Kazim Sahin

Summary

Publications

  1. doi request reprint The effects of vitamin C and E supplementation on heat shock protein 70 response of ovary and brain in heat-stressed quail
    N Sahin
    Faculty of Veterinary Science, Department of Animal Nutrition, Firat University, Elazig, Turkey
    Br Poult Sci 50:259-65. 2009
  2. doi request reprint Comparative in vivo evaluations of curcumin and its analog difluorinated curcumin against cisplatin-induced nephrotoxicity
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, 23100, Turkey
    Biol Trace Elem Res 157:156-63. 2014
  3. doi request reprint Chromium modulates expressions of neuronal plasticity markers and glial fibrillary acidic proteins in hypoglycemia-induced brain injury
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey Electronic address
    Life Sci 93:1039-48. 2013
  4. doi request reprint Berberis vulgaris root extract alleviates the adverse effects of heat stress via modulating hepatic nuclear transcription factors in quails
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig 23119, Turkey
    Br J Nutr 110:609-16. 2013
  5. pmc Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway
    Ulkan Kilic
    Department of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Bulvarı Vatan Caddesi, Fatih, TR 34093, Istanbul, Turkey
    Nutr Metab (Lond) 10:7. 2013
  6. doi request reprint Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig 23119, Turkey
    Br J Nutr 110:197-205. 2013
  7. doi request reprint A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats
    Nurhan Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Nutr Neurosci 15:42-7. 2012
  8. doi request reprint Inhibitory effects of combination of lycopene and genistein on 7,12- dimethyl benz(a)anthracene-induced breast cancer in rats
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Nutr Cancer 63:1279-86. 2011
  9. doi request reprint The effects of chromium picolinate and chromium histidinate administration on NF-κB and Nrf2/HO-1 pathway in the brain of diabetic rats
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, 23119, Elazig, Turkey
    Biol Trace Elem Res 150:291-6. 2012
  10. ncbi request reprint Resveratrol protects quail hepatocytes against heat stress: modulation of the Nrf2 transcription factor and heat shock proteins
    K Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    J Anim Physiol Anim Nutr (Berl) 96:66-74. 2012

Collaborators

Detail Information

Publications74

  1. doi request reprint The effects of vitamin C and E supplementation on heat shock protein 70 response of ovary and brain in heat-stressed quail
    N Sahin
    Faculty of Veterinary Science, Department of Animal Nutrition, Firat University, Elazig, Turkey
    Br Poult Sci 50:259-65. 2009
    ..5. The present study showed that a combination of dietary vitamin C (500 mg) and E supplementation (500 mg) may alleviate some heat stress effects of heat shock proteins of ovary and brain and egg production of Japanese quail...
  2. doi request reprint Comparative in vivo evaluations of curcumin and its analog difluorinated curcumin against cisplatin-induced nephrotoxicity
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, 23100, Turkey
    Biol Trace Elem Res 157:156-63. 2014
    ..The results also proved that compared to curcumin, CDF has superior protective effect in nephrotoxicity...
  3. doi request reprint Chromium modulates expressions of neuronal plasticity markers and glial fibrillary acidic proteins in hypoglycemia-induced brain injury
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey Electronic address
    Life Sci 93:1039-48. 2013
    ..This experiment investigated if chromium (Cr) as Cr-histidinate (CrHis) and Cr29 picolinate (CrPic) have a protective role in rats with hypoglycemia-induced brain injury, assessed by neuronal plasticity and regeneration potential...
  4. doi request reprint Berberis vulgaris root extract alleviates the adverse effects of heat stress via modulating hepatic nuclear transcription factors in quails
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, Elazig 23119, Turkey
    Br J Nutr 110:609-16. 2013
    ..In conclusion, dietary supplementation of B. vulgaris root extract to quails reduces the detrimental effects of oxidative stress and lipid peroxidation resulting from HS via activating the host defence system at the cellular level...
