N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) InhibitorsPäivi H Kiviranta
Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
J Med Chem 49:7907-11. 2006
..The most potent compound was N,N'-bis(2-hydroxybenzylidene)benzene-1,4-diamine, which was equipotent with the most potent hit compound and well-known SIRT2 inhibitor sirtinol...
- Amyloid-beta 1-42 induced endocytosis and clusterin/apoJ protein accumulation in cultured human astrocytes
Tapio Nuutinen
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Neurochem Int 50:540-7. 2007
..Endocytic response associated with the accumulation of clusterin/apoJ protein suggests that clusterin/apoJ has a role in the clearance of amyloid-beta peptides...
- Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden
Tarja M Malm
A I Virtanen Institute for Molecular Sciences, University of Kuopio, FIN 70211 Kuopio, Finland
J Neurosci 27:3712-21. 2007
..Because PDTC is capable of transferring external Cu2+ into a cell, and, in turn, Cu2+ is able to activate Akt, we hypothesize that PDTC provides the beneficial effect in transgenic AD mice through Cu2+-activated Akt pathway...
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotypeAntero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
Eur J Neurosci 34:3-11. 2011
..We will review the astroglial changes occurring during aging and emphasize that senescent astrocytes can have an important role in age-related neuroinflammation and neuronal degeneration...
Crosstalk between Oxidative Stress and SIRT1: Impact on the Aging ProcessAntero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Int J Mol Sci 14:3834-59. 2013
..We will review the major mechanisms controlling the signaling balance between the ROS production and SIRT1 activity emphasizing that this crosstalk has a crucial role in the regulation of the aging process...
- Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
Curr Opin Clin Nutr Metab Care 15:23-8. 2012
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- Inflammaging: disturbed interplay between autophagy and inflammasomes
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
Aging (Albany NY) 4:166-75. 2012
..We will provide here a perspective on the current research of the ROS-dependent activation of inflammasomes triggered by the decline in autophagic cleansing of dysfunctional mitochondria...
- Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211, Kuopio, Finland
Cell Mol Life Sci 69:2999-3013. 2012
..g., the metabolic syndrome. We will review here the emerging field of inflammasomes in the appearance of the proinflammatory phenotype during the aging process and in age-related diseases...
- AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
Ageing Res Rev 11:230-41. 2012
..We will review in detail the signaling pathways of this integrated network through which AMPK controls energy metabolism, autophagic degradation and stress resistance and ultimately the aging process...
- Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Cell Signal 24:835-45. 2012
..We will review in detail the signaling pathways which activate NF-κB signaling and trigger SASP in senescent cells...
- Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Prog Neurobiol 96:87-95. 2012
..We will review here the molecular and functional characteristics of p62 protein and outline its potential role in the regulation of Alzheimer's pathogenesis...
- Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Prog Neurobiol 93:99-110. 2011
..We will review the role of Hsp90 chaperone network in the regulation of tau biology and pathology in Alzheimer's disease...
- ER stress and hormetic regulation of the aging process
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Ageing Res Rev 9:211-7. 2010
..The efficiency of the stress recognition system and UPR signaling declines during aging. We will discuss the role of ER stress in hormetic regulation of aging process and longevity...
- Apoptosis and aging: increased resistance to apoptosis enhances the aging process
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
Cell Mol Life Sci 68:1021-31. 2011
..We will discuss the molecular basis of age-related resistance to apoptosis and emphasize that increased resistance could enhance the aging process...
- Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization
Antero Salminen
Department of Neurology, University of Eastern Finland, Kuopio, Finland
Mol Med 16:535-42. 2010
..We discuss the role of ER stress in the regulation of neovascularization and the conversion of dry AMD to its wet, detrimental counterpart...
- Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, PO Box 1627, FIN 70211 Kuopio, Finland
Cell Signal 23:747-52. 2011
..We will review the findings linking WIP1 and MIF to specific signaling responses of p53 and NF-κB and discuss their role in the regulation of cellular senescence and organismal aging...
- AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
J Mol Med (Berl) 89:667-76. 2011
..We also emphasize that the capacity of AMPK to repress inflammatory responses can have a significant impact on both healthspan and lifespan...
- AMP-activated protein kinase: a potential player in Alzheimer's disease
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
J Neurochem 118:460-74. 2011
..We will outline the potential role of AMPK function in respect to various aspects affecting AD pathogenesis...
- Celastrol: Molecular targets of Thunder God Vine
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Biochem Biophys Res Commun 394:439-42. 2010
..Celastrol needs still to pass several hurdles, e.g. ADMET assays, before it can enter the armoury of western drugs...
- Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone
Päivi H Kiviranta
Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
Bioorg Med Chem 16:8054-62. 2008
..The N-(3-phenylpropenoyl)-glycine tryptamide backbone is also a good backbone for SIRT2 inhibitors, and the series of compounds includes several potent SIRT2 inhibitors...
- Induction of clusterin/apoJ expression by histone deacetylase inhibitors in neural cells
Tapio Nuutinen
Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
Neurochem Int 47:528-38. 2005
..These observations suggest that clusterin induction is NF-kappaB-independent and unrelated to the inflammatory response in N9 microglia...
- Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19)
Tuomas Paimela
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, and Kuopio University Hospital, P O Box 1627, FIN 70211 Kuopio, Finland
Eur J Pharmacol 640:219-25. 2010
..These results indicate that estrogen and HM-D can suppress the lipopolysaccharide-induced inflammatory response but signalling is not mediated through estrogen response element transcription in human retinal pigment epithelial cells...
- p62/sequestosome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells
Johanna Viiri
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
Mol Vis 16:1399-414. 2010
..In the present study, the functional roles of p62 and HSP70 were evaluated in conjunction with proteasome inhibitor-induced autophagy in human RPE cells (ARPE-19)...
- Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells
Tuomas Ryhanen
Department of Ophthalmology, University of Eastern Finland, 70211 Kuopio, Finland
J Biomed Biotechnol 2011:798052. 2011
..These findings open new perspectives for understanding the pathogenesis of protein aggregation in retinal cells and can be useful for the development of therapeutic treatments to prevent retinal cell deterioration...
- Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90
Tiina Suuronen
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
Neurochem Res 33:1768-75. 2008
..Our results reveal that ER alpha signaling is dependent on protein acetylation and epigenetic regulation...
- Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells
Tuomas Ryhanen
Department of Ophthalmology, University of Kuopio, Kuopio, Finland
Eur J Pharmacol 584:229-36. 2008
..05) radicicol, but not in geldanamycin-treated RPE cells. These novel findings help in understanding the influence of HSP90 inhibition and regulatory mechanisms of drug delivery to retinal cells...
- The effect of 17beta-estradiol on IL-6 secretion and NF-kappaB DNA-binding activity in human retinal pigment epithelial cells
Tuomas Paimela
Department of Ophthalmology, University of Kuopio, Kuopio, Finland
Immunol Lett 110:139-44. 2007
..The level of TLR4 gene expression was not affected by LPS exposure. Our results indicate that IL-6 expression is regulated through NF-kappaB transcription factor and stereoid-receptor signalling pathways in ARPE-19 cells...
- Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells
Tuomas Ryhanen
Department of Ophthalmology, University of Kuopio, Kuopio, Finland
J Cell Mol Med 13:3616-31. 2009
..The molecular chaperone Hsp70, proteasomes and autophagy have an important regulatory role in the protein turnover of human RPE cells and may thus open new avenues for understanding degenerative processes in retinal cells...
- Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors
Tero Huhtiniemi
Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
J Med Chem 51:4377-80. 2008
..The most potent compound in the series was nearly as potent as the reference compound (6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide)...
- Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2
Tero Huhtiniemi
School of Pharmacy, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, 70211 Kuopio, Finland
J Med Chem 54:6456-68. 2011
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- Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, and Kuopio University Hospital, Kuopio, Finland
J Cell Mol Med 12:2255-62. 2008
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- ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
J Neuroinflammation 6:41. 2009
..We will describe the mechanisms which could link the ER stress of neurons to the activation of the inflammatory response and the evolution of pathological changes in AD...
- Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells
Kai Kaarniranta
Department of Ophthalmology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
Brain Res Mol Brain Res 137:126-31. 2005
..Interestingly, GA treatment accumulated Hsp70 protein and attenuated OA-induced cytotoxicity. This study suggests that Hsp70 and Hsp90 are closely related to cytoprotection of RPE cells in response to protein phosphatase inhibition...
- N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors
Päivi H Kiviranta
Department of Pharmaceutical Chemistry, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
Bioorg Med Chem Lett 17:2448-51. 2007
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- Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Prog Neurobiol 87:181-94. 2009
..In addition, we will discuss whether AD pathology could be the outcome of chronic activation of the innate immunity defence in the brain of AD patients...
- SIRT1 longevity factor suppresses NF-kappaB -driven immune responses: regulation of aging via NF-kappaB acetylation?
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Finland
Bioessays 30:939-42. 2008
..Longevity factors, such as SIRT1 and its activators, might regulate the efficiency of the NF-kappaB signaling, the major outcome of which is inflamm-aging via proinflammatory responses...
- Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells--implications for age-related macular degeneration (AMD)
Anu Kauppinen
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Immunol Lett 147:29-33. 2012
..In conclusion, our present data suggest that oxidative stress can activate NLRP3 inflammasomes in RPE cells which occupy center stage in the pathogenesis of AMD...
- Selective regulation of class I and class II histone deacetylases expression by inhibitors of histone deacetylases in cultured mouse neural cells
Farzam Ajamian
Department of Neurobiology, A.I. Virtanen Institute for Molecular Science, University of Kuopio, P.O. Box 1627 (Neulaniementie 2, FIN 70211 Kuopio, Finland
Neurosci Lett 365:64-8. 2004
..There exists an auto-regulatory feedback loop to the expression levels of several HDACs after inhibition of their biochemical activity, adding several HDAC genes to the list of genes regulated by HDAC inhibitors...
- Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells
Tuomas Paimela
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Pharmacol Res 64:501-8. 2011
..Our findings reveal that celastrol is a novel plant compound which suppresses innate immunity response in human retinal pigment epithelial cells via NF-κB and Hsp70 regulation, and that Hsp70 is a critical regulator of NF-κB...
- Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons
Petri Kerokoski
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
Neurosci Lett 368:181-5. 2004
..Different factors, such as maturation state of neurons or desensitization properties of non-NMDA receptors, may determine which receptor predominantly mediates the effect of glutamate on p35 cleavage...
- Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells
Tiina Suuronen
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Biochem Biophys Res Commun 357:397-401. 2007
..Our results indicate that epigenetic factors regulate the clusterin expression of RPE cells and thus might affect the pathogenesis of AMD via the inhibition of angiogenesis and inflammation...
- Regulation of microglial inflammatory response by histone deacetylase inhibitors
Tiina Suuronen
Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
J Neurochem 87:407-16. 2003
..Our results suggest that environmental stresses, ageing, diet and diseases that regulate protein acetylation status may also affect the inflammatory response...
- Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
Antero Salminen
Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
Ageing Res Rev 7:83-105. 2008
..Our conclusion is that NF-kB signaling seems to be the culprit of inflamm-aging, since this signaling system integrates the intracellular regulation of immune responses in both aging and age-related diseases...
- N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors
Päivi H Kiviranta
Department of Pharmaceutical Chemistry, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
J Med Chem 52:2153-6. 2009
..The most potent SIRT1 inhibitors were equipotent with the reference compound (6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) with the IC(50) values of 180-330 nM...
- Clusterin: a forgotten player in Alzheimer's disease
Tapio Nuutinen
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Brain Res Rev 61:89-104. 2009
..Though clusterin can be viewed as a multipotent guardian of brain, it is unable to prevent the progressive neuropathology in chronic AD...
