Takashi Sasaki

Summary

Publications

  1. ncbi request reprint Repair of recoarctation and aortic valve replacement with the On-X valve in a pediatric patient: a case report
    Takashi Sasaki
    Department of Pediatric Cardiac Surgery, Sakakibara Heart Institute, 3 16 1 Asahi cho, Fuchu shi, Tokyo 183 003, Japan
    J Nippon Med Sch 74:173-6. 2007
  2. doi request reprint Cerebral oxygen metabolism during total body flow and antegrade cerebral perfusion at deep and moderate hypothermia
    Takashi Sasaki
    Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA
    Artif Organs 34:980-6. 2010
  3. ncbi request reprint Edge-to-edge tricuspid valve repair in hypoplastic left heart syndrome
    Takashi Sasaki
    Department of Pediatric Cardiac Surgery, Sakakibara Heart Institute, 3 16 1 Asahi cho, Fuchu, Tokyo, 183 0003, Japan
    Gen Thorac Cardiovasc Surg 55:505-7. 2007
  4. doi request reprint Bilateral pulmonary artery banding for hypoplastic left heart syndrome and related anomalies
    Takashi Sasaki
    Department of Pediatric Cardiac Surgery, Sakakibara Heart Institute, 3 16 1 Asahi cho, Fuchu, Tokyo, 183 0003, Japan
    Gen Thorac Cardiovasc Surg 56:158-62. 2008
  5. doi request reprint Newly designed large cell Niti-S stent for malignant hilar biliary obstruction: a pilot study
    Hirofumi Kogure
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 25:463-7. 2011
  6. doi request reprint Clinical outcomes of chemotherapy for diabetic and nondiabetic patients with pancreatic cancer: better prognosis with statin use in diabetic patients
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pancreas 42:202-8. 2013
  7. doi request reprint Japanese multicenter estimation of WallFlex duodenal stent for unresectable malignant gastric outlet obstruction
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Dig Endosc 25:1-6. 2013
  8. doi request reprint Efficacy and safety of metallic stents in patients with unresectable pancreatic cancer receiving gemcitabine
    Yousuke Nakai
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Pancreas 37:405-10. 2008
  9. doi request reprint Predictive factors of solid food intake in patients with malignant gastric outlet obstruction receiving self-expandable metallic stents for palliation
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo Department of Gastroenterology, Tokyo, Japan
    Dig Endosc 24:226-30. 2012
  10. doi request reprint Feasibility study of gemcitabine and cisplatin combination chemotherapy for patients with refractory biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Invest New Drugs 29:1488-93. 2011

Detail Information

Publications80

  1. ncbi request reprint Repair of recoarctation and aortic valve replacement with the On-X valve in a pediatric patient: a case report
    Takashi Sasaki
    Department of Pediatric Cardiac Surgery, Sakakibara Heart Institute, 3 16 1 Asahi cho, Fuchu shi, Tokyo 183 003, Japan
    J Nippon Med Sch 74:173-6. 2007
    ..The postoperative course was uneventful, and aortography revealed a well-reconstructed aortic arch free of obstruction. There were no valve-related complications...
  2. doi request reprint Cerebral oxygen metabolism during total body flow and antegrade cerebral perfusion at deep and moderate hypothermia
    Takashi Sasaki
    Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA
    Artif Organs 34:980-6. 2010
    ..Although ACP provided minimum oxygenation to the brain which met the oxygen requirement, oxygen metabolism was altered during ACP at moderate hypothermia. ACP strategy at moderate hypothermia needs further investigation...
  3. ncbi request reprint Edge-to-edge tricuspid valve repair in hypoplastic left heart syndrome
    Takashi Sasaki
    Department of Pediatric Cardiac Surgery, Sakakibara Heart Institute, 3 16 1 Asahi cho, Fuchu, Tokyo, 183 0003, Japan
    Gen Thorac Cardiovasc Surg 55:505-7. 2007
    ..Discharge echocardiography revealed that the degree of TR was less than mild. The technique is simple, not time-consuming, and may be an effective adjunct for successful completion of the Fontan procedure in these patients...
