A Dessa Sadovnick

Summary

Publications

  1. ncbi request reprint The genetics of multiple sclerosis
    A Dessa Sadovnick
    Department of Medical Genetics, University of British Columbia, G920 Detwiller Pavilion, Vancouver Hospital and Health Sciences Center UBC, 2211 Wesbrook Mall, Vancouver, BC, Canada, V6T 2B5
    Clin Neurol Neurosurg 104:199-202. 2002
  2. doi request reprint Differential effects of genetic susceptibility factors in males and females with multiple sclerosis
    A Dessa Sadovnick
    Department of Medical Genetics, Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada Electronic address
    Clin Immunol 149:170-5. 2013
  3. doi request reprint Term pregnancies and the clinical characteristics of multiple sclerosis: a population based study
    Sreeram Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 83:793-5. 2012
  4. doi request reprint Genetic background of multiple sclerosis
    A Dessa Sadovnick
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Autoimmun Rev 11:163-6. 2012
  5. ncbi request reprint A timing-of-birth effect on multiple sclerosis clinical phenotype
    A D Sadovnick
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Neurology 69:60-2. 2007
  6. ncbi request reprint Multiple sclerosis and birth order: a longitudinal cohort study
    A Dessa Sadovnick
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Lancet Neurol 4:611-7. 2005
  7. ncbi request reprint Recurrence risks to sibs of MS index cases: impact of consanguineous matings
    A Dessa Sadovnick
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Neurology 56:784-5. 2001
  8. ncbi request reprint The multiple sclerosis trait: a disease waiting to happen?
    A D Sadovnick
    Department of Medical Genetics and Faculty of Medicine, University of British Columbia, Vancouver Coastal Health Authority UBC Hospital, G 920, Detwiller Pavilion, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5
    Clin Neurol Neurosurg 106:172-4. 2004
  9. pmc Age of onset in concordant twins and other relative pairs with multiple sclerosis
    A Dessa Sadovnick
    Department of Medical Genetics, Vancouver Coastal Health Authority University of British Columbia Hospital, G 920 Detwiller Pavilion, Vancouver, British Columbia, Canada
    Am J Epidemiol 170:289-96. 2009
  10. doi request reprint Parent-of-origin of HLA-DRB1*1501 and age of onset of multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Hum Genet 54:547-9. 2009

Collaborators

Detail Information

Publications56

  1. ncbi request reprint The genetics of multiple sclerosis
    A Dessa Sadovnick
    Department of Medical Genetics, University of British Columbia, G920 Detwiller Pavilion, Vancouver Hospital and Health Sciences Center UBC, 2211 Wesbrook Mall, Vancouver, BC, Canada, V6T 2B5
    Clin Neurol Neurosurg 104:199-202. 2002
  2. doi request reprint Differential effects of genetic susceptibility factors in males and females with multiple sclerosis
    A Dessa Sadovnick
    Department of Medical Genetics, Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada Electronic address
    Clin Immunol 149:170-5. 2013
    ..This maternal effect can range from intrauterine exposures to transmission of genotypes and epigenetics. ..
  3. doi request reprint Term pregnancies and the clinical characteristics of multiple sclerosis: a population based study
    Sreeram Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neurol Neurosurg Psychiatry 83:793-5. 2012
    ..However, it is unclear as to whether there are any long term effects on disability...
  4. doi request reprint Genetic background of multiple sclerosis
    A Dessa Sadovnick
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Autoimmun Rev 11:163-6. 2012
    ....
  5. ncbi request reprint A timing-of-birth effect on multiple sclerosis clinical phenotype
    A D Sadovnick
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Neurology 69:60-2. 2007
    ..A month-of-birth (MOB) effect has been shown in multiple sclerosis (MS)...
  6. ncbi request reprint Multiple sclerosis and birth order: a longitudinal cohort study
    A Dessa Sadovnick
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Lancet Neurol 4:611-7. 2005
    ..We aimed to study the effect of birth order on MS risk...