  5. pmc Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway
    Ulkan Kilic
    Department of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Bulvarı Vatan Caddesi, Fatih, TR 34093, Istanbul, Turkey
    Nutr Metab (Lond) 10:7. 2013
    ..abstract:..
  6. doi request reprint Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig 23119, Turkey
    Br J Nutr 110:197-205. 2013
    ..Results of the present study revealed that supplementing CrPic and biotin alone or in a combination exerts anti-diabetic activities, probably through modulation of PPAR-γ, IRS-1 and NF-κB proteins...
  7. doi request reprint A novel nutritional supplement containing chromium picolinate, phosphatidylserine, docosahexaenoic acid, and boron activates the antioxidant pathway Nrf2/HO-1 and protects the brain against oxidative stress in high-fat-fed rats
    Nurhan Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Nutr Neurosci 15:42-7. 2012
    ..The present study evaluated the complex's potential mechanism of action and its role in reducing oxidative stress in the brain of obese rats fed a high-fat diet (HFD)...
  8. doi request reprint Inhibitory effects of combination of lycopene and genistein on 7,12- dimethyl benz(a)anthracene-induced breast cancer in rats
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Nutr Cancer 63:1279-86. 2011
    ..Our results suggest that lycopene and genistein are potent antioxidants and, when given in combination, offer maximum protection against DMBA-induced mammary carcinogenesis...
  9. doi request reprint The effects of chromium picolinate and chromium histidinate administration on NF-κB and Nrf2/HO-1 pathway in the brain of diabetic rats
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, 23119, Elazig, Turkey
    Biol Trace Elem Res 150:291-6. 2012
    ..Histidinate form of Cr was superior to picolinate form of Cr in reducing NF-κB expression and increasing Nrf2 expression in the brain of diabetic rats...
  10. ncbi request reprint Resveratrol protects quail hepatocytes against heat stress: modulation of the Nrf2 transcription factor and heat shock proteins
    K Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    J Anim Physiol Anim Nutr (Berl) 96:66-74. 2012
    ..The results of the present study suggest that supplemental resveratrol reduces oxidative stress in heat-stressed quails through modulating the hepatic heat shock proteins and nuclear transcription factors...
  11. doi request reprint Curcumin ameloriates heat stress via inhibition of oxidative stress and modulation of Nrf2/HO-1 pathway in quail
    K Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, 23119 Elazig, Turkey
    Food Chem Toxicol 50:4035-41. 2012
    ..0001 for all). The results indicated that curcumin alleviates oxidative stress through modulating the hepatic nuclear transcription factors and heat shock proteins 70 in heat-stressed quails...
  12. pmc Chromium picolinate and chromium histidinate protects against renal dysfunction by modulation of NF-κB pathway in high-fat diet fed and Streptozotocin-induced diabetic rats
    Mustafa Yavuz Selcuk
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig 23119, Turkey
    Nutr Metab (Lond) 9:30. 2012
    ..abstract:..
  13. ncbi request reprint Effect of chromium on carbohydrate and lipid metabolism in a rat model of type 2 diabetes mellitus: the fat-fed, streptozotocin-treated rat
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, 23119, Elazig, Turkey
    Metabolism 56:1233-40. 2007
    ....
  14. doi request reprint Supplementation with organic or inorganic selenium in heat-distressed quail
    Nurhan Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, 23119, Elazig, Turkey
    Biol Trace Elem Res 122:229-37. 2008
    ..Results of the present study suggest that supplementation with Se-Met can be considered to be more protective than Na2SeO3 by reducing the negative effects of oxidative stress induced by heat stress in quail...
  15. doi request reprint The effects of tomato powder supplementation on performance and lipid peroxidation in quail
    N Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, 23119 Elazig, Turkey
    Poult Sci 87:276-83. 2008
    ..The results of the study indicate that tomato powder modulates the oxidation-antioxidation system of the muscles in Japanese quail exposed to high ambient temperature...