  4. doi request reprint Bilateral pulmonary artery banding for hypoplastic left heart syndrome and related anomalies
    Takashi Sasaki
    Department of Pediatric Cardiac Surgery, Sakakibara Heart Institute, 3 16 1 Asahi cho, Fuchu, Tokyo, 183 0003, Japan
    Gen Thorac Cardiovasc Surg 56:158-62. 2008
    ..In addition, there are still controversies regarding the optimal timing and choice of the second-stage operation...
  5. doi request reprint Newly designed large cell Niti-S stent for malignant hilar biliary obstruction: a pilot study
    Hirofumi Kogure
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 25:463-7. 2011
    ..This study evaluated the feasibility and efficacy of the Niti-S large cell D-type biliary stent (LCD) with a uniform large cell for both uni- and bilateral drainage of malignant hilar biliary obstruction...
  6. doi request reprint Clinical outcomes of chemotherapy for diabetic and nondiabetic patients with pancreatic cancer: better prognosis with statin use in diabetic patients
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pancreas 42:202-8. 2013
    ....
  7. doi request reprint Japanese multicenter estimation of WallFlex duodenal stent for unresectable malignant gastric outlet obstruction
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Dig Endosc 25:1-6. 2013
    ..This retrospective study estimated the efficacy and safety of the WallFlex duodenal stent for malignant gastric outlet obstruction (GOO) in Japan...
  8. doi request reprint Efficacy and safety of metallic stents in patients with unresectable pancreatic cancer receiving gemcitabine
    Yousuke Nakai
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Pancreas 37:405-10. 2008
    ..Expandable metallic stents (EMSs) are widely used to palliate unresectable malignant biliary obstructions. The efficacy and safety of EMS in patients receiving gemcitabine (GEM) for unresectable pancreatic cancer is evaluated...
  9. doi request reprint Predictive factors of solid food intake in patients with malignant gastric outlet obstruction receiving self-expandable metallic stents for palliation
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo Department of Gastroenterology, Tokyo, Japan
    Dig Endosc 24:226-30. 2012
    ..Therefore, we analyzed the predictive factors of oral food intake following SEMS placement...
  10. doi request reprint Feasibility study of gemcitabine and cisplatin combination chemotherapy for patients with refractory biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Invest New Drugs 29:1488-93. 2011
    ..Two patients treated for approximately 1 year developed cisplatin-related toxicities. In conclusion, gemcitabine and cisplatin combination chemotherapy produces a limited tumor response in BTC, but may prolong patient's survival...
  11. doi request reprint A pilot study for combination chemotherapy using gemcitabine and S-1 for advanced pancreatic cancer
    Yousuke Nakai
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Oncology 77:300-3. 2009
    ..We performed a pilot study of a modified combination chemotherapy regimen with S-1 plus gemcitabine for patients with advanced pancreatic cancer...
  12. ncbi request reprint A pilot study of salvage irinotecan monotherapy for advanced biliary tract cancer
    Takashi Sasaki
    Departments of 1Gastroenterology and 2Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Anticancer Res 33:2619-22. 2013
    ..To evaluate the treatment outcomes of irinotecan monotherapy for patients with advanced biliary tract cancer refractory to gemcitabine, cisplatin, and oral fluoropyrimidine...
  13. doi request reprint Management of late biliary complications in patients with gallbladder stones in situ after endoscopic papillary balloon dilation
    Takeshi Tsujino
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Eur J Gastroenterol Hepatol 21:376-80. 2009
    ..The aim of this study was to evaluate the outcome of late biliary complications in patients with gallbladder stones in situ after EPBD...
  14. doi request reprint Endoscopic papillary balloon dilation for bile duct stone removal in patients 60 years old or younger
    Takeshi Tsujino
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Gastroenterol 45:1072-9. 2010
    ..The aim of this study was to evaluate short- and long-term outcomes in relatively young patients (≤ 60 years old) who underwent endoscopic papillary balloon dilation (EPBD) for bile duct stone removal...
