Paola Sarchielli

Summary

Publications

  1. pmc Immunological profile of silent brain infarction and lacunar stroke
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
    PLoS ONE 8:e68428. 2013
  2. pmc Genes and primary headaches: discovering new potential therapeutic targets
    Innocenzo Rainero
    Headache Center, Neurology I, Department of Neuroscience, University of Torino, Via Cherasco 15, Torino 10126, Italy
    J Headache Pain 14:61. 2013
  3. pmc Cortical spreading depression as a target for anti-migraine agents
    Cinzia Costa
    Neurologic Clinic, Department of Public Health and Medical and Surgical Specialties, University of Perugia, Ospedale Santa Maria della Misericordia, Sant Andrea delle Fratte, 06132, Perugia, Italy
    J Headache Pain 14:62. 2013
  4. pmc Italian guidelines for primary headaches: 2012 revised version
    Paola Sarchielli
    Headache Centre, Neurologic Clinic, University of Perugia, Perugia, Italy
    J Headache Pain 13:S31-70. 2012
  5. doi request reprint Fibroblast growth factor-2 levels are elevated in the cerebrospinal fluid of multiple sclerosis patients
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
    Neurosci Lett 435:223-8. 2008
  6. ncbi request reprint Increased levels of neurotrophins are not specific for chronic migraine: evidence from primary fibromyalgia syndrome
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy
    J Pain 8:737-45. 2007
  7. ncbi request reprint Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally
    Paola Sarchielli
    Neurologic Clinic, Department of Medical Specialties and Public Health, University of Perugia, Italy
    Headache 46:200-7. 2006
  8. ncbi request reprint Expression of ionotropic glutamate receptor GLUR3 and effects of glutamate on MBP- and MOG-specific lymphocyte activation and chemotactic migration in multiple sclerosis patients
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
    J Neuroimmunol 188:146-58. 2007
  9. ncbi request reprint Application of the ICHD-II criteria to the diagnosis of primary chronic headaches via a computerized structured record
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
    Headache 47:38-44. 2007
  10. ncbi request reprint Endocannabinoids in chronic migraine: CSF findings suggest a system failure
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy
    Neuropsychopharmacology 32:1384-90. 2007

