Italian guidelines for primary headaches: 2012 revised versionPaola Sarchielli
Headache Centre, Neurologic Clinic, University of Perugia, Perugia, Italy
J Headache Pain 13:S31-70. 2012
..This article reports a summary of the revised version published in extenso in an Italian version...
Fibroblast growth factor-2 levels are elevated in the cerebrospinal fluid of multiple sclerosis patientsPaola Sarchielli
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
Neurosci Lett 435:223-8. 2008
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Increased levels of neurotrophins are not specific for chronic migraine: evidence from primary fibromyalgia syndromePaola Sarchielli
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy
J Pain 8:737-45. 2007
..This opens new insights into the pathogenic mechanisms of chronic pain and offers clinicians new therapeutic perspectives targeting the above mechanisms in both painful disorders...
- Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally
Paola Sarchielli
Neurologic Clinic, Department of Medical Specialties and Public Health, University of Perugia, Italy
Headache 46:200-7. 2006
..Levels of certain proinflammatory cytokines (tumor necrosis factor-alpha[TNF-alpha], interleukin-1beta[IL-1beta], IL-4, and IL-6) were also determined and correlated with those of adhesion molecules...
- Application of the ICHD-II criteria to the diagnosis of primary chronic headaches via a computerized structured record
Paola Sarchielli
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
Headache 47:38-44. 2007
..This software examines all the diagnoses of primary headaches on the basis of the variables needed to fulfill these mandatory criteria...
- Expression of ionotropic glutamate receptor GLUR3 and effects of glutamate on MBP- and MOG-specific lymphocyte activation and chemotactic migration in multiple sclerosis patients
Paola Sarchielli
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
J Neuroimmunol 188:146-58. 2007
..Excess glutamate levels seem to induce an inhibitory effect on lymphocyte function, and therefore the detrimental effect of this excitatory amino acid in this case could be attributed to a direct toxicity on glial and neuronal cells...
- Endocannabinoids in chronic migraine: CSF findings suggest a system failure
Paola Sarchielli
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy
Neuropsychopharmacology 32:1384-90. 2007
..These findings support the potential role of the cannabinoid (CB)1 receptor as a possible therapeutic target in CM...
- Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: relation with serotonin levels
Cristiana Rossi
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy
Eur J Clin Pharmacol 64:1-8. 2008
..Here we report on our assessment of the dysfunctioning of the endocannabinoid system as a potential underlying factor in pathogenic mechanisms involved in CM and MOH...
- Language disturbances as a side effect of prophylactic treatment of migraine
Francesca Coppola
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
Headache 48:86-94. 2008
..These disturbances have been recently reported in migraineurs in treatment with topiramate but they have never been defined and assessed in these patients with the aid of neuropsychological testing...
- Association between migraine and headache attributed to stroke: a case-control study
Katiuscia Nardi
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
Headache 48:1468-75. 2008
..Several studies were carried out to investigate the occurrence of headache attributed to acute stroke in patients with a lifetime history of migraine...
- Drug-dependence behaviour and outcome of medication-overuse headache after treatment
Ilenia Corbelli
Neurologic Clinic, Headache Centre, Santa Maria della Misericordia Hospital, University of Perugia, Sant Andrea delle Fratte, 06158, San Sisto, Perugia, Italy
J Headache Pain 13:653-60. 2012
..Conversely, in patients who positively responded to the procedure, drug-abuse behaviour seemed to be a consequence of chronic headache, reflecting the need for daily analgesic use to cope with everyday life...
- Migraine with aura in the locker room: three case reports
Ilenia Corbelli
Headache Centre, Neurologic Clinic, Santa Maria della Misericordia Hospital, University of Perugia, Sant Andrea delle Fratte, 06158, San Sisto, Perugia, Italy
J Headache Pain 13:91-3. 2012
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- Sensitization, glutamate, and the link between migraine and fibromyalgia
Paola Sarchielli
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Ospedale Santa Maria della Misericordia, Via Santa Andrea delle Fratte, San Sisto, 06158 Perugia, Italy
Curr Pain Headache Rep 11:343-51. 2007
..Limited clinical experience in this regard, although promising, does not exclude additional mechanisms contributing to the maintenance of pain, which can be the target of therapeutic approaches in both disorders...
- Chemokine levels in the jugular venous blood of migraine without aura patients during attacks
Paola Sarchielli
Neurologic Clinic, Department of Neuroscience, Institute of Clinical and Applied Biochemistry, University of Perugia, Italy
Headache 44:961-8. 2004
..Other events, including nitric oxide production, may contribute to counteract meningeal transvascular leukocyte migration during migraine attacks, as suggested by the model of sterile inflammation...
- Occipital arteriovenous malformations and migraine
Francesca Galletti
Clinica Neurologica, Universita degli Studi di Perugia, Ospedale Santa Maria della Misericordia, S Andrea delle Fratte, Perugia, Italy
Cephalalgia 31:1320-4. 2011
..Headache associated with AVMs often shows characteristics of migraine with and without aura. Angiographic characteristics of AVMs, such as their location, could determine the 'migraine-like' features of attacks...