  15. doi request reprint Management of malignant gastric outlet obstruction with a modified triple-layer covered metal stent
    Hiroyuki Isayama
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 75:757-63. 2012
    ..A newly modified, partially covered, triple-layer nitinol stent was developed that has a longer uncovered portion (5-15 mm) to prevent stent migration...
  16. doi request reprint Duodenal invasion is a risk factor for the early dysfunction of biliary metal stents in unresectable pancreatic cancer
    Tsuyoshi Hamada
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Gastrointest Endosc 74:548-55. 2011
    ..Although the placement of self-expandable metal stents (SEMSs) has been widely accepted as palliation for distal malignant biliary obstruction, the risk factors for their early dysfunction remain unclear...
  17. doi request reprint Endoscopic evaluation of factors contributing to intrapancreatic biliary stricture in autoimmune pancreatitis
    Kenji Hirano
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 71:85-90. 2010
    ..However, it is not known whether compression caused by pancreatic edema or biliary wall thickening causes such a biliary stricture...
  18. doi request reprint Gemcitabine and oxaliplatin combination chemotherapy for patients with refractory pancreatic cancer
    Hiroyuki Isayama
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Oncology 80:97-101. 2011
    ..The aim of this study was to investigate the effect of gemcitabine and oxaliplatin combination chemotherapy on refractory pancreatic cancer...
  19. doi request reprint One-step, simultaneous triple endoscopic nasobiliary drainage for hilar biliary stricture
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Dig Endosc 25:76-9. 2013
    ..One-step simultaneous triple ENBD is the most suitable drainage method for patients with advanced hilar biliary obstruction, especially in the setting of acute cholangitis due to occlusion of the previously placed stent...
  20. doi request reprint Role of intervention for biliary and gastric/intestinal obstruction in gastric cancer with peritoneal metastasis
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 27:1796-800. 2012
    ..The role of endoscopic or percutaneous interventions is not fully elucidated in this setting...
  21. ncbi request reprint Management of late biliary complications in patients with gallbladder stones in situ after endoscopic papillary balloon dilation
    Takeshi Tsujino
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Eur J Gastroenterol Hepatol 21:466-70. 2009
    ..The aim of this study was to evaluate the outcome of late biliary complications in patients with gallbladder stones in situ after EPBD...
  22. doi request reprint Endoscopic removal of a spontaneously fractured biliary uncovered self-expandable metal stent
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Dig Endosc 24:182-4. 2012
    ..We should be aware that stent fracture can occur when placing uncovered biliary SEMSs in patients with a long life expectancy. EPLBD is very useful for retrieving the fractured fragment of SEMS...
  23. doi request reprint Fever-based antibiotic therapy for acute cholangitis following successful endoscopic biliary drainage
    Hirofumi Kogure
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 46:1411-7. 2011
    ..We aimed to evaluate whether discontinuing antibiotic therapy for acute cholangitis immediately after the resolution of clinical symptoms, achieved by endoscopic biliary drainage, was safe and effective...
  24. doi request reprint Impact of S-1 on the survival of patients with advanced pancreatic cancer
    Yousuke Nakai
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Pancreas 39:989-93. 2010
    ..The aim of this study was to investigate the effect of S-1 on the prognosis of advanced pancreatic cancer...
  25. doi request reprint Uridine diphosphate glucuronosyl transferase 1 family polypeptide A1 gene (UGT1A1) polymorphisms are associated with toxicity and efficacy in irinotecan monotherapy for refractory pancreatic cancer
    Naminatsu Takahara
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Chemother Pharmacol 71:85-92. 2013
    ..The aim of this study was to evaluate the efficacy and safety of irinotecan monotherapy in patients with advanced pancreatic cancer (APC)...
  26. doi request reprint Clinical utility of single-operator cholangiopancreatoscopy using a SpyGlass probe through an endoscopic retrograde cholangiopancreatography catheter
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 27:1371-6. 2012
    ..The aim of this pilot study was to clarify the clinical utility of single-operator cholangiopancreatoscopy using a SpyGlass probe through an endoscopic retrograde cholangiopancreatography (ERCP) catheter...