  7. ncbi request reprint Recurrence risks to sibs of MS index cases: impact of consanguineous matings
    A Dessa Sadovnick
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Neurology 56:784-5. 2001
    ..These findings support the concept that multiple interacting genes increase the risk of MS...
  8. ncbi request reprint The multiple sclerosis trait: a disease waiting to happen?
    A D Sadovnick
    Department of Medical Genetics and Faculty of Medicine, University of British Columbia, Vancouver Coastal Health Authority UBC Hospital, G 920, Detwiller Pavilion, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5
    Clin Neurol Neurosurg 106:172-4. 2004
    ..The role of environment and chance must also be considered. Implications for counselling "at risk" individuals, based on family history, are discussed...
  9. pmc Age of onset in concordant twins and other relative pairs with multiple sclerosis
    A Dessa Sadovnick
    Department of Medical Genetics, Vancouver Coastal Health Authority University of British Columbia Hospital, G 920 Detwiller Pavilion, Vancouver, British Columbia, Canada
    Am J Epidemiol 170:289-96. 2009
    ..A maternal parent-of-origin effect on the age of onset in collinear generations was suggested...
  10. doi request reprint Parent-of-origin of HLA-DRB1*1501 and age of onset of multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Hum Genet 54:547-9. 2009
    ..4 years, paternal=30.3 years; P=0.009). HLA-DRB1*1501 exerts a modest, but significant effect on the AO of all forms of MS. Parent-of-origin effects at the MHC are further implicated in MS disease pathogenesis...
  11. ncbi request reprint Parental transmission of HLA-DRB1*15 in multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Hum Genet 122:661-3. 2008
    ..A significant over transmission of HLA-DRB1*15 from mothers was observed (chi (2) = 7.73, P = 0.0054), suggesting that parent of origin effects at the MHC determine susceptibility to MS...
  12. doi request reprint Rare variants in the CYP27B1 gene are associated with multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Ann Neurol 70:881-6. 2011
    ..Genetic linkage analysis and genotyping of candidate genes in families with 4 or more affected individuals more heavily loaded for susceptibility genes has not fully explained familial disease clustering...
  13. pmc Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 5:e1000369. 2009
    ..These findings support a connection between the main epidemiological and genetic features of this disease with major practical implications for studies of disease mechanism and prevention...
  14. doi request reprint Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex
    Michael J Chao
    Department of Clinical Neurology, Level 3 West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 7BN, UK
    Hum Mol Genet 18:261-6. 2009
    ..The comparison of transmission of the same allele in vertically affected pedigrees (AUNN) to collinear sibling pairs (ASP) may provide a useful screen for putative epigenetic marks...
  15. doi request reprint No effect of birth weight on the risk of multiple sclerosis. A population-based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Neuroepidemiology 31:181-4. 2008
    ..In a population-based Canadian cohort, we investigated whether there is any difference in birth weight for MS index cases compared to spousal controls...
  16. doi request reprint Parent-of-origin effects at the major histocompatibility complex in multiple sclerosis
    Michael J Chao
    Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Hum Mol Genet 19:3679-89. 2010
    ....
  17. ncbi request reprint A genome-wide scan in forty large pedigrees with multiple sclerosis
    Cristen J Willer
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Hum Genet 52:955-62. 2007
    ..30. The inability to find significant linkage in these highly penetrant families suggests that linkage is not the optimal tool for dissecting the inheritance of MS...
  18. pmc The inheritance of resistance alleles in multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 3:1607-13. 2007
    ..Restriction of antigen presentation by HLA-DRB1*15 seems an improbably simple mechanism of major histocompatibility complex-associated susceptibility...
  19. doi request reprint Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis
    Sreeram V Ramagopalan
    Dept of Clinical Neurology, University of Oxford, Level 3, West Wing, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    J Neurol 255:1215-9. 2008
    ....
