Omar M E Abdel Salam

Summary

Publications

  1. ncbi request reprint Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Centre, Tahrir Street, Dokki, Cairo, Egypt
    Pharmacol Res 49:133-42. 2004
  2. doi request reprint Brain and liver oxidative stress after sertraline and haloperidol treatment in mice
    Omar M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    J Basic Clin Physiol Pharmacol 24:115-23. 2013
  3. ncbi request reprint Neuroprotective and hepatoprotective effects of micronized purified flavonoid fraction (Daflon®) in lipopolysaccharide-treated rats
    Omar M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Cairo, Egypt
    Drug Discov Ther 6:306-14. 2012
  4. ncbi request reprint The effect of antidepressant drugs on thioacetamide-induced oxidative stress
    O M E Abdel Salam
    Departments of Toxicology and Narcotics, Medical Biochemistry, Pharmacology, and Pathology, National Research Centre, Cairo, Egypt
    Eur Rev Med Pharmacol Sci 17:735-44. 2013
  5. ncbi request reprint Studies on the effects of aspartame on memory and oxidative stress in brain of mice
    O M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Cairo, Egypt
    Eur Rev Med Pharmacol Sci 16:2092-101. 2012
  6. doi request reprint The effect of gabapentin on oxidative stress in a model of toxic demyelination in rat brain
    Omar M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Dokki, Cairo, Egypt
    J Basic Clin Physiol Pharmacol 23:61-8. 2012
  7. doi request reprint Modulation of lipopolysaccharide-induced oxidative stress by capsaicin
    Omar M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Inflammopharmacology 20:207-17. 2012
  8. doi request reprint Effect of aspartame on oxidative stress and monoamine neurotransmitter levels in lipopolysaccharide-treated mice
    Omar M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Neurotox Res 21:245-55. 2012
  9. ncbi request reprint Inhibition of gastric acid secretion by unfractionated and low molecular weight heparins in the rat
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Dokki, Cairo
    ScientificWorldJournal 6:221-30. 2006
  10. ncbi request reprint Antinociceptive and behavioral effects of ribavirin in mice
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Pharmacol Biochem Behav 83:230-8. 2006

Collaborators

  • Enayat A Omara
  • G Mozsik
  • J Szolcsanyi
  • Somaia A Nada
  • Mohamed A A Radwan
  • Wagnat W Wardakhan
  • Omar M E Abdel-Salam
  • Omar M E Abdel Salam
  • Ayman R Baiuomy
  • Amany A Sleem
  • Siham M el-Shenawy
  • Mahmoud S Arbid
  • O M E Abdel Salam
  • Eman R Youness
  • Seham A el-Batran
  • Nabila S Hassan
  • Yasser Ashry Khadrawy
  • Nadia A Mohammed
  • O M E Abdel-Salam
  • Neveen A Salem
  • Salwa M Nofal
  • Omar Mohamed E Abdel Salam
  • Ahmed O H El-Nezhawy
  • Gamal A Elmegeed
  • Siham El-Batran
  • A R Farrag
  • N A Mohammed
  • A A Sleem
  • N A Salem
  • O M Abdel-Salam
  • Mehrevan Abd-Elmoniem
  • M E S El-Nagar
  • J S Hussein
  • Jihan Seid Hussein
  • Abdel Razik Farrag
  • N A S Ahmed
  • M E S El-Shamarka
  • Rehab Fawzy Abdel-Rahman
  • Yasser A Khadrawy
  • Nermeen Shafee
  • Samir T Gaballah
  • Fatma A Morsy
  • Fatma Hassan Oraby
  • Ayman Ragab Bayomy
  • Ola A Heikal
  • Ihsan Hadajat
  • Amany Ameen
  • Siham El-Shinawy
  • Seham El-batran
  • A Debreceni
  • J Czimmer