- Migraine preventive drug-induced weight gain may be mediated by effects on hypothalamic peptides: the results of a pilot study
Stefano Caproni
Department of Medical and Surgical Specialties and Public Health, University of Perugia, Santa Maria della Misericordia Hospital, Sant Andrea delle Fratte, San Sisto, Perugia, Italy
Cephalalgia 31:543-9. 2011
..Orexin-A, orexin-B and neuropeptide-Y plasma levels were measured at the basal time, at the 1st, 2nd and 3rd months of preventive treatment...
- Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders
Massimiliano Di Filippo
Clinica Neurologica, Universita degli Studi di Perugia, Perugia, Italy
Trends Pharmacol Sci 29:402-12. 2008
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- Pathophysiological basis of migraine prophylaxis
Francesca Galletti
Clinica Neurologica, Universita degli Studi di Perugia, Ospedale Santa Maria della Misericordia, 06132, Perugia, Italy
Prog Neurobiol 89:176-92. 2009
..Targets of migraine preventive treatment are to reduce frequency and intensity of attacks and to decrease disability related to chronic headache...
- Palinopsia in patients with migraine: a case-control study
Vincenzo Belcastro
University of Perugia, Italy
Cephalalgia 31:999-1004. 2011
..This study was aimed at investigating the frequency of the visual phenomenon of palinopsia (visual perseveration) in patients with migraine...
- Plasma cytokine levels in patients with obstructive sleep apnea syndrome: a preliminary study
Andrea Alberti
Department of Neuroscience, Neurologic Clinic Department of Internal Medicine, University of Perugia, Perugia, Italy
J Sleep Res 12:305-11. 2003
..001). The role played by this further increase in TNF-alpha levels after the obstructive apnea in OSAS patients remains to be established in the light of the pathogenic mechanisms of this sleep disorder...
- Effects of central and peripheral inflammation on hippocampal synaptic plasticity
Massimiliano Di Filippo
Clinica Neurologica, Universita di Perugia, Perugia, Italy
Neurobiol Dis 52:229-36. 2013
..During direct CNS inflammation these events are accompanied by detectable changes in synaptic glutamate receptors subunit composition and in the levels of the pro-inflammatory cytokine IL1β...
- Headache attributed to airplane travel ("airplane headache"): first Italian case
Federico Mainardi
Headache Centre, Neurological Unit, SS Giovanni e Paolo Hospital, Castello 6777, I 30122 Venice, Italy
J Headache Pain 8:196-9. 2007
..A total of 7 cases have been published. Here we present the first Italian one. Furthermore the revision of the clinical characteristics of each patient leads us to propose provisional diagnostic criteria...
- Prevalence of essential tremor in the territory of Lake Trasimeno, Italy: results of a population-based study
Maria Luisa Mancini
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
Mov Disord 22:540-5. 2007
..Our results are in line with the most recent epidemiological findings, which suggest a lower prevalence of ET than in older studies. These results can be attributed to the application of more stringent diagnostic criteria...
- Application of ICHD 2nd edition criteria for primary headaches with the aid of a computerised, structured medical record for the specialist
Paola Sarchielli
Neurologic Clinic, Dept of Medical and Surgical Specialties and Public Health, University of Perugia, Silvestrini Hospital, S Andrea delle Fratte, I 06156 Perugia, Italy
J Headache Pain 6:205-10. 2005
..This computerised device may help to validate the new diagnostic criteria and to answer some emerging questions from the application of the new classification version, the relevance of which should be verified in clinical practice...
- Functional 1H-MRS findings in migraine patients with and without aura assessed interictally
Paola Sarchielli
Neuroscience Department, University of Perugia, Policlinico Monteluce, Via E dal Pozzo, 06126 Perugia, Italy
Neuroimage 24:1025-31. 2005
..The above findings support little differences in brain metabolites between the two patient groups assessed in interictal periods, which suggests a less efficient mitochondrial functioning in migraine with aura patients...
- Practical considerations for the treatment of elderly patients with migraine
Paola Sarchielli
Department of Medical and Surgical Specialties and Public Health, Neurologic Clinic, University of Perugia, Perugia, Italy
Drugs Aging 23:461-89. 2006
..Unfortunately, for most of these drugs, efficacy studies are lacking in the elderly...
- Nerve growth factor and chronic daily headache: a potential implication for therapy
Paola Sarchielli
Department of Neuroscience, Neurologic Clinic, Via E Dal Pozzo 06126, Perugia, Italy
Expert Rev Neurother 4:115-27. 2004
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- Excitatory amino acids and multiple sclerosis: evidence from cerebrospinal fluid
Paola Sarchielli
Neuroscience Department, Institute of Clinical and Applied Biochemistry, Policlinico Monteluce, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
Arch Neurol 60:1082-8. 2003
..Recent evidence suggests an altered glutamate homeostasis in the brain of patients with multiple sclerosis (MS), as seen in experimental models of MS...
- Brain-derived neurotrophic factor in patients with multiple sclerosis
Paola Sarchielli
Neuroscience Department, University of Perugia, Policlinico Monteluce, Via E Dal Pozzo 79, 06126 Perugia, Italy
J Neuroimmunol 132:180-8. 2002
..This can favor remyelination. The reduced production of BDNF by PBMCs of patients with SP MS can contribute to the progression of demyelinating disease and axonal loss in this form...
