Bechara J Saab

Summary

Publications

  1. doi NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory
    Bechara J Saab
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Neuron 63:643-56. 2009
  2. doi Statistical and theoretical considerations for the platform re-location water maze
    Bechara J Saab
    Department of Molecular Genetics, Program in Neuroscience, University of Toronto, Canada
    J Neurosci Methods 198:44-52. 2011
  3. doi Memantine affects cognitive flexibility in the Morris water maze
    Bechara J Saab
    Department of Molecular and Medical Genetics, Program in Neuroscience, University of Toronto, Toronto, Canada
    J Alzheimers Dis 27:477-82. 2011
  4. ncbi Neuronal calcium sensor-1 modulation of optimal calcium level for neurite outgrowth
    Kwokyin Hui
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, M5S 1A8, Canada
    Development 134:4479-89. 2007
  5. pmc Nck adaptor proteins control the organization of neuronal circuits important for walking
    James P Fawcett
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 104:20973-8. 2007
  6. doi Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708
    Bechara J Saab
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Anesthesiology 113:1061-71. 2010
  7. doi Acute pharmacokinetics of memantine in the mouse
    Bechara J Saab
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Molecular Genetics and Program in Neuroscience, University of Toronto, Toronto, Ont, Canada saab hifo uzh ch
    Pharmacology 88:284-7. 2011

Collaborators

Detail Information

Publications7

  1. doi NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory
    Bechara J Saab
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Neuron 63:643-56. 2009
    ..These data demonstrate a role for NCS-1 and D2R in DG plasticity and provide insight for understanding how the DG contributes to the origin of exploration and spatial memory acquisition...
  2. doi Statistical and theoretical considerations for the platform re-location water maze
    Bechara J Saab
    Department of Molecular Genetics, Program in Neuroscience, University of Toronto, Canada
    J Neurosci Methods 198:44-52. 2011
    ....
  3. doi Memantine affects cognitive flexibility in the Morris water maze
    Bechara J Saab
    Department of Molecular and Medical Genetics, Program in Neuroscience, University of Toronto, Toronto, Canada
    J Alzheimers Dis 27:477-82. 2011
    ..Strikingly, subjects receiving memantine demonstrated memory impairment relative to controls when re-trained off drug, revealing a novel and unusual disruption of cognitive flexibility...
  4. ncbi Neuronal calcium sensor-1 modulation of optimal calcium level for neurite outgrowth
    Kwokyin Hui
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, M5S 1A8, Canada
    Development 134:4479-89. 2007
    ..We describe a model in which NCS-1 regulates cytosolic Ca2+ around the optimal window level to differentially control neurite extension and branching...
  5. pmc Nck adaptor proteins control the organization of neuronal circuits important for walking
    James P Fawcett
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 104:20973-8. 2007
    ..Our data indicate that Nck adaptors couple pTyr guidance signals to cytoskeletal events required for the ipsilateral projections of spinal cord neurons and thus for normal limb movement...
  6. doi Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptor inverse agonist L-655,708
    Bechara J Saab
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Anesthesiology 113:1061-71. 2010
    ..We postulated that inhibiting the activity of α5GABAA receptors during isoflurane anesthesia would prevent memory deficits in the early postanesthesia period...
  7. doi Acute pharmacokinetics of memantine in the mouse
    Bechara J Saab
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and Department of Molecular Genetics and Program in Neuroscience, University of Toronto, Toronto, Ont, Canada saab hifo uzh ch
    Pharmacology 88:284-7. 2011
    ..The data help shed light on the mechanism of memantine action in vivo, and demonstrate that subcutaneous doses above 10 mg/kg in the mouse are most likely not therapeutically relevant to the human...