  27. doi request reprint Risk factors for pancreatitis following transpapillary self-expandable metal stent placement
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 26:771-6. 2012
    ..Pancreatitis is one of complications after self-expandable metal stent (SEMS) placement. The purpose of this study was to evaluate risk factors for pancreatitis after endoscopic SEMS placement for malignant biliary obstruction (MBO)...
  28. doi request reprint Management of distal malignant biliary obstruction with the ComVi stent, a new covered metallic stent
    Hiroyuki Isayama
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Surg Endosc 24:131-7. 2010
    ..This covered metallic stent consists of an e-PTFE membrane sandwiched between two uncovered metallic stents with weak axial (straightening) force. Wire is exposed on both the inner and outer surfaces...
  29. doi request reprint High alcohol consumption increases the risk of pancreatic stone formation and pancreatic atrophy in autoimmune pancreatitis
    Kenji Hirano
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pancreas 42:502-5. 2013
    ..This study aimed to investigate risk factors for pancreatic stones and atrophy in autoimmune pancreatitis (AIP)...
  30. doi request reprint Risk factors and early signs of pancreatic cancer in diabetes: screening strategy based on diabetes onset age
    Suguru Mizuno
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    J Gastroenterol 48:238-46. 2013
    ..Diabetes is expected to be a clue for the early detection of PaC; however, no effective screening strategy has been established...
  31. doi request reprint Efficacy of gemcitabine for locally advanced pancreatic cancer: comparison with 5-fluorouracil-based chemoradiotherapy
    Minoru Tada
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Chemotherapy 54:302-8. 2008
    ..The efficacy of gemcitabine alone has not been established in comparison with conventional chemoradiotherapy for locally advanced pancreatic cancer...
  32. doi request reprint Multicenter, phase II study of gemcitabine and S-1 combination chemotherapy in patients with advanced biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Cancer Chemother Pharmacol 65:1101-7. 2010
    ..To evaluate the efficacy and safety of gemcitabine and S-1 combination chemotherapy in patients with advanced biliary tract cancer...
  33. doi request reprint Endoscopic papillary balloon dilation for bile duct stones in patients on hemodialysis
    Naminatsu Takahara
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 47:918-23. 2012
    ..However, little information on EPBD is available for patients with bile duct stones who are undergoing hemodialysis (HD). We aimed to evaluate the safety and efficacy of EPBD for such patients...
  34. doi request reprint S-1 monotherapy in patients with advanced biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Oncology 77:71-4. 2009
    ..The aim of this study was to evaluate the efficacy and safety of single-agent S-1 in patients with advanced biliary tract cancer...
  35. doi request reprint Measurement of radial and axial forces of biliary self-expandable metallic stents
    Hiroyuki Isayama
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 70:37-44. 2009
    ..Among them, radial force (RF) is well known as an expanding force, but axial force (AF) has not been measured before. Correlations of these properties to clinical results are not well known...
  36. doi request reprint Covered metallic stents in the management of malignant and benign pancreatobiliary strictures
    Hiroyuki Isayama
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Hepatobiliary Pancreat Surg 16:624-7. 2009
    ..AF is particularly important when developing CMSs because of related complications...
  37. doi request reprint NOTES and endoscopic pancreatic necrosectomy for the GI endoscopist
    Hiroyuki Isayama
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Hepatobiliary Pancreat Surg 16:270-3. 2009
    ..We believe that endoscopic necrosectomy and NOTES represent a major shift in the treatment paradigm because physicians can treat beyond the gastrointestinal wall and endoscopic procedures will replace surgical treatment...
  38. doi request reprint Phase I trial of gemcitabine and candesartan combination therapy in normotensive patients with advanced pancreatic cancer: GECA1
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 103:1489-92. 2012
    ..Progression-free survival and overall survival were 7.6 and 22.9 months, respectively. Candesartan 16 mg is the recommended dose in combination with gemcitabine in the treatment of advanced pancreatic cancer. (UMIN CTR: UMIN000002152)...
