Effects of lamotrigine and lithium on body weight during maintenance treatment of bipolar I disorderGary Sachs
Department of Psychiatry, Harvard University, Harvard Bipolar Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Bipolar Disord 8:175-81. 2006
....
Adjunctive oral ziprasidone in patients with acute mania treated with lithium or divalproex, part 2: influence of protocol-specific eligibility criteria on signal detectionGary S Sachs
Bipolar Clinic and Research Program, Massachusetts General Hospital, 50 Staniford St, 5th Floor, Boston, MA 02114, USA
J Clin Psychiatry 73:1420-5. 2012
..Data collected by computer interviews and by site-based raters were analyzed to examine the impact of eligibility criteria on signal detection...
- Adjunctive oral ziprasidone in patients with acute mania treated with lithium or divalproex, part 1: results of a randomized, double-blind, placebo-controlled trial
Gary S Sachs
Bipolar Clinic and Research Program, Massachusetts General Hospital, 50 Staniford St, 5th Floor, Boston, MA 02114, USA
J Clin Psychiatry 73:1412-9. 2012
..To assess the efficacy and safety of adjunctive ziprasidone in subjects with acute mania treated with lithium or divalproex, with an inadequate response to the mood stabilizer...
- The pharmacologic treatment of bipolar disorder
Gary S Sachs
Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 72:704-15. 2011
..A paradigm for implementing evidence-based treatment is offered along with consideration of patterns emerging across clinical trials...
- Response, remission, and recovery in bipolar disorders: what are the realistic treatment goals?
Gary S Sachs
Harvard Bipolar Research Program, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 64:18-22; discussion 28. 2003
..Despite effective treatment, relapse is common. Realistic treatment goals should strive for sustained symptom abatement while maximizing patient quality of life from visit to visit...
- Unmet clinical needs in bipolar disorder
Gary S Sachs
Harvard Bipolar Research Program, Massachusetts General Hospital, Boston, 02114, USA
J Clin Psychopharmacol 23:S2-8. 2003
..The role of atypical antipsychotics in maintenance therapy for bipolar disorder is currently being evaluated in a number of large clinical trials...
- Efficacy and safety of adjunctive oral ziprasidone for acute treatment of depression in patients with bipolar I disorder: a randomized, double-blind, placebo-controlled trial
Gary S Sachs
Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston MA 02114, USA
J Clin Psychiatry 72:1413-22. 2011
..To assess efficacy and safety of adjunctive ziprasidone in subjects with bipolar depression treated with lithium, lamotrigine, or valproate...
- Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety
Gary S Sachs
Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Suite 580, Boston, MA 02114, USA
Am J Psychiatry 159:1146-54. 2002
..The study assessed the efficacy and safety of risperidone as an adjunctive agent to mood stabilizers in the treatment of acute mania...
- Decision tree for the treatment of bipolar disorder
Gary S Sachs
Partners Bipolar Treatment Center, Massachusetts General Hospital, Boston, Mass, USA
J Clin Psychiatry 64:35-40. 2003
....
- Antimanic response to aripiprazole in bipolar I disorder patients is independent of the agitation level at baseline
Gary S Sachs
Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 68:1377-83. 2007
..To examine the antimanic efficacy of the relatively nonsedating antipsychotic aripiprazole in patients with bipolar I disorder and high or low baseline levels of agitation...
- Aripiprazole in the treatment of acute manic or mixed episodes in patients with bipolar I disorder: a 3-week placebo-controlled study
Gary Sachs
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 2114, USA
J Psychopharmacol 20:536-46. 2006
..In conclusion, aripiprazole demonstrated superior efficacy to placebo in the treatment of patients with bipolar I disorder presenting with acute manic or mixed episodes, and exhibited a favourable safety and tolerability profile...
- Quetiapine with lithium or divalproex for the treatment of bipolar mania: a randomized, double-blind, placebo-controlled study
G Sachs
Harvard Bipolar Research Program, Massachusetts General Hospital, Boston, 02114, USA
Bipolar Disord 6:213-23. 2004
..Evaluate the efficacy and tolerability of quetiapine (QTP) combined with lithium (Li) or divalproex (DVP) in the treatment of acute mania...
