Synthetic direct and indirect factor Xa inhibitorsMeyer Michel Samama
Hotel-Dieu University Hospital, Paris, France
Thromb Res 106:V267-73. 2002
Newer anticoagulants in 2009Meyer Michel Samama
Hotel Dieu University Hospital, 1, Place du Parvis Notre Dame, 75181 Paris Cedex 04, France
J Thromb Thrombolysis 29:92-104. 2010
..Their use in the general world will hopefully confirm the promising results of clinical trials...
- Monitoring plasma levels of factor Xa inhibitors: how, why and when?
Meyer Michel Samama
Biomnis Laboratory, Ivry sur Seine, Paris, France
Expert Rev Hematol 6:155-64. 2013
..The physicians must be aware of the possibility to measure the plasma concentration of FXa inhibitors in patients at high risk of bleeding and in several other special clinical situations...
- Measurement of dabigatran and rivaroxaban in primary prevention of venous thromboembolism in 106 patients, who have undergone major orthopedic surgery: an observational study
Meyer Michel Samama
Cochin Broca Hôtel Dieu University Hospital, Paris, France
J Thromb Thrombolysis 35:140-6. 2013
..An interference by pantoprazole, a drug which reduces dabigatran absorption, could explain the observed lower than expected results...
- Do new oral anticoagulants require laboratory monitoring? The clinician point of view
Meyer Michel Samama
Cochin Broca Hôtel Dieu University Hospital, Paris, France
Thromb Res 130:S88-9. 2012
..Trials are needed to determine the relationship of assay results with bleeding or thrombotic complications. Pros and Cons laboratory measurements are discussed...
- In vitro study of the anticoagulant effects of edoxaban and its effect on thrombin generation in comparison to fondaparinux
Meyer Michel Samama
Haematology Department, Hotel Dieu University Hospital, Paris, France
Thromb Res 129:e77-82. 2012
..Secondary objectives included evaluation of edoxaban and inhibition of coagulation parameters (prothrombin time [PT], activated partial thromboplastin time [aPTT]), anti-FXa activity and clotting times...
- Evaluation of the prothrombin time for measuring rivaroxaban plasma concentrations using calibrators and controls: results of a multicenter field trial
Meyer Michel Samama
Hotel Dieu University Hospital, Paris, France
Clin Appl Thromb Hemost 18:150-8. 2012
..The widely available PT assay, in conjunction with rivaroxaban calibrators, may be useful for the measurement of peak plasma levels of rivaroxaban...
- Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls
Meyer Michel Samama
Hotel Dieu University Hospital, Paris, France
Thromb Haemost 107:379-87. 2012
....
- Laboratory assessment of new anticoagulants
Meyer M Samama
Hotel Dieu University Hospital, Paris, France
Clin Chem Lab Med 49:761-72. 2011
..The tests show variations in response to anticoagulants - some of which have clinical relevance. Thus, it is important to be aware of the observed variations in order to prevent the misinterpretation of test results...
- The mechanism of action of rivaroxaban--an oral, direct Factor Xa inhibitor--compared with other anticoagulants
Meyer Michel Samama
Hotel Dieu University Hospital, Paris, France
Thromb Res 127:497-504. 2011
..Although the mechanism of action differs between the direct Factor Xa and direct thrombin inhibitors, phase III studies of these new agents confirmed that both Factor Xa and thrombin are viable anticoagulation targets...
- Comparison of a direct Factor Xa inhibitor, edoxaban, with dalteparin and ximelagatran: a randomised controlled trial in healthy elderly adults
Meyer M Samama
Biomnis, 78 Avenue de Verdun, 94208 Ivry sur Seine Cedex, France
Thromb Res 126:e286-93. 2010
..Edoxaban (the free base of DU-176b) is a new, oral direct Factor Xa inhibitor. This is the first study to compare the hemostatic response to edoxaban, ximelagatran, and dalteparin in healthy, elderly adults...
- [Perioperative use of antithrombotic agents: recommendations of the American College of Chest Physicians (ACCP) and the French Superior Health Authority (HAS)]
M M Samama
Groupe interdisciplinaire Trousseau sur les antithrombotiques, Unité hémostase thrombose, Hotel Dieu, Parvis Notre Dame, 75181 Paris Cedex 04, France
J Mal Vasc 35:220-34. 2010
..Grade 2 recommendations are considered to be suggestions. They imply that the individual physician chooses between different therapeutic strategies. For the purpose of this work, the most important recommendations are the following:..
- Assessment of laboratory assays to measure rivaroxaban--an oral, direct factor Xa inhibitor
Meyer Michel Samama
Hotel Dieu University Hospital, Paris, France 2Biomnis Laboratory, Ivry sur Seine, France
Thromb Haemost 103:815-25. 2010
..Finally, all clotting and chromogenic assays showed a concentration-dependent effect induced by rivaroxaban...
- [From old to new anticoagulants: the role of the biologist]
Mm Samama
Laboratoire Biomnis, 78, avenue de Verdun, 94200 Ivry sur Seine
Ann Biol Clin (Paris) 67:525-34. 2009
..Both do not require routine laboratory monitoring. However, coagulation assays for measuring their activity have been studied. A small number of standardized tests should be perfected...
- Is the inhibition of both clot-associated thrombin and factor Xa more clinically relevant than either one alone?
Sadia Meddahi
Service d Hematologie Biologique, Hotel Dieu, Paris, France
Blood Coagul Fibrinolysis 20:207-14. 2009
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- Clinical studies with anticoagulants to improve survival in cancer patients
Grigoris T Gerotziafas
EA3499, Faculty of Medicine, University Pierre and Marie Curie Paris VI, Paris, France
Pathophysiol Haemost Thromb 36:204-11. 2008
..The forthcoming clinical trials have to address some issues regarding the optimal dose, the timing and the duration of treatment with LMWH in relation to chemotherapy or other anticancer therapies...
- Standard measurement of clot-bound thrombin by using a chromogenic substrate for thrombin
Sadia Meddahi
, , Paris, France
Thromb Res 114:51-6. 2004
..We suggest that clot-bound thrombin can be measured using a chromogenic substrate specific for thrombin under our experimental condition...
