T S Zamolodchikova

Summary

Country: Russia

Publications

  1. ncbi request reprint Expression of duodenase-like protein in epitheliocytes of Brunner's glands in human duodenal mucosa
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 78:954-7. 2013
  2. doi request reprint Serine proteases in immune protection of the small intestine
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Biochemistry (Mosc) 78:213-20. 2013
  3. doi request reprint Serine proteases of small intestine mucosa--localization, functional properties, and physiological role
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, 117997 Moscow, Russia
    Biochemistry (Mosc) 77:820-9. 2012
  4. ncbi request reprint Subcellular localization, substrate specificity and crystallization of duodenase, a potential activator of enteropeptidase
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, Russia
    Eur J Biochem 249:612-21. 1997
  5. ncbi request reprint Effect of reactive center loop structure of antichymotrypsin on inhibition of duodenase activity
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 74:824-33. 2009
  6. ncbi request reprint Duodenase, a new serine protease of unusual specificity from bovine duodenal mucosa. Primary structure of the enzyme
    T S Zamolodchikova
    Laboratory of Proteolytic Enzymes Chemistry, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
    Eur J Biochem 227:873-9. 1995
  7. ncbi request reprint Cloning and molecular modeling of duodenase with respect to evolution of substrate specificity within mammalian serine proteases that have lost a conserved active-site disulfide bond
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, 117997 Moscow, Russia
    Biochemistry (Mosc) 70:672-84. 2005
  8. ncbi request reprint Interaction between duodenase and alpha1-proteinase inhibitor
    I P Gladysheva
    Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 66:682-7. 2001
  9. ncbi request reprint Comparative study of the action of bovine duodenal proteinases (duodenases) on polypeptide substrates
    E A Sokolova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117871 Russia
    Biochemistry (Mosc) 66:62-7. 2001
  10. ncbi request reprint Activation of recombinant proenteropeptidase by duodenase
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
    FEBS Lett 466:295-9. 2000

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Expression of duodenase-like protein in epitheliocytes of Brunner's glands in human duodenal mucosa
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 78:954-7. 2013
    ..These data indicate the presence of a protein immunologically similar to duodenase in the human duodenal mucosa. Our study demonstrated the absence of its co-localization with cathepsin G in Brunner's glands. ..
  2. doi request reprint Serine proteases in immune protection of the small intestine
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Biochemistry (Mosc) 78:213-20. 2013
    ....
  3. doi request reprint Serine proteases of small intestine mucosa--localization, functional properties, and physiological role
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, 117997 Moscow, Russia
    Biochemistry (Mosc) 77:820-9. 2012
    ..They participate in renewal and remodeling of tissues, retractive activity of smooth musculature, hormonal regulation, and defense mechanisms of the intestine...
  4. ncbi request reprint Subcellular localization, substrate specificity and crystallization of duodenase, a potential activator of enteropeptidase
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, Russia
    Eur J Biochem 249:612-21. 1997
    ..4 s[-1]; k[cat]/Km of 16000 M[-1] s[-1]). Crystals of duodenase frozen in a stream of liquid nitrogen diffracted synchrotron X-rays to 0.2-nm resolution...
  5. ncbi request reprint Effect of reactive center loop structure of antichymotrypsin on inhibition of duodenase activity
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 74:824-33. 2009
    ..Constants of inhibition (K(i)) were measured. Efficacy of interaction between the enzyme (duodenase) and inhibitor depends on topochemical correspondence between a substrate-binding pocket of the enzyme and substrate structure...
  6. ncbi request reprint Duodenase, a new serine protease of unusual specificity from bovine duodenal mucosa. Primary structure of the enzyme
    T S Zamolodchikova
    Laboratory of Proteolytic Enzymes Chemistry, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
    Eur J Biochem 227:873-9. 1995
    ..These results are discussed with respect to the relation between the duodenase unique residues within the primary specificity pocket S1 and the unusual dual specificity of the enzyme...
  7. ncbi request reprint Cloning and molecular modeling of duodenase with respect to evolution of substrate specificity within mammalian serine proteases that have lost a conserved active-site disulfide bond
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, 117997 Moscow, Russia
    Biochemistry (Mosc) 70:672-84. 2005
    ..We conclude that the marked selectivity of granases that is crucial to their role as regulatory proteases has evolved through the fine-tuning of specificity at three levels--primary, secondary, and conformational...
  8. ncbi request reprint Interaction between duodenase and alpha1-proteinase inhibitor
    I P Gladysheva
    Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 66:682-7. 2001
    ..3).105 M-1.sec-1, respectively. Based on the association rate constant of the enzyme-inhibitor complex and localization of duodenase and alpha1-PI in identical compartments, alpha1-PI is suggested to be a duodenase inhibitor in vivo...
  9. ncbi request reprint Comparative study of the action of bovine duodenal proteinases (duodenases) on polypeptide substrates
    E A Sokolova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117871 Russia
    Biochemistry (Mosc) 66:62-7. 2001
    ..The kinetic parameters of angiotensinogen fragment 1-14 cleavage by ChlD and dsD were determined (k(cat)/K(m) = 80,500 M(-1) x sec(-1) for ChlD and 103,000 M(-1) x sec(-1) for dsD)...
  10. ncbi request reprint Activation of recombinant proenteropeptidase by duodenase
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
    FEBS Lett 466:295-9. 2000
    ..A new scheme of proteolytic activation cascade of digestive proteases is discussed...
  11. ncbi request reprint Interaction between human alpha2-macroglobulin and duodenase, a serine proteinase with dual specificity
    O O Denisenko
    Department of Chemical Enzymology, Faculty of Chemistry, Lomonosov Moscow State University, Moscow, 119992, Russia
    Biochemistry (Mosc) 71:658-66. 2006
    ..Based on the association rate constant and the termination time of the duodenase and alpha(2)-MG in vivo association, alpha(2)-MG is suggested to be a physiological regulator of the enzyme...
  12. ncbi request reprint Graspases--a special group of serine proteases of the chymotrypsin family that has lost a conserved active site disulfide bond
    T S Zamolodchikova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia
    Biochemistry (Mosc) 68:309-16. 2003
    ..The correctness of the proposed classification was confirmed by phylogenic analysis...
  13. ncbi request reprint Crystal structure of bovine duodenase, a serine protease, with dual trypsin and chymotrypsin-like specificities
    V Z Pletnev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences Ul, Miklukho Maklaya, Moscow, Russia
    Proteins 41:8-16. 2000
    ..The determination of structural features associated with functional variation in the enzyme family may permit design of enzymes with a specific ratio of trypsin and chymotrypsin activities...
  14. ncbi request reprint Duodenase, a new serine protease of unusual specificity from bovine duodenal mucosa. Purification and properties
    T S Zamolodchikova
    Laboratory of Proteolytic Enzymes Chemistry, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
    Eur J Biochem 227:866-72. 1995
    ..The biological role of duodenase is discussed...