James T Ryaby

Summary

Publications

  1. ncbi request reprint Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues
    James T Ryaby
    OrthoLogic Corp, 1275 West Washington Street, Tempe, AZ 85281, USA
    J Bone Joint Surg Am 88:132-9. 2006
  2. ncbi request reprint Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis
    Hali Wang
    Research and Development, OrthoLogic Corp, Tempe, AZ 85281, USA
    J Orthop Res 23:671-9. 2005
  3. ncbi request reprint Repair of rabbit segmental defects with the thrombin peptide, TP508
    Michael R Sheller
    Research and Development, OrthoLogic Corp, Tempe, AZ 85281, USA
    J Orthop Res 22:1094-9. 2004
  4. ncbi request reprint Bone formation is enhanced by thrombin-related peptide TP508 during distraction osteogenesis
    Gang Li
    Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Belfast BT9 7JB, UK
    J Orthop Res 23:196-202. 2005
  5. ncbi request reprint Early signals for fracture healing
    Xinmin Li
    Shanxi Agricultural University, Taigu, Shanxi, China 030801
    J Cell Biochem 95:189-205. 2005
  6. ncbi request reprint TP508 accelerates fracture repair by promoting cell growth over cell death
    Xinmin Li
    College of Animal Science and Technology, Shanxi Agricultural University, Taigu, Shanxi 030801, China
    Biochem Biophys Res Commun 364:187-93. 2007
  7. ncbi request reprint Thrombin peptide Chrysalin stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study
    Caroline Fife
    Department of Anesthesiology, University of Texas Health Science Center, Houston, Texas 77555 0645, USA
    Wound Repair Regen 15:23-34. 2007
  8. ncbi request reprint Combined magnetic fields accelerate and increase spine fusion: a double-blind, randomized, placebo controlled study
    Raymond J Linovitz
    San Dieguito Orthopaedics, Encinitas, California 92024, USA
    Spine (Phila Pa 1976) 27:1383-9; discussion 1389. 2002
  9. ncbi request reprint Genetic network and pathway analysis of differentially expressed proteins during critical cellular events in fracture repair
    Xinmin Li
    College of Animal Science and Technology, Shanxi Agricutural University, Taigu, Shanxi 030801, People s Republic of China
    J Cell Biochem 100:527-43. 2007
  10. ncbi request reprint Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair
    Charles H Rundle
    Musculoskeletal Disease Center, Jerry L Pettis V A Medical Center, Loma Linda, CA 92357, USA
    Bone 38:521-9. 2006

Collaborators

  • Darrell H Carney
  • John H Kinney
  • Hali Wang
  • Gang Li
  • S Mohan
  • Joseph Michael Lane
  • K H William Lau
  • J E Wergedal
  • Xinmin Li
  • Richard J Quigg
  • Yan Wang
  • Edward Touma
  • Caroline Fife
  • Emma Rousseau
  • Charles H Rundle
  • Keri B Vartanian
  • Michael R Sheller
  • Raymond J Linovitz
  • George Szoke
  • Chao Wan
  • Jeffery Stone
  • Kathleen Satterfield
  • Leon Brill
  • Jon T Mader
  • Amber Zwernemann
  • Andrea Norfleet
  • Yuchen Qi
  • Helen Y S Chen
  • Janelle Kennedy
  • Shaleen K Beck
  • Emile I Davis
  • K H William Lau
  • David J Baylink
  • Hongrun Yu
  • Robert B Chadwick
  • James B Hoying
  • Jian Zhou
  • Roger S Crowther
  • Tom Breunig
  • Sherry Di Jorio
  • Jinping Yang
  • Melvin D Law
  • Pasquale X Montesano
  • Daniel Green
  • Mini Pathria
  • Joel S Faden
  • Steven A Garfin
  • Glen Rechtine
  • Mark Bernhardt
  • Robert A McGuire
  • Regina Ponder
  • Frank P Magee
  • Richard M Salib
  • Larry R Muenz

