E D Sverdlov

Summary

Country: Russia

Publications

  1. ncbi Retroviruses and primate evolution
    E D Sverdlov
    Institute of Molecular Genetics RAS, Kurchatov Sq, 123182 Moscow, Russia
    Bioessays 22:161-71. 2000
  2. ncbi [Retroviral regulators of gene expression in the human genome as possible factors for its evolution]
    E D Sverdlov
    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia
    Bioorg Khim 25:821-7. 1999
  3. doi Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter
    D A Didych
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia
    Gene 515:34-41. 2013
  4. ncbi Assay of insulator enhancer-blocking activity with the use of transient transfection
    N A Smirnov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 78:895-903. 2013
  5. ncbi Enhancer element potentially involved in human survivin gene promoter regulation in lung cancer cell lines
    M V Mityaev
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 75:182-91. 2010
  6. doi Functional dissection of an enhancer-like element located within the second intron of the human U2AF1L4 gene
    D A Didych
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 76:951-7. 2011
  7. ncbi Differences in HERV-K LTR insertions in orthologous loci of humans and great apes
    Y B Lebedev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya St, Moscow, Russia
    Gene 247:265-77. 2000
  8. ncbi Long terminal repeats of human endogenous retrovirus K family (HERV-K) specifically bind host cell nuclear proteins
    S B Akopov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
    FEBS Lett 421:229-33. 1998
  9. ncbi Identification of paralogous HERV-K LTRs on human chromosomes 3, 4, 7 and 11 in regions containing clusters of olfactory receptor genes
    E V Nadezhdin
    Laboratory of Human Genes Structure and Functions, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
    Mol Genet Genomics 265:820-5. 2001
  10. ncbi Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development
    M V Zinovyeva
    Laboratory of Structure and Functions of Human Genes, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Dis Esophagus 23:260-70. 2010

Collaborators

  • M V Shepelev
  • O D Ermolaeva
  • N D Abrarova
  • G T Sukhikh
  • S B Akopov
  • M V Zinovyeva
  • M V Mityaev
  • A A Buzdin
  • D V Glazkova
  • D A Didych
  • L G Nikolaev
  • N A Smirnov
  • O S Bychenko
  • T L Azhikina
  • E S Kotova
  • T V Vinogradova
  • Y B Lebedev
  • E P Kopantzev
  • L V Sukhanova
  • Y V Skvortsova
  • A E Illarionova
  • S G Kurdyukov
  • T V Chalaya
  • E V Snezhkov
  • N Y Uspenskaya
  • M F Shamsutdinov
  • G S Monastyrskaya
  • I V Sorokina
  • E V Nadezhdin
  • I I Artamonova
  • G Hunsmann
  • M Pikunov
  • I B Zborovskaya
  • M R Kopantseva
  • N A Vayshlya
  • V I Egorov
  • L L Zavalova
  • N V Skaptsova
  • T A Skvortsov
  • V K Potapov
  • S S Ukolova
  • E A Stukacheva
  • I P Arman
  • I Z Mamedov
  • A V Batrak
  • K Gardiner
  • S P Legchilina
  • T N Gorodentseva
  • D Bornholdt
  • K H Grzeschik
  • I G Efimenko
  • S A Lukyanov
  • O S Belonovitch
  • V A Nesmeyanov
  • A V Sass
  • D G Kozlov
  • V I Kiseleva
  • I P Baskova
  • P P Khil
  • S V Benevolensky
  • N V Zybrova
  • A M Poverenny
  • V S Archipova

