Vani Santosh

Summary

Publications

  1. ncbi request reprint Infectious lesions mimicking central nervous system neoplasms
    Vani Santosh
    Department of Neuropathology, National Institute of Mental Health, Bangalore, India
    Semin Diagn Pathol 27:122-35. 2010
  2. doi request reprint Identification of potential serum biomarkers of glioblastoma: serum osteopontin levels correlate with poor prognosis
    Peddagangannagari Sreekanthreddy
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Cancer Epidemiol Biomarkers Prev 19:1409-22. 2010
  3. doi request reprint IDH1 mutations in diffusely infiltrating astrocytomas: grade specificity, association with protein expression, and clinical relevance
    Balaram Thota
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Am J Clin Pathol 138:177-84. 2012
  4. ncbi request reprint PBEF1/NAmPRTase/Visfatin: a potential malignant astrocytoma/glioblastoma serum marker with prognostic value
    P Sreekanth Reddy
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Cancer Biol Ther 7:663-8. 2008
  5. doi request reprint Homozygous 10q23/PTEN deletion and its impact on outcome in glioblastoma: a prospective translational study on a uniformly treated cohort of adult patients
    Mallavarapu R Srividya
    Departments of Neuropathology, Neurosurgery and Biostatistics, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
    Neuropathology 31:376-83. 2011
  6. doi request reprint A DNA methylation prognostic signature of glioblastoma: identification of NPTX2-PTEN-NF-κB nexus
    Sudhanshu Shukla
    Authors Affiliations Department of Microbiology and Cell Biology, Indian Institute of Science Sri SatyaSai Institute of Higher Medical Sciences Departments of Neurosurgery and Neuropathology, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    Cancer Res 73:6563-73. 2013
  7. doi request reprint Grade-specific expression of insulin-like growth factor-binding proteins-2, -3, and -5 in astrocytomas: IGFBP-3 emerges as a strong predictor of survival in patients with newly diagnosed glioblastoma
    Vani Santosh
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Cancer Epidemiol Biomarkers Prev 19:1399-408. 2010
  8. doi request reprint Supratentorial and cerebellar liponeurocytomas: report of four cases with review of literature
    Shrijeet Chakraborti
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, 560 029 Karnataka, India
    J Neurooncol 103:121-7. 2011
  9. pmc miR-219-5p inhibits receptor tyrosine kinase pathway by targeting EGFR in glioblastoma
    Soumya Alige Mahabala Rao
    Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India
    PLoS ONE 8:e63164. 2013
  10. pmc A fourteen gene GBM prognostic signature identifies association of immune response pathway and mesenchymal subtype with high risk group
    Arivazhagan Arimappamagan
    Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    PLoS ONE 8:e62042. 2013

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Infectious lesions mimicking central nervous system neoplasms
    Vani Santosh
    Department of Neuropathology, National Institute of Mental Health, Bangalore, India
    Semin Diagn Pathol 27:122-35. 2010
    ....
  2. doi request reprint Identification of potential serum biomarkers of glioblastoma: serum osteopontin levels correlate with poor prognosis
    Peddagangannagari Sreekanthreddy
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Cancer Epidemiol Biomarkers Prev 19:1409-22. 2010
    ..The aim of this study is to identify serum biomarkers with classification and prognosis utility for astrocytoma, in particular glioblastoma (GBM)...
  3. doi request reprint IDH1 mutations in diffusely infiltrating astrocytomas: grade specificity, association with protein expression, and clinical relevance
    Balaram Thota
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Am J Clin Pathol 138:177-84. 2012
    ..001). Our study validates IDH1 mutant protein expression across various grades of astrocytoma, and demonstrates a high incidence of IDH1 mutations in DA, AA, and secondary GBM...
  4. ncbi request reprint PBEF1/NAmPRTase/Visfatin: a potential malignant astrocytoma/glioblastoma serum marker with prognostic value
    P Sreekanth Reddy
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Cancer Biol Ther 7:663-8. 2008
    ..Thus, we have identified PBEF1 as a potential malignant astrocytoma serum marker and prognostic indicator among GBMs...
  5. doi request reprint Homozygous 10q23/PTEN deletion and its impact on outcome in glioblastoma: a prospective translational study on a uniformly treated cohort of adult patients
    Mallavarapu R Srividya
    Departments of Neuropathology, Neurosurgery and Biostatistics, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
    Neuropathology 31:376-83. 2011
    ..Our study highlights the independent prognostic/predictive value of 10q23/PTEN deletion status as identified by FISH, particularly in glioblastoma patients aged >45 years...