- N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2
Tero Huhtiniemi
School of Pharmacy, University of Eastern Finland, Kuopio Campus, PO Box 1627, 70211 Kuopio, Finland
Bioorg Med Chem 18:5616-25. 2010
..These results are applicable for further screening of N(epsilon)-acetyl analogues...
- NEMO shuttle: a link between DNA damage and NF-kappaB activation in progeroid syndromes?
Antero Salminen
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Biochem Biophys Res Commun 367:715-8. 2008
..The NEMO shuttle may link genotoxic stress to the activation of the innate immunity system and cause premature aging via inflamm-aging process...
- Age-related macular degeneration (AMD): Alzheimer's disease in the eye?
Kai Kaarniranta
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
J Alzheimers Dis 24:615-31. 2011
..However, it seems that these diseases have a different genetic background. In this review, differences and similarities of AMD and AD are thoroughly discussed...
- Regulation of microglial inflammatory response by sodium butyrate and short-chain fatty acids
Jari Huuskonen
Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, FIN-70211 Kuopio, Finland
Br J Pharmacol 141:874-80. 2004
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- Comparative and pharmacophore model for deacetylase SIRT1
Tero Huhtiniemi
Department of Pharmaceutical Chemistry, University of Kuopio, P O Box 1627, Kuopio, FIN 70211, Finland
J Comput Aided Mol Des 20:589-99. 2006
..To distinguish between active and inactive compounds, a post-docking filter based on H-bond network was constructed. Docking results were used to investigate the pharmacophore and to identify a filter for database mining...
- Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro
Hanna Mari Jauhonen
Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland
Mol Vis 17:2311-7. 2011
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- The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells
Tuomas Paimela
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
Mol Vis 18:1189-96. 2012
..004%) and Systane Ultra eye drops with benzalkonium chloride (BAK) alone or BAK-preserved Xalatan (0.005% latanoprost) eye drops in HCE-2 human corneal epithelial cell culture...
- 5'-Adenosine monophosphate-activated protein kinase--mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration
Juha M T Hyttinen
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, P O Box 1627, FI 70211 Kuopio, Finland
Rejuvenation Res 14:651-60. 2011
..This review examines the novel potential therapeutic targets on the AMPK-mTOR axis and the ways in which autophagy clearance can suppress or prevent RPE degeneration and development of AMD...
- Mechanisms of protein aggregation in the retinal pigment epithelial cells
Kai Kaarniranta
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, PO Box 1627, FIN 70211 Kuopio, Finland
Front Biosci (Elite Ed) 2:1374-84. 2010
..This review examines the cross-talk between lysosomes, autophagy and proteasomes in RPE cell protein aggregation, their role as a possible therapeutic target and their involvement in the pathogenesis of AMD...
- Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease
Tapio Nuutinen
Department of Neurology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
Neurosci Lett 475:64-8. 2010
..One could postulate that valproic acid may be able to prevent amyloid-beta aggregation in AD, as observed in transgenic AD mice, by increasing clusterin expression...
- SIRT1 regulates the ribosomal DNA locus: epigenetic candles twinkle longevity in the Christmas tree
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Biochem Biophys Res Commun 378:6-9. 2009
..The eNoSC complex links SIRT1-induced longevity regulation to the metabolic rate theory of aging...
- NF-kappaB signaling in the aging process
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
J Clin Immunol 29:397-405. 2009
..Explaining the aging process has given rise to a cornucopia for different theories in which the basic difference has been the question whether aging is genetically regulated or an entropic degeneration process...
- Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells
Johanna O Ojala
University of Kuopio, Institute of Clinical Medicine Neurology, Canthia, P O B 1627, FIN 70211 Kuopio, Finland
J Neuroimmunol 205:86-93. 2008
..Tau phosphorylation and expression of cyclin G1, involved in neuronal regeneration, increased at 72 h. In vivo, over-expression of IL-18 may induce hyperphosphorylation of tau and induce cell cycle activators...
