Aberrant drainage of sentinel lymph nodes in colon cancer and its impact on staging and extent of operationSukamal Saha
McLaren Flint, 3500 Calkins Road, Flint, MI 48532, USA
Am J Surg 205:302-5; discussion 305-6. 2013
..The role of aberrant lymphatic drainage in changing operations for patients undergoing sentinel lymph node mapping in colon cancer has not been described on a large scale...
Sentinel lymph node mapping in colorectal cancer--a reviewS Saha
Department of Surgery, Michigan State University College of Human Medicine, Flint, USA
Surg Clin North Am 80:1811-9. 2000
..This article reviews the in vivo and ex vivo techniques for SLN mapping in colorectal cancer, along with its limitations and pitfalls...
- A multicenter trial of sentinel lymph node mapping in colorectal cancer: prognostic implications for nodal staging and recurrence
Sukamal Saha
McLaren Regional Medical Center, Michigan State University, 3500 Calkins Road, Suite A, Flint, MI 48532, USA
Am J Surg 191:305-10. 2006
..Sentinel lymph node (SLN) mapping (M) for staging in colorectal cancer (CRCa) remains controversial and needs to be validated. This study analyzes results of SLNM at a multi-institutional level for CRCa...
- Ultrastaging of colorectal cancer by sentinel lymph node mapping technique--a multicenter trial
S Saha
McLaren Regional Medical Center, Michigan State University, Flint, USA
Ann Surg Oncol 8:94S-98S. 2001
..These patients may then benefit from adjuvant chemotherapy...
- Historical review of lymphatic mapping in gastrointestinal malignancies
Sukamal Saha
Departments of Surgery, Michigan State University and McLaren Regional Medical Center, Flint, Michigan, USA
Ann Surg Oncol 11:245S-9S. 2004
..Over the past 2 years, research and publications related to gastrointestinal lymphatic mapping have dramatically increased worldwide...
- Nodal positivity in breast cancer correlated with the number of lesions detected by magnetic resonance imaging versus mammogram
Sukamal Saha
Department of Surgical Oncology, Michigan State University, Regional Medical Imaging, Flint, MI 48532 3685, USA
Am J Surg 201:390-4; discussion 394-5. 2011
..We investigated lymph node metastases rates in patients with multifocal or multicentric disease detected by MRI compared with patients with a single lesion detected by mammography and magnetic resonance imaging...
- Lymphazurin 1% versus 99mTc sulfur colloid for lymphatic mapping in colorectal tumors: a comparative analysis
Sukamal Saha
McLaren Regional Medical Center, Michigan State University Department of Surgery, Flint, Michigan 48532, USA
Ann Surg Oncol 11:21-6. 2004
..The combination of isosulfan blue (Lymphazurin) 1% and 99(m)Tc sulfur colloid (TSC) may improve the feasibility and accuracy of lymphatic mapping for colorectal cancer...
- Comparison of nodal positivity between SLNM vs conventional surgery in colon cancer patients with <12 and ≥12 lymph nodes harvested
Mehul Soni
Department of Surgical Oncology, McLaren Regional Medical Center, Flint, MI, USA
Am J Surg 202:207-13. 2011
..The aim of this study was to compare nodal positivity between sentinel LN mapping (SLNM) and conventional surgery in patients with <12 and ≥12 LNs harvested...
- Comparative analysis of nodal upstaging between colon and rectal cancers by sentinel lymph node mapping: a prospective trial
Sukamal Saha
Department of Surgery, Michigan State University, East Lansing, Michigan, USA
Dis Colon Rectum 47:1767-72. 2004
..5 percent) in rectal patients. Nodal upstaging, skip metastases, and occult metastases were similar...
- Sentinel lymph node mapping technique in colon cancer
Sukamal Saha
Department of Surgery, Michigan State University, Flint, USA
Semin Oncol 31:374-81. 2004
..Those patients who are upstaged can then benefit from adjuvant chemotherapy, which has been shown to improve survival of colon cancer patients with nodal disease by at least 33%...
