Saberi S, FarrÃ© P, Cuvier O, Emberly E. Probing long-range interactions by extracting free energies from genome-wide chromosome conformation capture data. BMC Bioinformatics. 2015;16:171 pubmed publisher
..PCA filtering can improve the fit, and the predicted coupling energies lead to biologically meaningful insights for how various chromatin bound factors influence the stability of DNA loops in chromatin. ..