  39. doi request reprint Incidental pancreatic cysts found by magnetic resonance imaging and their relationship with pancreatic cancer
    Saburo Matsubara
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Pancreas 41:1241-6. 2012
    ..We examined whether the presence of pancreatic cysts could be a risk for pancreatic cancer by comparing the incidence and characteristics of cysts found by magnetic resonance (MR) imaging in patients with and without pancreatic cancer...
  40. doi request reprint Long-term prognosis of autoimmune pancreatitis in terms of glucose tolerance
    Kenji Hirano
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pancreas 41:691-5. 2012
    ..Glucose intolerance is often observed in autoimmune pancreatitis (AIP), although its long-term prognosis after steroid treatment (ST) is still unclear...
  41. doi request reprint Challenges in longer-term mechanical support of fontan circulation in sheep
    Lorenzo Boni
    Department of Cardiothoracic Surgery, Division of Pediatric Cardiac Surgery, Stanford University, California 94305 5407, USA
    ASAIO J 58:60-4. 2012
    ..The performance of the Thoratec Heartmate II has been good, but the issue of effective anticoagulation has not yet been solved...
  42. doi request reprint Impact of introduction of wire-guided cannulation in therapeutic biliary endoscopic retrograde cholangiopancreatography
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:1552-8. 2011
    ..We assessed the learning curve for WGC in therapeutic biliary ERCP (study 1) and compared WGC and conventional contrast-assisted cannulation (CC) by a matched case-control study (study 2)...
  43. doi request reprint CA 19-9 response as an early indicator of the effectiveness of gemcitabine in patients with advanced pancreatic cancer
    Yousuke Nakai
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Oncology 75:120-6. 2008
    ..We assessed the prognostic value of changes in CA 19-9 levels 4 weeks after treatment initiation on overall survival (OS) and time to progression (TTP)...
  44. doi request reprint A multicenter phase II trial of gemcitabine and candesartan combination therapy in patients with advanced pancreatic cancer: GECA2
    Yousuke Nakai
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, Japan, 113 8655
    Invest New Drugs 31:1294-9. 2013
    ..Conclusions In this multicenter phase 2 trial, gemcitabine and candesartan combination therapy was tolerable but failed to demonstrate activity against advanced pancreatic cancer. (UMIN CTR: UMIN000005580). ..
  45. doi request reprint Clinical utility of an endoscopic ultrasound-guided rendezvous technique via various approach routes
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Surg Endosc 27:3437-43. 2013
    ..We evaluated the clinical utility of an EUS-rendezvous technique using various approach routes...
  46. doi request reprint The results of the Tokyo Trial of Prevention of Post-ERCP Pancreatitis with Risperidone (Tokyo P3R): a multicenter, randomized, phase II, non-placebo-controlled trial
    Takeshi Tsujino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 48:982-8. 2013
    ..In experimental models, risperidone, a selective serotonin 2A antagonist, ameliorated acute pancreatitis. We assessed the effect of risperidone combined with ulinastatin for the prevention of PEP in high-risk patients...
  47. doi request reprint Diabetes is a useful diagnostic clue to improve the prognosis of pancreatic cancer
    Suguru Mizuno
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Pancreatology 13:285-9. 2013
    ..Diabetes mellitus (DM) is recognized as a risk factor for pancreatic cancer (PaC) and expected to be a clue for early diagnosis. However, it is still obscure whether a diagnostic strategy using DM as a clue can improve the prognosis or not...
  48. doi request reprint Risk for mortality from causes other than pancreatic cancer in patients with intraductal papillary mucinous neoplasm of the pancreas
    Kazumichi Kawakubo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pancreas 42:687-91. 2013
    ..The long-term prognosis in patients with intraductal papillary mucinous neoplasm (IPMN) has not been determined. The aim of this study was to elucidate the risk for nonpancreatic cancer-specific mortality in patients with IPMN...
  49. doi request reprint Duodenal metal stent placement is a risk factor for biliary metal stent dysfunction: an analysis using a time-dependent covariate
    Tsuyoshi Hamada
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 8655, Japan
    Surg Endosc 27:1243-8. 2013
    ..We conducted a multicenter retrospective study to evaluate the effect of duodenal SEMS placement on biliary SEMS...