  16. doi request reprint Effects of dietary resveratrol supplementation on egg production and antioxidant status
    K Sahin
    Department of Animal Nutrition and Nutritional Disorders, Faculty of Veterinary Medicine, Firat University, Elazig 23119, Turkey
    Poult Sci 89:1190-8. 2010
    ..Further studies should investigate the carryover effects of dietary resveratrol supplementation on product quality with respect to shelf life, antioxidant stability, and its nutritive value for human consumption...
  17. doi request reprint Role of dietary zinc in heat-stressed poultry: a review
    K Sahin
    Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, 23119 Elazig, Turkey
    Poult Sci 88:2176-83. 2009
    ..One of the most important functions of Zn is related to its antioxidant role and its participation in the antioxidant defense system. This work compiles past and present information about the role of Zn in heat-stressed poultry health...
  18. doi request reprint Effects of 25-hydroxycholecalciferol and soy isoflavones supplementation on bone mineralisation of quail
    N Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, 23119 Elazig, Turkey
    Br Poult Sci 50:709-15. 2009
    ..4. In conclusion, a combination of 25-OH-D(3) and soy isoflavones supplementation to basal diet significantly improved bone mineralisation in quail...
  19. doi request reprint Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Food Chem Toxicol 48:2670-4. 2010
    ..Correlation between NF-kappaB and Nrf2 is discussed...
  20. doi request reprint Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Life Sci 87:240-5. 2010
    ....
  21. doi request reprint Epigallocatechin-3-gallate prevents lipid peroxidation and enhances antioxidant defense system via modulating hepatic nuclear transcription factors in heat-stressed quails
    K Sahin
    Department of Animal Nutrition and Nutritional Disorders, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey
    Poult Sci 89:2251-8. 2010
    ..In conclusion, supplemental EGCG alleviates oxidative stress through modulating the hepatic nuclear transcription factors in heat-stressed quails...
  22. doi request reprint Lycopene and chemotherapy toxicity
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Nutr Cancer 62:988-95. 2010
    ..Lycopene may reduce or prevent the side effects of chemotherapy due to its antioxidant and anti-inflammatory properties. This review focuses on the protective effects of lycopene against antineoplastic agent induced toxicity...
  23. doi request reprint The effects of chromium complex and level on glucose metabolism and memory acquisition in rats fed high-fat diet
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Medicine, Firat University, 23119, Elazig, Turkey
    Biol Trace Elem Res 143:1018-30. 2011
    ..Supplemental Cr as CrGly may have therapeutic potential to enhance insulin action and alleviate memory acquisition in a dose-dependent manner, through restoring tissue Cr reserve and enhancing cerebral GLUTs expressions...
  24. pmc Impact of chromium histidinate on high fat diet induced obesity in rats
    Mehmet Tuzcu
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, 23119 Elazig, Turkey
    Nutr Metab (Lond) 8:28. 2011
    ..abstract:..
  25. ncbi request reprint The effect of soy isoflavones on egg quality and bone mineralisation during the late laying period of quail
    N Sahin
    Faculty of Veterinary Science, Department of Animal Nutrition, Elazig, Turkey
    Br Poult Sci 48:363-9. 2007
    ..5. Soy isoflavone supplementation of basal diet significantly improved egg quality and bone mineralisation in quail during the late laying period...
  26. ncbi request reprint Ascorbic acid and melatonin reduce heat-induced performance inhibition and oxidative stress in Japanese quails
    N Sahin
    Veterinary Control and Research Institute, School of Medicine, Firat University, Elazig, Turkey
    Br Poult Sci 45:116-22. 2004
    ....
  27. ncbi request reprint In vivo antioxidant properties of vitamin E and chromium in cold-stressed Japanese quails
    N Sahin
    Veterinary Control and Research Institute of Ministry of Agriculture, Elazig, Turkey
    Arch Tierernahr 57:207-15. 2003
    ..Results of the present study indicate that combined antioxidant supplements increased performance, egg quality and serum antioxidant levels while lowering MDA in cold-stressed quails...
  28. ncbi request reprint Zinc supplementation alleviates heat stress in laying Japanese quail
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig Turkey
    J Nutr 133:2808-11. 2003
    ..No significant differences in any values were observed in the TN groups (P > 0.05). Results of the present study suggest that supplementation with 60 mg zinc/kg diet protects quail by reducing the negative effects of heat stress...