- Influence of phosphorylation of p35, an activator of cyclin-dependent kinase 5 (cdk5), on the proteolysis of p35
Petri Kerokoski
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, Finland
Brain Res Mol Brain Res 106:50-6. 2002
..We conclude that p35 phosphorylation influences the proteasome-mediated degradation of p35 and calpain-mediated cleavage of p35 to p25...
- Heat shock proteins as gatekeepers of proteolytic pathways-Implications for age-related macular degeneration (AMD)
Kai Kaarniranta
Department of Ophthalmology, Kuopio University Hospital and University of Kuopio, Kuopio, Finland
Ageing Res Rev 8:128-39. 2009
..In addition to classical lysosomal proteolysis, we focus on the increasing evidence that, HSPs, proteasomes and autophagy regulate protein turnover in the RPE cells and thus have important roles in AMD disease...
- Upregulation of class II histone deacetylases mRNA during neural differentiation of cultured rat hippocampal progenitor cells
Farzam Ajamian
Department of Neurobiology, A I Virtanen Institute for Molecular Science, University of Kuopio, FIN 70211, Kuopio, Finland
Neurosci Lett 346:57-60. 2003
..mRNAs for HDAC 4, 8 and 10 were not detectable by Northern analysis. We suggest that the changes in HDAC mRNA expression levels might be connected with chromatin rearrangement during neural differentiation...
- A refined in vitro model to study inflammatory responses in organotypic membrane culture of postnatal rat hippocampal slices
Jari Huuskonen
Department of Neuroscience and Neurology, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
J Neuroinflammation 2:25. 2005
..Our aim was to gain a more detailed insight and understanding of the behaviour of hippocampus tissue slices in serum-free, interface culture per se and after exposure to different pro- and anti-inflammatory compounds...
- Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
J Cell Physiol 224:1-6. 2010
..We will discuss the role of p53 in the regulation of glycolysis-dependent activation of NF-kappaB signaling in both cancer and aging process...
- Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90
Antero Salminen
Department of Neuroscience and Neurology, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Immunol Lett 117:9-15. 2008
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- ROCK, PAK, and Toll of synapses in Alzheimer's disease
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
Biochem Biophys Res Commun 371:587-90. 2008
..We will review here the dysfunction of ROCK, PAK, and Toll signaling associated with AD pathology. The protection of synapses in AD may provide new therapeutic approaches to combatting the cognitive impairment in AD...
- Regulation of the aging process by autophagy
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
Trends Mol Med 15:217-24. 2009
..We discuss the possibility that these well-known stress resistance and longevity factors regulate the aging process via autophagy...
- NF-kappaB signaling as a putative target for omega-3 metabolites in the prevention of age-related macular degeneration (AMD)
Kai Kaarniranta
Department of Ophthalmology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Exp Gerontol 44:685-8. 2009
..In this review, we propose that resolvins and protectins mediate their beneficial effects by preventing NF-kappaB signaling and this that may represent a new target for regulating the inflammatory responses in AMD...
- Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, Kuopio FIN 70211, Finland
Cell Signal 22:573-7. 2010
..We will discuss the evidence that insulin/IGF-1 signaling can enhance the NF-kappaB signaling and subsequently potentiate the aging process and aggravate age-related degenerative diseases...
- SIRT1: regulation of longevity via autophagy
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, Kuopio, Finland
Cell Signal 21:1356-60. 2009
..The interactions of SIRT1 with the FoxO and p53 signaling can also regulate both the autophagic degradation and lifespan extension emphasizing the key role of autophagy in the regulation of lifespan...
- Genetics vs. entropy: longevity factors suppress the NF-kappaB-driven entropic aging process
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland
Ageing Res Rev 9:298-314. 2010
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- Siglec receptors and hiding plaques in Alzheimer's disease
Antero Salminen
Department of Neurology, Institute of Clinical Medicine, University of Kuopio, P O Box 1627, 70211, Kuopio, Finland
J Mol Med (Berl) 87:697-701. 2009
..This kind of immune evasion can prevent the microglial cleansing process of aggregating amyloid plaques in AD...