Detail Information

Publications39

  1. ncbi request reprint Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Centre, Tahrir Street, Dokki, Cairo, Egypt
    Pharmacol Res 49:133-42. 2004
    ..Results suggest that GbE may be of clinical value as an anti-inflammatory and analgesic drug alone or in conjunction with NSAIDs...
  2. doi request reprint Brain and liver oxidative stress after sertraline and haloperidol treatment in mice
    Omar M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    J Basic Clin Physiol Pharmacol 24:115-23. 2013
    ..Sertraline is an antidepressant drug which has been reported to cause extrapyramidal symptoms. We aimed to see whether treatment with sertraline would worsen the effect of haloperidol on oxidative stress in the brains of mice...
  3. ncbi request reprint Neuroprotective and hepatoprotective effects of micronized purified flavonoid fraction (Daflon®) in lipopolysaccharide-treated rats
    Omar M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Cairo, Egypt
    Drug Discov Ther 6:306-14. 2012
    ..MPFF thus prevented the increased oxidative stress and inflammation in brain and liver as well as the liver dysfunction caused by endotoxemia in the rat...
  4. ncbi request reprint The effect of antidepressant drugs on thioacetamide-induced oxidative stress
    O M E Abdel Salam
    Departments of Toxicology and Narcotics, Medical Biochemistry, Pharmacology, and Pathology, National Research Centre, Cairo, Egypt
    Eur Rev Med Pharmacol Sci 17:735-44. 2013
    ....
  5. ncbi request reprint Studies on the effects of aspartame on memory and oxidative stress in brain of mice
    O M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Cairo, Egypt
    Eur Rev Med Pharmacol Sci 16:2092-101. 2012
    ..The present study aimed to investigate the effect of repeated administration of aspartame in the working memory version of Morris water maze test, on oxidative stress and brain monoamines in brain of mice...
  6. doi request reprint The effect of gabapentin on oxidative stress in a model of toxic demyelination in rat brain
    Omar M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Dokki, Cairo, Egypt
    J Basic Clin Physiol Pharmacol 23:61-8. 2012
    ..Gabapentin, a structural analog of γ-aminobutyric acid (GABA), is used in the treatment of neuropathic pain in multiple sclerosis...
  7. doi request reprint Modulation of lipopolysaccharide-induced oxidative stress by capsaicin
    Omar M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Inflammopharmacology 20:207-17. 2012
    ..Capsaicin exerted protective effects in the liver and lung against the LPS-induced tissue damage...
  8. doi request reprint Effect of aspartame on oxidative stress and monoamine neurotransmitter levels in lipopolysaccharide-treated mice
    Omar M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Neurotox Res 21:245-55. 2012
    ..Thus, the administration of aspartame alone or in the presence of mild systemic inflammatory response increases oxidative stress and inflammation in the brain, but not in the liver...
  9. ncbi request reprint Inhibition of gastric acid secretion by unfractionated and low molecular weight heparins in the rat
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Dokki, Cairo
    ScientificWorldJournal 6:221-30. 2006
    ..It is concluded that both UFH and LMWHs administered peripherally inhibit stimulated gastric acid secretion in the rat. This effect of heparins is determined by cholinergic and partly by adrenergic mechanisms...
  10. ncbi request reprint Antinociceptive and behavioral effects of ribavirin in mice
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Pharmacol Biochem Behav 83:230-8. 2006
    ..The present data demonstrate that ribavirin administered via systemic route possesses visceral and thermal anti-nociceptive properties. The ribavirin analgesic effect was partially reversed by naloxone, an opioid antagonist...
  11. ncbi request reprint Effects of biphenyldimethyl-dicarboxylate administration alone or combined with silymarin in the CCL4 model of liver fibrosis in rats
    Omar M E Abdel-Salam
    Pharmacology, National Research Centre, Dokki, Cairo, Egypt
    ScientificWorldJournal 7:1242-55. 2007
    ..It is suggested, therefore, that DDB alone or in combination with silymarin might prove of benefit in the therapy of chronic liver disease. Monitoring of kidney functions in patients taking DDB is warranted...
  12. doi request reprint Vinpocetine ameliorates acute hepatic damage caused by administration of carbon tetrachloride in rats
    O M E Abdel Salam
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Acta Biol Hung 58:411-9. 2007
    ..2 mg/kg of vinpocetine was similar to that obtained by 30 mg/kg silymarin. Therefore, it is suggested that vinpocetine might be a good pharmacological agent in the treatment of liver disease besides its neuroprotective effects...
  13. ncbi request reprint Drugs used to treat Parkinson's disease, present status and future directions
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Centre, Cairo, Egypt
    CNS Neurol Disord Drug Targets 7:321-42. 2008
    ..Finally, stem cell therapy may offer the promise of restoring functionality...