- The treatment of bipolar depression
G S Sachs
Massachusetts General Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Boston 02114, USA
Bipolar Disord 2:256-60. 2000
..This paper reviews the available literature on the treatment of bipolar depression and offers recommendations for clinical management...
- Implementing evidence-based treatment of manic and mixed episodes
Gary S Sachs
Partners Bipolar Treatment Center, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 67:12-7. 2006
....
- Comorbidity of attention deficit hyperactivity disorder with early- and late-onset bipolar disorder
G S Sachs
Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 157:466-8. 2000
..The relationship between attention deficit hyperactivity disorder (ADHD) and earlier age at onset of affective illness was examined in probands with a history of bipolar disorder...
- A clinical monitoring form for mood disorders
Gary S Sachs
Department of Psychiatry, Harvard Bipolar Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Bipolar Disord 4:323-7. 2002
..This report presents preliminary data evaluating the correlation between the CMF's dimensional subscales for depression and mood elevation and formal mood rating scales across a wide spectrum of mood states...
- Adjunctive clonazepam for maintenance treatment of bipolar affective disorder
G S Sachs
Clinical Psychopharmacology Unit, Massachusetts General Hospital, Boston 02176
J Clin Psychopharmacol 10:42-7. 1990
..Overall, eight patients were rated much improved or very much improved, including three of the five cases initially rated most severely ill. Possible mechanisms and treatment strategies are discussed...
- Ergoloid mesylates and ECT
G S Sachs
Department of Psychiatry, Harvard Medical School, Boston, MA
J Clin Psychiatry 50:87-90. 1989
..Unexpectedly, patients treated with ergoloid mesylates had a significantly better antidepressant response...
- Pramipexole augmentation in the treatment of unipolar and bipolar depression: a retrospective chart review
J Sporn
Department of Psychiatry, Massachusetts General Hospital, USA
Ann Clin Psychiatry 12:137-40. 2000
..To assess the effectiveness and safety of pramipexole as an adjunctive medication in refractory bipolar and unipolar depression in a naturalistic setting...
- Citalopram as adjunctive therapy in bipolar depression
D J Kupfer
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
J Clin Psychiatry 62:985-90. 2001
..The treatment of bipolar depression remains a major clinical challenge. The effectiveness and safety of adjunctive citalopram were evaluated in DSM-IV-diagnosed bipolar depressed patients in a 5-site study...
- Whole-genome association study of bipolar disorder
P Sklar
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Mol Psychiatry 13:558-69. 2008
..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
- Aims and results of the NIMH systematic treatment enhancement program for bipolar disorder (STEP-BD)
C L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
CNS Neurosci Ther 18:243-9. 2012
..STEP-BD has established procedures that are relevant to future collaborative research programs aimed at the systematic study of the complex, intrinsically important elements of bipolar disorders...
- Administration of antidepressants. Single versus split dosing: a meta-analysis
A Yýldýz
Harvard Medical School, Massachussets General Hospital, Bipolar Clinic and Research Program, Boston, MA, USA
J Affect Disord 66:199-206. 2001
..To evaluate the literature comparing antidepressant effects of multiple daily dosing versus single daily dosing of antidepressants...
- Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders
M W Otto
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Br J Psychiatry 189:20-5. 2006
..The impact of anxiety disorders has not been well delineated in prospective studies of bipolar disorder...
- Integration of suicide prevention into outpatient management of bipolar disorder
G S Sachs
Partners Bipolar Treatment Center, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 62:3-11. 2001
....
- A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder
Joseph R Calabrese
University Hospitals of Cleveland Case Western Reserve School of Medicine, Department of Psychiatry, 11400 Euclid Ave, Ste 200, Cleveland, OH 44106, USA
J Clin Psychiatry 64:1013-24. 2003
..This study assessed the efficacy and tolerability of lamotrigine and lithium compared with placebo for the prevention of mood episodes in bipolar disorder...