Detail Information

Publications32

  1. pmc Immunological profile of silent brain infarction and lacunar stroke
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
    PLoS ONE 8:e68428. 2013
    ..The differences in plasma profile of inflammatory molecules may underlie different pathological mechanisms in SBI and LI patients. ..
  2. pmc Genes and primary headaches: discovering new potential therapeutic targets
    Innocenzo Rainero
    Headache Center, Neurology I, Department of Neuroscience, University of Torino, Via Cherasco 15, Torino 10126, Italy
    J Headache Pain 14:61. 2013
    ..Involvement of these genes in primary headaches, as well as their potential role in the therapy of these disorders, will be discussed. ..
  3. pmc Cortical spreading depression as a target for anti-migraine agents
    Cinzia Costa
    Neurologic Clinic, Department of Public Health and Medical and Surgical Specialties, University of Perugia, Ospedale Santa Maria della Misericordia, Sant Andrea delle Fratte, 06132, Perugia, Italy
    J Headache Pain 14:62. 2013
    ..CSD models are useful tools for testing current and novel prophylactic drugs, providing knowledge on mechanisms of action relevant for migraine...
  4. pmc Italian guidelines for primary headaches: 2012 revised version
    Paola Sarchielli
    Headache Centre, Neurologic Clinic, University of Perugia, Perugia, Italy
    J Headache Pain 13:S31-70. 2012
    ..This article reports a summary of the revised version published in extenso in an Italian version...
  5. doi request reprint Fibroblast growth factor-2 levels are elevated in the cerebrospinal fluid of multiple sclerosis patients
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
    Neurosci Lett 435:223-8. 2008
    ....
  6. ncbi request reprint Increased levels of neurotrophins are not specific for chronic migraine: evidence from primary fibromyalgia syndrome
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy
    J Pain 8:737-45. 2007
    ..NGF might indirectly exert its effect through enhancing glutamatergic transmission via BDNF. The above mechanisms could account for sustained central sensitization in both chronic pain states...
  7. ncbi request reprint Proinflammatory cytokines, adhesion molecules, and lymphocyte integrin expression in the internal jugular blood of migraine patients without aura assessed ictally
    Paola Sarchielli
    Neurologic Clinic, Department of Medical Specialties and Public Health, University of Perugia, Italy
    Headache 46:200-7. 2006
    ..Levels of certain proinflammatory cytokines (tumor necrosis factor-alpha[TNF-alpha], interleukin-1beta[IL-1beta], IL-4, and IL-6) were also determined and correlated with those of adhesion molecules...
  8. ncbi request reprint Expression of ionotropic glutamate receptor GLUR3 and effects of glutamate on MBP- and MOG-specific lymphocyte activation and chemotactic migration in multiple sclerosis patients
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
    J Neuroimmunol 188:146-58. 2007
    ..Excess glutamate levels seem to induce an inhibitory effect on lymphocyte function, and therefore the detrimental effect of this excitatory amino acid in this case could be attributed to a direct toxicity on glial and neuronal cells...
  9. ncbi request reprint Application of the ICHD-II criteria to the diagnosis of primary chronic headaches via a computerized structured record
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
    Headache 47:38-44. 2007
    ..This software examines all the diagnoses of primary headaches on the basis of the variables needed to fulfill these mandatory criteria...
  10. ncbi request reprint Endocannabinoids in chronic migraine: CSF findings suggest a system failure
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy
    Neuropsychopharmacology 32:1384-90. 2007
    ..These findings support the potential role of the cannabinoid (CB)1 receptor as a possible therapeutic target in CM...
  11. ncbi request reprint Endocannabinoids in platelets of chronic migraine patients and medication-overuse headache patients: relation with serotonin levels
    Cristiana Rossi
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy
    Eur J Clin Pharmacol 64:1-8. 2008
    ..Here we report on our assessment of the dysfunctioning of the endocannabinoid system as a potential underlying factor in pathogenic mechanisms involved in CM and MOH...
  12. doi request reprint Language disturbances as a side effect of prophylactic treatment of migraine
    Francesca Coppola
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
    Headache 48:86-94. 2008
    ..These disturbances have been recently reported in migraineurs in treatment with topiramate but they have never been defined and assessed in these patients with the aid of neuropsychological testing...
  13. ncbi request reprint Chemokine levels in the jugular venous blood of migraine without aura patients during attacks
    Paola Sarchielli
    Neurologic Clinic, Department of Neuroscience, Institute of Clinical and Applied Biochemistry, University of Perugia, Italy
    Headache 44:961-8. 2004
    ....
  14. doi request reprint Effects of central and peripheral inflammation on hippocampal synaptic plasticity
    Massimiliano Di Filippo
    Clinica Neurologica, Universita di Perugia, Perugia, Italy
    Neurobiol Dis 52:229-36. 2013
    ..During direct CNS inflammation these events are accompanied by detectable changes in synaptic glutamate receptors subunit composition and in the levels of the pro-inflammatory cytokine IL1β...
  15. doi request reprint Association between migraine and headache attributed to stroke: a case-control study
    Katiuscia Nardi
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
    Headache 48:1468-75. 2008
    ..Several studies were carried out to investigate the occurrence of headache attributed to acute stroke in patients with a lifetime history of migraine...
  16. doi request reprint Occipital arteriovenous malformations and migraine
    Francesca Galletti
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale Santa Maria della Misericordia, S Andrea delle Fratte, Perugia, Italy
    Cephalalgia 31:1320-4. 2011
    ..Headache associated with AVMs often shows characteristics of migraine with and without aura. Angiographic characteristics of AVMs, such as their location, could determine the 'migraine-like' features of attacks...
  17. pmc Drug-dependence behaviour and outcome of medication-overuse headache after treatment
    Ilenia Corbelli
    Neurologic Clinic, Headache Centre, Santa Maria della Misericordia Hospital, University of Perugia, Sant Andrea delle Fratte, 06158, San Sisto, Perugia, Italy
