Quercetin pretreatment increases the bioavailability of pioglitazone in rats: involvement of CYP3A inhibitionSudhir N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj RTM Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur 440 033, India
Biochem Pharmacol 75:1670-6. 2008
..In conclusion, add-on preparations containing quercetin may increase the bioavailability of pioglitazone, and hence should be cautiously used...
- Gonadotropin-releasing hormone agonist blocks anxiogenic-like and depressant-like effect of corticotrophin-releasing hormone in mice
S N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, Maharashtra, India
Neuropeptides 42:399-410. 2008
..v.), or d-Trp-6-LHRH (20 ng/mouse, i.c.v.) also produced significant anxiolytic- and antidepressant-like effect. These observations suggest reciprocating role of GnRH in modulating the CRF induced anxiogenic- and depressant-like effects...
- Differential effects of acute morphine, and chronic morphine-withdrawal on obsessive-compulsive behavior: inhibitory influence of CRF receptor antagonists on chronic morphine-withdrawal
S N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440033, Maharashtra, India
Neuropeptides 46:217-21. 2012
..c.v.) along with morphine blocked the morphine-withdrawal associated exacerbation of OCB. These results indicate that OCB associated with morphine withdrawal state is partly mediated by the activation of central CRF receptors...
- Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor
Sudhir N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur 440033, Maharastra, India
Neuropharmacology 62:2024-33. 2012
..Thus, the study indicates the biphasic influence of anandamide on MBB, and chronic administration of capsazepine either alone or with URB597 might be an effective tool in the treatment of OCD...
- Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice
Sudhir N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Nagpur 440033, Maharastra, India
Behav Brain Res 223:125-34. 2011
..None of the treatments had any influence on locomotor activity. Thus, the study indicates an interaction between endocannabinoid and serotonergic system in regulation of depressive and compulsive-like behavior...
- Role of nitric oxide in obsessive-compulsive behavior and its involvement in the anti-compulsive effect of paroxetine in mice
S N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotibha Fuley Parisar, Nagpur 440 033, India
Nitric Oxide 21:140-7. 2009
..In conclusion, obsessive compulsive behavior in mice appears related to nitric oxide in brain, and anti-compulsive effect of paroxetine appears to be related to decrease central levels of nitric oxide...
- Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors
Sudhir N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Nagpur, MS 440033, India
Prog Neuropsychopharmacol Biol Psychiatry 33:1191-9. 2009
..In conclusion, the findings suggested that acetaminophen (50, 100, or 200 mg/kg, i.p.) exhibited dose dependent anxiolytic effect in mice and probably involved endocannabinoid-mediated mechanism in its effect...
- Neurosteroids modulate compulsive and persistent behavior in rodents: implications for obsessive-compulsive disorder
Umathe S N
University Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur, MS 440 033, India
Prog Neuropsychopharmacol Biol Psychiatry 33:1161-6. 2009
..p.) had an opposite effect. In conclusion, the studies indicate that neurosteroids can modulate obsessive-compulsive behavior in a bidirectional manner, and could serve as an effective target in the management of OCD...
- A possible participation of gonadotropin-releasing hormone in the neuroleptic and cataleptic effect of haloperidol
S N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur, Maharashtra 440 033, India
Neuropeptides 43:251-7. 2009
..In conclusion, the studies suggest a possible role of GnRH in the neuroleptic and cataleptic effect of haloperidol...
- The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice
Sudhir N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India
Behav Pharmacol 20:78-83. 2009
..Therefore, the results raise the possibility that ondansetron blocked the development and expression of ethanol-induced locomotor sensitization by acting on 5-HT3 receptors...
- Gastrointestinal dysfunction in diabetic rats relates with a decline in tissue L-arginine content and consequent low levels of nitric oxide
S N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra 440 033, India
Nitric Oxide 20:129-33. 2009
..However, extensive clinical investigations are necessary to recommend the use of L-arginine for the treatment of GI dysfunctions in diabetes...
- Effects of central administration of gonadotropin-releasing hormone agonists and antagonist on elevated plus-maze and social interaction behavior in rats
Sudhir N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India
Behav Pharmacol 19:308-16. 2008
....
- Increased marble-burying behavior in ethanol-withdrawal state: modulation by gonadotropin-releasing hormone agonist
Sudhir Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440033, Maharashtra, India
Eur J Pharmacol 587:175-80. 2008
..p.). In conclusion, ethanol-withdrawal on chronic administration increases marble-burying behavior in mice; its development and expression is attenuated by leuprolide...
- Leuprolide: a luteinizing hormone releasing hormone agonist attenuates ethanol withdrawal syndrome and ethanol-induced locomotor sensitization in mice
S N Umathe
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India
Neuropeptides 42:345-53. 2008
..In conclusion, the present study demonstrated that leuprolide treatment attenuates expression and development of ethanol dependence and sensitization in mice...
Leuprolide--a GnRH agonist--prevents restraint stress-induced immunosuppression via sex steroid-independent peripheral mechanism in miceS N Umathe
University Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur 440 033 MS, India
Int Immunopharmacol 8:71-9. 2008
..Thus, the investigations revealed that leuprolide prevented stress-induced immunosuppression through a peripheral mechanism, which is independent of systemic sex steroids...
- Beneficial effects of L-arginine against diabetes-induced oxidative stress in gastrointestinal tissues in rats
Nitin I Kochar
University Department of Pharmaceutical Sciences, Rastrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur, Maharashtra 440033, India
Pharmacol Rep 61:665-72. 2009
..In addition, the study supports the beneficial effects of L-arginine. These effects might be attributed to its direct, NO-dependent antioxidant capacity and/or NO-independent pathways...
- Inhibitory influence of mecamylamine on the development and the expression of ethanol-induced locomotor sensitization in mice
Pravinkumar S Bhutada
Agnihotri College of Pharmacy, Pharmacology Division, Bapuji Wadi, Sindhi Meghe, Wardha 442 001, Maharashtra, India
Pharmacol Biochem Behav 96:266-73. 2010
..These results support the hypothesis that neuroadaptive changes in nAChRs may participate in the development and the expression of ethanol-induced locomotor sensitization...