- Suicide prevention: increasing education and awareness
L D Grandin
Harvard Bipolar Research Program, Boston, Mass 02114, USA
J Clin Psychiatry 62:12-6. 2001
..Suicide rates continue to rise, making the education of the public and physicians regarding awareness and prevention, recognition of a wide range of risk factors, and research into suicide prevention strategies very important...
- Correlates of subjective and objective burden among caregivers of patients with bipolar disorder
M J Ostacher
Massachusetts General Hospital, Bipolar Clinic and Research Program, Boston, MA, and Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
Acta Psychiatr Scand 118:49-56. 2008
..We examined the relationship between mood symptoms and episodes in patients with bipolar disorder and burden reported by their primary caregivers...
- Olanzapine versus placebo in acute mania: treatment responses in subgroups
Ross J Baldessarini
International Consortium for Bipolar Disorder Research, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
J Clin Psychopharmacol 23:370-6. 2003
..5-1.7, all P < 0.01). These well-powered comparisons of subgroups of interest indicate broad efficacy of olanzapine in the treatment of acute mania...
- A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder
Charles L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229, USA
Arch Gen Psychiatry 60:392-400. 2003
....
- Weight gain during treatment of bipolar I patients with olanzapine
John Hennen
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
J Clin Psychiatry 65:1679-87. 2004
..Body weight increase during long-term treatment with olanzapine in schizophrenia patients is well documented, but weight gain and its association with other medical measures are less well evaluated in bipolar disorder patients...
- A double-blind, placebo-controlled trial of adjunctive donepezil in treatment-resistant mania
A Eden Evins
Department of Psychiatry of the Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Bipolar Disord 8:75-80. 2006
..In an open trial, donepezil augmentation was associated with improvement in manic symptoms in 9 of 11 subjects...
- Clinical outcome of adjunctive topiramate treatment in a sample of refractory bipolar patients with comorbid conditions
Constance Guille
Harvard Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Prog Neuropsychopharmacol Biol Psychiatry 26:1035-9. 2002
..7 lb while on topiramate. Topiramate appears to be a promising agent for the treatment of bipolar disorder associated with comorbid psychiatric conditions and obesity...
- Comparing anxiety disorders and anxiety-related traits in bipolar disorder and unipolar depression
Naomi M Simon
WACC 815, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
J Psychiatr Res 37:187-92. 2003
..Further research is needed to clarify the etiologic basis of anxiety disorder/BPD comorbidity and to optimize treatment strategies for patients with these co-occurring disorders...
- Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorder
Thilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 59:138-46. 2006
..The most consistently reported cognitive difficulty in euthymic subjects with bipolar disorder is impairment in verbal episodic memory (i.e., the ability to learn new verbal information)...
- Brief report: paroxetine in younger and adult individuals at high risk for suicide
Mark S Bauer
Department of Psychiatry, Brown University, USA
Psychopharmacol Bull 39:31-7. 2006
..In fact, the younger group showed a trend for decreased suicidality (P = .13). Thus, increased suicidality risk with paroxetine exposure does not extend to this other high-risk mood disordered population, even among younger individuals...
- Spontaneous and directed application of verbal learning strategies in bipolar disorder and obsessive-compulsive disorder
Thilo Deckersbach
Harvard Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Bipolar Disord 7:166-75. 2005
....
- An fMRI investigation of working memory and sadness in females with bipolar disorder: a brief report
Thilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, 2nd Floor, Charlestown, MA 02129, USA
Bipolar Disord 10:928-42. 2008
..The purpose of the present study was to investigate with fMRI the interaction between acute sadness and working memory functioning in individuals with bipolar disorder...
- Methodological issues and controversies in clinical trials with child and adolescent patients with bipolar disorder: report of a consensus conference
Gabrielle A Carlson
Department of Psychiatry, Stony Brook University Putnam Hall, Stony Brook, NY 11794 8790, USA
J Child Adolesc Psychopharmacol 13:13-27. 2003
..To achieve consensus among researchers, pharmaceutical industry representatives, federal regulatory agency staff, and family advocates on a template for clinical trials of acute mania/bipolar disorder in children and adolescents...
