Lev Berstein

Summary

Affiliation: St. Petersburg
Country: Russia

Publications

  1. doi request reprint Serum Levels of 8-Hydroxy-2'-Deoxyguanosine DNA in Patients with Breast Cancer and Endometrial Cancer with and without Diabetes Mellitus
    L M Berstein
    N N Petrov Institute of Oncology, Ministry of Health of the Russian Federation, St Petersburg, Russia
    Bull Exp Biol Med 161:547-9. 2016
  2. ncbi request reprint Induction of the estrogen effect-switching phenomenon by ethanol and its correction
    L M Bershtein
    Professor N N Petrov Science Research Institute of Oncology, Ministry of Health of the Russian Federation, 68 Leningradskaya Street, Pesochnyi 2, 189646 St Petersburg, Russia
    Neurosci Behav Physiol 32:603-7. 2002
  3. ncbi request reprint CHEK2 1100delC mutation is frequent among Russian breast cancer patients
    Elena V Chekmariova
    N N Petrov Institute of Oncology, St Petersburg, Russia
    Breast Cancer Res Treat 100:99-102. 2006
  4. pmc Genetic polymorphisms potentially associated with response to metformin in postmenopausal diabetics suffering and not suffering with cancer
    Lev M Berstein
    Laboratory of Oncoendocrinology N N Petrov Research Institute of Oncology St Petersburg, Russia
    Cell Cycle 12:3681-8. 2013
  5. ncbi request reprint Rapid determination of Epstein-Barr virus latent or lytic infection in single human cells using in situ hybridization
    Elena E Leenman
    Research Institute of Radiology and Roentgenology, St Petersburg, Russia
    Mod Pathol 17:1564-72. 2004
  6. doi request reprint Cancer endocrinology through own experience: areas for further thought and development
    Lev M Berstein
    Laboratory Oncoendocrinology, NN Petrov Research Institute of Oncology, Pesochny, St Petersburg, 197758, Russia
    Future Oncol 9:933-7. 2013
  7. doi request reprint Cancer and heterogeneity of obesity: a potential contribution of brown fat
    Lev M Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, St Petersburg 197758, Russia
    Future Oncol 8:1537-48. 2012
  8. pmc Metformin in obesity, cancer and aging: addressing controversies
    Lev M Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Aging (Albany NY) 4:320-9. 2012
  9. ncbi request reprint Endocrine metabolic disorders in patients with breast cancer, carriers of BRCA1 gene mutations
    L M Berstein
    N N Petrov Institute of Oncology, Ministry of Health and Social Development of the Russian Federation, St Petersburg, Russia
    Bull Exp Biol Med 152:610-2. 2012
  10. doi request reprint Familial diabetes is associated with reduced risk of cancer in diabetic patients: a possible role for metformin
    Lev M Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, Pesochny 2, St, 197758 Petersburg, Russia
    Med Oncol 29:1308-13. 2012

Collaborators

  • Vladimir N Anisimov
  • H Adlercreutz
  • A A Larionov
  • Pascal Pujol
  • Jos H H Thijssen
  • Wei Yue
  • Richard Santen
  • ANATOLIY YASHIN
  • Evgeny N Imyanitov
  • M Provinciali
  • Ji Ping Z Wang
  • C Franceschi
  • Vladimir F Semiglazov
  • Elena V Chekmariova
  • Alexandr V Togo
  • Konstantin G Buslov
  • Elena E Leenman
  • Evgeny N Suspitsin
  • L M Bershtein
  • Garik A Dashyan
  • Alla A Bozhok
  • Olga A Melnikova
  • Vladislav V Semiglazov
  • Ruslan M Paltuev
  • Vadim G Ivanov
  • Elena K Ziltsova
  • Alexander Kletzel
  • Yulia M Ulibina
  • Natalia V Mitiushkina
  • Dmitry A Voskresenskiy
  • Peter Devilee
  • Dmitry E Matsko
  • Anna P Sokolenko
  • Cees Cornelisse
  • Aglaya G Iyevleva
  • Oleg L Chagunava
  • Maxim E Rozanov
  • Renate E Panzer-Grümayer
  • Heather A Leitch
  • Helmut Gadner
  • Susanna Fischer
  • Peter F Ambros
  • Valia S Lestou
  • Thomas Lion
  • Douglas E Horsman
  • Maxim Yu Grigoriev
  • Kaido P Hanson
  • Kazymir M Pozharisski
  • Julia M Ulibina
  • Victoria M Gorodinskaya
  • Julia G Ishutkina
  • N V Bychkova
  • E V Tsyrlina
  • T E Poroshina
  • D A Vasil'ev
  • I G Kovalenko
  • V B Gamayunova
  • N M Kalinina
  • O G Kryukova

