Research Topics

Goutam Sahana

Summary

Publications

  1. Wu X, Lund M, Sahana G, Guldbrandtsen B, Sun D, Zhang Q, et al. Association analysis for udder health based on SNP-panel and sequence data in Danish Holsteins. Genet Sel Evol. 2015;47:50 pubmed publisher
    ..The comparison between these candidate QTL regions and known genes suggested that NPFFR2, SLC4A4, DCK, LIFR, and EDN3 may be considered as candidate genes for mastitis susceptibility. ..
  2. Sahana G, Iso Touru T, Wu X, Nielsen U, de Koning D, Lund M, et al. A 0.5-Mbp deletion on bovine chromosome 23 is a strong candidate for stillbirth in Nordic Red cattle. Genet Sel Evol. 2016;48:35 pubmed publisher
    ..A deleted region of approximately 500 kb that spans three genes on BTA23 was identified and is a strong candidate QTL with a large effect on BI by increasing stillbirth. ..
  3. Höglund J, Guldbrandtsen B, Lund M, Sahana G. Identification of genomic regions associated with female fertility in Danish Jersey using whole genome sequence data. BMC Genet. 2015;16:60 pubmed publisher
    ..The result of this study contributed to a better insight into the genetic control of FTI in the Danish Jersey. ..
  4. Zhang Q, Calus M, Guldbrandtsen B, Lund M, Sahana G. Estimation of inbreeding using pedigree, 50k SNP chip genotypes and full sequence data in three cattle breeds. BMC Genet. 2015;16:88 pubmed publisher
    ..However, genotypes denser than 50k are required to accurately detect short ROH that are most likely identical by descent (IBD). ..
  5. Kadri N, Guldbrandtsen B, Lund M, Sahana G. Genetic dissection of milk yield traits and mastitis resistance quantitative trait loci on chromosome 20 in dairy cattle. J Dairy Sci. 2015;98:9015-25 pubmed publisher
    ..These findings suggest that it may be possible to separate these beneficial and detrimental genetic factors through targeted selective breeding. ..
  6. Wu X, Guldbrandtsen B, Nielsen U, Lund M, Sahana G. Association analysis for young stock survival index with imputed whole-genome sequence variants in Nordic Holstein cattle. J Dairy Sci. 2017;100:6356-6370 pubmed publisher
    ..Several genes (EPS8, LOC100138951, and KLK family genes) contained a lead associated SNP or were included in haplotypes with large detrimental effects on YSS in Nordic Holstein cattle. ..
  7. Jardim J, Guldbrandtsen B, Lund M, Sahana G. Association analysis for udder index and milking speed with imputed whole-genome sequence variants in Nordic Holstein cattle. J Dairy Sci. 2018;101:2199-2212 pubmed publisher
    ..Moreover, this region was located close to the FYB gene, which is involved in platelet activation and controls IL-2 expression; FYB is a strong candidate gene for udder health and worthy of further investigation. ..
  8. Sahana G, Höglund J, Guldbrandtsen B, Lund M. Loci associated with adult stature also affect calf birth survival in cattle. BMC Genet. 2015;16:47 pubmed publisher
    ..We present robust evidence that variation at the LCORL and NCAPG locus affects calf size at birth and adult stature. We suggest the two deviant haplotypes within the QTL were due to two independent mutations. ..
  9. Höglund J, Buitenhuis B, Guldbrandtsen B, Lund M, Sahana G. Genome-wide association study for female fertility in Nordic Red cattle. BMC Genet. 2015;16:110 pubmed publisher

More Information

Publications12

  1. Zhang Q, Calus M, Guldbrandtsen B, Lund M, Sahana G. Contribution of rare and low-frequency whole-genome sequence variants to complex traits variation in dairy cattle. Genet Sel Evol. 2017;49:60 pubmed publisher
    ..For a reliable estimate of the explained DRP variance for different MAF classes, larger sample sizes are needed. ..
  2. Zhang Q, Guldbrandtsen B, Bosse M, Lund M, Sahana G. Runs of homozygosity and distribution of functional variants in the cattle genome. BMC Genomics. 2015;16:542 pubmed publisher
    ..These findings contribute to understanding the effects of inbreeding and probably selection in shaping the distribution of functional variants in the cattle genome. ..
  3. Fang L, Sahana G, Ma P, Su G, Yu Y, Zhang S, et al. Use of biological priors enhances understanding of genetic architecture and genomic prediction of complex traits within and between dairy cattle breeds. BMC Genomics. 2017;18:604 pubmed publisher
    ..020). Our genomic feature modelling approaches provide a framework to simultaneously explore the genetic architecture and genomic prediction of complex traits by taking advantage of independent biological knowledge. ..