Omar M E Abdel Salam

..Results suggest that GbE may be of clinical value as an anti-inflammatory and analgesic drug alone or in conjunction with NSAIDs...

..lt;strong>..

..Gabapentin, a structural analog of γ-aminobutyric acid (GABA), is used in the treatment of neuropathic pain in multiple sclerosis...

..Capsaicin exerted protective effects in the liver and lung against the LPS-induced tissue damage...

..Thus, the administration of aspartame alone or in the presence of mild systemic inflammatory response increases oxidative stress and inflammation in the brain, but not in the liver...

..In contrast, PTX is equally protective, when given either as a pretreatment or with acetaminophen exposure...

..It is concluded that both UFH and LMWHs administered peripherally inhibit stimulated gastric acid secretion in the rat. This effect of heparins is determined by cholinergic and partly by adrenergic mechanisms...

..The present data demonstrate that ribavirin administered via systemic route possesses visceral and thermal anti-nociceptive properties. The ribavirin analgesic effect was partially reversed by naloxone, an opioid antagonist...

..It is suggested, therefore, that DDB alone or in combination with silymarin might prove of benefit in the therapy of chronic liver disease. Monitoring of kidney functions in patients taking DDB is warranted...

..2 mg/kg of vinpocetine was similar to that obtained by 30 mg/kg silymarin. Therefore, it is suggested that vinpocetine might be a good pharmacological agent in the treatment of liver disease besides its neuroprotective effects...

..Finally, stem cell therapy may offer the promise of restoring functionality...

..7%). These results indicate that treatment with misoprostol protects against hepatocellular necrosis induced by CCl(4). This study suggests a potential therapeutic use for misoprostol in liver injury...

..These results indicates that treatment with 5-ISMN protects against hepatocellular necrosis induced by CCl(4). The study suggests a potential therapeutic use for 5-ISMN in combination with silymarin in liver injury...

..GSH increased by the higher dose of piracetam and by vinpocetine which also decreased serum nitric oxide. Vinpocetine and piracetam displayed variable effects on regional AChE activity...

..This paved the way towards exploring the possible pharmacological manipulation of neurogenesis which would offer an alternative approach for the treatment of AD...

..This study indicates that trimetazidine possesses antinociceptive and gastric protective properties. The antinociceptive properties of trimetazidine are likely to be centrally mediated, but do not involve opioid pathways...

..perforatum exhibits antiedematogenic and antinociceptive properties, which may be of value for the management of inflammatory painful conditions. The agent, however, causes gastric irritation and may aggravate that of NSAIDs...

..The effect of cysteamine is likely to be mediated via central action...

..The findings indicate the need for clinical trials for the effect of this herb on bile composition and flow in man in view of a possible modulatory effect for the herb on gallstone formation...

..There is also an intriguing possibility for the use of topical preparations for the management of local inflammatory conditions...

..Taken together, data in the present study confirm anti-inflammatory and anti-nociceptive effect for some antidepressant drugs and indicate that SSRIs differently affects inflammation...

..Both the serotonergic and the opioid systems are likely to be involved in the modulating action of fluoxetine on peripheral inflammation...

..The aim of this paper is to review the experimental and clinical data dealing with the role of mucosal blood flow and in particular the microcirculation in both damage and protection of the gastric mucosa...

..Data indicate a stimulatory effect for fluoxetine and sertraline mediated by vagal nerve on gastric acid secretion in urethane-anaesthetised rats...

..Exposure to irradiation is likely to result in failure of the parietal cell to respond to direct stimulation with histamine or pentagastrin...

..The present data from bile duct ligated rats suggest an antifibrotic effect for nadroparin and enoxaparin...

..The results suggest that acute administration of cysteamine inhibits protein, cholesterol and lipid secretion into bile...

..Results also indicate that administration of capsaicin reduces bile flow and biliary proteins in the rat...

..These results indicate that melatonin possesses anti-inflammatory and anti-nociceptive properties in the rat and enhance those of indomethacin. This effect is likely to be centrally mediated...

..Compounds 5 and 12 were more potent as anti-nociceptive drugs; they are more potent in this respect than melatonin...

..Compounds 6, 7, 10, 13, 15, and 16 showed significant anti-inflammatory and analgesic activities...

..No compound showed sedative effect. Visceral pain evoked by i.p. injection of acetic acid in mice was significantly inhibited by all compounds at a high doses...

..Results also indicate that the combined application of ribavirin and sily-marin is likely to be a useful additive in reducing liver injury...

..This study indicates that vinpocetine and piracetam possess visceral antinociceptive properties. This effect depends on activation of adenosine receptors. Piracetam in addition inhibits GABA-mediated antinociception...

..On the other hand, all the investigated drugs showed a significant decrease in serum low density lipoprotein (LDL) in normal and diabetic rats...

..This study was designed to investigate the effect of 1 month treatment with nateglinide, rosiglitazone, metformin and their different combinations on streptozotocin (STZ) diabetic rats...