Detail Information

Publications12

  1. ncbi request reprint Thrombin peptide TP508 stimulates cellular events leading to angiogenesis, revascularization, and repair of dermal and musculoskeletal tissues
    James T Ryaby
    OrthoLogic Corp, 1275 West Washington Street, Tempe, AZ 85281, USA
    J Bone Joint Surg Am 88:132-9. 2006
    ..Collectively, these studies suggest that TP508 accelerates tissue repair by initiating a cascade of events that lead to an increased rate of tissue revascularization and regeneration...
  2. ncbi request reprint Thrombin peptide (TP508) promotes fracture repair by up-regulating inflammatory mediators, early growth factors, and increasing angiogenesis
    Hali Wang
    Research and Development, OrthoLogic Corp, Tempe, AZ 85281, USA
    J Orthop Res 23:671-9. 2005
    ..This study therefore suggests that TP508 promotes fracture repair through a mechanism that involves an increased induction of a number of growth factors, enhanced expression of inflammatory mediators, and angiogenesis-related genes...
  3. ncbi request reprint Repair of rabbit segmental defects with the thrombin peptide, TP508
    Michael R Sheller
    Research and Development, OrthoLogic Corp, Tempe, AZ 85281, USA
    J Orthop Res 22:1094-9. 2004
    ..01 for both measures). These results suggest that TP508 in a controlled release delivery vehicle has the potential to enhance healing of segmental defects in both critically and non-critically sized defects...
  4. ncbi request reprint Bone formation is enhanced by thrombin-related peptide TP508 during distraction osteogenesis
    Gang Li
    Department of Trauma and Orthopaedic Surgery, Queen s University Belfast, Musgrave Park Hospital, Belfast BT9 7JB, UK
    J Orthop Res 23:196-202. 2005
    ..The findings indicate that TP508 may be useful in promoting osteogenesis in situations when augmentative treatment for bone formation and consolidation are needed...
  5. ncbi request reprint Early signals for fracture healing
    Xinmin Li
    Shanxi Agricultural University, Taigu, Shanxi, China 030801
    J Cell Biochem 95:189-205. 2005
    ..Knowledge acquired through this analysis of transcriptional activities at the early stage of bone healing will contribute to our understanding of fracture repair and bone-related pathological conditions...
  6. ncbi request reprint TP508 accelerates fracture repair by promoting cell growth over cell death
    Xinmin Li
    College of Animal Science and Technology, Shanxi Agricultural University, Taigu, Shanxi 030801, China
    Biochem Biophys Res Commun 364:187-93. 2007
    ..This appears to occur through the stimulation of several bone healing pathways including cell cycle-G1/S checkpoint regulation, apoptosis, JAK/STAT, NF-kappaB, PDGF, PI3K/AKT, PTEN, and ERK/MAPK...
  7. ncbi request reprint Thrombin peptide Chrysalin stimulates healing of diabetic foot ulcers in a placebo-controlled phase I/II study
    Caroline Fife
    Department of Anesthesiology, University of Texas Health Science Center, Houston, Texas 77555 0645, USA
    Wound Repair Regen 15:23-34. 2007
    ..These results indicate the potential safety and efficacy of Chrysalin for treatment of diabetic foot ulcers...
  8. ncbi request reprint Combined magnetic fields accelerate and increase spine fusion: a double-blind, randomized, placebo controlled study
    Raymond J Linovitz
    San Dieguito Orthopaedics, Encinitas, California 92024, USA
    Spine (Phila Pa 1976) 27:1383-9; discussion 1389. 2002
    ..The clinical study conducted was a prospective, randomized, double-blind, placebo-controlled trial...
  9. ncbi request reprint Genetic network and pathway analysis of differentially expressed proteins during critical cellular events in fracture repair
    Xinmin Li
    College of Animal Science and Technology, Shanxi Agricutural University, Taigu, Shanxi 030801, People s Republic of China
    J Cell Biochem 100:527-43. 2007
    ..The distinct changes in protein expression during these cellular events provide a molecular basis for developing cellular event-targeted therapeutic strategy to accelerate bone healing...
  10. ncbi request reprint Microarray analysis of gene expression during the inflammation and endochondral bone formation stages of rat femur fracture repair
    Charles H Rundle
    Musculoskeletal Disease Center, Jerry L Pettis V A Medical Center, Loma Linda, CA 92357, USA
    Bone 38:521-9. 2006
    ..These observations suggest that these genes might also regulate the scarless healing characteristic of bone regeneration by similar mechanisms...
  11. ncbi request reprint The non-proteolytically active thrombin peptide TP508 stimulates angiogenic sprouting
    Keri B Vartanian
    Division of Microcirculation, Arizona Research Laboratories, University of Arizona, Tucson, Arizona 85724, USA
    J Cell Physiol 206:175-80. 2006
    ..These results suggest that TP508 acts early in angiogenesis and directly on microvascular cells to accelerate sprouting, but not to induce more sprouting, in a manner different than the intact thrombin molecule...
  12. ncbi request reprint Local injection of thrombin-related peptide (TP508) in PPF/PLGA microparticles-enhanced bone formation during distraction osteogenesis
    Yan Wang
    Department of Orthopaedic Surgery, General Hospital of Chinese People s Liberation Army, Beijing 100853, People s Republic of China
    J Orthop Res 26:539-46. 2008
    ....