  20. pmc Methylation of class II transactivator gene promoter IV is not associated with susceptibility to multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    BMC Med Genet 9:63. 2008
    ..In this study we sought to assess whether or not methylation of the MHC2TA promoter pIV could contribute to MS disease aetiology...
  21. ncbi request reprint A first stage genome-wide screen for regions shared identical-by-descent in Hutterite families with multiple sclerosis
    David Alexandre Dyment
    The Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK
    Am J Med Genet B Neuropsychiatr Genet 147:467-72. 2008
    ..Additional genotyping to refine the haplotypes followed by screening for potential variants may lead to the identification of a novel MS susceptibility gene(s) in this unique population...
  22. doi request reprint No effect of parental age on risk of multiple sclerosis: a population-based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Neuroepidemiology 34:106-9. 2010
    ..In a population-based Canadian cohort, we investigated whether there is any difference in parental age at birth for MS index cases compared to spouse controls...
  23. ncbi request reprint Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium
    Michael J Chao
    Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Hum Mol Genet 16:1951-8. 2007
    ..The frequency of allelic associations not being replicated emphasizes the requirement for constructing multi-locus haplotypes in dissecting associations in regions of tight LD...
  24. doi request reprint Childhood cow's milk allergy and the risk of multiple sclerosis: a population based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neurol Sci 291:86-8. 2010
    ..Frequency of CMA was compared between index cases and controls. No significant differences were found. Childhood CMA thus does not appear to be a risk factor for MS...
  25. ncbi request reprint No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5
    Adam E Handel
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    J Neuroimmunol 223:120-3. 2010
    ..We found no significant effect of DNA methylation across HLA-DRB1*1501 and HLA-DRB5 on severity, although we cannot rule out time- or tissue-specific effects of DNA methylation...
  26. doi request reprint Vitamin D metabolic pathway genes and risk of multiple sclerosis in Canadians
    Sarah Michelle Orton
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
    J Neurol Sci 305:116-20. 2011
    ..Previous studies have shown that serum 25-hydroxyvitamin D (25(OH)D) levels are genetically influenced. Polymorphisms in vitamin D pathway genes are candidates for association with MS susceptibility...
  27. doi request reprint Association of infectious mononucleosis with multiple sclerosis. A population-based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    Neuroepidemiology 32:257-62. 2009
    ..Here in a population-based Canadian cohort, we investigate the relationship between prior clinical infection or vaccination and the risk of MS...
  28. pmc No effect of preterm birth on the risk of multiple sclerosis: a population based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK
    BMC Neurol 8:30. 2008
    ..Here, in a population-based cohort, we investigate whether preterm birth increases the risk to subsequently develop MS...
  29. ncbi request reprint Obstetrical epidural and spinal anesthesia in multiple sclerosis
    Ellen Lu
    Division of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Room S178, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada
    J Neurol 260:2620-8. 2013
    ..1). Contrary to previous studies, epidural anesthesia use differed between women with MS and the general population and was influenced by parity and MS disease duration; these findings warrant further investigation...
  30. pmc An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene
    Sreeram V Ramagopalan
    1Department of Clinical Neurology, University of Oxford, The West Wing, The John Radcliffe Hospital, Oxford, OX3 9DU, UK
    BMC Med Genet 10:10. 2009
    ..Given the role of this locus in antigen presentation it has been suggested that variations in the peptide binding site of the allele may underlie allelic variation in disease risk...
  31. doi request reprint Mutations in the hemochromatosis gene and the clinical outcome of multiple sclerosis
    Sreeram V Ramagopalan
    Department of Clinical Neurology, University of Oxford, UK
    J Neuroimmunol 203:104-7. 2008
    ..The frequency of HFE mutations was not different in MS compared to the general population...
  32. doi request reprint Association of smoking with risk of multiple sclerosis: a population-based study
    Sreeram V Ramagopalan
    Medical Research Council Functional Genomics Unit and Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    J Neurol 260:1778-81. 2013
    ..No association was seen with maternal active or passive smoking exposure during pregnancy. Ever-smoking is associated with increased MS risk in males. Further work is needed to understand the mechanism underlying this association...
