Risk of precancer and follow-up management strategies for women with human papillomavirus-negative atypical squamous cells of undetermined significanceMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA
Obstet Gynecol 109:1325-31. 2007
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Chlamydia trachomatis and risk of prevalent and incident cervical premalignancy in a population-based cohortMahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
J Natl Cancer Inst 102:1794-804. 2010
..In a large prospective cohort, we assessed the role of C trachomatis in cervical premalignancy and addressed confounding by HPV...
- Single nucleotide polymorphisms in the PRDX3 and RPS19 and risk of HPV persistence and cervical precancer/cancer
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 7:e33619. 2012
..Host genetic factors might affect the risk of progression from infection with carcinogenic human papillomavirus (HPV), the etiologic agent for cervical cancer, to persistent HPV infection, and hence to cervical precancer and cancer...
- Determinants of seropositivity among HPV-16/18 DNA positive young women
Carolina Porras
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
BMC Infect Dis 10:238. 2010
..We evaluated determinants of seropositivity among 646 women infected with HPV-16 and/or HPV-18...
- Determinants and correlation of systemic and cervical concentrations of total IgA and IgG
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
Cancer Epidemiol Biomarkers Prev 18:2672-6. 2009
..17 and 0.16, respectively). The lack of correlation between systemic and cervical total IgA and IgG suggests that systemic concentrations are not reflective of cervical levels...
- Epidemiological study of anti-HPV16/18 seropositivity and subsequent risk of HPV16 and -18 infections
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, Ste 550, Rockville, MD 20852, USA
J Natl Cancer Inst 102:1653-62. 2010
..Infection with human papillomavirus (HPV) 16 or HPV18 elicits an antibody response, but whether the elicited antibodies protect women against subsequent infection by a homologous HPV type compared with seronegative women is unknown...
Seroprevalence and correlates of human papillomavirus 16/18 seropositivity among young women in Costa RicaSarah Coseo
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Blvd, EPS, Room 7079, Rockville, MD 20852, USA
Sex Transm Dis 37:706-14. 2010
..We investigated HPV16 and 18 seroepidemiology among young, unvaccinated women aged between 18 and 25...
- A population-based prospective study of carcinogenic human papillomavirus variant lineages, viral persistence, and cervical neoplasia
Mark Schiffman
Divisions of Cancer Epidemiology and Genetics and Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20852, USA
Cancer Res 70:3159-69. 2010
..Larger viral genomic studies are warranted, especially to identify the genetic basis for HPV16's unique carcinogenicity...
- Direct comparison of HPV16 serological assays used to define HPV-naïve women in HPV vaccine trials
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Infections and Immunoepidemiology Branch, National Cancer Institute, NIH, Bethesda, MD, USA
Cancer Epidemiol Biomarkers Prev 21:1547-54. 2012
..Some of the variation in estimated vaccine efficacies may be due to the differences in these assays used to define the HPV-naïve subgroups. To guide the interpretation of published results, we compared these assays...
- Human papillomavirus cofactors by disease progression and human papillomavirus types in the study to understand cervical cancer early endpoints and determinants
Sophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5104, Rockville, MD 20854 7234, USA
Cancer Epidemiol Biomarkers Prev 18:113-20. 2009
..Investigations on the molecular distinctions along the disease continuum of cervical pathogenesis by HPV type are needed...
- HPV16 seropositivity and subsequent HPV16 infection risk in a naturally infected population: comparison of serological assays
Shih Wen Lin
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
PLoS ONE 8:e53067. 2013
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- A competitive serological assay shows naturally acquired immunity to human papillomavirus infections in the Guanacaste Natural History Study
Nicolas Wentzensen
National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 204:94-102. 2011
..A competitive Luminex Immunoassay (cLIA) has been developed to measure neutralizing antibodies against human papillomavirus (HPV) types 6, 11, 16 and 18...
- Evaluation of the polyclonal ELISA HPV serology assay as a biomarker for human papillomavirus exposure
Sarah E Coseo
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852, USA
Sex Transm Dis 38:976-82. 2011
..Overall performance of these assays, as a measure of HPV exposure, has not been evaluated...
- Lack of heterogeneity of HPV16 E7 sequence compared with HPV31 and HPV73 may be related to its unique carcinogenic properties
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, USA
Arch Virol 155:367-70. 2010
..The lack of heterogeneity of HPV16 E7 suggests high evolutionary purifying selection that might be related to the unique carcinogenicity of HPV16...
- Detection of precancerous cervical lesions is differential by human papillomavirus type
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland, USA
Cancer Res 69:3262-6. 2009
..001). These results indicate the underrepresentation of HPV18/45 in precancers, whereas HPV16-associated CIN3+ is diagnosed much earlier. Whether the underrepresentation of 18/45 may be due to occult pathology needs further investigation...
- Comparability of self-collected vaginal swabs and physician-collected cervical swabs for detection of human papillomavirus infections in Rakai, Uganda
Mahboobeh Safaeian
Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland 20852, USA
Sex Transm Dis 34:429-36. 2007
..The objective of this study was to compare human papillomavirus (HPV) DNA testing between self-administered vaginal swabs and physician-administered cervical swabs in women from rural Rakai District, Uganda...
- Factors associated with fluctuations in IgA and IgG levels at the cervix during the menstrual cycle
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
J Infect Dis 199:455-63. 2009
..The objective of this analysis was to describe patterns and determinants of cervical immunoglobulin A (IgA) and G (IgG) levels during the menstrual cycle...
- Cervical cancer prevention--cervical screening: science in evolution
Mahboobeh Safaeian
Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health DHHS, 6120 Executive Blvd, Rockville, MD 20852, USA
Obstet Gynecol Clin North Am 34:739-60, ix. 2007
..This article describes the traditional methods of screening for cervical cancer and innovative methods that might help overcome financial and cultural barriers to more widespread screening...
- Medical history and the risk of biliary tract cancers in Shanghai, China: implications for a role of inflammation
Gabriella Andreotti
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8011, MSC 7240, Bethesda, MD 20892, USA
Cancer Causes Control 22:1289-96. 2011
..2-15.0) or duodenal ulcers (OR = 3.7, 1.2-12.0) was associated with an excess risk of gallbladder cancer. Although the mechanisms are unclear, our results further support the role for inflammation in the etiology of biliary tract cancers...
- Comparison of the SPF10-LiPA system to the Hybrid Capture 2 Assay for detection of carcinogenic human papillomavirus genotypes among 5,683 young women in Guanacaste, Costa Rica
Mahboobeh Safaeian
Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA
J Clin Microbiol 45:1447-54. 2007
..The crude agreement between the two assays was 88%, with a kappa value of 0.75 (95% confidence limits, 0.73 to 0.76). We observed very good agreement between HC2 and SPF(10)-LiPA for carcinogenic HPV type detection...