- Cognitive behavioral therapy for rapid-cycling bipolar disorder: a pilot study
Noreen A Reilly-Harrington
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
J Psychiatr Pract 13:291-7. 2007
..Completers showed significant decreases in depressive mood, and improvements remained stable during the 2-month follow-up. This suggests that CBT for rapid cycling may have beneficial effects...
- Caregiver burden and health in bipolar disorder: a cluster analytic approach
Deborah A Perlick
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10019, USA
J Nerv Ment Dis 196:484-91. 2008
..Cluster analysis is a promising method for identifying subgroups of caregivers with different stress and coping profiles associated with different health-related outcomes...
- Retrospective age at onset of bipolar disorder and outcome during two-year follow-up: results from the STEP-BD study
Roy H Perlis
Bipolar Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, ACC 812 15 Parkman Street, Boston, MA 02114, USA
Bipolar Disord 11:391-400. 2009
..Symptoms of bipolar disorder are increasingly recognized among children and adolescents, but little is known about the course of bipolar disorder among adults who experience childhood onset of symptoms...
- Episodic memory impairment in bipolar disorder and obsessive-compulsive disorder: the role of memory strategies
Thilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Bipolar Disord 6:233-44. 2004
....
- Impact of lamotrigine and lithium on weight in obese and nonobese patients with bipolar I disorder
Charles L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
Am J Psychiatry 163:1199-201. 2006
..This study assessed weight changes in a large cohort of patients with bipolar disorder who were treated with randomly assigned maintenance monotherapies...
- Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
Mark H Pollack
Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
J Clin Psychiatry 67:394-9. 2006
....
- Menstrual dysfunction prior to onset of psychiatric illness is reported more commonly by women with bipolar disorder than by women with unipolar depression and healthy controls
Hadine Joffe
Perinatal and Reproductive Psychiatry Clinical Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 67:297-304. 2006
..However, it is not always clear whether such abnormalities, reflecting disruption of the hypothalamic-pituitary-gonadal (HPG) axis, are caused by psychotropic treatments or associated with the disorder per se...
- Contributors to suicidal ideation among bipolar patients with and without a history of suicide attempts
Michael H Allen
University of Colorado Health Science Center, University North Pavilion, 4455 East 12th Avenue, Denver, CO, USA
Suicide Life Threat Behav 35:671-80. 2005
..Bipolar patients with suicidal ideation may benefit from different treatment strategies depending on their prior attempt status...
- The prospective course of rapid-cycling bipolar disorder: findings from the STEP-BD
Christopher D Schneck
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO 80220, USA
Am J Psychiatry 165:370-7; quiz 410. 2008
..In a naturalistic follow-up of adult bipolar patients, the authors examined the contributions of demographic, phenomenological, and clinical variables, including antidepressant use, to prospectively observed mood episode frequency...
- Longitudinal follow-up of reproductive and metabolic features of valproate-associated polycystic ovarian syndrome features: A preliminary report
Hadine Joffe
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 60:1378-81. 2006
..5% of 86 women. We now determine whether polycystic ovarian syndrome (PCOS) features reverse on valproate discontinutation...
Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trialDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Am J Psychiatry 164:1340-7. 2007
..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode...
- The integration of measurement and management for the treatment of bipolar disorder: a STEP-BD model of collaborative care in psychiatry
Andrew A Nierenberg
Bipolar Clinic and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 67:3-7. 2006
..This method was shown to be successful in the National Institute of Mental Health (NIMH) Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)...
- Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program
David J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Arch Gen Psychiatry 64:419-26. 2007
..Psychosocial interventions have been shown to enhance pharmacotherapy outcomes in bipolar disorder...
- Effectiveness of adjunctive antidepressant treatment for bipolar depression
Gary S Sachs
Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
N Engl J Med 356:1711-22. 2007
..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania...
- Adjunctive antidepressant use and symptomatic recovery among bipolar depressed patients with concomitant manic symptoms: findings from the STEP-BD
Joseph F Goldberg
Affective Disorders Program, Silver Hill Hospital, New Canaan, Connecticut, USA
Am J Psychiatry 164:1348-55. 2007
..However, few studies have examined the outcomes of patients with co-occurring manic and depressive symptoms who are treated with antidepressants plus mood stabilizing drugs...