- A prospective trial comparing 1% lymphazurin vs 1% methylene blue in sentinel lymph node mapping of gastrointestinal tumors
Mehul Soni
Department of Surgical Oncology, McLaren Regional Medical Center, Flint, MI, USA
Ann Surg Oncol 16:2224-30. 2009
..M has been evaluated in breast cancer in multiple studies with favorable results. Our study compares L with M in the SLNM of gastrointestinal (GI) tumors...
- 1% lymphazurin vs 10% fluorescein for sentinel node mapping in colorectal tumors
Adrian G Dan
Department of Surgery, Michigan State University, McLaren Regional Medical Center, Flint, USA
Arch Surg 139:1180-4. 2004
..In patients with known hypersensitivity to Lymphazurin and when availability and cost are an issue, fluorescein may be used effectively for SLN mapping in colorectal tumors...
- Detection and prognostic impact of micrometastasis in colorectal cancer
Saad Sirop
Department of Surgical Oncology, McLaren Regional Medical Center, Michigan State University, Flint, Michigan, USA
J Surg Oncol 103:534-7. 2011
..The results of those studies were compared with our pilot study of 109 patients with colon cancer, showing improved prognosis of micrometastasis after being upstaged and treated with chemotherapy when compared with NND...
- Sentinel lymph node mapping in colon and rectal cancer: its impact on staging, limitations, and pitfalls
Sukamal Saha
Michigan State University, College of Human Medicine, Flint, Michigan, USA
Cancer Treat Res 127:105-22. 2005
..Finally, we will also discuss the current role as well as the future research directions for SLN mapping in colon and rectal cancer...
- Ultrastaging of sentinel lymph nodes (SLNs) vs. non-SLNs in colorectal cancer--do we need both?
David Wiese
Department of Surgical Oncology, McLaren Regional Medical Center, Michigan State University, Flint, MI, USA
Am J Surg 199:354-8; discussion 358. 2010
..The aim of this study to analyze whether ultrastaging of initially negative nonsentinel lymph nodes (non-SLNs) would increase nodal positivity in colon cancer and rectal cancer...
- Prognostic impact of micrometastases in colon cancer: interim results of a prospective multicenter trial
Anton J Bilchik
Department of Gastrointestinal Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, and Michigan State University McLaren Regional Medical Center, Flint, MI, USA
Ann Surg 246:568-75; discussion 575-7. 2007
..6% rate of micrometastases (MM) identified by immunohistochemical staining (IHC) of H&E-negative SNs in CC. We hypothesized that these MM have prognostic importance...
- Comparative analysis of bone marrow micrometastases with sentinel lymph node status in early-stage breast cancer
Sukamal Saha
McLaren Regional Medical Center, Flint, MI, USA
Ann Surg Oncol 16:276-80. 2009
..BMM occur in node-negative pts and may assist in identifying pts at high risk for disease recurrence. Obtaining bone marrow aspirate from two locations resulted in a significant increase in detection of micrometastases...
- Selective lymph node mapping in colorectal cancer--a prospective study for impact on staging, limitations and pitfalls
Sukamal Saha
Michiagan State University College of Human Medicine, Department of Surgery, McLaren Regional Medical Center, Flint, Michigan, USA
Cancer Treat Res 111:109-16. 2002
- Association of angiogenesis markers with lymph node metastasis in early colorectal cancer
Douglas M Iddings
Department of Surgical Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
Arch Surg 142:738-44; discussion 744-5. 2007
..We hypothesized that p53 mutations (mp53) are associated with decreased expression of thrombospondin 1 (TSP-1) and that decreased TSP-1 expression is associated with lymph node metastases...
- Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients
Stanley P L Leong
Center for Melanoma Research and Treatment, Department of Surgery, California Pacific Medical and Research Institute, San Francisco, California 94115, USA
J Surg Oncol 103:518-30. 2011
....
- A prospective study of false-positive diagnosis of micrometastatic cells in the sentinel lymph nodes in colorectal cancer
D Wiese
Department of Pathology, Michigan State University, McLaren Regional Medical Center, Flint, MI, USA
Ann Surg Oncol 16:2166-9. 2009
..Our prospective study evaluated whether colorectal mapping procedures alone caused false positives...