  14. doi request reprint Hepatoprotective effects of misoprostol and silymarin on carbon tetrachloride-induced hepatic damage in rats
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Dokki, Cairo, Egypt
    Fundam Clin Pharmacol 23:179-88. 2009
    ..7%). These results indicate that treatment with misoprostol protects against hepatocellular necrosis induced by CCl(4). This study suggests a potential therapeutic use for misoprostol in liver injury...
  15. doi request reprint Hepatoprotective effects of the nitric oxide donor isosorbide-5-mononitrate alone and in combination with the natural hepatoprotectant, silymarin, on carbon tetrachloride-induced hepatic injury in rats
    Omar Mohamed E Abdel Salam
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Inflammopharmacology 18:87-94. 2010
    ..These results indicates that treatment with 5-ISMN protects against hepatocellular necrosis induced by CCl(4). The study suggests a potential therapeutic use for 5-ISMN in combination with silymarin in liver injury...
  16. doi request reprint Oxidative stress in a model of toxic demyelination in rat brain: the effect of piracetam and vinpocetine
    Omar M E Abdel-Salam
    Department of Toxicology and Narcotics, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Neurochem Res 36:1062-72. 2011
    ..GSH increased by the higher dose of piracetam and by vinpocetine which also decreased serum nitric oxide. Vinpocetine and piracetam displayed variable effects on regional AChE activity...
  17. ncbi request reprint Stem cell therapy for Alzheimer's disease
    Omar M E Abdel-Salam
    Department of Pharmacology and Department of Toxicology and Narcotics, National Research Centre, Cairo, Egypt
    CNS Neurol Disord Drug Targets 10:459-85. 2011
    ..This paved the way towards exploring the possible pharmacological manipulation of neurogenesis which would offer an alternative approach for the treatment of AD...
  18. ncbi request reprint Effect of pentoxifylline on hepatic injury caused in the rat by the administration of carbon tetrachloride or acetaminophen
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Pharmacol Rep 57:596-603. 2005
    ..In contrast, PTX is equally protective, when given either as a pretreatment or with acetaminophen exposure...
  19. ncbi request reprint Gastric mucosal integrity: gastric mucosal blood flow and microcirculation. An overview
    O M Abdel-Salam
    Department of Pharmacology, National Research Centre, PO Box 12311, El Tahrir St, Dokki, Cairo, Egypt
    J Physiol Paris 95:105-27. 2001
    ..The aim of this paper is to review the experimental and clinical data dealing with the role of mucosal blood flow and in particular the microcirculation in both damage and protection of the gastric mucosa...
  20. ncbi request reprint Modulation of inflammatory paw oedema by cysteamine in the rat
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Pharmacol Res 45:275-84. 2002
    ..The effect of cysteamine is likely to be mediated via central action...
  21. ncbi request reprint The effect of ginseng on bile-pancreatic secretion in the rat. Increase in proteins and inhibition of total lipids and cholesterol secretion
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Dokki, Cairo, Egypt
    Pharmacol Res 45:349-53. 2002
    ..The findings indicate the need for clinical trials for the effect of this herb on bile composition and flow in man in view of a possible modulatory effect for the herb on gallstone formation...
  22. ncbi request reprint The anti-inflammatory effects of the phosphodiesterase inhibitor pentoxifylline in the rat
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Centre, Tahrir Street, Dokki, Cairo, Egypt
    Pharmacol Res 47:331-40. 2003
    ..There is also an intriguing possibility for the use of topical preparations for the management of local inflammatory conditions...
  23. ncbi request reprint Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Centre, Tahrir Street, Dokki, Cairo, Egypt
    Pharmacol Res 48:157-65. 2003
    ..Taken together, data in the present study confirm anti-inflammatory and anti-nociceptive effect for some antidepressant drugs and indicate that SSRIs differently affects inflammation...
  24. ncbi request reprint Studies on the anti-inflammatory effect of fluoxetine in the rat
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Centre, Tahrir Street, Dokki, Cairo, Egypt
    Pharmacol Res 49:119-31. 2004
    ..Both the serotonergic and the opioid systems are likely to be involved in the modulating action of fluoxetine on peripheral inflammation...
  25. ncbi request reprint Fluoxetine and sertraline stimulate gastric acid secretion via a vagal pathway in anaesthetised rats
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Pharmacol Res 50:309-16. 2004
    ..Data indicate a stimulatory effect for fluoxetine and sertraline mediated by vagal nerve on gastric acid secretion in urethane-anaesthetised rats...
  26. ncbi request reprint A study of unfractionated and low molecular weight heparins in a model of cholestatic liver injury in the rat
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Centre, Tahrir Street, Dokki, Cairo, Egypt
    Pharmacol Res 51:59-67. 2005