  6. doi request reprint A DNA methylation prognostic signature of glioblastoma: identification of NPTX2-PTEN-NF-κB nexus
    Sudhanshu Shukla
    Authors Affiliations Department of Microbiology and Cell Biology, Indian Institute of Science Sri SatyaSai Institute of Higher Medical Sciences Departments of Neurosurgery and Neuropathology, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    Cancer Res 73:6563-73. 2013
    ..Prosurvival NF-κB pathway activation characterized high-risk patients with poor prognosis, indicating it to be a therapeutic target...
  7. doi request reprint Grade-specific expression of insulin-like growth factor-binding proteins-2, -3, and -5 in astrocytomas: IGFBP-3 emerges as a strong predictor of survival in patients with newly diagnosed glioblastoma
    Vani Santosh
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Cancer Epidemiol Biomarkers Prev 19:1399-408. 2010
    ..In view of this, we evaluated the expression of IGFBP isoforms (IGFBP-2, -3, and -5) during malignant progression of astrocytoma and their prognostic significance in glioblastoma...
  8. doi request reprint Supratentorial and cerebellar liponeurocytomas: report of four cases with review of literature
    Shrijeet Chakraborti
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, 560 029 Karnataka, India
    J Neurooncol 103:121-7. 2011
    ..The immunohistochemical pattern of supratentorial and infratentorial liponeurocytomas are almost identical, which indicates that these tumors are homologous...
  9. pmc miR-219-5p inhibits receptor tyrosine kinase pathway by targeting EGFR in glioblastoma
    Soumya Alige Mahabala Rao
    Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, India
    PLoS ONE 8:e63164. 2013
    ..Thus, we have identified and characterized miR-219-5p as the RTK regulating novel tumor suppressor miRNA in glioblastoma...
  10. pmc A fourteen gene GBM prognostic signature identifies association of immune response pathway and mesenchymal subtype with high risk group
    Arivazhagan Arimappamagan
    Department of Neurosurgery, National Institute of Mental Health and Neuro Sciences, Bangalore, India
    PLoS ONE 8:e62042. 2013
    ..Recent research on glioblastoma (GBM) has focused on deducing gene signatures predicting prognosis. The present study evaluated the mRNA expression of selected genes and correlated with outcome to arrive at a prognostic gene signature...
  11. doi request reprint Clinicopathological study of tuberculous brain abscess
    Shrijeet Chakraborti
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore 560029, Karnataka, India
    Pathol Res Pract 205:815-22. 2009
    ..A high index of clinical suspicion is necessary particularly in countries endemic for tuberculosis to ensure an accurate diagnosis and application of an appropriate therapy...
  12. ncbi request reprint Characterization of human immunodeficiency virus (HIV)-infected cells in infiltrates associated with CNS opportunistic infections in patients with HIV clade C infection
    Anita Mahadevan
    Departments of Neuropathology, National Institute of Mental Health and Neurological Sciences, Bangalore, India
    J Neuropathol Exp Neurol 66:799-808. 2007
    ..These findings suggest the possibility that patients, even if successfully treated for an opportunistic inflection, may be at high risk of developing HIV encephalitis and subsequent dementia...
  13. doi request reprint Glioblastoma-specific protein interaction network identifies PP1A and CSK21 as connecting molecules between cell cycle-associated genes
    Jayashree Ladha
    Chromatin Biology Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Institute of Bioinformatics and Applied Biotechnology, Bangalore, India
    Cancer Res 70:6437-47. 2010
    ..Immunohistochemical staining revealed nuclear expression of PP1A only in GBM samples. Thus, CSK21 and PP1A, whose functions are intimately associated with cell cycle regulation, might play key role in gliomagenesis...
  14. ncbi request reprint Neuropathology of HIV/AIDS with an overview of the Indian scene
    S K Shankar
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India
    Indian J Med Res 121:468-88. 2005
    ..Lacunae in the epidemiology, diagnosis and study of biology of HIV/AIDS are outlined for future research...
  15. doi request reprint Case of fulminant-SSPE associated with measles genotype D7 from India: an autopsy study
    Anita Mahadevan
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
    Neuropathology 28:621-6. 2008
    ..Measles virus was isolated from the brain with hypermutation in M gene confirming the diagnosis. Phylogenetic analysis of the viral genotype indicated that it belonged to D7 genotype which is considered rare in India...
  16. doi request reprint Factors predicting progression of low-grade diffusely infiltrating astrocytoma
    Manish Ranjan
    Department of Neuropathology, NIMHANS, Bangalore, India
    Neurol India 59:248-53. 2011
    ..Low-grade diffuse astrocytoma (DA) is considered benign tumor (World Health Organization [WHO] grade II), but it has an inherent tendency for malignant progression, which is quite variable...
