Antero Salminen

Summary

Publications

  1. ncbi request reprint N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors
    Päivi H Kiviranta
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    J Med Chem 49:7907-11. 2006
  2. ncbi request reprint Amyloid-beta 1-42 induced endocytosis and clusterin/apoJ protein accumulation in cultured human astrocytes
    Tapio Nuutinen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurochem Int 50:540-7. 2007
  3. ncbi request reprint Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
    Tarja M Malm
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurosci 27:3712-21. 2007
  4. doi request reprint Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Eur J Neurosci 34:3-11. 2011
  5. doi request reprint Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 106:33-54. 2013
  6. doi request reprint Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Ageing Res Rev 12:520-34. 2013
  7. pmc Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Int J Mol Sci 14:3834-59. 2013
  8. doi request reprint Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Curr Opin Clin Nutr Metab Care 15:23-8. 2012
  9. pmc Inflammaging: disturbed interplay between autophagy and inflammasomes
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Aging (Albany NY) 4:166-75. 2012
  10. doi request reprint Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211, Kuopio, Finland
    Cell Mol Life Sci 69:2999-3013. 2012

Collaborators

Detail Information

Publications79

  1. ncbi request reprint N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors
    Päivi H Kiviranta
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    J Med Chem 49:7907-11. 2006
    ..The most potent compound was N,N'-bis(2-hydroxybenzylidene)benzene-1,4-diamine, which was equipotent with the most potent hit compound and well-known SIRT2 inhibitor sirtinol...
  2. ncbi request reprint Amyloid-beta 1-42 induced endocytosis and clusterin/apoJ protein accumulation in cultured human astrocytes
    Tapio Nuutinen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurochem Int 50:540-7. 2007
    ..Endocytic response associated with the accumulation of clusterin/apoJ protein suggests that clusterin/apoJ has a role in the clearance of amyloid-beta peptides...
  3. ncbi request reprint Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
    Tarja M Malm
    A I Virtanen Institute for Molecular Sciences, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurosci 27:3712-21. 2007
    ..Because PDTC is capable of transferring external Cu2+ into a cell, and, in turn, Cu2+ is able to activate Akt, we hypothesize that PDTC provides the beneficial effect in transgenic AD mice through Cu2+-activated Akt pathway...
  4. doi request reprint Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Eur J Neurosci 34:3-11. 2011
    ..We will review the astroglial changes occurring during aging and emphasize that senescent astrocytes can have an important role in age-related neuroinflammation and neuronal degeneration...
  5. doi request reprint Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 106:33-54. 2013
    ....
  6. doi request reprint Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Ageing Res Rev 12:520-34. 2013
    ..We will review the role of Beclin 1 interactome in the crosstalk between apoptosis, autophagy and inflammasomes emphasizing that disturbances in Beclin 1-dependent autophagy can have a crucial impact on the aging process...
  7. pmc Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging Process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Int J Mol Sci 14:3834-59. 2013
    ..We will review the major mechanisms controlling the signaling balance between the ROS production and SIRT1 activity emphasizing that this crosstalk has a crucial role in the regulation of the aging process...
  8. doi request reprint Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Curr Opin Clin Nutr Metab Care 15:23-8. 2012
    ....
  9. pmc Inflammaging: disturbed interplay between autophagy and inflammasomes
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Aging (Albany NY) 4:166-75. 2012
    ..We will provide here a perspective on the current research of the ROS-dependent activation of inflammasomes triggered by the decline in autophagic cleansing of dysfunctional mitochondria...
  10. doi request reprint Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211, Kuopio, Finland
    Cell Mol Life Sci 69:2999-3013. 2012
    ..g., the metabolic syndrome. We will review here the emerging field of inflammasomes in the appearance of the proinflammatory phenotype during the aging process and in age-related diseases...
  11. doi request reprint AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Ageing Res Rev 11:230-41. 2012
    ..We will review in detail the signaling pathways of this integrated network through which AMPK controls energy metabolism, autophagic degradation and stress resistance and ultimately the aging process...