    ..The present data from bile duct ligated rats suggest an antifibrotic effect for nadroparin and enoxaparin...
  27. ncbi request reprint Effect of capsaicin on bile secretion in the rat
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Cairo, Egypt
    Pharmacology 73:121-8. 2005
    ..Results also indicate that administration of capsaicin reduces bile flow and biliary proteins in the rat...
  28. ncbi request reprint Pharmacological investigation of trimetazidine in models of inflammation, pain and gastric injury in rodents
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Centre, Cairo, Egypt
    Pharmacology 75:122-32. 2005
    ..This study indicates that trimetazidine possesses antinociceptive and gastric protective properties. The antinociceptive properties of trimetazidine are likely to be centrally mediated, but do not involve opioid pathways...
  29. ncbi request reprint Acute effect of gamma irradiation on gastric acid secretion and gastric mucosal integrity in the rat
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Dokki, Cairo
    ScientificWorldJournal 5:195-204. 2005
    ..Exposure to irradiation is likely to result in failure of the parietal cell to respond to direct stimulation with histamine or pentagastrin...
  30. ncbi request reprint Effect of cysteamine on bile secretion in the rat
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Pharmacol Rep 57:345-51. 2005
    ..The results suggest that acute administration of cysteamine inhibits protein, cholesterol and lipid secretion into bile...
  31. ncbi request reprint Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats
    Omar M E Abdel-Salam
    Department of Pharmacology, National Research Center, Tahrir St, Dokki, Cairo, Egypt
    ScientificWorldJournal 5:586-95. 2005
    ..perforatum exhibits antiedematogenic and antinociceptive properties, which may be of value for the management of inflammatory painful conditions. The agent, however, causes gastric irritation and may aggravate that of NSAIDs...
  32. ncbi request reprint Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat
    Siham M el-Shenawy
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Pharmacol Res 46:235-43. 2002
    ..These results indicate that melatonin possesses anti-inflammatory and anti-nociceptive properties in the rat and enhance those of indomethacin. This effect is likely to be centrally mediated...
  33. ncbi request reprint Structure-based design of benzimidazole sugar conjugates: synthesis, SAR and in vivo anti-inflammatory and analgesic activities
    Ahmed O H El-Nezhawy
    Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Cairo, Egypt
    Med Chem 5:558-69. 2009
    ..Compounds 6, 7, 10, 13, 15, and 16 showed significant anti-inflammatory and analgesic activities...
  34. ncbi request reprint Evaluation of the anti-inflammatory and anti-nociceptive activities of novel synthesized melatonin analogues
    Gamal A Elmegeed
    Hormone Department, National Research Centre, Dokki, Giza 12622, Cairo, Egypt
    Eur J Med Chem 42:1285-92. 2007
    ..Compounds 5 and 12 were more potent as anti-nociceptive drugs; they are more potent in this respect than melatonin...
  35. doi request reprint Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivatives
    Wagnat W Wardakhan
    National Organization for Drug Control and Research, P O 29 Cairo, Egypt
    Acta Pharm 58:1-14. 2008
    ..No compound showed sedative effect. Visceral pain evoked by i.p. injection of acetic acid in mice was significantly inhibited by all compounds at a high doses...
  36. pmc Effect of ribavirin alone or combined with silymarin on carbon tetrachloride induced hepatic damage in rats
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Drug Target Insights 2:19-27. 2007
    ..Results also indicate that the combined application of ribavirin and sily-marin is likely to be a useful additive in reducing liver injury...
  37. ncbi request reprint Vinpocetine and piracetam exert antinociceptive effect in visceral pain model in mice
    Omar M E Abdel Salam
    Department of Pharmacology, National Research Centre, Tahrir St, Dokki, Cairo, Egypt
    Pharmacol Rep 58:680-91. 2006
    ..This study indicates that vinpocetine and piracetam possess visceral antinociceptive properties. This effect depends on activation of adenosine receptors. Piracetam in addition inhibits GABA-mediated antinociception...
  38. ncbi request reprint Studies on the glycemic and lipidemic effect of monopril and losartan in normal and diabetic rats
    Seham A el-Batran
    Department of Pharmacology, National Research Center, Doki, Cairo, Egypt
    Pharmacol Res 50:131-6. 2004
    ..On the other hand, all the investigated drugs showed a significant decrease in serum low density lipoprotein (LDL) in normal and diabetic rats...
  39. ncbi request reprint Effect of rosiglitazone and nateglinide on serum glucose and lipid profile alone or in combination with the biguanide metformin in diabetic rats
    Seham A el-Batran
    Department of Pharmacology, National Research Center, Dokki, Cairo, Egypt
    Pharmacol Res 53:69-74. 2006
    ..This study was designed to investigate the effect of 1 month treatment with nateglinide, rosiglitazone, metformin and their different combinations on streptozotocin (STZ) diabetic rats...