  17. doi request reprint Histological and immunohistochemical characterization of AT/RT: a report of 15 cases from India
    Ishani Mohapatra
    Department of Neuropathology, National Institutes of Mental Health and Neurosciences NIMHANS, Bangalore, India
    Neuropathology 30:251-9. 2010
    ..CK staining was prominent in epithelial areas, while PNET cells labeled prominently with synaptophysin. There was lack of INI1 expression in all cases. Follow-up was available in 46.6% of cases which revealed a uniform poor prognosis...
  18. doi request reprint Histopathologic and immunohistochemical profile of spinal glioblastoma: a study of six cases
    Aparna Govindan
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, Karnataka, India
    Brain Tumor Pathol 28:297-303. 2011
    ..Nevertheless, inactivation of the p53 tumor suppressor pathway could play a major role in the genesis of these neoplasms...
  19. doi request reprint Glycogen storage disease type V (Mc Ardle's disease): a report on three cases
    Naveen Krishnamoorthy
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 59:884-6. 2011
    ..Several mutations in the PYGM gene and geographic variations have been described. We report three biopsy confirmed cases of McArdle's disease...
  20. doi request reprint Metachronous occurrence of a temporal ganglioglioma and a bifrontal anaplastic ependymoma: coincidence or an explainable pathological curiosity?
    Sumit Thakar
    Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Whitefield, Bangalore 560066, India
    Br J Neurosurg 25:741-3. 2011
    ..Histopathological examination revealed an anaplastic ependymoma. While a co-incidental occurrence is a possibility, there could be possible mechanisms to explain this pathological oddity...
  21. doi request reprint Genome-wide expression profiling identifies deregulated miRNAs in malignant astrocytoma
    Soumya A M Rao
    Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Mod Pathol 23:1404-17. 2010
    ..Thus we have identified the miRNA expression signature for malignant astrocytoma, in particular glioblastoma, and showed the miRNA involvement and their importance in astrocytoma development...
  22. ncbi request reprint Pathobiology of fungal infections of the central nervous system with special reference to the Indian scenario
    S K Shankar
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 55:198-215. 2007
    ..Detailed clinical and mycological investigations related to the interaction between the fungus and host environment is a fertile area of research to understand the basic pathogenetic mechanisms...
  23. ncbi request reprint Cysticercal chronic basal arachnoiditis with infarcts, mimicking tuberculous pathology in endemic areas
    Gopaliah Shivane Aditya
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neuropathology 24:320-5. 2004
    ..The present case report highlights the importance of considering the non-tuberculous etiologies of chronic basal arachnoiditis like NCC before initiating therapy especially in countries endemic to both NCC and tuberculosis, like India...
  24. doi request reprint Primary myxopapillary ependymoma of the fourth ventricle with cartilaginous metaplasia: a case report and review of the literature
    Shrijeet Chakraborti
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, 560 029, India
    Brain Tumor Pathol 29:25-30. 2012
    ..Intracranial MPE needs further evaluation by craniospinal MRI to exclude an unrecognized primary in the spinal region, which could warrant surgical attention...
  25. doi request reprint Rosai Dorfman disease: case with extensive dural involvement and cerebrospinal fluid pleocytosis
    Atchayaram Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Neurol Sci 314:152-4. 2012
    ..Histiocytes were strongly positive for CD-68 and S-100 proteins. The illness relentlessly progressed with patient developing total deafness and near total blindness at last follow-up...
  26. ncbi request reprint Subarachnoid spread of germinoma mimicking tuberculous meningitis
    T N Suresh
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India
    Neurol India 52:251-3. 2004
    ..Need to carry out CSF cytology of even hemorrhagic CSF is stressed, to diagnose the condition...
  27. doi request reprint Dysferlinopathy: spectrum of pathological changes in skeletal muscle tissue
    N Gayathri
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India
    Indian J Pathol Microbiol 54:350-4. 2011
    ..Awareness of the variants and their relative frequency is essential for accurate diagnosis...
  28. ncbi request reprint Acute aortic dissection presenting as painful paraplegia
    B N Nandeesh
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Clin Neurol Neurosurg 109:531-4. 2007
    ..Prompt diagnosis and timely intervention may help save life and limb...
  29. ncbi request reprint A 30-year-old male with diffuse white matter lesions
    T C Yasha
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 53:358-60. 2005
  30. ncbi request reprint Endoscopic options in management of posterior third ventricular tumors
    S V Roopesh Kumar
    Department of Neurosurgery, National Institute of Mental Health and Neurosciences NIMHANS, Hosur Road, Bangalore, India
    Childs Nerv Syst 23:1135-45. 2007
    ..Most of these are associated with hydrocephalus requiring a cerebrospinal fluid diversion procedure. The present study aims to assess the effectiveness of endoscopic biopsy and third ventriculostomy (ETV) in these patients...