  29. ncbi request reprint Magnesium proteinate is more protective than magnesium oxide in heat-stressed quail
    N Sahin
    Veterinary Control and Research Institute, Faculty of Veterinary Science, Elazig, Turkey
    J Nutr 135:1732-7. 2005
    ..05) were found for several variables. Results of the present study suggest that supplementation with Mg-proteinate is more protective than Mg-oxide in reducing the negative effects of heat stress in quail...
  30. ncbi request reprint Dietary vitamin C and folic acid supplementation ameliorates the detrimental effects of heat stress in Japanese quail
    K Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    J Nutr 133:1882-6. 2003
    ..Such supplementation may offer protection against heat stress-related depression in performance of Japanese quail...
  31. ncbi request reprint Dietary arginine silicate inositol complex improves bone mineralization in quail
    K Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, 23119 Elazig, Turkey
    Poult Sci 85:486-92. 2006
    ..05). In conclusion, ASI supplementation to the basal diet significantly improved bone mineralization in quail and did not impact feed consumption, BW gain, or feed efficiency...
  32. ncbi request reprint Chromium supplementation can alleviate negative effects of heat stress on egg production, egg quality and some serum metabolites of laying Japanese quail
    K Sahin
    Department of Animal Nutrition, Veterinary Faculty, University of Firat, 23119 Elazig, Turkey
    J Nutr 132:1265-8. 2002
    ..The best results were obtained with 1200 microg Cr/kg diet, and chromium supplementation at such a level can be considered to be protective management practice in a quail diet, reducing the negative effects of heat stress...
  33. doi request reprint The effects of selenium supplementation on the spontaneously occurring fibroid tumors of oviduct, 8-hydroxy-2'-deoxyguanosine levels, and heat shock protein 70 response in Japanese quail
    Mehmet Tuzcu
    Faculty of Science, Firat University, Elazig, Turkey
    Nutr Cancer 62:495-500. 2010
    ..01). Selenium supplementation decreased Hsp70 in the tissue of birds. The results indicate that dietary supplementation with selenium reduces the size of spontaneously occurring leiomyoma of the oviduct in the Japanese quail...
  34. doi request reprint Genistein suppresses spontaneous oviduct tumorigenesis in quail
    Kazim Sahin
    Firat University, Elazig, Turkey
    Nutr Cancer 61:799-806. 2009
    ..Clinical trials should be conducted to investigate the efficacy of genistein supplementation in the prevention and treatment of uterine leiomyoma in humans...
  35. doi request reprint A tomato lycopene complex protects the kidney from cisplatin-induced injury via affecting oxidative stress as well as Bax, Bcl-2, and HSPs expression
    Ayhan Dogukan
    Department of Nephrology, School of Medicine, Firat University, Elazig, Turkey
    Nutr Cancer 63:427-34. 2011
    ..001). These results suggest that tomato lycopene complex has protective effects against cisplatin-induced nephrotoxicity and lipid peroxidation in rats...
  36. ncbi request reprint The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet
    Suleyman Serdar Koca
    Faculty of Medicine, Department of Internal Medicine and Rheumatology, Firat University, Elazig, Turkey
    Inflammation 31:91-8. 2008
    ..05 for each). This study indicates that anti-TNF-alpha antibody is effective on necrosis, inflammation and fibrosis in the experimental model of non-alcoholic steatohepatitis, induced by MCD diet...
  37. doi request reprint The effects of chromium histidinate on mineral status of serum and tissue in fat-fed and streptozotocin-treated type II diabetic rats
    Ayhan Dogukan
    Department of Nephrology, School of Medicine, Firat University, Elazig, Turkey
    Biol Trace Elem Res 131:124-32. 2009
    ..05). The results of the present study conclude that supplementing Cr to the diet of diabetic rats influences serum and tissue Cr, Zn, Se, Mn, and Cu concentrations...