  33. ncbi request reprint Sex ratio of multiple sclerosis in Canada: a longitudinal study
    Sarah Michelle Orton
    Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK
    Lancet Neurol 5:932-6. 2006
    ..We reasoned that if a sex-specific change in incidence was occurring, the female to male sex ratio would serve as a surrogate of incidence change...
  34. doi request reprint Early life child exposure and the risk of multiple sclerosis: a population based study
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neurol Sci 307:162-3. 2011
    ..Frequency of infant day care attendance was compared for index cases and controls and the results were not statistically significant. Exposure to other infants during early childhood thus does not appear to be a risk factor for MS...
  35. ncbi request reprint A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis
    Matthew R Lincoln
    Department of Clinical Neurology, Radcliffe Infirmary, University of Oxford, Oxford OX2 6HE, UK
    Nat Genet 37:1108-12. 2005
    ..This study therefore indicates that MHC-associated susceptibility to multiple sclerosis is determined by HLA class II alleles, their interactions and closely neighboring variants...
  36. ncbi request reprint Birth outcomes in newborns fathered by men with multiple sclerosis exposed to disease-modifying drugs
    Ellen Lu
    Brain Research Centre and Department of Medicine Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    CNS Drugs 28:475-82. 2014
    ....
  37. ncbi request reprint Analysis of CYP27B1 in multiple sclerosis
    Jay P Ross
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    J Neuroimmunol 266:64-6. 2014
    ..03%) in which the p.R389H mutation segregates with disease in five family members diagnosed with MS, thus providing additional support for CYP27B1 p.R389H in the pathogenicity of MS. ..
  38. doi request reprint Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, Oxford, UK
    J Neuroimmunol 212:142-4. 2009
    ..No significant association was found in the entire sample or when stratifying by transmitting parent, indicating that this gene plays little or no role in susceptibility to MS in the Canadian population...
  39. doi request reprint Safety of disease-modifying drugs for multiple sclerosis in pregnancy: current challenges and future considerations for effective pharmacovigilance
    Ellen Lu
    Department of Medicine, Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
    Expert Rev Neurother 13:251-60; quiz 261. 2013
    ..Future pharmacovigilance studies should continue to pursue multicenter collaboration with an emphasis on appropriate study design...
  40. ncbi request reprint Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance
    David A Dyment
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Hum Mol Genet 14:2019-26. 2005
    ..These studies demonstrate that it is the Class II genotype that determines susceptibility and resistance to MS. By analogy with celiac disease and type I diabetes, the pattern of susceptibility strongly supports an autoimmune aetiology...
  41. ncbi request reprint An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study Group
    David A Dyment
    The Wellcome Trust Center for Human Genetics, Oxford, UK
    Hum Mol Genet 13:1005-15. 2004
    ..This observation is most consistent with a model of genetic heterogeneity between HLA and other genetic loci. These findings offer guidance for future genetic studies including dense SNP linkage disequilibrium analysis...
  42. ncbi request reprint A review of safety-related pregnancy data surrounding the oral disease-modifying drugs for multiple sclerosis
    Ellen Lu
    Division of Neurology, Brain Research Centre and Department of Medicine, Faculty of Medicine, University of British Columbia, Room S178, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada
    CNS Drugs 28:89-94. 2014
    ....
  43. doi request reprint 2010 McDonald criteria for diagnosing pediatric multiple sclerosis
    Yair Sadaka
    Division of Neurology, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, Canada
    Ann Neurol 72:211-23. 2012
    ..The 2010 McDonald criteria simplified MRI requirements, and newly proposed that the criteria are also suitable for the diagnosis of pediatric MS...