Detail Information

Publications46

  1. doi request reprint Serum Levels of 8-Hydroxy-2'-Deoxyguanosine DNA in Patients with Breast Cancer and Endometrial Cancer with and without Diabetes Mellitus
    L M Berstein
    N N Petrov Institute of Oncology, Ministry of Health of the Russian Federation, St Petersburg, Russia
    Bull Exp Biol Med 161:547-9. 2016
    ..The causes of the trend to a less favorable course of tumor process in patients with breast cancer and diabetes in comparison with endometrial cancer and diabetes deserve further studies. ..
  2. ncbi request reprint Induction of the estrogen effect-switching phenomenon by ethanol and its correction
    L M Bershtein
    Professor N N Petrov Science Research Institute of Oncology, Ministry of Health of the Russian Federation, 68 Leningradskaya Street, Pesochnyi 2, 189646 St Petersburg, Russia
    Neurosci Behav Physiol 32:603-7. 2002
    ....
  3. ncbi request reprint CHEK2 1100delC mutation is frequent among Russian breast cancer patients
    Elena V Chekmariova
    N N Petrov Institute of Oncology, St Petersburg, Russia
    Breast Cancer Res Treat 100:99-102. 2006
    ....
  4. pmc Genetic polymorphisms potentially associated with response to metformin in postmenopausal diabetics suffering and not suffering with cancer
    Lev M Berstein
    Laboratory of Oncoendocrinology N N Petrov Research Institute of Oncology St Petersburg, Russia
    Cell Cycle 12:3681-8. 2013
    ..As genetic polymorphisms associated with metabolic and anticancer metformin (and, possibly, phenformin) effects may be different, this subject requires further investigation. ..
  5. ncbi request reprint Rapid determination of Epstein-Barr virus latent or lytic infection in single human cells using in situ hybridization
    Elena E Leenman
    Research Institute of Radiology and Roentgenology, St Petersburg, Russia
    Mod Pathol 17:1564-72. 2004
    ..In situ hybridization may prove useful in rapidly screening large series of tissue microarrays and other clinical specimens for the presence of lytic or latent EBV...
  6. doi request reprint Cancer endocrinology through own experience: areas for further thought and development
    Lev M Berstein
    Laboratory Oncoendocrinology, NN Petrov Research Institute of Oncology, Pesochny, St Petersburg, 197758, Russia
    Future Oncol 9:933-7. 2013
    b>Lev Berstein speaks to Natasha Galukande, Assistant Commissioning Editor. Lev Berstein is Chief of Laboratory of Oncoendocrinology at the Petrov Research Institute of Oncology, St Petersburg, Russia...
  7. doi request reprint Cancer and heterogeneity of obesity: a potential contribution of brown fat
    Lev M Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, St Petersburg 197758, Russia
    Future Oncol 8:1537-48. 2012
    ....
  8. pmc Metformin in obesity, cancer and aging: addressing controversies
    Lev M Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Aging (Albany NY) 4:320-9. 2012
    ..Here we discuss whether the discrepancies in different studies are merely methodological or inherently related to individual differences in responsiveness to the drug...
  9. ncbi request reprint Endocrine metabolic disorders in patients with breast cancer, carriers of BRCA1 gene mutations
    L M Berstein
    N N Petrov Institute of Oncology, Ministry of Health and Social Development of the Russian Federation, St Petersburg, Russia
    Bull Exp Biol Med 152:610-2. 2012
    ..BRCA1 gene mutations in breast cancer patients were associated with signs of estrogenization and a pro-genotoxic shift in the estrogen and glucose system, which could modulate the disease course and requires correction...
  10. doi request reprint Familial diabetes is associated with reduced risk of cancer in diabetic patients: a possible role for metformin
    Lev M Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, Pesochny 2, St, 197758 Petersburg, Russia
    Med Oncol 29:1308-13. 2012
    ..Our data indicate that familial DM2 may have a protective effect for some cancer types and that the type of anti-diabetes therapy may be a factor of influence in the associations observed...
  11. doi request reprint Aromatase, CYP1B1 and fatty acid synthase expression in breast tumors of BRCA1 mutation carriers
    Lev M Berstein
    N N Petrov Research Institute of Oncology, Pesochny, St Petersburg 197758, Russia
    Pathol Oncol Res 15:407-9. 2009
    ....