  38. doi request reprint Lycopene counteracts the hepatic response to 7,12-dimethylbenz[a]anthracene by altering the expression of Bax, Bcl-2, caspases, and oxidative stress biomarkers
    Can Ali Agca
    Department of Biology, Faculty of Science Firat University, Elazig, Turkey
    Pharm Biol 50:1513-8. 2012
    ..It has also been reported to provide protection against cellular damage caused by reactive oxygen species, which makes it worthwhile to study the effect of lycopene on liver damage in rat model...
  39. doi request reprint Hepatoprotective effect of infliximab, an anti-TNF-alpha agent, on carbon tetrachloride-induced hepatic fibrosis
    Ibrahim Halil Bahcecioglu
    Department of Gastroenterology, Faculty of Medicine, Firat University, Elazig, Turkey
    Inflammation 31:215-21. 2008
    ..0+/-153.1 vs. 280.8+/-127.1 pg/ml). Treatment with infliximab attenuated the necro-inflammation and fibrogenesis in the CCI(4)-induced hepatic fibrosis, and thus it might be effective as a therapeutic anti-fibrotic agent...
  40. ncbi request reprint Preventive role of genistein in an experimental non-alcoholic steatohepatitis model
    Mehmet Yalniz
    Division of Gastroenterology, Firat University School of Medicine, Elazig, Turkey
    J Gastroenterol Hepatol 22:2009-14. 2007
    ..The aim of the present study was to evaluate the preventive role of genistein, a phytoestrogen with a wide variety of pharmacological effects, in an experimental non-alcoholic steatohepatitis (NASH) model...
  41. doi request reprint Effects of chromium histidinate on renal function, oxidative stress, and heat-shock proteins in fat-fed and streptozotocin-treated rats
    Ayhan Dogukan
    Department of Nephrology, School of Medicine, Firat University, Elazig, Turkey
    J Ren Nutr 20:112-20. 2010
    ..The present study investigated the effects of CrHis on serum parameters of renal function, on oxidative stress markers (malondialdehyde [MDA] and 8-isoprostane), and on the expression of heat-shock proteins (HSPs) in rats...
  42. ncbi request reprint Dietary tomato powder supplementation in the prevention of leiomyoma of the oviduct in the Japanese quail
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Nutr Cancer 59:70-5. 2007
    ..Clinical trials should be conducted to investigate the efficacy of tomato powder supplementation in the prevention and treatment of uterine leiomyoma in humans...
  43. doi request reprint Protective role of zinc picolinate on cisplatin-induced nephrotoxicity in rats
    Mehmet Tuzcu
    Department of Biology, Faculty of Science, Firat University, Elazig, Turkey
    J Ren Nutr 20:398-407. 2010
    ..To date, the protective role of zinc picolinate on cisplatin-induced renal injury has not been investigated. The purpose of the present study was to examine the effect of zinc picolinate on cisplatin-induced renal injury...
  44. ncbi request reprint Chemoprevention of fibroid tumors by [-]-epigallocatechin-3-gallate in quail
    Ibrahim H Ozercan
    Department of Pathology, School of Medicine, University of Firat, 23119 Elazig, Turkey
    Nutr Res 28:92-7. 2008
    ..Clinical trials should be conducted to investigate the efficacy of EGCG supplementation in the prevention and treatment of uterine leiomyoma in humans...
  45. ncbi request reprint Effects of dietary combination of chromium and biotin on growth performance, carcass characteristics, and oxidative stress markers in heat-distressed Japanese quail
    Muhittin Onderci
    Veterinary Control and Research Institute, Elazig, 23119 Turkey
    Biol Trace Elem Res 106:165-76. 2005
    ..Results of the present study suggest that Diachrome can be considered a protective dietary supplement by reducing the negative effects of high environment temperature on performance and oxidative stress in quail...
  46. ncbi request reprint Protective role of supplemental vitamin E and selenium on lipid peroxidation, vitamin E, vitamin A, and some mineral concentrations of Japanese quails reared under heat stress
    Kazim Sahin
    Department of Animal Nutrition, Veterinary Faculty, University of Firat, Elazig, Turkey
    Biol Trace Elem Res 85:59-70. 2002
    ..2 mg/kg of diet) offers a good management practice to reduce heat stress-related depression in performance of Japanese quails...