  12. doi request reprint Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Cell Signal 24:835-45. 2012
    ..We will review in detail the signaling pathways which activate NF-κB signaling and trigger SASP in senescent cells...
  13. doi request reprint Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 96:87-95. 2012
    ..We will review here the molecular and functional characteristics of p62 protein and outline its potential role in the regulation of Alzheimer's pathogenesis...
  14. doi request reprint Apoptosis and aging: increased resistance to apoptosis enhances the aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Cell Mol Life Sci 68:1021-31. 2011
    ..We will discuss the molecular basis of age-related resistance to apoptosis and emphasize that increased resistance could enhance the aging process...
  15. pmc AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    J Mol Med (Berl) 89:667-76. 2011
    ..We also emphasize that the capacity of AMPK to repress inflammatory responses can have a significant impact on both healthspan and lifespan...
  16. doi request reprint AMP-activated protein kinase: a potential player in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    J Neurochem 118:460-74. 2011
    ..We will outline the potential role of AMPK function in respect to various aspects affecting AD pathogenesis...
  17. doi request reprint Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 93:99-110. 2011
    ..We will review the role of Hsp90 chaperone network in the regulation of tau biology and pathology in Alzheimer's disease...
  18. doi request reprint Celastrol: Molecular targets of Thunder God Vine
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Biochem Biophys Res Commun 394:439-42. 2010
    ..Celastrol needs still to pass several hurdles, e.g. ADMET assays, before it can enter the armoury of western drugs...
  19. doi request reprint ER stress and hormetic regulation of the aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Ageing Res Rev 9:211-7. 2010
    ..The efficiency of the stress recognition system and UPR signaling declines during aging. We will discuss the role of ER stress in hormetic regulation of aging process and longevity...
  20. pmc Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization
    Antero Salminen
    Department of Neurology, University of Eastern Finland, Kuopio, Finland
    Mol Med 16:535-42. 2010
    ..We discuss the role of ER stress in the regulation of neovascularization and the conversion of dry AMD to its wet, detrimental counterpart...
  21. doi request reprint Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, PO Box 1627, FIN 70211 Kuopio, Finland
    Cell Signal 23:747-52. 2011
    ..We will review the findings linking WIP1 and MIF to specific signaling responses of p53 and NF-κB and discuss their role in the regulation of cellular senescence and organismal aging...
  22. doi request reprint Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone
    Päivi H Kiviranta
    Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Bioorg Med Chem 16:8054-62. 2008
    ..The N-(3-phenylpropenoyl)-glycine tryptamide backbone is also a good backbone for SIRT2 inhibitors, and the series of compounds includes several potent SIRT2 inhibitors...
  23. doi request reprint Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90
    Tiina Suuronen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    Neurochem Res 33:1768-75. 2008
    ..Our results reveal that ER alpha signaling is dependent on protein acetylation and epigenetic regulation...
  24. ncbi request reprint Induction of clusterin/apoJ expression by histone deacetylase inhibitors in neural cells
    Tapio Nuutinen
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Neurochem Int 47:528-38. 2005
    ..These observations suggest that clusterin induction is NF-kappaB-independent and unrelated to the inflammatory response in N9 microglia...
  25. pmc p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells
    Johanna Viiri
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Mol Vis 16:1399-414. 2010
    ..In the present study, the functional roles of p62 and HSP70 were evaluated in conjunction with proteasome inhibitor-induced autophagy in human RPE cells (ARPE-19)...
  26. doi request reprint Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19)
    Tuomas Paimela
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, and Kuopio University Hospital, P O Box 1627, FIN 70211 Kuopio, Finland
    Eur J Pharmacol 640:219-25. 2010
    ..These results indicate that estrogen and HM-D can suppress the lipopolysaccharide-induced inflammatory response but signalling is not mediated through estrogen response element transcription in human retinal pigment epithelial cells...
