive agents
    Koneni V Sashidhara
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow 226001, Uttar Pradesh, India
    Eur J Med Chem 44:432-6. 2009
    ..These findings may help in understanding the mechanism of action of this traditional plant leading to control of activated mast cells on inflammatory conditions like arthritis, for which the crude extract has been used...
  19. doi request reprint Synthesis and antihyperlipidemic activity of novel coumarin bisindole derivatives
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute CSIR, Lucknow 226 001, India
    Bioorg Med Chem Lett 20:6504-7. 2010
    ....
  20. ncbi request reprint Novel keto-enamine Schiffs bases from 7-hydroxy-4-methyl-2-oxo-2H-benzo[h] chromene-8,10-dicarbaldehyde as potential antidyslipidemic and antioxidant agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, Uttar Pradesh 226 001, India
    Eur J Med Chem 43:2592-6. 2008
    ..The compounds were evaluated in vitro for their antioxidant and in vivo for their antidyslipidemic activity for the first time. Compounds 3 and 7 possess significant lipid lowering and antioxidant activity...
  21. doi request reprint Cytotoxic clerodane diterpenoids from the leaves of Polyalthia longifolia
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India
    Nat Prod Res 24:1687-94. 2010
    ..Both 1 and 2 were tested for their growth inhibitory activity on four cancer cell lines in vitro. IC(50) values suggest that they are effective as cytotoxic agents...
  22. doi request reprint Novel coumarin derivatives as potential antidyslipidemic agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India
    Bioorg Med Chem Lett 20:4248-51. 2010
    ..Among 11 compounds tested, 2 compounds showed potent antidyslipidemic activity and 3 compounds showed potent antioxidant activity...
  23. doi request reprint Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute CSIR CDRI, Lucknow, India
    Bioorg Med Chem Lett 21:4480-4. 2011
    ..These compounds thus constitute an interesting template for the design of new therapeutic tools against inflammation...
  24. doi request reprint Discovery and synthesis of novel 3-phenylcoumarin derivatives as antidepressant agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India
    Bioorg Med Chem Lett 21:1937-41. 2011
    ..The potent compounds did not show any neurotoxicity in the rotarod test and the preliminary results are promising enough to warrant further studies around this scaffold...
  25. doi request reprint Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, CDRI CSIR, Lucknow, India
    Bioorg Med Chem Lett 20:7205-11. 2010
    ..59 to 8.12 μM. The most promising compound 26 showed around 30-fold more selectivity towards C33A (cervical carcinoma) cells over normal fibroblast NIH3T3 cells with an IC(50) value of 3.59 μM...
  26. doi request reprint Identification of the antioxidant principles of Polyalthia longifolia var. pendula using TEAC assay
    Koneni V Sashidhara
    Division of Medicinal and Process Chemistry, Central Drug Research Institute CSIR, Uttar Pradesh, India
    Nat Prod Res 25:918-26. 2011
    ..10, 1.91 and 2.38 mM, respectively, while the kaempferol glycosides were found to be inactive. This is the first study on the antioxidant activity of this plant species...
  27. doi request reprint Discovery of a new class of HMG-CoA reductase inhibitor from Polyalthia longifolia as potential lipid lowering agent
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute CSIR, Chattar Manzil Palace, M G Marg, Lucknow 226001, India
    Eur J Med Chem 46:5206-11. 2011
    ..Importantly, the in vivo effects of 1 corroborated well with its molecular docking analysis and also with its hamster plasma pharmacokinetics...
  28. doi request reprint Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Lucknow 226 001, India
    Bioorg Med Chem Lett 22:5455-9. 2012
    ..Furthermore, to unfold the mechanism of action of these synthesized hybrid molecules, we carried out hemin dependent studies, in which three compounds were found to be active...
  29. doi request reprint Antiplasmodial activity of novel keto-enamine chalcone-chloroquine based hybrid pharmacophores
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Lucknow 226 001, India
    Bioorg Med Chem 20:2971-81. 2012
    ..9% parasitaemia on day 4. Biochemical studies reveal that inhibition of hemozoin formation is the primary mechanism of action of these analogues...
  30. doi request reprint Discovery of amide based fibrates as possible antidyslipidemic and antioxidant agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, Uttar Pradesh, India
    Eur J Med Chem 57:302-10. 2012
    ..The results of the above studies shows that the compounds synthesized on fibrate based pharmacophores might result in identification of new lead for dyslipidemia...
  31. doi request reprint Discovery and synthesis of novel substituted benzocoumarins as orally active lipid modulating agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute CSIR CDRI, Lucknow 226 001, India
    Bioorg Med Chem Lett 21:6709-13. 2011
    ....
  32. doi request reprint Neo-tanshinlactone inspired synthesis, in vitro evaluation of novel substituted benzocoumarin derivatives as potent anti-breast cancer agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, CDRI CSIR, Lucknow, India
    Bioorg Med Chem Lett 20:7127-31. 2010
    ..In addition, these derivatives were devoid of cytotoxic effect against normal osteoblast cells. These synthetic benzocoumarins hold promises for developing safer alternative to the existing anti-breast cancer agents...
  33. doi request reprint Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India
    Bioorg Med Chem Lett 20:5767-71. 2010
    ..Furthermore, Compounds 1 and 2 were evaluated for their cytotoxic effects against four human cancer cell lines and found to be most active against cervical carcinoma cell lines with IC(50) value of 10.03 and 4.12 μg/mL, respectively...
  34. doi request reprint Discovery of coumarin-dihydropyridine hybrids as bone anabolic agents
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, CSIR Central Drug Research Institute CSIR CDRI, Lucknow 226001, India
    J Med Chem 56:109-22. 2013
    ....
  35. ncbi request reprint Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro
    Koneni V Sashidhara
    Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India
    Phytother Res 21:1105-8. 2007
    ..The antiproliferative activity of 13-epi-sclareol is comparable to Tamoxifen in terms of IC50 and also showed concentration dependent increased apoptotic changes in the breast cancer cell line, MCF-7...
  36. doi request reprint Simultaneous estimation of 16α-hydroxycleroda-3,13(14) Z-dien-15,16-olide from Polyalthia longifolia and its metabolite in hamster plasma: application to pharmacokinetic study
    R S Bhatta
    Pharmacokinetics and Metabolism Division, Central Drug Research Institute, CSIR, Post Box 173, Lucknow 226001, India
    Biomed Chromatogr 26:559-65. 2012
    ..This method will therefore be highly useful for future studies of K-09 and metabolite K-9T pharmacokinetics in preclinical and clinical studies...
  37. ncbi request reprint Anti-tumour activity of a novel coumarin-chalcone hybrid is mediated through intrinsic apoptotic pathway by inducing PUMA and altering Bax/Bcl-2 ratio
    Neetu Singh
    Biochemistry Division, CSIR Central Drug Research Institute, Sector 10, Jankipuram Extension, Lucknow, 226 031, India
    Apoptosis 19:1017-28. 2014
    ..These results suggest that S009-131 is a potent candidate for the chemotherapy of cervical carcinoma. ..
  38. pmc 16alpha-Hydroxycleroda-3,13 (14)Z-dien-15,16-olide from Polyalthia longifolia: a safe and orally active antileishmanial agent
    Pragya Misra
    CDRI, CSIR, Lucknow, India
    Br J Pharmacol 159:1143-50. 2010
    ..This prompted us to determine its target and, using molecular modelling, identify the interactions responsible for its specific antileishmanial activity...