  47. doi request reprint Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury
    Ramazan Ulu
    Department of Nephrology, Faculty of Medicine, Firat University, Elazig, Turkey
    Food Chem Toxicol 50:1675-9. 2012
    ..In conclusion, the present study shows that the TQ synergizes with its nephroprotective effect against cisplatin-induced acute kidney injury in rats...
  48. ncbi request reprint Effects of vitamin C and vitamin E on lipid peroxidation status, serum hormone, metabolite, and mineral concentrations of Japanese quails reared under heat stress (34 degrees C)
    Kazim Sahin
    Department of Animal Nutrition, Veterinary Faculty, University of Firat, 23119 Elazig, Turkey
    Int J Vitam Nutr Res 72:91-100. 2002
    ..Results of the present study conclude that supplementing a combination of dietary vitamin C (200 mg) and vitamin E (250-500 mg) offers a good management practice to reduce heat stress-related decreases in performance of Japanese quails...
  49. doi request reprint Allopurinol ameliorates thioacetamide-induced acute liver failure by regulating cellular redox-sensitive transcription factors in rats
    Ulvi Demirel
    Department of Gastroenterology, School of Medicine, Firat University, 23119, Elazig, Turkey
    Inflammation 35:1549-57. 2012
    ..AP probably exerts these beneficiary features by its free radical scavenging ability in a dose-dependent manner...
  50. ncbi request reprint Effects of dietary genistein on nutrient use and mineral status in heat-stressed quails
    Nurhan Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Exp Anim 55:75-82. 2006
    ..In conclusion, genistein supplementation to the basal diet improved digestibility of CP, DM and ash and levels of Ca and P and bone mineralization in quails reared under heat stress conditions...
  51. ncbi request reprint Effects of dietary chromium and zinc on egg production, egg quality, and some blood metabolites of laying hens reared under low ambient temperature
    Nurhan Sahin
    Veterinary Control and Research Institute of Ministry of Agriculture, Elazig, Turkey
    Biol Trace Elem Res 85:47-58. 2002
    ....
  52. ncbi request reprint Supplemental zinc and vitamin A can alleviate negative effects of heat stress in broiler chickens
    Osman Kucuk
    Department of Animal Nutrition, Faculty of Veterinary, University of Firat, 23100 Elazig, Turkey
    Biol Trace Elem Res 94:225-35. 2003
    ....
  53. ncbi request reprint Vitamin E and selenium supplementation to alleviate cold-stress-associated deterioration in egg quality and egg yolk mineral concentrations of Japanese quails
    Nurhan Sahin
    Veterinary Control and Research Institute, 23100 Elazig, Turkey
    Biol Trace Elem Res 96:179-89. 2003
    ....
  54. ncbi request reprint Epigallocatechin gallate attenuates experimental non-alcoholic steatohepatitis induced by high fat diet
    Nalan Kuzu
    Department of Internal Medicine, Gastroenterology, School of Medicine, Firat University, Elazig, Turkey
    J Gastroenterol Hepatol 23:e465-70. 2008
    ..In the present study, we examined the preventive role of epigallocatechin gallate (EGCG) in an experimental non-alcoholic steatohepatitis model induced by a high fat diet...
  55. pmc Protective role of genistein in acute liver damage induced by carbon tetrachloride
    Nalan Kuzu
    Department of Internal Medicine, School of Medicine, Firat University, 23119 Elazig, Turkey
    Mediators Inflamm 2007:36381. 2007
    ..In the present study, we investigated the protective effect of genistein in experimental acute liver damage induced by CCl4...