  27. pmc Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells
    Tuomas Ryhanen
    Department of Ophthalmology, University of Eastern Finland, 70211 Kuopio, Finland
    J Biomed Biotechnol 2011:798052. 2011
    ..These findings open new perspectives for understanding the pathogenesis of protein aggregation in retinal cells and can be useful for the development of therapeutic treatments to prevent retinal cell deterioration...
  28. ncbi request reprint Characterization of the pro-inflammatory signaling induced by protein acetylation in microglia
    Tiina Suuronen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurochem Int 49:610-8. 2006
    ..These results indicate that PI 3-kinase regulates the transactivation efficiency of NF-kappaB-dependent transcription rather than transduction of NF-kappaB signaling...
  29. ncbi request reprint The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells
    Tuomas Paimela
    Department of Ophthalmology, University of Kuopio, Kuopio, Finland
    Immunol Lett 110:139-44. 2007
    ..The level of TLR4 gene expression was not affected by LPS exposure. Our results indicate that IL-6 expression is regulated through NF-kappaB transcription factor and stereoid-receptor signalling pathways in ARPE-19 cells...
  30. doi request reprint Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2
    Tero Huhtiniemi
    School of Pharmacy, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, 70211 Kuopio, Finland
    J Med Chem 54:6456-68. 2011
    ....
  31. doi request reprint Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells
    Tuomas Ryhanen
    Department of Ophthalmology, University of Kuopio, Kuopio, Finland
    Eur J Pharmacol 584:229-36. 2008
    ..05) radicicol, but not in geldanamycin-treated RPE cells. These novel findings help in understanding the influence of HSP90 inhibition and regulatory mechanisms of drug delivery to retinal cells...
  32. doi request reprint Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells
    Tuomas Ryhanen
    Department of Ophthalmology, University of Kuopio, Kuopio, Finland
    J Cell Mol Med 13:3616-31. 2009
    ..The molecular chaperone Hsp70, proteasomes and autophagy have an important regulatory role in the protein turnover of human RPE cells and may thus open new avenues for understanding degenerative processes in retinal cells...
  33. doi request reprint Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors
    Tero Huhtiniemi
    Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    J Med Chem 51:4377-80. 2008
    ..The most potent compound in the series was nearly as potent as the reference compound (6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide)...
  34. doi request reprint Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, and Kuopio University Hospital, Kuopio, Finland
    J Cell Mol Med 12:2255-62. 2008
    ....
  35. ncbi request reprint Discovering inhibitors of human sirtuin type 2: novel structural scaffolds
    Anu J Tervo
    Department of Pharmaceutical Chemistry, University of Kuopio, and Department of Neurology, Kuopio University Hospital, Post Office Box 1777, 70211 Kuopio, Finland
    J Med Chem 49:7239-41. 2006
    ..Two of these compounds inhibited SIRT2 with IC50 (microM) values of 51 and 91; moreover, one of the new inhibitors was comprised of an entirely new SIRT2-inhibiting structural scaffold...
  36. ncbi request reprint Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells
    Kai Kaarniranta
    Department of Ophthalmology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Brain Res Mol Brain Res 137:126-31. 2005
    ..Interestingly, GA treatment accumulated Hsp70 protein and attenuated OA-induced cytotoxicity. This study suggests that Hsp70 and Hsp90 are closely related to cytoprotection of RPE cells in response to protein phosphatase inhibition...
  37. ncbi request reprint Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Prog Neurobiol 87:181-94. 2009
    ..In addition, we will discuss whether AD pathology could be the outcome of chronic activation of the innate immunity defence in the brain of AD patients...
  38. ncbi request reprint N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors
    Päivi H Kiviranta
    Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Bioorg Med Chem Lett 17:2448-51. 2007
    ....
  39. doi request reprint SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Finland
    Bioessays 30:939-42. 2008
    ..Longevity factors, such as SIRT1 and its activators, might regulate the efficiency of the NF-kappaB signaling, the major outcome of which is inflamm-aging via proinflammatory responses...