Detail Information

Publications27

  1. ncbi Retroviruses and primate evolution
    E D Sverdlov
    Institute of Molecular Genetics RAS, Kurchatov Sq, 123182 Moscow, Russia
    Bioessays 22:161-71. 2000
    ..BioEssays 22:161-171, 2000...
  2. ncbi [Retroviral regulators of gene expression in the human genome as possible factors for its evolution]
    E D Sverdlov
    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia
    Bioorg Khim 25:821-7. 1999
    ..Human endogenous viruses, including their possible role in evolution, are reviewed...
  3. doi Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter
    D A Didych
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia
    Gene 515:34-41. 2013
    ..Concerted transcription of PSENEN and U2AF1L4 can be necessary for regulation of T-cell activity...
  4. ncbi Assay of insulator enhancer-blocking activity with the use of transient transfection
    N A Smirnov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 78:895-903. 2013
    ..Thus, the transfection model may be used for quantitative analysis of the enhancer-blocking activity of the potential insulators. ..
  5. ncbi Enhancer element potentially involved in human survivin gene promoter regulation in lung cancer cell lines
    M V Mityaev
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 75:182-91. 2010
    ..The data provide another possibility to increase survivin promoter activity without changing its cancer specificity for application in cancer (in particular, lung cancer) gene therapy...
  6. doi Functional dissection of an enhancer-like element located within the second intron of the human U2AF1L4 gene
    D A Didych
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 76:951-7. 2011
    ..The ability of orthologous primate sequences to compete with enhancer 12 for binding with HeLa cell nuclear extract proteins and to enhance the activity of the reporter gene in transient transfection of HeLa cells is demonstrated...
  7. ncbi Differences in HERV-K LTR insertions in orthologous loci of humans and great apes
    Y B Lebedev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya St, Moscow, Russia
    Gene 247:265-77. 2000
    ..Human-specific integrations for some very young LTRs were demonstrated. The possibility of LTRs and HERVs involvement in the evolution of primates is discussed...
  8. ncbi Long terminal repeats of human endogenous retrovirus K family (HERV-K) specifically bind host cell nuclear proteins
    S B Akopov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
    FEBS Lett 421:229-33. 1998
    ..This binding site is located in the 5' region of the LTR U3 element. The preservation of the specific protein binding site in different HERV-K LTR sequences suggests their possible role in regulation of nearby located genes...
  9. ncbi Identification of paralogous HERV-K LTRs on human chromosomes 3, 4, 7 and 11 in regions containing clusters of olfactory receptor genes
    E V Nadezhdin
    Laboratory of Human Genes Structure and Functions, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
    Mol Genet Genomics 265:820-5. 2001
    ..2) Insertion of the LTR (most probably as a provirus) into this ancestral locus took place 13 Mya. (3) Duplication of the LTR-containing ancestral locus occurred 11 Mya, forming the paralogous modern loci on Chr 3 and 7...
  10. ncbi Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development
    M V Zinovyeva
    Laboratory of Structure and Functions of Human Genes, Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Dis Esophagus 23:260-70. 2010
    ..This tumor 'embryonization' supports the idea that stem or progenitor cells are implicated in esophageal cancer emergence...
  11. ncbi Studies on functional role of DNA methylation within the FXYD5-COX7A1 region of human chromosome 19
    Y V Skvortsova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 74:874-81. 2009
    ..In total, our data provide new evidence for the necessity of revising currently prevailing views on the functional significance of methyl groups in genomic DNA...
  12. ncbi Identification and mapping of ten new potential insulators in the FXYD5-COX7A1 region of human chromosome 19q13.12
    D A Didych
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 74:728-33. 2009
    ..Relative positions of insulators and genes are in accord with the hypothesis that insulators subdivide genomic DNA into independently regulated loop domains...
  13. ncbi [Functional analysis of the HERV-K LTR residing in the KIAA1245/NBPF subfamily]
    N D Abrarova
    Shemy akin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Mol Biol (Mosk) 44:627-34. 2010
    ..The data obtained are in line with the hypothesis suggesting that KIAA1245/NBPF LTR may affect the regulation of the KIAA1245/NBPF subfamily genes transcription...
  14. ncbi Only those genes of the KIAA1245 gene subfamily that contain HERV(K) LTRs in their introns are transcriptionally active
    A E Illarionova
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, Moscow 117997, Russia
    Virology 358:39-47. 2007
    ..The expression of the LTR-containing genes in embryonic tissues might suggest their involvement in evolutionary events during primate speciation...
