Lev Berstein


Affiliation: St. Petersburg
Country: Russia


  1. Berstein L. Dark and light side of obesity: mortality of metabolically healthy obese people. Expert Rev Endocrinol Metab. 2012;7:629-632 pubmed publisher
    ..By adding new information to the data collected previously, this important paper calls for further clarifications, including an analysis of mortality in cancer and diabetic patients with various obesity types. ..
  2. request reprint
    Berstein L, Tsyrlina E, Kolesnik O, Gamajunova V, Adlercreutz H. Catecholestrogens excretion in smoking and non-smoking postmenopausal women receiving estrogen replacement therapy. J Steroid Biochem Mol Biol. 2000;72:143-7 pubmed
  3. Berstein L. Endocrinology of the wild and mutant BRCA1 gene and types of hormonal carcinogenesis. Future Oncol. 2008;4:23-39 pubmed publisher
  4. request reprint
    Berstein L. Role of endocrine-genotoxic switchings in cancer and other human diseases: basic triad. Adv Exp Med Biol. 2008;630:35-51 pubmed
    ..The measures to correct components of the 'triad' can be divided into several groups aimed to optimally orchestrate the balance between endocrine and DNA-damagingeffects of estrogens, glucose and adipose tissue-related factors. ..
  5. Berstein L, Pozharisski K, Imyanitov E, Maximova N, Kovalevskij A. Aromatase, CYP1B1 and fatty acid synthase expression in breast tumors of BRCA1 mutation carriers. Pathol Oncol Res. 2009;15:407-9 pubmed publisher
  6. request reprint
    Berstein L. [Endocrinology of cancer and age: early and late stages of ontogenesis]. Adv Gerontol. 2017;30:177-191 pubmed
  7. request reprint
    Berstein L, Tchernobrovkina A, Gamajunova V, Kovalevskij A, Vasilyev D, Chepik O, et al. Tumor estrogen content and clinico-morphological and endocrine features of endometrial cancer. J Cancer Res Clin Oncol. 2003;129:245-9 pubmed
    ..The role of local estrogen production (aromatase activity) in this setting deserves special study. ..
  8. Berstein L, Poroshina T, Kovalenko I, Vasilyev D. Serum Levels of 8-Hydroxy-2'-Deoxyguanosine DNA in Patients with Breast Cancer and Endometrial Cancer with and without Diabetes Mellitus. Bull Exp Biol Med. 2016;161:547-9 pubmed publisher
    ..The causes of the trend to a less favorable course of tumor process in patients with breast cancer and diabetes in comparison with endometrial cancer and diabetes deserve further studies. ..
  9. Berstein L, Yue W, Wang J, Santen R. Isolated and combined action of tamoxifen and metformin in wild-type, tamoxifen-resistant, and estrogen-deprived MCF-7 cells. Breast Cancer Res Treat. 2011;128:109-17 pubmed publisher
    ..The cellular context (including loss of sensitivity to TAM and estrogen deprivation) is of importance in influencing breast cancer responses to MF and to a combination of MF and TAM. ..

More Information


  1. Berstein L. Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond. Future Oncol. 2010;6:1313-23 pubmed publisher
  2. Berstein L. Metformin in obesity, cancer and aging: addressing controversies. Aging (Albany NY). 2012;4:320-9 pubmed
    ..Here we discuss whether the discrepancies in different studies are merely methodological or inherently related to individual differences in responsiveness to the drug. ..
  3. request reprint
    Berstein L, Boyarkina M, Vasilyev D, Poroshina T, Kovalenko I, Imyanitov E, et al. Endocrine metabolic disorders in patients with breast cancer, carriers of BRCA1 gene mutations. Bull Exp Biol Med. 2012;152:610-2 pubmed
    ..BRCA1 gene mutations in breast cancer patients were associated with signs of estrogenization and a pro-genotoxic shift in the estrogen and glucose system, which could modulate the disease course and requires correction. ..
  4. request reprint
    Berstein L, Imyanitov E, Suspitsin E, Grigoriev M, Sokolov E, Togo A, et al. CYP19 gene polymorphism in endometrial cancer patients. J Cancer Res Clin Oncol. 2001;127:135-8 pubmed
    ..Thus, CYP19 polymorphism might be one of the genetic risk factors for endometrial cancer development. ..
  5. request reprint
    Berstein L, Imyanitov E, Kovalevskij A, Maximov S, Vasilyev D, Buslov K, et al. CYP17 and CYP19 genetic polymorphisms in endometrial cancer: association with intratumoral aromatase activity. Cancer Lett. 2004;207:191-6 pubmed
    ..Further studies are warranted to connect revealed regularities with the type I or II of EC. ..
  6. request reprint
    Berstein L, Koskela A, Boyarkina M, Adlercreutz H. Excretion of estrogens, catecholestrogens and phytoestrogens in carriers of BRCA1 gene mutations: effects of metformin. Neoplasma. 2010;57:333-8 pubmed