  12. ncbi request reprint Role of endocrine-genotoxic switchings in cancer and other human diseases: basic triad
    Lev M Berstein
    Laboratory of Oncoendocrinology, Prof N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Adv Exp Med Biol 630:35-51. 2008
    ..The measures to correct components of the 'triad' can be divided into several groups aimed to optimally orchestrate the balance between endocrine and DNA-damagingeffects of estrogens, glucose and adipose tissue-related factors...
  13. doi request reprint Endocrinology of the wild and mutant BRCA1 gene and types of hormonal carcinogenesis
    Lev M Berstein
    N N Petrov Research Institute of Oncology, Pesochny 2, Leningradskaja 68, St Petersburg 197758, Russia
    Future Oncol 4:23-39. 2008
    ....
  14. ncbi request reprint Signs of proinflammatory/genotoxic switch (adipogenotoxicosis) in mammary fat of breast cancer patients: role of menopausal status, estrogens and hyperglycemia
    Lev M Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Int J Cancer 121:514-9. 2007
    ..This condition is likely being maintained through estrogen- and glucose-related factors and mechanisms presumably associated with less favorable types of hormonal carcinogenesis...
  15. ncbi request reprint Glucose-induced effects and joker function of glucose: endocrine or genotoxic prevalence?
    L M Berstein
    N N Petrov Research Institute of Oncology, Pesochny 2, Leningradskaja 68, St Petersburg 197758, Russia
    Horm Metab Res 38:650-5. 2006
    ..Whether such changes may serve as a pro-mutagenic or pro-endocrine basis for the rise of different chronic diseases or, rather, different features/aggressiveness of the same disease warrants further study...
  16. doi request reprint More favorable progesterone receptor phenotype of breast cancer in diabetics treated with metformin
    Lev M Berstein
    N N Petrov Research Institute of Oncology, Pesochny 2, 197758, St Petersburg, Russia
    Med Oncol 28:1260-3. 2011
    ..The data may be used as an explanation of the distinctions in cancer characteristics and course between diabetic patients treated with either metformin or sulfonylurea derivatives and insulin...
  17. doi request reprint Metformin, insulin, breast cancer and more
    Lev M Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, Leningradskaya 68, Pesochny, St Petersburg 197758, Russia
    Future Oncol 5:309-12. 2009
    ....
  18. ncbi request reprint Excretion of estrogens, catecholestrogens and phytoestrogens in carriers of BRCA1 gene mutations: effects of metformin
    L M Berstein
    N N Petrov Research Insititute of Oncology, St Petersburg, Russia
    Neoplasma 57:333-8. 2010
    ....
  19. doi request reprint Isolated and combined action of tamoxifen and metformin in wild-type, tamoxifen-resistant, and estrogen-deprived MCF-7 cells
    Lev M Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, Pesochny, St Petersburg, Russia
    Breast Cancer Res Treat 128:109-17. 2011
    ..The cellular context (including loss of sensitivity to TAM and estrogen deprivation) is of importance in influencing breast cancer responses to MF and to a combination of MF and TAM...
  20. doi request reprint Modern approach to metabolic rehabilitation of cancer patients: biguanides (phenformin and metformin) and beyond
    Lev M Berstein
    N N Petrov Research Institute of Oncology, Pesochny 2, Leningradskaja 68, St Petersburg, Russia
    Future Oncol 6:1313-23. 2010
    ....
  21. ncbi request reprint Evaluation of the proportion of hormonal and progenotoxic effects of estrogens and glucose in cancer patients
    L M Berstein
    N N Petrov Institute of Oncology, Ministry of Health and Social Development, St Petersburg, Russia
    Bull Exp Biol Med 150:243-6. 2010
    ..hormonal effect. This fact can be used as a landmark in search for means for optimization of the status and proportion of effects in the estrogen and glucose systems...
  22. ncbi request reprint CYP19 gene polymorphism in endometrial cancer patients
    L M Berstein
    Laboratory of Oncoendocrinology, NN Petrov Research Institute of Oncology, Pesochny, St Petersburg, Russia
    J Cancer Res Clin Oncol 127:135-8. 2001
    ..Therefore, it is possible that some allelic polymorphisms of the genes involved in steroidogenesis or steroid metabolism contribute to endometrial cancer susceptibility...