  40. pmc ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    J Neuroinflammation 6:41. 2009
    ..We will describe the mechanisms which could link the ER stress of neurons to the activation of the inflammatory response and the evolution of pathological changes in AD...
  41. doi request reprint Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD)
    Anu Kauppinen
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Immunol Lett 147:29-33. 2012
    ..In conclusion, our present data suggest that oxidative stress can activate NLRP3 inflammasomes in RPE cells which occupy center stage in the pathogenesis of AMD...
  42. ncbi request reprint Selective regulation of class I and class II histone deacetylases expression by inhibitors of histone deacetylases in cultured mouse neural cells
    Farzam Ajamian
    Department of Neurobiology, A I Virtanen Institute for Molecular Science, University of Kuopio, P O Box 1627 Neulaniementie 2, FIN 70211 Kuopio, Finland
    Neurosci Lett 365:64-8. 2004
    ..There exists an auto-regulatory feedback loop to the expression levels of several HDACs after inhibition of their biochemical activity, adding several HDAC genes to the list of genes regulated by HDAC inhibitors...
  43. doi request reprint Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells
    Tuomas Paimela
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Pharmacol Res 64:501-8. 2011
    ..Our findings reveal that celastrol is a novel plant compound which suppresses innate immunity response in human retinal pigment epithelial cells via NF-κB and Hsp70 regulation, and that Hsp70 is a critical regulator of NF-κB...
  44. ncbi request reprint Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
    Antero Salminen
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    Ageing Res Rev 7:83-105. 2008
    ..Our conclusion is that NF-kB signaling seems to be the culprit of inflamm-aging, since this signaling system integrates the intracellular regulation of immune responses in both aging and age-related diseases...
  45. ncbi request reprint Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells
    Tiina Suuronen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biochem Biophys Res Commun 357:397-401. 2007
    ..Our results indicate that epigenetic factors regulate the clusterin expression of RPE cells and thus might affect the pathogenesis of AMD via the inhibition of angiogenesis and inflammation...
  46. ncbi request reprint Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons
    Petri Kerokoski
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Neurosci Lett 368:181-5. 2004
    ..Different factors, such as maturation state of neurons or desensitization properties of non-NMDA receptors, may determine which receptor predominantly mediates the effect of glutamate on p35 cleavage...
  47. doi request reprint Clusterin: a forgotten player in Alzheimer's disease
    Tapio Nuutinen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Brain Res Rev 61:89-104. 2009
    ..Though clusterin can be viewed as a multipotent guardian of brain, it is unable to prevent the progressive neuropathology in chronic AD...
  48. doi request reprint N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors
    Päivi H Kiviranta
    Department of Pharmaceutical Chemistry, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
    J Med Chem 52:2153-6. 2009
    ..The most potent SIRT1 inhibitors were equipotent with the reference compound (6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) with the IC(50) values of 180-330 nM...
  49. ncbi request reprint Regulation of microglial inflammatory response by histone deacetylase inhibitors
    Tiina Suuronen
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    J Neurochem 87:407-16. 2003
    ..Our results suggest that environmental stresses, ageing, diet and diseases that regulate protein acetylation status may also affect the inflammatory response...
  50. doi request reprint N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2
    Tero Huhtiniemi
    School of Pharmacy, University of Eastern Finland, Kuopio Campus, PO Box 1627, 70211 Kuopio, Finland
    Bioorg Med Chem 18:5616-25. 2010
    ..These results are applicable for further screening of N(epsilon)-acetyl analogues...
  51. pmc Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells
    Johanna Viiri
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    PLoS ONE 8:e69563. 2013
    ..Interestingly, when compared to human controls, AMD donor samples show strong SQSTM1/p62 rather than ELAVL1/HuR accumulation in the drusen rich macular area suggesting impaired autophagy in the pathology of AMD. ..
  52. doi request reprint NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?
    Antero Salminen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biochem Biophys Res Commun 367:715-8. 2008
    ..The NEMO shuttle may link genotoxic stress to the activation of the innate immunity system and cause premature aging via inflamm-aging process...