  15. ncbi Expression of chicken CTCF gene in COS-1 cells and partial purification of CTCF protein
    E S Kotova
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 78:879-83. 2013
    ..The expressed protein localized in the cell nucleus and was shown to be functionally active in the electrophoretic mobility shift assay and specifically interacted with anti-CTCF antibodies. ..
  16. ncbi Perpetually mobile footprints of ancient infections in human genome
    E D Sverdlov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
    FEBS Lett 428:1-6. 1998
    ..This review describes the integration specificity and distribution of the HERVs and LTRs in the human genome and discusses possible functional consequences of their integration in the vicinity of genes...
  17. pmc Cellular and molecular phenotypes of proliferating stromal cells from human carcinomas
    E P Kopantzev
    M M Shemyakin and Yu A Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia
    Br J Cancer 102:1533-40. 2010
    ..Stromal cells are a functionally important component of human carcinomas. The aim of this study was to obtain and characterise primary cultures of stromal cells from human carcinomas and the corresponding surrounding normal tissue...
  18. ncbi Full-sized HERV-K (HML-2) human endogenous retroviral LTR sequences on human chromosome 21: map locations and evolutionary history
    S G Kurdyukov
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, 16/10 Miklukho-Maklaya, Moscow, 117871, Russia
    Gene 273:51-61. 2001
    ..As evidenced in previous studies of chromosomes 19 and 22, this is a characteristic of HERV-K integration...
  19. pmc Vertebrate Protein CTCF and its Multiple Roles in a Large-Scale Regulation of Genome Activity
    L G Nikolaev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, 117997, Moscow, Russia
    Curr Genomics 10:294-302. 2009
    ....
  20. ncbi [Differential expression of DTSsa4 Tc1-like transposons in closely related populations of Baikal ciscoes.]
    O S Bychenko
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, Moscow, 117997 Russia
    Bioorg Khim 35:853-6. 2009
    ..Probably, Tc1-like transposons affect the activity of neighboring genes, providing the adaptive divergence of the cisco population...
  21. ncbi Destabilase from the medicinal leech is a representative of a novel family of lysozymes
    L L Zavalova
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117871, Moscow, Russia
    Biochim Biophys Acta 1478:69-77. 2000
    ..It remains to be investigated whether the two enzymatic activities (isopeptidase and lysozyme-like) are attributes of one and the same protein...
  22. ncbi The mathematical model of subtractive hybridization and its practical application
    O D Ermolaeva
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, Russia
    Proc Int Conf Intell Syst Mol Biol 4:52-8. 1996
    ..The method was applied to studies of the genetic mechanisms of embryogenesis, regeneration, cell differentiation and tumor transformation...
  23. ncbi Functional significance of a putative sp1 transcription factor binding site in the survivin gene promoter
    M V Mityaev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 73:1183-91. 2008
    ..Mutation within this sequence led to a sharp decrease of promoter activity. The functional architecture of the survivin promoter is discussed based on results known from the literature and those obtained here...
  24. ncbi Application of mRNA regulatory regions to improve tumor specificity of transgene expression
    M V Shepelev
    Department of Cancer Gene Therapy, Institute of Gene Biology, Russian Academy of Sciences, Moscow
    Cancer Gene Ther 18:682-4. 2011
    ..We showed that DNMT1 and to the lesser extent TOP2A 3'-UTR do not alter significantly therapeutic transgene expression level in tumor cells, thus, confirming the functionality of the proposed approach...
  25. ncbi Tissue specificity of methylation of cytosines in regulatory regions of four genes located in the locus FXYD5-COX7A1 of human chromosome 19: correlation with their expression level
    T V Chalaya
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow
    Biochemistry (Mosc) 71:294-9. 2006
    ....
  26. ncbi [Nucleotide sequences of long terminal repeats of the human endogenous retrovirus (LTR HERV-K) on the short arm of chromosome 7: identification, analysis and evaluation of transcriptional activity]
    D V Glazkova
    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182 Russia
    Genetika 39:702-8. 2003
    ..All three DNA fragments containing solitary LTRs were transcribed in normal germline cells (testicular parenchyma tissue). The differences in the expression of these clones in the germline tumor cells (seminoma) were observed...
  27. ncbi [Genome similarity of Baikal omul and sig.]
    O S Bychenko
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, Moscow, 117997, Russia
    Bioorg Khim 35:95-102. 2009
    ..This is another endorsement of the hypothesis on the close relationship between Baikal sig and omul and their evolutionarily recent divergence from a common ancestor...