  23. ncbi request reprint Hormonal imbalance in two types of endometrial cancer and genetic polymorphism of steroidogenic enzymes
    Lev Berstein
    Lab Oncoendocrinology, N N Petrov Research Institute of Oncology, Pesochny, St Petersburg 197758, Russia
    Maturitas 54:352-5. 2006
    ....
  24. ncbi request reprint Genotoxic factors associated with the development of receptor-negative breast cancer: potential role of the phenomenon of switching of estrogen effects
    L M Berstein
    Prof NN Petrov Research Institute of Oncology, St Petersburg, Russia
    Exp Oncol 28:64-9. 2006
    ..The aim of this paper has been to study the role of DNA-damaging factors as the potential modifiers of the receptor-negative tumors incidence...
  25. ncbi request reprint Tumor estrogen content and clinico-morphological and endocrine features of endometrial cancer
    L M Berstein
    Lab Oncoendocrinology, N N Petrov Research Institute of Oncology, Pesochny 2, 197758, St Petersburg, Russia
    J Cancer Res Clin Oncol 129:245-9. 2003
    ..To compare estrogen concentrations in endometrial cancer tissue with those in macroscopically normal endometrium and with certain morphological characteristics of the tumor and endocrine parameters in patients...
  26. ncbi request reprint Neoadjuvant therapy of endometrial cancer with the aromatase inhibitor letrozole: endocrine and clinical effects
    Lev Berstein
    Laboratory Oncoendocrinology, N N Petrov Research Institute of Oncology, St Petersburg 197758, Russia
    Eur J Obstet Gynecol Reprod Biol 105:161-5. 2002
    ..To investigate the short-term hormonal and clinical effects of the aromatase inhibitor letrozole (Femara) in patients with endometrial cancer...
  27. ncbi request reprint Aromatase (CYP19) expression in tumor-infiltrating lymphocytes and blood mononuclears
    L M Berstein
    Lab of Oncoendocrinology, Prof N N Petrov Research Institute of Oncology, St Petersburg, Russia
    J Cancer Res Clin Oncol 128:173-6. 2002
    ..To clarify the role of lymphocytes as a possible source of estrogens...
  28. ncbi request reprint CYP17 genetic polymorphism in endometrial cancer: are only steroids involved?
    Lev M Berstein
    Laboratory of Oncoendocrinology, Prof N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg, Russia
    Cancer Lett 180:47-53. 2002
    ..A1/A1 CYP17 variant may be associated with untraditional (non-steroidal) pathways that calls for corresponding preventive measures in high-risk groups...
  29. ncbi request reprint Catecholestrogens excretion in smoking and non-smoking postmenopausal women receiving estrogen replacement therapy
    L M Berstein
    Laboratory Oncoendocrinology, Prof N N Petrov Research Institute of Oncology, St Petersburg, Russia
    J Steroid Biochem Mol Biol 72:143-7. 2000
    ....
  30. ncbi request reprint Study of tobacco smoke influence on content of estrogens and DNA flow cytometry data in uterine tissue of rats of different age
    L M Berstein
    Lab Oncoendocrinology, Prof N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Horm Metab Res 31:27-30. 1999
    ....
  31. ncbi request reprint Ability of lymphocytes infiltrating breast-cancer tissue to convert androstenedione
    L M Berstein
    Endocrinology Laboratory, Prof N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Int J Cancer 77:485-7. 1998
    ..The data obtained suggest that factors secreted by a neoplasm are able to induce aromatase gene expression in TIL...
  32. ncbi request reprint Influence of tobacco smoke on DNA unwinding and uterotrophic effect of estrogens in rats
    L M Berstein
    Lab Endocrinology, Prof N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cancer Lett 127:95-8. 1998
    ..The conclusion was made that different phases exist in hormonal and genotoxic responses to the combined effect of tobacco smoke and estrogens, which may be related to the mechanisms and types of hormonal carcinogenesis...
  33. ncbi request reprint CYP17 and CYP19 genetic polymorphisms in endometrial cancer: association with intratumoral aromatase activity
    Lev M Berstein
    Laboratory of Oncoendocrinology, Prof N N Petrov Research Institute of Oncology, St Petersburg, 197758 Russian Federation
    Cancer Lett 207:191-6. 2004
    ..Further studies are warranted to connect revealed regularities with the type I or II of EC...
  34. ncbi request reprint Insulin resistance, its consequences for the clinical course of the disease, and possibilities of correction in endometrial cancer