  53. doi request reprint Age-related macular degeneration (AMD): Alzheimer's disease in the eye?
    Kai Kaarniranta
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    J Alzheimers Dis 24:615-31. 2011
    ..However, it seems that these diseases have a different genetic background. In this review, differences and similarities of AMD and AD are thoroughly discussed...
  54. pmc Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids
    Jari Huuskonen
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Br J Pharmacol 141:874-80. 2004
    ....
  55. ncbi request reprint Comparative and pharmacophore model for deacetylase SIRT1
    Tero Huhtiniemi
    Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, Kuopio, FIN 70211, Finland
    J Comput Aided Mol Des 20:589-99. 2006
    ..To distinguish between active and inactive compounds, a post-docking filter based on H-bond network was constructed. Docking results were used to investigate the pharmacophore and to identify a filter for database mining...
  56. pmc Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro
    Hanna Mari Jauhonen
    Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland
    Mol Vis 17:2311-7. 2011
    ....
  57. doi request reprint Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
    Anu Kauppinen
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Cell Signal 25:1939-48. 2013
    ..In addition, we will discuss how disturbances in this signaling crosstalk induce the appearance of chronic inflammation in metabolic diseases. ..
  58. pmc The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells
    Tuomas Paimela
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Mol Vis 18:1189-96. 2012
    ..004%) and Systane Ultra eye drops with benzalkonium chloride (BAK) alone or BAK-preserved Xalatan (0.005% latanoprost) eye drops in HCE-2 human corneal epithelial cell culture...
  59. doi request reprint Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells
    Johanna O Ojala
    University of Kuopio, Institute of Clinical Medicine Neurology, Canthia, P O B 1627, FIN 70211 Kuopio, Finland
    J Neuroimmunol 205:86-93. 2008
    ..Tau phosphorylation and expression of cyclin G1, involved in neuronal regeneration, increased at 72 h. In vivo, over-expression of IL-18 may induce hyperphosphorylation of tau and induce cell cycle activators...
  60. pmc Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells
    Elina M Sutinen
    University of Eastern Finland, Institute of Clinical Medicine Neurology, Canthia, FI 70211, Kuopio, Finland
    J Neuroinflammation 9:199. 2012
    ..Elevated IL-18 has been detected in several risk conditions for AD, including obesity, type-II diabetes, and cardiovascular diseases as well as in stress...
  61. doi request reprint 5'-Adenosine monophosphate-activated protein kinase--mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration
    Juha M T Hyttinen
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FI 70211 Kuopio, Finland
    Rejuvenation Res 14:651-60. 2011
    ..This review examines the novel potential therapeutic targets on the AMPK-mTOR axis and the ways in which autophagy clearance can suppress or prevent RPE degeneration and development of AMD...
  62. doi request reprint SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Biochem Biophys Res Commun 378:6-9. 2009
    ..The eNoSC complex links SIRT1-induced longevity regulation to the metabolic rate theory of aging...
  63. doi request reprint NF-kappaB signaling in the aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
    J Clin Immunol 29:397-405. 2009
    ..Explaining the aging process has given rise to a cornucopia for different theories in which the basic difference has been the question whether aging is genetically regulated or an entropic degeneration process...
  64. ncbi request reprint Mechanisms of protein aggregation in the retinal pigment epithelial cells
    Kai Kaarniranta
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, PO Box 1627, FIN 70211 Kuopio, Finland
    Front Biosci (Elite Ed) 2:1374-84. 2010
    ..This review examines the cross-talk between lysosomes, autophagy and proteasomes in RPE cell protein aggregation, their role as a possible therapeutic target and their involvement in the pathogenesis of AMD...
  65. doi request reprint Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease
    Tapio Nuutinen
    Department of Neurology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Neurosci Lett 475:64-8. 2010
    ..One could postulate that valproic acid may be able to prevent amyloid-beta aggregation in AD, as observed in transgenic AD mice, by increasing clusterin expression...
