Vijay G Sankaran

Summary

Publications

  1. doi request reprint Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis
    Vijay G Sankaran
    Division of Hematology Oncology, Boston Children s Hospital and Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, United States
    Curr Opin Genet Dev 23:339-44. 2013
  2. pmc The switch from fetal to adult hemoglobin
    Vijay G Sankaran
    Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cold Spring Harb Perspect Med 3:a011643. 2013
  3. pmc A functional element necessary for fetal hemoglobin silencing
    Vijay G Sankaran
    Department of Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    N Engl J Med 365:807-14. 2011
  4. doi request reprint Targeted therapeutic strategies for fetal hemoglobin induction
    Vijay G Sankaran
    Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Hematology Am Soc Hematol Educ Program 2011:459-65. 2011
  5. pmc Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing
    Jian Xu
    Division of Hematology Oncology, Children s Hospital Boston and Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 334:993-6. 2011
  6. pmc Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6
    Jian Xu
    Children s Hospital Boston, Massachusetts 02115, USA
    Genes Dev 24:783-98. 2010
  7. doi request reprint Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A
    Vijay G Sankaran
    Division of Hematology Oncology, Children s Hospital Boston, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 322:1839-42. 2008
  8. doi request reprint Transcriptional silencing of fetal hemoglobin by BCL11A
    Vijay G Sankaran
    Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1202:64-8. 2010
  9. doi request reprint Advances in the understanding of haemoglobin switching
    Vijay G Sankaran
    Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Br J Haematol 149:181-94. 2010
  10. pmc Developmental and species-divergent globin switching are driven by BCL11A
    Vijay G Sankaran
    Division of Hematology Oncology, Children s Hospital Boston and Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 460:1093-7. 2009

Detail Information

Publications18

  1. doi request reprint Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis
    Vijay G Sankaran
    Division of Hematology Oncology, Boston Children s Hospital and Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, United States
    Curr Opin Genet Dev 23:339-44. 2013
    ..We discuss how the resulting insight from these studies promises to increase our understanding of human hematopoiesis and outline the challenges that lay ahead in this field. ..
  2. pmc The switch from fetal to adult hemoglobin
    Vijay G Sankaran
    Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Cold Spring Harb Perspect Med 3:a011643. 2013
    ....
  3. pmc A functional element necessary for fetal hemoglobin silencing
    Vijay G Sankaran
    Department of Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    N Engl J Med 365:807-14. 2011
    ..Although recent studies have uncovered trans-acting factors necessary for this regulation, limited insight has been gained into the cis-regulatory elements involved...
  4. doi request reprint Targeted therapeutic strategies for fetal hemoglobin induction
    Vijay G Sankaran
    Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Hematology Am Soc Hematol Educ Program 2011:459-65. 2011
    ....
  5. pmc Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing
    Jian Xu
    Division of Hematology Oncology, Children s Hospital Boston and Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 334:993-6. 2011
    ..Thus, interference with HbF silencing by manipulation of a single target protein is sufficient to reverse SCD...
  6. pmc Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6
    Jian Xu
    Children s Hospital Boston, Massachusetts 02115, USA
    Genes Dev 24:783-98. 2010
    ..Our findings provide insight into the mechanism of BCL11A action and new clues for the developmental gene regulatory programs that function at the beta-globin locus...
  7. doi request reprint Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A
    Vijay G Sankaran
    Division of Hematology Oncology, Children s Hospital Boston, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 322:1839-42. 2008
    ..BCL11A emerges as a therapeutic target for reactivation of HbF in beta-hemoglobin disorders...
  8. doi request reprint Transcriptional silencing of fetal hemoglobin by BCL11A
    Vijay G Sankaran
    Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1202:64-8. 2010
    ..As a factor critical for gamma-globin gene silencing, BCL11A should be considered as a therapeutic target to increase HbF in a directed manner in beta-thalassemia patients...
  9. doi request reprint Advances in the understanding of haemoglobin switching
    Vijay G Sankaran
    Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Br J Haematol 149:181-94. 2010
    ....
  10. pmc Developmental and species-divergent globin switching are driven by BCL11A
    Vijay G Sankaran
    Division of Hematology Oncology, Children s Hospital Boston and Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 460:1093-7. 2009
    ..By comparing the ontogeny of beta-globin gene regulation in mice and humans, we have shown that alterations in the expression of a trans-acting factor constitute a critical driver of gene expression changes during evolution...
  11. pmc Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia
    Vijay G Sankaran
    Broad Institute, Cambridge, MA, USA
    J Clin Invest 122:2439-43. 2012
    ..These results also illustrate the multifactorial role of GATA1 in human hematopoiesis...
  12. doi request reprint Modifier genes in Mendelian disorders: the example of hemoglobin disorders
    Vijay G Sankaran
    Division of Hematology Oncology, Children s Hospital Boston, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1214:47-56. 2010
    ..We finally go on to discuss future avenues of research that may allow us to gain further insight into the poorly understood clinical heterogeneity of this fascinating set of common genetic diseases...
  13. pmc MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13
    Vijay G Sankaran
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 108:1519-24. 2011
    ....
  14. pmc Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number
    Vijay G Sankaran
    Broad Institute, Cambridge, Massachusetts 02142, USA
    Genes Dev 26:2075-87. 2012
    ..We illustrate how cell type-specific specialization can occur for general cell cycle components-a finding resulting from the biological follow-up of unbiased human genetic studies...
  15. pmc DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 105:11869-74. 2008
    ..We also have shown that HbF-associated SNPs associate with pain crisis rate in SCD patients. These results provide a clear example of inherited common sequence variants modifying the severity of a monogenic disease...
  16. pmc Rb and hematopoiesis: stem cells to anemia
    Carl R Walkley
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Division of Hematology Oncology and Stem Cell Program, Children s Hospital Boston, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA, 02115, USA
    Cell Div 3:13. 2008
    ....
  17. pmc Applications of high-throughput DNA sequencing to benign hematology
    Vijay G Sankaran
    Division of Hematology Oncology, Boston Children s Hospital, and Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA
    Blood 122:3575-82. 2013
    ....
  18. doi request reprint Thalassemia: an overview of 50 years of clinical research
    Vijay G Sankaran
    Harvard Medical School, Boston, MA 02115, USA
    Hematol Oncol Clin North Am 24:1005-20. 2010
    ..This article emphasizes how the increasing knowledge of cellular and molecular biology are facilitating the development of more effective therapies for these patients...