- Influence of sub-syndromal symptoms after remission from manic or mixed episodes
Mauricio Tohen
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Br J Psychiatry 189:515-9. 2006
..Sub-syndromal symptoms in bipolar disorder impair functioning and diminish quality of life...
- Predictors of bipolar disorder risk among patients currently treated for major depression
Joseph R Calabrese
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
MedGenMed 8:38. 2006
..PATIENTS, DESIGN, AND SETTING: Psychiatrists from community and private practice settings sequentially selected patients with unipolar depression who exhibited nonresponse to at least 1 antidepressant (AD) trial...
- Psychosocial strategies to improve concordance and adherence in bipolar disorder
Noreen Reilly-Harrington
Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, USA
J Clin Psychiatry 67:e04. 2006
..Using a variety of psychosocial strategies, patients can train themselves and a support team to effectively deal with bipolar disorder...
- Update on bipolar disorder and substance abuse: recent findings and treatment strategies
Michael J Ostacher
Bipolar Clinic and Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, USA
J Clin Psychiatry 67:e10. 2006
..Once treatment has begun, clinicians should ensure that medication and psychotherapy are administered appropriately and that treatment is modified when there is inadequate response...
- Self-reported history of manic/hypomanic switch associated with antidepressant use: data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
Christine J Truman
Finney Psychotherapy Associates, Norfolk, VA, USA
J Clin Psychiatry 68:1472-9. 2007
....
- Psychotherapy, symptom outcomes, and role functioning over one year among patients with bipolar disorder
David J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Psychiatr Serv 57:959-65. 2006
..A one-year naturalistic-prospective design was used to examine the association between psychotherapy use and the symptomatic and functional outcomes of patients with bipolar disorder...
- Inositol augmentation of lithium or valproate for bipolar depression
A Eden Evins
Harvard Bipolar Research Program and Department of Psychiatry of the Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Bipolar Disord 8:168-74. 2006
..Up to half of patients do not respond adequately to currently approved treatments. This study evaluated the efficacy of adjunctive inositol for bipolar depression...
- Overweight and obesity in bipolar disorders
Po W Wang
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Room 2117, CA 94305-5723, USA
J Psychiatr Res 40:762-4. 2006
- Phenomenology of rapid-cycling bipolar disorder: data from the first 500 participants in the Systematic Treatment Enhancement Program
Christopher D Schneck
Department of Psychiatry, University of Colorado Health Sciences Center, 4455 East 12th Ave, Box A011 15, Denver, CO 80220, USA
Am J Psychiatry 161:1902-8. 2004
..This study compared demographic and phenomenological variables between bipolar patients with and without rapid cycling as a function of bipolar I versus bipolar II status...
- Pharmacotherapy for bipolar disorder and comorbid conditions: baseline data from STEP-BD
Naomi M Simon
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 24:512-20. 2004
..Our findings highlight the need for greater clinical guidance and treatment options for patients with bipolar disorder and comorbidity...
- Relapse prevention in bipolar I disorder: 18-month comparison of olanzapine plus mood stabiliser v. mood stabiliser alone
Mauricio Tohen
Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
Br J Psychiatry 184:337-45. 2004
..Aims To evaluate whether olanzapine plus either lithium or valproate reduces the rate of relapse, compared with lithium or valproate alone...
- Lamotrigine treatment of bipolar disorder: data from the first 500 patients in STEP-BD
Lauren B Marangell
Mood Disorders Program, Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
Bipolar Disord 6:139-43. 2004
..To describe the frequency and correlates of lamotrigine therapy among the first 500 patients enrolled into the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study...
- Rates of study completion with single versus split daily dosing of antidepressants: a meta-analysis
Aysegul Yildiz
Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey
J Affect Disord 78:157-62. 2004
..To examine the tolerability of single versus multiple daily dosing (SDD vs. MDD) of antidepressant drugs in clinical practice...
- Do antidepressants induce rapid cycling? A gender-specific association
Aysegul Yildiz
Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey
J Clin Psychiatry 64:814-8. 2003
..To investigate the influence of antidepressant use and gender in the genesis of rapid-cycling bipolar illness...
- Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)
Gary S Sachs
Partners Bipolar Treatment Center, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 53:1028-42. 2003
....
- Treatment of bipolar depression: current status, continued challenges, and the STEP-BD approach
Michael E Thase
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
Psychiatr Clin North Am 26:495-518. 2003
....
- Psychoeducational and cognitive-behavioral strategies in the management of bipolar disorder
Michael W Otto
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Affect Disord 73:171-81. 2003
....
- Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management
Joseph R Calabrese
Department of Psychiatry, Case Western Reserve University University Hospitals of Cleveland, Cleveland, Ohio, USA
J Clin Psychiatry 63:1012-9. 2002
..The objective of this report was to determine rash rates in clinical trials of lamotrigine in DSM-IV unipolar depression or bipolar disorder...
- Effect of abrupt change from standard to low serum levels of lithium: a reanalysis of double-blind lithium maintenance data
Roy H Perlis
Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA
Am J Psychiatry 159:1155-9. 2002
..To assess the effect of abrupt change in lithium dose, the authors reanalyzed data from a previously reported, randomized, double-blind trial of standard- versus low-dose lithium for maintenance therapy in bipolar disorder...
- Report of the Texas Consensus Conference Panel on medication treatment of bipolar disorder 2000
Trisha Suppes
Department of Psychiatry The University of Texas Southwestern Medical Center Dallas, 75390 9070, USA
J Clin Psychiatry 63:288-99. 2002
....
- National Depressive and Manic-Depressive Association consensus statement on the use of placebo in clinical trials of mood disorders
Dennis S Charney
Division of Intramural Research Programs, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
Arch Gen Psychiatry 59:262-70. 2002
..Research is needed on the ethical conduct of studies to limit risks of medication-free intervals and facilitate poststudy treatment. Patients must fully understand the risks and lack of individualized treatment involved in research...
- Demographic and diagnostic characteristics of the first 1000 patients enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
Jane N Kogan
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Bipolar Disord 6:460-9. 2004
..The current report provides a context for interpreting studies resulting from STEP-BD by summarizing the baseline demographic and diagnostic characteristics of the first 1000 enrolled...
- Anxiety disorder comorbidity in bipolar disorder patients: data from the first 500 participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
Naomi M Simon
Center for Anxiety and Traumatic Stress Related Disorders, Wang ACC 815, Massachusetts General Hospital, 15 Parkman St, Boston, MA 02114, USA
Am J Psychiatry 161:2222-9. 2004
..The authors provide a detailed perspective on the correlates of comorbid anxiety in a large, well-characterized sample of bipolar disorder patients...
- Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy
Mauricio Tohen
Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
Arch Gen Psychiatry 59:62-9. 2002
..CONCLUSION: Compared with the use of valproate or lithium alone, the addition of olanzapine provided superior efficacy in the treatment of manic and mixed bipolar episodes...
- Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapine
Mauricio Tohen
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Am J Psychiatry 163:247-56. 2006
..In a placebo-controlled, double-blind study, the authors investigated the efficacy and safety of olanzapine as monotherapy in relapse prevention in bipolar I disorder...
- Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
Roy H Perlis
Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
Am J Psychiatry 163:217-24. 2006
..The authors looked for the features associated with risk of recurrence...
- Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone
Andrew A Nierenberg
Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
Am J Psychiatry 163:210-6. 2006
..This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone...
- Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorder
Hadine Joffe
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 59:1078-86. 2006
..The development of PCOS features after initiation of valproate was therefore examined in women with bipolar disorder using a standardized definition of PCOS...
- Are antidepressants associated with new-onset suicidality in bipolar disorder? A prospective study of participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
Mark S Bauer
Providence Veterans Affairs Medical Center and the Department of Psychiatry and Human Behavior, Brown University, VAMC 116R, 830 Chalkstone Avenue, Providence, R I 02908 4799, USA
J Clin Psychiatry 67:48-55. 2006
..However, few data are available to inform the suicidality risk assessment of antidepressant use specifically in bipolar disorder...