  66. doi request reprint Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration
    Kai Kaarniranta
    Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
    Future Med Chem 4:2153-61. 2012
    ..Since AMD pathology is clearly associated with accumulated protein deposits, the autophagy clearance system might represent a potential future therapeutic target for AMD as is thoroughly discussed here...
  67. ncbi request reprint Heat shock proteins as gatekeepers of proteolytic pathways-Implications for age-related macular degeneration (AMD)
    Kai Kaarniranta
    Department of Ophthalmology, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
    Ageing Res Rev 8:128-39. 2009
    ..In addition to classical lysosomal proteolysis, we focus on the increasing evidence that, HSPs, proteasomes and autophagy regulate protein turnover in the RPE cells and thus have important roles in AMD disease...
  68. ncbi request reprint Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35
    Petri Kerokoski
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, Finland
    Brain Res Mol Brain Res 106:50-6. 2002
    ..We conclude that p35 phosphorylation influences the proteasome-mediated degradation of p35 and calpain-mediated cleavage of p35 to p25...
  69. ncbi request reprint Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells
    Farzam Ajamian
    Department of Neurobiology, A I Virtanen Institute for Molecular Science, University of Kuopio, FIN 70211, Kuopio, Finland
    Neurosci Lett 346:57-60. 2003
    ..mRNAs for HDAC 4, 8 and 10 were not detectable by Northern analysis. We suggest that the changes in HDAC mRNA expression levels might be connected with chromatin rearrangement during neural differentiation...
  70. pmc A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices
    Jari Huuskonen
    Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    J Neuroinflammation 2:25. 2005
    ..Our aim was to gain a more detailed insight and understanding of the behaviour of hippocampus tissue slices in serum-free, interface culture per se and after exposure to different pro- and anti-inflammatory compounds...
  71. doi request reprint Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90
    Antero Salminen
    Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Immunol Lett 117:9-15. 2008
    ....
  72. doi request reprint ROCK, PAK, and Toll of synapses in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
    Biochem Biophys Res Commun 371:587-90. 2008
    ..We will review here the dysfunction of ROCK, PAK, and Toll signaling associated with AD pathology. The protection of synapses in AD may provide new therapeutic approaches to combatting the cognitive impairment in AD...
  73. doi request reprint Regulation of the aging process by autophagy
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
    Trends Mol Med 15:217-24. 2009
    ..We discuss the possibility that these well-known stress resistance and longevity factors regulate the aging process via autophagy...
  74. doi request reprint NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD)
    Kai Kaarniranta
    Department of Ophthalmology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Exp Gerontol 44:685-8. 2009
    ..In this review, we propose that resolvins and protectins mediate their beneficial effects by preventing NF-kappaB signaling and this that may represent a new target for regulating the inflammatory responses in AMD...
  75. doi request reprint Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
    J Cell Physiol 224:1-6. 2010
    ..We will discuss the role of p53 in the regulation of glycolysis-dependent activation of NF-kappaB signaling in both cancer and aging process...
  76. doi request reprint SIRT1: regulation of longevity via autophagy
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
    Cell Signal 21:1356-60. 2009
    ..The interactions of SIRT1 with the FoxO and p53 signaling can also regulate both the autophagic degradation and lifespan extension emphasizing the key role of autophagy in the regulation of lifespan...
  77. doi request reprint Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
    Cell Signal 22:573-7. 2010
    ..We will discuss the evidence that insulin/IGF-1 signaling can enhance the NF-kappaB signaling and subsequently potentiate the aging process and aggravate age-related degenerative diseases...
  78. doi request reprint Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
    Ageing Res Rev 9:298-314. 2010
    ....
  79. doi request reprint Siglec receptors and hiding plaques in Alzheimer's disease
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
    J Mol Med (Berl) 87:697-701. 2009
    ..This kind of immune evasion can prevent the microglial cleansing process of aggregating amyloid plaques in AD...