  44. doi request reprint Genetic counseling for early-onset familial Alzheimer disease in large Aboriginal kindred from a remote community in British Columbia: unique challenges and possible solutions
    Rachel Butler
    Medical Genetics, University of British Columbia, Vancouver, BC, Canada
    J Genet Couns 20:136-42. 2011
    ..To our knowledge, this is the first time a specific genetic counseling approach has been needed for early-onset familial Alzheimer disease (EOFAD) in a North American Aboriginal community...
  45. ncbi request reprint Multiple sclerosis and pregnancy: a comparison study
    Sura Alwan
    Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada
    Can J Neurol Sci 40:590-6. 2013
    ....
  46. doi request reprint Epidemiology of multiple sclerosis
    Sreeram V Ramagopalan
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Neurol Clin 29:207-17. 2011
    ..It seems unlikely that MS results from a single causative event, but rather is the result of genetic and environmental factors and the interactions thereof. This article discusses the epidemiology of MS...
  47. ncbi request reprint Genetics of multiple sclerosis
    David A Dyment
    The Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK
    Lancet Neurol 3:104-10. 2004
    ....
  48. pmc Birth hospitalization in mothers with multiple sclerosis and their newborns
    Ellen Lu
    Department of Medicine, Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Neurology 80:447-52. 2013
    ....
  49. pmc Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging
    Ging Yuek R Hsiung
    Department of Medicine, Clinic for Alzheimer s Disease and Related Disorders, University of British Columbia, Vancouver, BC
    CMAJ 171:863-7. 2004
    ..However, its effect on predicting conversion from normal to "cognitive impairment, no dementia" (CIND) and from CIND to AD is less clear...
  50. doi request reprint Multiple sclerosis and pregnancy: maternal considerations
    Sura Alwan
    Department of Medical Genetics, University of British Columbia, and Vancouver Coastal Health Authority UBC Hospital, Vancouver, BC, Canada
    Womens Health (Lond Engl) 8:399-414. 2012
    ....
  51. ncbi request reprint A novel PS1 gene mutation in a large Aboriginal kindred
    Rachel Butler
    Department of Medical Genetics, UBC Hospital Clinic for Alzheimer Disease and Related Disorders, Vancouver, BC, Canada
    Can J Neurol Sci 37:359-64. 2010
    ..There is currently little information on the genetic epidemiology of Alzheimer disease (AD) among North American Aboriginal populations. No cases of familial AD (FAD) in these populations have been published to date...
  52. doi request reprint Accuracy of reported family history and effectiveness of medical record requests in genetic counseling for Alzheimer disease
    Emily L R Alexander
    Prenatal Biochemistry Laboratory, Women s Health Centre of British Columbia, Vancouver, BC, Canada
    J Genet Couns 20:129-35. 2011
    ..During the study period, almost 500 h of genetic counselor work time was spent obtaining, reviewing, and following-up on records received. Changes made to UBCH-CARD procedure in response to these findings are discussed...
  53. doi request reprint Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population
    Ardeshir Omoumi
    Division of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Neurobiol Aging 35:936.e5-12. 2014
    ..In addition, pooled analysis of our AD patients confirmed that CR1, TOMM40, BIN1, and CD33 contribute to late-onset AD susceptibility, in addition to apolipoprotein E...
  54. ncbi request reprint A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17
    Ian R Mackenzie
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Brain 129:853-67. 2006
    ....
  55. ncbi request reprint Microchimerism in autoimmunity and transplantation: potential relevance to multiple sclerosis
    Cristen J Willer
    Wellcome Trust Centre for Human Genetics, University of Oxford, OX3 7BN, UK
    J Neuroimmunol 126:126-33. 2002
    ..Potential research questions regarding microchimerism, human leukocyte antigen (HLA) similarity, and autoimmune diseases in the context of multiple sclerosis (MS) are discussed...
  56. doi request reprint Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosis
    Sreeram V Ramagopalan
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    J Neuroimmunol 196:170-2. 2008
    ..No significant transmission differences between mothers and fathers were found, suggesting that non-inherited resistance alleles do not appear to play a role in MS...