Jean Francois Leonard

Summary

Affiliation: Sanofi-Aventis Deutschland GmbH

Publications

  1. ncbi request reprint Proteomic characterization of the effects of clofibrate on protein expression in rat liver
    Jean Francois Leonard
    Drug Safety Evaluation, Sanofi Aventis, Vitry sur Seine, France
    Proteomics 6:1915-33. 2006
  2. doi request reprint Optimization of SELDI for biomarker detection in plasma
    Jean Francois Leonard
    Disposition, Safety and Animal Research, sanofi aventis R and D, Vitry sur Seine, France
    Methods Mol Biol 691:351-68. 2011
  3. ncbi request reprint Early drug safety evaluation: biomarkers, signatures, and fingerprints
    Ruth Roberts
    Aventis Pharma, Drug Safety Evaluation, Centre de Recherche de Paris, Paris, France
    Drug Metab Rev 35:269-75. 2003

Collaborators

Detail Information

Publications3

  1. ncbi request reprint Proteomic characterization of the effects of clofibrate on protein expression in rat liver
    Jean Francois Leonard
    Drug Safety Evaluation, Sanofi Aventis, Vitry sur Seine, France
    Proteomics 6:1915-33. 2006
    ..Differential effects on those variants could result from specific PTM and could be a specific molecular signature of the clofibrate-induced protein expression modulation in rat liver...
  2. doi request reprint Optimization of SELDI for biomarker detection in plasma
    Jean Francois Leonard
    Disposition, Safety and Animal Research, sanofi aventis R and D, Vitry sur Seine, France
    Methods Mol Biol 691:351-68. 2011
    ..Last, a systematic evaluation of technical bias such as the spot and chip position and the bioprocessor sequence number may be achieved using the appropriate multivariate statistical analyses...
  3. ncbi request reprint Early drug safety evaluation: biomarkers, signatures, and fingerprints
    Ruth Roberts
    Aventis Pharma, Drug Safety Evaluation, Centre de Recherche de Paris, Paris, France
    Drug Metab Rev 35:269-75. 2003
    ..the efficacious dose can provide clues on MOA for the toxicity and may allow differentiation of the pathways of the toxic response from those required for pharmacological activity...