Umathe S N

Summary

Publications

  1. doi request reprint Quercetin pretreatment increases the bioavailability of pioglitazone in rats: involvement of CYP3A inhibition
    Sudhir N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj RTM Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur 440 033, India
    Biochem Pharmacol 75:1670-6. 2008
  2. doi request reprint Gonadotropin-releasing hormone agonist blocks anxiogenic-like and depressant-like effect of corticotrophin-releasing hormone in mice
    S N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, Maharashtra, India
    Neuropeptides 42:399-410. 2008
  3. doi request reprint Differential effects of acute morphine, and chronic morphine-withdrawal on obsessive-compulsive behavior: inhibitory influence of CRF receptor antagonists on chronic morphine-withdrawal
    S N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440033, Maharashtra, India
    Neuropeptides 46:217-21. 2012
  4. doi request reprint Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor
    Sudhir N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur 440033, Maharastra, India
    Neuropharmacology 62:2024-33. 2012
  5. doi request reprint Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice
    Sudhir N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Nagpur 440033, Maharastra, India
    Behav Brain Res 223:125-34. 2011
  6. doi request reprint Role of nitric oxide in obsessive-compulsive behavior and its involvement in the anti-compulsive effect of paroxetine in mice
    S N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotibha Fuley Parisar, Nagpur 440 033, India
    Nitric Oxide 21:140-7. 2009
  7. doi request reprint Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors
    Sudhir N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Nagpur, MS 440033, India
    Prog Neuropsychopharmacol Biol Psychiatry 33:1191-9. 2009
  8. doi request reprint Neurosteroids modulate compulsive and persistent behavior in rodents: implications for obsessive-compulsive disorder
    Umathe S N
    University Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur, MS 440 033, India
    Prog Neuropsychopharmacol Biol Psychiatry 33:1161-6. 2009
  9. doi request reprint A possible participation of gonadotropin-releasing hormone in the neuroleptic and cataleptic effect of haloperidol
    S N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur, Maharashtra 440 033, India
    Neuropeptides 43:251-7. 2009
  10. doi request reprint The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice
    Sudhir N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India
    Behav Pharmacol 20:78-83. 2009