  50. doi request reprint One- and two-step self-expandable metal stent placement for distal malignant biliary obstruction: a propensity analysis
    Tsuyoshi Hamada
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:1248-56. 2012
    ....
  51. doi request reprint Multicenter phase II study of S-1 monotherapy as second-line chemotherapy for advanced biliary tract cancer refractory to gemcitabine
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Invest New Drugs 30:708-13. 2012
    ..The most common non-hematological toxicities were nausea (27%), anorexia (55%), and pigmentation (32%). In conclusion, S-1 monotherapy is feasible and moderately efficacious second-line chemotherapy for advanced BTC...
  52. doi request reprint Preliminary report on a new, fully covered, metal stent designed for the treatment of pancreatic fluid collections
    Natsuyo Yamamoto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 77:809-14. 2013
    ..Endoscopic transluminal treatment of pancreatic fluid collections (PFC) has been reported as an effective alternative approach to surgical treatment. A wide, short stent with an anti-migration system has been developed...
  53. doi request reprint Reconstruction of pulmonary artery with porcine small intestinal submucosa in a lamb surgical model: Viability and growth potential
    Lorenzo Boni
    Division of Pediatric Cardiac Surgery, Department of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA
    J Thorac Cardiovasc Surg 144:963-969.e1; discussion 969. 2012
    ..This study investigated the time-dependent remodeling and growth potential of porcine small intestine submucosa as a biomaterial for the reconstruction of pulmonary arteries in a lamb model...
  54. doi request reprint Acoustic radiation force impulse elastography for noninvasive assessment of chronic pancreatitis
    Yoko Yashima
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:427-32. 2012
    ....
  55. doi request reprint Optimal flow rate for antegrade cerebral perfusion
    Takashi Sasaki
    Stanford University, Division of Pediatric Cardiac Surgery, Department of Cardiothoracic Surgery, 300 Pasteur Drive, Falk Rm CV116C, Stanford, CA 94305 5407, USA
    J Thorac Cardiovasc Surg 139:530-5; discussion 535. 2010
    ..The objective of this study was to determine the antegrade cerebral perfusion flow rate that most closely matches standard cardiopulmonary bypass conditions...
  56. doi request reprint Bezafibrate for the treatment of primary sclerosing cholangitis
    Suguru Mizuno
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 45:758-62. 2010
    ..However, there has been little evidence of its efficacy for the treatment of primary sclerosing cholangitis (PSC)...
  57. doi request reprint A randomized phase II study of gemcitabine and S-1 combination therapy versus gemcitabine monotherapy for advanced biliary tract cancer
    Takashi Sasaki
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cancer Chemother Pharmacol 71:973-9. 2013
    ..In order to confirm the impact of adding S-1 to gemcitabine, we conducted a randomized phase II study to compare the combination therapy of gemcitabine plus S-1 to gemcitabine monotherapy in patients with advanced biliary tract cancer...
  58. pmc Simultaneous Duodenal Metal Stent Placement and EUS-Guided Choledochoduodenostomy for Unresectable Pancreatic Cancer
    Kazumichi Kawakubo
    Department of Gastroenterology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Gut Liver 6:399-402. 2012
    ..EUS-CDS combined with duodenal metal stent placement may be an ideal treatment strategy in patients with pancreatic cancer with both duodenal and biliary malignant obstruction...
  59. doi request reprint Diagnostic utility of biopsy specimens for autoimmune pancreatitis
    Kenji Hirano
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 44:765-73. 2009
    ..However, it is undetermined whether needle or forceps biopsy of pancreas or other organs is indeed useful for the diagnosis of AIP. We aimed to clarify this point...
  60. doi request reprint Characterization of canine filaggrin: gene structure and protein expression in dog skin
    Satoko Kanda
    Laboratory of Veterinary Internal Medicine, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Vet Dermatol 24:25-31.e7. 2013
    ..Although similar pathogenesis and clinical manifestation have been argued in canine atopic dermatitis, our understanding of canine FLG is limited...