  56. ncbi request reprint Antioxidant properties of chromium and zinc: in vivo effects on digestibility, lipid peroxidation, antioxidant vitamins, and some minerals under a low ambient temperature
    Muhittin Onderci
    Veterinary Control and Research Institute of Ministry of Agriculture, 23119 Elazig, Turkey
    Biol Trace Elem Res 92:139-50. 2003
    ..Data obtained in the present study suggest that such supplementation can be considered as a protective management practice in a diet of laying hens for alleviating negative effects of cold stress...
  57. ncbi request reprint Tomato powder impedes the development of azoxymethane-induced colorectal cancer in rats through suppression of COX-2 expression via NF-κB and regulating Nrf2/HO-1 pathway
    Mehmet Tuzcu
    Department of Biology, Faculty of Science, Firat University, Elazig, Turkey
    Mol Nutr Food Res 56:1477-81. 2012
    ....
  58. ncbi request reprint Melatonin supplementation can ameliorate the detrimental effects of heat stress on performance and carcass traits of Japanese quail
    Nurhan Sahin
    Veterinary Control and Research Institute, Firat University, 23119 Elazig, Turkey
    Biol Trace Elem Res 96:169-77. 2003
    ..Our data suggest that melatonin might offer protection against heat-stress-related depression in the performance of broiler quails...
  59. ncbi request reprint Optimal dietary concentration of chromium for alleviating the effect of heat stress on growth, carcass qualities, and some serum metabolites of broiler chickens
    Kazim Sahin
    Department of Animal Nutrition, Veterinary Faculty, University of Firat, Elazig, Turkey
    Biol Trace Elem Res 89:53-64. 2002
    ..001) with higher dietary chromium supplementation. Results of the present study conclude that a supplementation of diet with chromium at 1200 ppb can alleviate the detrimental effects of heat stress in broiler...
  60. doi request reprint Nadroparin sodium activates Nrf2/HO-1 pathway in acetic acid-induced colitis in rats
    Mehmet Yalniz
    Department of Gastroenterology, School of Medicine, Firat University, 23200 Elazig, Turkey
    Inflammation 35:1213-21. 2012
    ..001). Nadroparin sodium has both protective and therapeutic effects against colonic inflammation via exerting anti-oxidative and anti-inflammatory effects by modulating Nrf2/HO-1 and NF-κB pathways...
  61. doi request reprint Zinc picolinate in the prevention of leiomyoma in Japanese quail
    Nurhan Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    J Med Food 12:1368-74. 2009
    ..Clinical trials should be conducted to investigate the efficacy of zinc supplementation in the prevention and treatment of uterine leiomyoma in humans...
  62. ncbi request reprint Effects of dietary chromium and ascorbic acid supplementation on digestion of nutrients, serum antioxidant status, and mineral concentrations in laying hens reared at a low ambient temperature
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary, University of Firat, Elazig, Turkey
    Biol Trace Elem Res 87:113-24. 2002
    ....
  63. ncbi request reprint Orally Administered Lycopene Attenuates Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats by Modulating Nrf-2/HO-1 and Akt/mTOR Pathways
    Kazim Sahin
    a Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Nutr Cancer 66:590-8. 2014
    ..05). Lycopene is an active chemopreventive agent that offers protection against DEN-induced hepatocarcinogenesis by inhibiting NF-κB and mTOR pathways. ..
  64. ncbi request reprint Lycopene supplementation prevents the development of spontaneous smooth muscle tumors of the oviduct in Japanese quail
    Kazim Sahin
    Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey
    Nutr Cancer 50:181-9. 2004
    ..Clinical trials should be conducted to investigate the efficacy of lycopene supplementation in the prevention and treatment of uterine leiomyoma in humans...
  65. ncbi request reprint Effects of vitamin C and vitamin E on lipid peroxidation, blood serum metabolites, and mineral concentrations of laying hens reared at high ambient temperature
    Kazim Sahin
    Department of Animal Nutrition, Veterinary Faculty, University of Firat, Elazig, Turkey
    Biol Trace Elem Res 85:35-45. 2002
    ..In addition, the results suggest that dietary vitamin C and vitamin E act synergistically...