    J Headache Pain 13:653-60. 2012
    ..Conversely, in patients who positively responded to the procedure, drug-abuse behaviour seemed to be a consequence of chronic headache, reflecting the need for daily analgesic use to cope with everyday life...
  18. pmc Migraine with aura in the locker room: three case reports
    Ilenia Corbelli
    Headache Centre, Neurologic Clinic, Santa Maria della Misericordia Hospital, University of Perugia, Sant Andrea delle Fratte, 06158, San Sisto, Perugia, Italy
    J Headache Pain 13:91-3. 2012
    ....
  19. ncbi request reprint Sensitization, glutamate, and the link between migraine and fibromyalgia
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Ospedale Santa Maria della Misericordia, Via Santa Andrea delle Fratte, San Sisto, 06158 Perugia, Italy
    Curr Pain Headache Rep 11:343-51. 2007
    ..Limited clinical experience in this regard, although promising, does not exclude additional mechanisms contributing to the maintenance of pain, which can be the target of therapeutic approaches in both disorders...
  20. doi request reprint Pathophysiological basis of migraine prophylaxis
    Francesca Galletti
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale Santa Maria della Misericordia, 06132, Perugia, Italy
    Prog Neurobiol 89:176-92. 2009
    ..Targets of migraine preventive treatment are to reduce frequency and intensity of attacks and to decrease disability related to chronic headache...
  21. doi request reprint Migraine preventive drug-induced weight gain may be mediated by effects on hypothalamic peptides: the results of a pilot study
    Stefano Caproni
    Department of Medical and Surgical Specialties and Public Health, University of Perugia, Santa Maria della Misericordia Hospital, Sant Andrea delle Fratte, San Sisto, Perugia, Italy
    Cephalalgia 31:543-9. 2011
    ..Orexin-A, orexin-B and neuropeptide-Y plasma levels were measured at the basal time, at the 1st, 2nd and 3rd months of preventive treatment...
  22. doi request reprint Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders
    Massimiliano Di Filippo
    Clinica Neurologica, Universita degli Studi di Perugia, Perugia, Italy
    Trends Pharmacol Sci 29:402-12. 2008
    ....
  23. doi request reprint Palinopsia in patients with migraine: a case-control study
    Vincenzo Belcastro
    University of Perugia, Italy
    Cephalalgia 31:999-1004. 2011
    ..This study was aimed at investigating the frequency of the visual phenomenon of palinopsia (visual perseveration) in patients with migraine...
  24. ncbi request reprint Plasma cytokine levels in patients with obstructive sleep apnea syndrome: a preliminary study
    Andrea Alberti
    Department of Neuroscience, Neurologic Clinic Department of Internal Medicine, University of Perugia, Perugia, Italy
    J Sleep Res 12:305-11. 2003
    ..001). The role played by this further increase in TNF-alpha levels after the obstructive apnea in OSAS patients remains to be established in the light of the pathogenic mechanisms of this sleep disorder...
  25. ncbi request reprint Practical considerations for the treatment of elderly patients with migraine
    Paola Sarchielli
    Department of Medical and Surgical Specialties and Public Health, Neurologic Clinic, University of Perugia, Perugia, Italy
    Drugs Aging 23:461-89. 2006
    ..Unfortunately, for most of these drugs, efficacy studies are lacking in the elderly...
  26. pmc Headache attributed to airplane travel ("airplane headache"): first Italian case
    Federico Mainardi
    Headache Centre, Neurological Unit, SS Giovanni e Paolo Hospital, Castello 6777, I 30122 Venice, Italy
    J Headache Pain 8:196-9. 2007
    ..A total of 7 cases have been published. Here we present the first Italian one. Furthermore the revision of the clinical characteristics of each patient leads us to propose provisional diagnostic criteria...
  27. ncbi request reprint Prevalence of essential tremor in the territory of Lake Trasimeno, Italy: results of a population-based study
    Maria Luisa Mancini
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
    Mov Disord 22:540-5. 2007
    ..Our results are in line with the most recent epidemiological findings, which suggest a lower prevalence of ET than in older studies. These results can be attributed to the application of more stringent diagnostic criteria...
  28. ncbi request reprint Functional 1H-MRS findings in migraine patients with and without aura assessed interictally
    Paola Sarchielli
    Neuroscience Department, University of Perugia, Policlinico Monteluce, Via E dal Pozzo, 06126 Perugia, Italy
    Neuroimage 24:1025-31. 2005
    ..The above findings support little differences in brain metabolites between the two patient groups assessed in interictal periods, which suggests a less efficient mitochondrial functioning in migraine with aura patients...
  29. pmc Application of ICHD 2nd edition criteria for primary headaches with the aid of a computerised, structured medical record for the specialist
    Paola Sarchielli
    Neurologic Clinic, Dept of Medical and Surgical Specialties and Public Health, University of Perugia, Silvestrini Hospital, S Andrea delle Fratte, I 06156 Perugia, Italy
    J Headache Pain 6:205-10. 2005
    ..This computerised device may help to validate the new diagnostic criteria and to answer some emerging questions from the application of the new classification version, the relevance of which should be verified in clinical practice...
  30. ncbi request reprint Nerve growth factor and chronic daily headache: a potential implication for therapy
    Paola Sarchielli
    Department of Neuroscience, Neurologic Clinic, Via E Dal Pozzo 06126, Perugia, Italy
    Expert Rev Neurother 4:115-27. 2004
    ....
  31. ncbi request reprint Excitatory amino acids and multiple sclerosis: evidence from cerebrospinal fluid
    Paola Sarchielli
    Neuroscience Department, Institute of Clinical and Applied Biochemistry, Policlinico Monteluce, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Arch Neurol 60:1082-8. 2003
    ..Recent evidence suggests an altered glutamate homeostasis in the brain of patients with multiple sclerosis (MS), as seen in experimental models of MS...
  32. ncbi request reprint Brain-derived neurotrophic factor in patients with multiple sclerosis
    Paola Sarchielli
    Neuroscience Department, University of Perugia, Policlinico Monteluce, Via E Dal Pozzo 79, 06126 Perugia, Italy
    J Neuroimmunol 132:180-8. 2002
    ..The production of BDNF by PBMCs was also evaluated in 20 age- and sex-matched control subjects. Levels of BDNF were also determined in CSF of both patient groups and 20 control subjects...