  61. doi request reprint Lower incidence of biliary carcinoma in patients with primary sclerosing cholangitis and high serum levels of immunoglobulin E
    Kenji Hirano
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 10:79-83. 2012
    ..High serum levels of immunoglobulin (Ig)E often are detected in patients with primary sclerosing cholangitis (PSC), but the clinical significance is not known...
  62. doi request reprint Intraductal US in the assessment of tumor involvement to the orifice of the cystic duct by malignant biliary obstruction
    Yousuke Nakai
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Gastrointest Endosc 68:78-83. 2008
    ..Tumor involvement to the orifice of the cystic duct (OCD) is a risk factor for cholecystitis after metallic stent (MS) placement...
  63. doi request reprint A genetic polymorphism of CYP2C19 is associated with susceptibility to biliary tract cancer
    Yoshihiro Isomura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Gastroenterol 45:1045-52. 2010
    ..Cell lines of various gastroenterological cancers were screened in the first phase. A clinical investigation was then conducted to confirm the association with the candidate cancer in the second phase...
  64. doi request reprint Maintenance dose of warfarin in sheep and effect of diet: a preliminary report
    Takashi Sasaki
    Division of Pediatric Cardiac Surgery, Department of Cardiothoracic Surgery, Stanford University, Stanford, California, USA
    J Invest Surg 25:29-32. 2012
    ..4 mg/kg of warfarin to achieve the goal. Hay raised the INR faster and higher than pellets with the same warfarin dose. Hay may be advantageous when using oral warfarin therapy in sheep...
  65. doi request reprint Recovery during mid-term mechanical support of fontan circulation in sheep
    Shoichi Tsuda
    Department of Cardiothoracic Surgery, Stanford University, Stanford, California 94305 5407, USA
    ASAIO J 55:406-11. 2009
    ..43 +/- 0.62 L/min and IVC pressure 4.05 +/- 3.21 mm Hg (mean +/- SD). Lactate levels remained normal. Low pressure and high-volume IVC flow was sustained by mechanical support. We will next attempt chronic pump implantation...
  66. doi request reprint Human induced pluripotent stem cell-derived ectodermal precursor cells contribute to hair follicle morphogenesis in vivo
    Ophelia Veraitch
    Department of Dermatology, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Invest Dermatol 133:1479-88. 2013
    ..The current study suggests a, to our knowledge, previously unrecognized advantage of using hiPSCs to enhance epithelial-mesenchymal interactions in HF bioengineering...
  67. doi request reprint Identification of mutations in the prostaglandin transporter gene SLCO2A1 and its phenotype-genotype correlation in Japanese patients with pachydermoperiostosis
    Takashi Sasaki
    Center for Integrated Medical Research, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Dermatol Sci 68:36-44. 2012
    ..Recently, a homozygous mutation in the gene HPGD, which encodes 15-hydroxyprostaglandin dehydrogenase (15-PGDH), was found to be associated with PDP. However, mutations in HPGD have not been identified in Japanese PDP patients...
  68. pmc Population genetic structures of Staphylococcus aureus isolates from cats and dogs in Japan
    Takashi Sasaki
    Department of Infection Control Science, Faculty of Medicine, Juntendo University, Tokyo, Japan
    J Clin Microbiol 50:2152-5. 2012
    ..In contrast, S. aureus populations do not likely include any clone that exhibits tropism in domestic dogs. Even if S. aureus infections occur in dogs, the pathologies are likely exogenous infections...
  69. doi request reprint Single ventricle repair in children with Down's syndrome
    Naoki Wada
    Department of Cardiovascular Surgery, Sakakibara Heart Institute, Japan Promotion Society for Cardiovascular Diseases, 3 16 1 Asahi cho, Fuchu, Tokyo, 183 0003, Japan
    Gen Thorac Cardiovasc Surg 56:104-8. 2008
    ..We report the results of bidirectional superior cavopulmonary shunts in six patients with Down's syndrome with a functional single ventricle...