  66. doi request reprint Antioxidant effect of zinc picolinate in patients with chronic obstructive pulmonary disease
    Gamze Kirkil
    Department of Chest Disease, Faculty of Medicine, Firat University, 23200 Elazig, Turkey
    Respir Med 102:840-4. 2008
    ..The lack of an effect on PFT may be due to the short duration of the supplementation. Longer duration of zinc supplementation may be necessary to see clinical benefit...
  67. ncbi request reprint Protective effect of soy isoflavones and activity levels of plasma paraoxonase and arylesterase in the experimental nonalcoholic steatohepatitis model
    Bilal Ustundag
    Department of Biochemistry and Clinical Biochemistry, College of Medicine, Firat Euphrates University, Elazig, Turkey
    Dig Dis Sci 52:2006-14. 2007
    ..They stimulate and increase the activity of the antioxidative paraoxanase enyzme while decreasing the total cholesterol and triglyceride levels...
  68. doi request reprint Proteasome inhibition prevents development of experimental dermal fibrosis
    Suleyman Serdar Koca
    Department of Rheumatology, Faculty of Medicine, Firat University, Elazig, Turkey
    Inflammation 35:810-7. 2012
    ..These findings suggest that the effect of proteasome inhibition in early stages of dermal fibrosis may be related to its anti-inflammatory effects...
  69. doi request reprint Soy isoflavones ameliorate the adverse effects of chemotherapy in children
    Nurdan Tacyildiz
    Ankara University School of Medicine, Department of Pediatric Oncology, Ankara, Turkey
    Nutr Cancer 62:1001-5. 2010
    ..Further clinical investigation of soy isoflavones in pediatric cancer patients receiving chemotherapy and/or radiation should be conducted...
  70. ncbi request reprint Comparison of serum copper, zinc, calcium, and magnesium levels in preeclamptic and healthy pregnant women
    Selahattin Kumru
    Department of Obstetric Gynecology, Faculty of Science, Firat University Medical School, Elazig, Turkey
    Biol Trace Elem Res 94:105-12. 2003
    ..0001), whereas the magnesium concentration showed nonsignificant differences between the two groups. Measurement of these elements may be useful for the early diagnosis of a preeclamptic condition...
  71. ncbi request reprint Levels of serum hyaluronic acid, TNF-alpha and IL-8 in patients with nonalcoholic steatohepatitis
    Ibrahim Halil Bahcecioglu
    Division of Gastroenterology, Firat University, Elazig, Turkey
    Hepatogastroenterology 52:1549-53. 2005
    ..The aim of this study is to investigate serum hyaluronic acid (HA), TNF-alpha, IL-8 levels in patients with non-alcoholic steatohepatitis and to assess their potential value as a noninvasive marker for the severity of histopathology...
  72. ncbi request reprint Homocysteine, lipid profile, nitric oxide, vitamin B12, and folate values in patients with premature coronary artery disease and their children
    Feyzanur Ayse Pac
    Faculty of Medicine, Department of Pediatrics, Inonu University, Malatya, Turkey
    Angiology 56:253-7. 2005
    ..001 and p < 0.031, respectively). B12 values were significantly higher in both groups (p < 0.05 and p < 0.033, respectively). Lipoprotein A levels were higher in both groups but not significantly so...
  73. doi request reprint Lycopene in cancer prevention and treatment
    Soley Seren
    Department of Internal Medicine, Wayne State University, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan 48201, USA
    Am J Ther 15:66-81. 2008
    ..Further mechanistic studies and randomized controlled clinical intervention trials with lycopene involving cancer patients are warranted...
  74. ncbi request reprint Amelioration of steatohepatitis with pentoxifylline in a novel nonalcoholic steatohepatitis model induced by high-fat diet
    Mehmet Yalniz
    Firat University School of Medicine, Division of Gastroenterology, Tip Merkezi Gastroenteroloji BD, 23200 Elazig, Turkey
    Dig Dis Sci 52:2380-6. 2007
    ..In conclusion, PTX strikingly ameliorates steatohepatitis in this novel NASH model not only by inhibiting the TNF-alpha but also suppressing the oxidative stress markers...