- Technical details of sentinel lymph node mapping in colorectal cancer and its impact on staging
S Saha
Department of Anatomy, Michigan State University, McLaren Regional Medical Center, Flint, USA
Ann Surg Oncol 7:120-4. 2000
..The purpose of this study was to see if SLN mapping technique could be used to identify SLNs in colorectal cancer and to assess its impact on pathological staging and treatment...
- Impact of immediate versus delayed axillary node dissection on surgical outcomes in breast cancer patients with positive sentinel nodes: results from American College of Surgeons Oncology Group Trials Z0010 and Z0011
John A Olson
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Clin Oncol 26:3530-5. 2008
..The impact of the timing of cALND on pathologic results and complications in these patients has not been examined...
- A phosphatase associated with metastasis of colorectal cancer
S Saha
Howard Hughes Medical Institute, The Oncology Center, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Science 294:1343-6. 2001
..3. These data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions...
- Prospective multicenter trial of staging adequacy in colon cancer: preliminary results
Anton J Bilchik
John Wayne Cancer Institute and Saint Johns Health Center, Santa Monica, CA 90404, USA
Arch Surg 141:527-33; discussion 533-4. 2006
..A 25% recurrence rate in patients with node-negative CRC suggests that current staging practices are inadequate. Focused analysis of the sentinel node (SN) by multiple sectioning and immunohistochemistry improves staging accuracy...
- Novel intraoperative molecular test for sentinel lymph node metastases in patients with early-stage breast cancer
Thomas B Julian
Allegheny Breast Care Center, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212, USA
J Clin Oncol 26:3338-45. 2008
..We present the results from a large, prospective evaluation of the first rapid molecular SLN test, the Breast Lymph Node (BLN) Assay...
- Sentinel node for gastrointestinal malignancies
Yuko Kitagawa
Department of Surgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Surg Oncol Clin N Am 16:71-80. 2007
..A combination of SN mapping and endoscopic surgery will contribute to the improvement in quality of life after surgical treatment of GI cancer...
- The use of molecular profiling of early colorectal cancer to predict micrometastases
Anton J Bilchik
Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
Arch Surg 137:1377-83. 2002
..Lymphatic mapping followed by focused analysis of the sentinel node is highly accurate in identifying micrometastases...
- Sentinel lymph node mapping with GI cancer
Takashi Aikou
Department of Surgical Oncology and Digestive Surgery, Kagoshima University, Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Cancer Metastasis Rev 25:269-77. 2006
..Although more evidence from large-scale multicenter clinical trials is required, SLN mapping may be very useful for individualizing multi-modal treatment for esophageal cancer and might be widely acceptable even for GI cancer...
- Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes
Bret Taback
Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA 90404, USA
Int J Cancer 111:409-14. 2004
..This study demonstrates the utility, specificity and sensitivity of PNA clamp PCR assay in identifying occult micrometastases in the SLN of CRC patients by single-base mutation analysis...
- c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases
Hiroya Takeuchi
Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
Clin Cancer Res 9:1480-8. 2003
..CONCLUSIONS: This study indicates c-MET mRNA overexpression in primary CRC may be an important prognostic marker for early stage invasion and regional disease metastasis...
- Scientific Impact Recognition Award. Sentinel node staging for breast cancer: intraoperative molecular pathology overcomes conventional histologic sampling errors
Peter Blumencranz
Breast Health Services, Morton Plant Mease Health Care, 303 Pinellas St, Ste 310, Clearwater, FL 33756, USA
Am J Surg 194:426-32. 2007
..A new intraoperative molecular assay (GeneSearch BLN Assay; Veridex, LLC, Warren, NJ) was evaluated to determine its efficiency in identifying significant sentinel lymph node metastases (>.2 mm)...
- Current status and future clinical applications of lymphatic mapping in gastrointestinal cancer
Yuko Kitagawa
Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
J Gastroenterol 42:927-31. 2007
- Comparative analysis of mesenteric and peripheral blood circulating tumor DNA in colorectal cancer patients
Bret Taback
Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
Ann N Y Acad Sci 1075:197-203. 2006
..The findings provide important evidence supporting the origin of tumor-associated DNA in circulation, which merits consideration when devising blood-based nucleic acid assays for the assessment of CRC...
