I Saenz de Tejada

Summary

Publications

  1. ncbi request reprint Design and evaluation of nitrosylated alpha-adrenergic receptor antagonists as potential agents for the treatment of impotence
    I S de Tejada
    Departamento de Investigacion, Hospital Ramon y Cajal, Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
    J Pharmacol Exp Ther 290:121-8. 1999
  2. ncbi request reprint Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum
    I Saenz de Tejada
    Fundación para la Investigación y el Desarollo en Andrología, Madrid, Spain
    Int J Impot Res 12:S20-25. 2000
  3. ncbi request reprint The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil
    I Saenz de Tejada
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
    Int J Impot Res 13:282-90. 2001
  4. ncbi request reprint Combination of phentolamine and L-arginine or sildenafil synergistically improves neurogenic relaxation of rabbit corpus cavernosum smooth muscle
    J Angulo
    , Madrid, Spain
    Urology 57:585-9. 2001
  5. ncbi request reprint Vardenafil reverses erectile dysfunction induced by paroxetine in rats
    J Angulo
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Dept de Investigación, Hospital Ramon y Cajal, Madrid, Spain
    Int J Impot Res 15:90-3. 2003
  6. ncbi request reprint Vardenafil enhances clitoral and vaginal blood flow responses to pelvic nerve stimulation in female dogs
    J Angulo
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
    Int J Impot Res 15:137-41. 2003
  7. ncbi request reprint Adrenoceptor-mediated regulation of the contractility in horse penile resistance arteries
    U Simonsen
    Departamento de Fisiologia, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    J Vasc Res 34:90-102. 1997
  8. pmc Ca2+ -activated K+ channel (KCa) stimulation improves relaxant capacity of PDE5 inhibitors in human penile arteries and recovers the reduced efficacy of PDE5 inhibition in diabetic erectile dysfunction
    R Gonzalez-Corrochano
    Servicio de Histología Investigación, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Br J Pharmacol 169:449-61. 2013
  9. ncbi request reprint Molecular mechanisms for the regulation of penile smooth muscle contractility
    I Saenz de Tejada
    Departmento de Investigacion, Hospital Ramon y Cajal, Madrid, Spain
    Int J Impot Res 12:S34-8. 2000
  10. ncbi request reprint Molecular mechanisms for the regulation of penile smooth muscle contractility
    I Saenz de Tejada
    Fi DA, Antonio Robles, Madrid, Spain
    Int J Impot Res 14:S6-10. 2002

Collaborators

  • E Bischoff
  • U Simonsen
  • I Goldstein
  • S W Tam
  • J Angulo
  • P Cuevas
  • R Gonzalez-Corrochano
  • S Gabancho
  • A Fernandez
  • Jm La Fuente
  • Mx Chen
  • B Cuevas
  • I S de Tejada
  • D S Garvey
  • J D Schroeder
  • P Marek
  • L G Letts
  • M Trocha
  • T Shelekhin
  • V Martinez

Detail Information

Publications10

  1. ncbi request reprint Design and evaluation of nitrosylated alpha-adrenergic receptor antagonists as potential agents for the treatment of impotence
    I S de Tejada
    Departamento de Investigacion, Hospital Ramon y Cajal, Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
    J Pharmacol Exp Ther 290:121-8. 1999
    ..These drugs induced penile erection in animals, suggesting their possible therapeutic value as agents for the local pharmacological treatment of impotence...
  2. ncbi request reprint Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum
    I Saenz de Tejada
    Fundación para la Investigación y el Desarollo en Andrología, Madrid, Spain
    Int J Impot Res 12:S20-25. 2000
    ..This will also enhance the release of nitric oxide, which increases smooth muscle relaxation and decreases contraction resulting in penile erection...
  3. ncbi request reprint The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil
    I Saenz de Tejada
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
    Int J Impot Res 13:282-90. 2001
    ..Vardenafil was more potent and selective than sildenafil on its inhibitory activity on PDE5...
  4. ncbi request reprint Combination of phentolamine and L-arginine or sildenafil synergistically improves neurogenic relaxation of rabbit corpus cavernosum smooth muscle
    J Angulo
    , Madrid, Spain
    Urology 57:585-9. 2001
    ..This fact suggests that the combination of alpha-adrenergic receptor blockade with L-arginine or sildenafil could represent a therapeutic advantage in the treatment of erectile dysfunction...
  5. ncbi request reprint Vardenafil reverses erectile dysfunction induced by paroxetine in rats
    J Angulo
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Dept de Investigación, Hospital Ramon y Cajal, Madrid, Spain
    Int J Impot Res 15:90-3. 2003
    ....
  6. ncbi request reprint Vardenafil enhances clitoral and vaginal blood flow responses to pelvic nerve stimulation in female dogs
    J Angulo
    Fundacion para la Investigacion y el Desarrollo en Andrologia, Madrid, Spain
    Int J Impot Res 15:137-41. 2003
    ....
  7. ncbi request reprint Adrenoceptor-mediated regulation of the contractility in horse penile resistance arteries
    U Simonsen
    Departamento de Fisiologia, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    J Vasc Res 34:90-102. 1997
    ..Functional beta 2-adrenoceptors are also present in these arteries...
  8. pmc Ca2+ -activated K+ channel (KCa) stimulation improves relaxant capacity of PDE5 inhibitors in human penile arteries and recovers the reduced efficacy of PDE5 inhibition in diabetic erectile dysfunction
    R Gonzalez-Corrochano
    Servicio de Histología Investigación, Instituto Ramón y Cajal de Investigación Sanitaria, Hospital Universitario Ramon y Cajal, Madrid, Spain
    Br J Pharmacol 169:449-61. 2013
    ....
  9. ncbi request reprint Molecular mechanisms for the regulation of penile smooth muscle contractility
    I Saenz de Tejada
    Departmento de Investigacion, Hospital Ramon y Cajal, Madrid, Spain
    Int J Impot Res 12:S34-8. 2000
    ..This manuscript briefly reviews the molecular mechanisms affected by muscle relaxants and vasodilators in the treatment of erectile dysfunction. International Journal of Impotence Research (2000) 12, Suppl 4, S34-S38...
  10. ncbi request reprint Molecular mechanisms for the regulation of penile smooth muscle contractility
    I Saenz de Tejada
    Fi DA, Antonio Robles, Madrid, Spain
    Int J Impot Res 14:S6-10. 2002
    ..These substances react with membrane receptors coupled to a GS-type protein that stimulates adenylate cyclase, which catalyzes the accumulation of cAMP. DOI: 10.1038/sj/ijir/3900790..