  70. ncbi request reprint Intrahepatic cholangiocarcinoma with intrahepatic biliary lithiasis arising 47 years after the excision of a congenital biliary dilatation: report of a case
    Suguru Yamashita
    Hepato Biliary Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Biosci Trends 6:98-102. 2012
    ..She underwent biliary lithotomy through a percutaneous transhepatic cholangioscopy and subsequent systemic chemotherapy...
  71. pmc Suppression of feline coronavirus replication in vitro by cyclosporin A
    Yoshikazu Tanaka
    Department of Veterinary Hygiene, Veterinary School, Nippon Veterinary and Life Science University, 1 7 1 Kyounan, Musashino, Tokyo, 180 8602, Japan
    Vet Res 43:41. 2012
    ..Therefore, CsA does not seem to exert inhibitory effects via the NF-AT pathway. In conclusion, CsA inhibited FIPV replication in vitro and further studies are needed to verify the practical value of CsA as an anti-FIPV treatment in vivo...
  72. doi request reprint Loss-of-function mutations within the filaggrin gene and atopic dermatitis
    Hiroshi Kawasaki
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Curr Probl Dermatol 41:35-46. 2011
    ..Taken together, these findings provide novel perspectives on the pathophysiology of AD and effective therapeutic methods for the treatment and/or prevention of AD through the modification of skin barrier dysfunction...
  73. pmc Emergence of quinolone-resistant Bordetella pertussis in Japan
    Masayuki Ohtsuka
    Department of Infection Control Science, Faculty of Medicine, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Antimicrob Agents Chemother 53:3147-9. 2009
    ..All of the NAL-resistant strains had the same D87G mutation in gyrA...
  74. doi request reprint Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris
    Tsuyoshi Hata
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Dermatol Sci 63:33-9. 2011
    ..The B6-Dsg3(-/-) mice did not grow old enough to provide splenocytes, probably due to severe oral erosions, with resulting inhibition of food intake...
  75. doi request reprint Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka
    Takahiro Negishi
    Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Hepatology 51:1037-45. 2010
    ..These results suggest that a common molecular mechanism may underlie liver and pectoral fin specification during piscine embryogenesis...
  76. doi request reprint Management of occluded uncovered metallic stents in patients with malignant distal biliary obstructions using covered metallic stents
    Osamu Togawa
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Gastroenterol 42:546-9. 2008
    ..Currently, there is no consensus on the management of occluded EMSs. We evaluated the efficacy of a covered EMS as a second endoprosthesis in patients with an occluded EMS...
  77. ncbi request reprint Stromal cell-derived factor-1alpha improves infarcted heart function through angiogenesis in mice
    Takashi Sasaki
    Department of Surgery, Cardiovascular Surgery, Nippon Medical School, Tokyo, Japan
    Pediatr Int 49:966-71. 2007
    ..It was hypothesized that local administration of SDF-1 also contributes to neovascularization of ischemic heart...
  78. ncbi request reprint Efficacy and safety of low-pressured and short-time dilation in endoscopic papillary balloon dilation for bile duct stone removal
    Takeshi Tsujino
    Departments of Gastroenterology, Japanese Red Cross Medical Center, Tokyo, Japan
    J Gastroenterol Hepatol 23:867-71. 2008
    ..Pancreatitis after EPBD is believed to be related to papillary damage after balloon dilation. We changed the dilation method to a theoretically less hazardous one. This modified dilation method was compared with the initial method...
  79. ncbi request reprint Role of TBX1 in human del22q11.2 syndrome
    Hisato Yagi
    Division of Genomic Medicine, Institute of Advanced Biomedical Engineering and Science, Graduate School of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Lancet 362:1366-73. 2003
    ..At least 30 genes have been mapped to the deleted region. However, the association of these genes with the cause of this syndrome is not clearly understood...
  80. ncbi request reprint Endoscopic papillary balloon dilation for bile duct stone: immediate and long-term outcomes in 1000 patients
    Takeshi Tsujino
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 5:130-7. 2007
    ..The long-term outcomes of endoscopic papillary balloon dilation (EPBD) for bile duct stone removal are not well known...