    L M Berstein
    Lab Oncoendocrinology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    J Cancer Res Clin Oncol 130:687-93. 2004
    ....
  35. ncbi request reprint CYP19 gene expression and aromatase activity in endometrial cancer tissue: importance of the type of the disease
    L Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, St Petersburg 197758, Russia
    Neoplasma 52:115-8. 2005
    ....
  36. ncbi request reprint The phenomenon of the switching of estrogen effects and joker function of glucose: similarities and relation to age-associated pathology and approaches to correction
    Lev M Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, Pesochny, St Petersburg 197758, Russia
    Ann N Y Acad Sci 1057:235-46. 2005
    ..as well as other compounds aimed to optimally orchestrate the balance between endocrine and DNA-damaging effects of estrogens and glucose...
  37. ncbi request reprint Aromatase and comparative response to its inhibitors in two types of endometrial cancer
    L Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, St Petersburg 197758, Russia
    J Steroid Biochem Mol Biol 95:71-4. 2005
    ..The search of possible ethnic differences in AA and in the biologic response to aromatase inhibitors in EC can be of importance too...
  38. ncbi request reprint Clinical usage of hypolipidemic and antidiabetic drugs in the prevention and treatment of cancer
    Lev M Berstein
    Laboratory of Oncoendocrinology, Prof N N Petrov Research Institute of Oncology, Pesochny, St Petersburg 197758, Russian Federation
    Cancer Lett 224:203-12. 2005
    ..This makes it timely to apply hypolipidemic and antidiabetic drugs (in combination with reasonable dieting, increased physical fitness, and an in-depth knowledge of drug-gene interactions) as an approach warranting further study...
  39. ncbi request reprint Hormone-metabolic status in moderately smoking breast cancer patients
    L M Berstein
    Prof N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Acta Oncol 36:137-40. 1997
    ..It is suggested that a possible relation between hormone-mediated effects inherent to smoking and the mechanisms promoting genotoxic type of hormonal carcinogenesis and the factors of breast cancer prognosis cannot be excluded...
  40. ncbi request reprint Metformin slows down aging and extends life span of female SHR mice
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cell Cycle 7:2769-73. 2008
    ..Thus, antidiabetic biguanide metformin dramatically extends life span, even without cancer prevention in this model...
  41. ncbi request reprint Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
    Exp Gerontol 40:685-93. 2005
    ..26 times. The metformin-treatment significantly decreased the incidence and size of mammary adenocarcinomas in mice and increased the mean latency of the tumors...
  42. ncbi request reprint Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, St Petersburg 197758, Russia
    Ann N Y Acad Sci 1057:220-34. 2005
    ..Some literature and our own observations suggest that antidiabetic drugs could be promising candidates for both life span extension and prevention of cancer...
  43. ncbi request reprint Long-term exposure to tamoxifen induces hypersensitivity to estradiol
    Lev M Berstein
    Laboratory of Oncoendocrinology, N N Petrov Research Institute of Oncology, Pesochny, St Petersburg, Russia
    Clin Cancer Res 10:1530-4. 2004
    ..These studies provide evidence that long-term TAM exposure enhances sensitivity to the estrogenic effects of TAM and also to E(2) itself...
  44. ncbi request reprint Phase 2 randomized trial of primary endocrine therapy versus chemotherapy in postmenopausal patients with estrogen receptor-positive breast cancer
    Vladimir F Semiglazov
    N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cancer 110:244-54. 2007
    ..This randomized, controlled, phase 2 study evaluated the efficacy of neoadjuvant chemotherapy compared with endocrine treatment with aromatase inhibitors in postmenopausal women with ER-positive and/or PgR-positive breast cancer...
  45. ncbi request reprint Innovative endocrinology of cancer. Preface
    Lev M Berstein
    Adv Exp Med Biol 630:v. 2008
  46. ncbi request reprint Evidence against involvement of p53 polymorphism in breast cancer predisposition
    Evgeny N Suspitsin
    Int J Cancer 103:431-3. 2003