Collaborators

Detail Information

Publications17

  1. doi request reprint Quercetin pretreatment increases the bioavailability of pioglitazone in rats: involvement of CYP3A inhibition
    Sudhir N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj RTM Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur 440 033, India
    Biochem Pharmacol 75:1670-6. 2008
    ..In conclusion, add-on preparations containing quercetin may increase the bioavailability of pioglitazone, and hence should be cautiously used...
  2. doi request reprint Gonadotropin-releasing hormone agonist blocks anxiogenic-like and depressant-like effect of corticotrophin-releasing hormone in mice
    S N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440 033, Maharashtra, India
    Neuropeptides 42:399-410. 2008
    ..v.), or d-Trp-6-LHRH (20 ng/mouse, i.c.v.) also produced significant anxiolytic- and antidepressant-like effect. These observations suggest reciprocating role of GnRH in modulating the CRF induced anxiogenic- and depressant-like effects...
  3. doi request reprint Differential effects of acute morphine, and chronic morphine-withdrawal on obsessive-compulsive behavior: inhibitory influence of CRF receptor antagonists on chronic morphine-withdrawal
    S N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440033, Maharashtra, India
    Neuropeptides 46:217-21. 2012
    ..c.v.) along with morphine blocked the morphine-withdrawal associated exacerbation of OCB. These results indicate that OCB associated with morphine withdrawal state is partly mediated by the activation of central CRF receptors...
  4. doi request reprint Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor
    Sudhir N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur 440033, Maharastra, India
    Neuropharmacology 62:2024-33. 2012
    ..Thus, the study indicates the biphasic influence of anandamide on MBB, and chronic administration of capsazepine either alone or with URB597 might be an effective tool in the treatment of OCD...
  5. doi request reprint Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice
    Sudhir N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Nagpur 440033, Maharastra, India
    Behav Brain Res 223:125-34. 2011
    ..None of the treatments had any influence on locomotor activity. Thus, the study indicates an interaction between endocannabinoid and serotonergic system in regulation of depressive and compulsive-like behavior...
  6. doi request reprint Role of nitric oxide in obsessive-compulsive behavior and its involvement in the anti-compulsive effect of paroxetine in mice
    S N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotibha Fuley Parisar, Nagpur 440 033, India
    Nitric Oxide 21:140-7. 2009
    ..In conclusion, obsessive compulsive behavior in mice appears related to nitric oxide in brain, and anti-compulsive effect of paroxetine appears to be related to decrease central levels of nitric oxide...
  7. doi request reprint Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors
    Sudhir N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Nagpur, MS 440033, India
    Prog Neuropsychopharmacol Biol Psychiatry 33:1191-9. 2009
    ..In conclusion, the findings suggested that acetaminophen (50, 100, or 200 mg/kg, i.p.) exhibited dose dependent anxiolytic effect in mice and probably involved endocannabinoid-mediated mechanism in its effect...
  8. doi request reprint Neurosteroids modulate compulsive and persistent behavior in rodents: implications for obsessive-compulsive disorder
    Umathe S N
    University Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur, MS 440 033, India
    Prog Neuropsychopharmacol Biol Psychiatry 33:1161-6. 2009
    ..p.) had an opposite effect. In conclusion, the studies indicate that neurosteroids can modulate obsessive-compulsive behavior in a bidirectional manner, and could serve as an effective target in the management of OCD...
  9. doi request reprint A possible participation of gonadotropin-releasing hormone in the neuroleptic and cataleptic effect of haloperidol
    S N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur, Maharashtra 440 033, India
    Neuropeptides 43:251-7. 2009
    ..In conclusion, the studies suggest a possible role of GnRH in the neuroleptic and cataleptic effect of haloperidol...
  10. doi request reprint The 5-HT3 receptor antagonist, ondansetron, blocks the development and expression of ethanol-induced locomotor sensitization in mice
    Sudhir N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India
    Behav Pharmacol 20:78-83. 2009
    ..Therefore, the results raise the possibility that ondansetron blocked the development and expression of ethanol-induced locomotor sensitization by acting on 5-HT3 receptors...
  11. doi request reprint Gastrointestinal dysfunction in diabetic rats relates with a decline in tissue L-arginine content and consequent low levels of nitric oxide
    S N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra 440 033, India
    Nitric Oxide 20:129-33. 2009
    ..However, extensive clinical investigations are necessary to recommend the use of L-arginine for the treatment of GI dysfunctions in diabetes...
  12. doi request reprint Effects of central administration of gonadotropin-releasing hormone agonists and antagonist on elevated plus-maze and social interaction behavior in rats
    Sudhir N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, India
    Behav Pharmacol 19:308-16. 2008
    ....
  13. doi request reprint Increased marble-burying behavior in ethanol-withdrawal state: modulation by gonadotropin-releasing hormone agonist
    Sudhir Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur 440033, Maharashtra, India
    Eur J Pharmacol 587:175-80. 2008
    ..p.). In conclusion, ethanol-withdrawal on chronic administration increases marble-burying behavior in mice; its development and expression is attenuated by leuprolide...
  14. doi request reprint Leuprolide: a luteinizing hormone releasing hormone agonist attenuates ethanol withdrawal syndrome and ethanol-induced locomotor sensitization in mice
    S N Umathe
    Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India
    Neuropeptides 42:345-53. 2008
    ..In conclusion, the present study demonstrated that leuprolide treatment attenuates expression and development of ethanol dependence and sensitization in mice...
  15. ncbi request reprint Leuprolide--a GnRH agonist--prevents restraint stress-induced immunosuppression via sex steroid-independent peripheral mechanism in mice
    S N Umathe
    University Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur 440 033 MS, India
    Int Immunopharmacol 8:71-9. 2008
    ..Thus, the investigations revealed that leuprolide prevented stress-induced immunosuppression through a peripheral mechanism, which is independent of systemic sex steroids...
  16. ncbi request reprint Beneficial effects of L-arginine against diabetes-induced oxidative stress in gastrointestinal tissues in rats
    Nitin I Kochar
    University Department of Pharmaceutical Sciences, Rastrasant Tukadoji Maharaj Nagpur University, Mahatma Jyotiba Fuley Shaikshanik Parisar, Amravati Road, Nagpur, Maharashtra 440033, India
    Pharmacol Rep 61:665-72. 2009
    ..In addition, the study supports the beneficial effects of L-arginine. These effects might be attributed to its direct, NO-dependent antioxidant capacity and/or NO-independent pathways...
  17. doi request reprint Inhibitory influence of mecamylamine on the development and the expression of ethanol-induced locomotor sensitization in mice
    Pravinkumar S Bhutada
    Agnihotri College of Pharmacy, Pharmacology Division, Bapuji Wadi, Sindhi Meghe, Wardha 442 001, Maharashtra, India
    Pharmacol Biochem Behav 96:266-73. 2010
    ..These results support the hypothesis that neuroadaptive changes in nAChRs may participate in the development and the expression of ethanol-induced locomotor sensitization...