- Focus on bipolar disorder treatment
Charles L Bowden
Department of Psychiatry, University of Texas Health Science Center at San Antonio, TX, USA
J Clin Psychiatry 66:1598-609. 2005
- Suicidal ideation and pharmacotherapy among STEP-BD patients
Joseph F Goldberg
Affective Disorders Program, Silver Hill Hospital, 208 Valley Road, New Canaan, Connecticut 06840, and Department of Psychiatry, University of Colorado School of Medicine, Denver, USA
Psychiatr Serv 56:1534-40. 2005
..Little is known about the effects of lithium on suicidal ideation or about the possible antisuicidal effects of divalproex, second-generation antipsychotics, or antidepressants among persons with bipolar disorder...
- Psychopathology in the offspring of parents with bipolar disorder: a controlled study
Aude Henin
Pediatric Psychopharmacology Unit and Harvard Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02138, USA
Biol Psychiatry 58:554-61. 2005
..To examine the risk for psychopathology in offspring at risk for bipolar disorder and the course of psychiatric disorders in these youth...
- The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder
Trisha Suppes
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9121, USA
J Clin Psychiatry 66:870-86. 2005
..The guidelines for evaluating possible medications, the criteria for selection and ranking, and the updated algorithms are described...
- Olanzapine versus lithium in the maintenance treatment of bipolar disorder: a 12-month, randomized, double-blind, controlled clinical trial
Mauricio Tohen
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Am J Psychiatry 162:1281-90. 2005
..The authors compared the efficacy of olanzapine and lithium in the prevention of mood episode relapse/recurrence...
- Does recovery from substance use disorder matter in patients with bipolar disorder?
Roger D Weiss
Department of Psychiatry, Harvard Medical School, Boston, USA
J Clin Psychiatry 66:730-5; quiz 808-9. 2005
..To examine the potential impact of recovery from substance use disorder (SUD) on the course of bipolar disorder among patients diagnosed with both bipolar and substance use disorders according to DSM-IV criteria...
- Clinical and diagnostic implications of lifetime attention-deficit/hyperactivity disorder comorbidity in adults with bipolar disorder: data from the first 1000 STEP-BD participants
Andrew A Nierenberg
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Depression and Clinical Research Program ACC 812, Boston, Massachusetts 02114, USA
Biol Psychiatry 57:1467-73. 2005
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- Lithium-induced alterations in nucleoside triphosphate levels in human brain: a proton-decoupled 31P magnetic resonance spectroscopy study
Aysegul Yildiz
Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey
Psychiatry Res 138:51-9. 2005
..The theoretical relevance of the lithium-induced alterations on brain high-energy phosphates to the lithium-induced modifications of neuroplasticity is discussed...
- Age onset of psychotic versus non-psychotic bipolar illness in men and in women
Aysegul Yildiz
Dokuz Eylul Medical School, Department of Psychiatry, Izmir, Turkey
J Affect Disord 74:197-201. 2003
..To investigate the relationship between psychotic symptoms and age at onset of bipolar illness...
- The prevalence and clinical correlates of anger attacks during depressive episodes in bipolar disorder
Roy H Perlis
Massachusetts General Hospital Department of Psychiatry, Boston, MA, USA
J Affect Disord 79:291-5. 2004
..This study compared the prevalence and clinical significance of anger attacks in unipolar versus bipolar depression...
- Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
Roy H Perlis
Partners Bipolar Treatment Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 55:875-81. 2004
..CONCLUSIONS: Very early or early onset of bipolar disorder might herald a more severe disease course in terms of chronicity and comorbidity. Whether early intervention might modify this risk merits further investigation...
- The relationship between smoking and suicidal behavior, comorbidity, and course of illness in bipolar disorder
Michael J Ostacher
Massachusetts General Hospital, Bipolar Clinic and Research Program, Boston, MA 02114, USA
J Clin Psychiatry 67:1907-11. 2006
..The purpose of this retrospective study was to examine the relationship between smoking, severity of bipolar disorder, suicidal behavior, and psychiatric and substance use disorder comorbidity...