  31. ncbi request reprint Epithelioid and retiform hemangioendothelioma of the skull bone--report of four cases
    G S Aditya
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, NIMHANS, Hosur Road, Bangalore
    Indian J Pathol Microbiol 46:645-9. 2003
    ..The tumour cells lacked cytological atypia and mitosis was sparse. These features were important in prognostication as low-grade tumours can be cured by complete wide-resection...
  32. ncbi request reprint Shift in AP-2alpha localization characterizes astrocytoma progression
    Ramona Britto
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India
    Cancer Biol Ther 6:413-8. 2007
    ..The striking observation was the shift in localization of this protein from the nucleus to the cytoplasm with increasing tumor grade, pointing to a crucial role for this transcription factor in the progression of astrocytomas...
  33. doi request reprint Multicompartmental trigeminal schwannoma--a clinical report
    Aliasgar V Moiyadi
    Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India
    J Craniofac Surg 19:1177-80. 2008
    ..We report one such patient. The tumor was approached via a modified frontotemporal craniotomy with orbitozygomatic osteotomy. It was completely extradural and could be totally excised with minimal morbidity...
  34. ncbi request reprint Optic nerve axonal pathology is related to abnormal visual evoked responses in AIDS
    Anita Mahadevan
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
    Acta Neuropathol 112:461-9. 2006
    ..Opportunistic infections could be contributing to the axonal pathology in the optic nerve in patients with AIDS...
  35. doi request reprint Novel glioblastoma markers with diagnostic and prognostic value identified through transcriptome analysis
    Sreekanth P Reddy
    Department of Molecular Reproduction, Indian Institute of Science, Bangalore, Karnataka, India
    Clin Cancer Res 14:2978-87. 2008
    ..Therefore, the aim of this study was to identify glioblastoma diagnostic and prognostic markers through microarray analysis...
  36. ncbi request reprint Co-existing fibrous dysplasia and atypical lymphoplasmacyte-rich meningioma
    Nandita Ghosal
    Department of Pathology and Transfusion Medicine, Sri Sathya Sai Institute of Higher Medical Sciences, Bangalore, India
    Neuropathology 27:269-72. 2007
    ..Although no definite causative factors are described for the coexistence of these tumors, however, a common yet undetermined denominator in the origin has been proposed in the literature...
  37. ncbi request reprint Primary central nervous system lymphoma--a hospital based study of incidence and clinicopathological features from India (1980-2003)
    Chitra Sarkar
    Department of Pathology, All India Institute of Medical Sciences, New Delhi, Bangalore, India
    J Neurooncol 71:199-204. 2005
    ..The association of PCNSL with HIV/AIDS has been low in India, possibly due to early death in AIDS on account of opportunistic infections...
  38. ncbi request reprint A rare case of cellular schwannoma involving the trigeminal ganglion
    Ravindranath Tagore Koyye
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India
    Brain Tumor Pathol 20:79-83. 2003
    ....
  39. ncbi request reprint Desmoplastic infantile ganglioglioma--clinicopathological and immunohistochemical study of four cases
    Pritilata Rout
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
    Childs Nerv Syst 18:463-7. 2002
    ..DIGs are a distinct form of developmental neuroepithelial tumour, probably arising from neural progenitor cells in subcortical zone along with mature subpial astrocytes...
  40. ncbi request reprint Neuronal ceroid lipofuscinosis: a clinicopathological study
    Sanjib Sinha
    Department of Neurology, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
    Seizure 13:235-40. 2004
    ..To conclude, this neurodegenerative disease had varied but characteristic clinical presentations and required histopathological confirmation of diagnosis...
  41. ncbi request reprint Primary spinal paragangliomas: a clinicopathological and immunohistochemical study of six cases
    M Rumana
    Department of Neuropathology, NIMHANS, Bangalore
    Indian J Pathol Microbiol 50:528-32. 2007
    ..01-2% was noted in five cases and in the sixth it was 5%. None of the tumours recurred. Immunohistochemistry assisted in differentiating these relatively benign neural crest tumours from the more aggressive spinal ependymomas...
  42. ncbi request reprint Ullrich congenital muscular dystrophy: report of nine cases from India
    A Nalini
    Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India
    Neurol India 57:41-5. 2009
    ....
  43. doi request reprint Recurrence in medulloblastoma - influence of clinical, histological and immunohistochemical factors
    Umesh Srikantha
    Department of Neurosurgery, NIMHANS, Bangalore, India
    Br J Neurosurg 24:280-8. 2010
    ..The therapy for medulloblastomas has gone through several changes over the years. Research has shown that patients with medulloblastoma cannot be satisfactorily stratified into risk groups based on clinical and therapeutic factors alone...