Kira A Markossian

Summary

Affiliation: Russian Academy of Sciences
Country: Russia

Publications

  1. pmc Mechanism of suppression of protein aggregation by α-crystallin
    Kira A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Int J Mol Sci 10:1314-45. 2009
  2. ncbi request reprint Copper chaperones, intracellular copper trafficking proteins. Function, structure, and mechanism of action
    K A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow 119071, Russia
    Biochemistry (Mosc) 68:827-37. 2003
  3. ncbi request reprint Protein folding, misfolding, and aggregation. Formation of inclusion bodies and aggresomes
    K A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia
    Biochemistry (Mosc) 69:971-84. 2004
  4. ncbi request reprint Antibacterial proline-rich oligopeptides and their target proteins
    K A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr 33, Moscow 119071, Russia
    Biochemistry (Mosc) 69:1082-91. 2004
  5. ncbi request reprint Mechanism of thermal aggregation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase
    Kira A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky 33, Moscow 119071, Russia
    Biochemistry 45:13375-84. 2006
  6. doi request reprint Comparative analysis of the effects of alpha-crystallin and GroEL on the kinetics of thermal aggregation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase
    Kira A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, 119071, Moscow, Russia
    Protein J 29:11-25. 2010
  7. ncbi request reprint Effect of alpha-crystallin on thermal denaturation and aggregation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase
    Helen A Khanova
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Biophys Chem 125:521-31. 2007
  8. doi request reprint Thermal stability and aggregation of creatine kinase from rabbit skeletal muscle. Effect of 2-hydroxypropyl-beta-cyclodextrin
    Olga I Maloletkina
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Biophys Chem 148:121-30. 2010
  9. doi request reprint Kinetics of aggregation of UV-irradiated glyceraldehyde-3-phosphate dehydrogenase from rabbit skeletal muscle. Effect of agents possessing chaperone-like activity
    Olga I Maloletkina
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Biophys Chem 163:11-20. 2012
  10. doi request reprint Study of kinetics of thermal aggregation of mitochondrial aspartate aminotransferase by dynamic light scattering: protective effect of alpha-crystallin
    Nikolay V Golub
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Eur Biophys J 38:547-56. 2009

Collaborators

Detail Information

Publications17

  1. pmc Mechanism of suppression of protein aggregation by α-crystallin
    Kira A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Int J Mol Sci 10:1314-45. 2009
    ....
  2. ncbi request reprint Copper chaperones, intracellular copper trafficking proteins. Function, structure, and mechanism of action
    K A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow 119071, Russia
    Biochemistry (Mosc) 68:827-37. 2003
    ..The copper chaperone CCS delivers Cu(I) to Cu,Zn-superoxide dismutase 1. Cox17 and Cox11 proteins serve as copper chaperones for cytochrome c oxidase, a copper-dependent enzyme...
  3. ncbi request reprint Protein folding, misfolding, and aggregation. Formation of inclusion bodies and aggresomes
    K A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia
    Biochemistry (Mosc) 69:971-84. 2004
    ..The role of aggresomes in disturbance of the proteasomal system operation and in cellular death, particularly in the so-called "protein conformational diseases", is discussed...
  4. ncbi request reprint Antibacterial proline-rich oligopeptides and their target proteins
    K A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr 33, Moscow 119071, Russia
    Biochemistry (Mosc) 69:1082-91. 2004
    ..Evidence that pyrrhocoricin, drosocin, apidaecin, and formaecin are nontoxic for human and animal cells serves as a prerequisite for their use as novel antibiotic drugs...
  5. ncbi request reprint Mechanism of thermal aggregation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase
    Kira A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky 33, Moscow 119071, Russia
    Biochemistry 45:13375-84. 2006
    ..5). A strict correlation between thermal aggregation of GAPDH registered by the increase in the light scattering intensity and protein denaturation characterized by DSC has been proved...
  6. doi request reprint Comparative analysis of the effects of alpha-crystallin and GroEL on the kinetics of thermal aggregation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase
    Kira A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, 119071, Moscow, Russia
    Protein J 29:11-25. 2010
    ....
  7. ncbi request reprint Effect of alpha-crystallin on thermal denaturation and aggregation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase
    Helen A Khanova
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Biophys Chem 125:521-31. 2007
    ..When aggregation of GAPDH was studied in the presence of alpha-crystallin, the start aggregates of lesser size were observed...
  8. doi request reprint Thermal stability and aggregation of creatine kinase from rabbit skeletal muscle. Effect of 2-hydroxypropyl-beta-cyclodextrin
    Olga I Maloletkina
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Biophys Chem 148:121-30. 2010
    ..Judging from the data on the kinetics of RMCK inactivation and the data on differential scanning calorimetry of RMCK, HP-beta-CD does not affect the rate of RMCK unfolding...
  9. doi request reprint Kinetics of aggregation of UV-irradiated glyceraldehyde-3-phosphate dehydrogenase from rabbit skeletal muscle. Effect of agents possessing chaperone-like activity
    Olga I Maloletkina
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Biophys Chem 163:11-20. 2012
    ..Despite the fact that HP-β-CD accelerates thermal aggregation of non-irradiated GAPDH, in the case of aggregation of UV-irradiated GAPDH HP-β-CD reveals a purely protective effect...
  10. doi request reprint Study of kinetics of thermal aggregation of mitochondrial aspartate aminotransferase by dynamic light scattering: protective effect of alpha-crystallin
    Nikolay V Golub
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Eur Biophys J 38:547-56. 2009
    ..Realization of this regime of aggregation means that the sticking probability for the colliding particles is less than unity...
  11. doi request reprint Mechanism of thermal aggregation of yeast alcohol dehydrogenase I: role of intramolecular chaperone
    Kira A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Biochim Biophys Acta 1784:1286-93. 2008
    ..Thermodynamic parameters for thermal denaturation of yADH have been calculated from the differential scanning calorimetry data...
  12. ncbi request reprint Mechanism of chaperone-like activity. Suppression of thermal aggregation of betaL-crystallin by alpha-crystallin
    Helen A Khanova
    Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky 33, 119071, Moscow, Russia
    Biochemistry 44:15480-7. 2005
    ..The aggregates of the other kind grow until they reach the size characteristic of aggregates prone to precipitation. The DSC data show that alpha-crystallin has no appreciable influence on thermal denaturation of beta(L)-crystallin...
  13. doi request reprint Mechanism of aggregation of UV-irradiated β(L)-crystallin
    Konstantin O Muranov
    Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia
    Exp Eye Res 92:76-86. 2011
    ..Further sticking of the start aggregates proceeded in the regime of reaction-limited cluster-cluster aggregation. Splitting of the aggregate population into two components occurred above a definite point in time...
  14. doi request reprint Effect of alpha-crystallin on thermostability of mitochondrial aspartate aminotransferase
    Kira A Markossian
    Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr 33, 119071 Moscow, Russia
    Int J Biol Macromol 44:441-6. 2009
    ..The obtained data show that aggregation of mAAT in the presence of alpha-crystallin proceeds in the regime of reaction-limited cluster-cluster aggregation...
  15. doi request reprint Effect of 2-hydroxypropyl-beta-cyclodextrin on thermal inactivation, denaturation and aggregation of glyceraldehyde-3-phosphate dehydrogenase from rabbit skeletal muscle
    Olga I Maloletkina
    Bach Institute of Biochemistry, Russian Academy of Sciences, Leninsky pr 33, 119071, Moscow, Russia
    Int J Biol Macromol 46:487-92. 2010
    ..The acceleration of GAPDH aggregation was due to destabilization of the enzyme molecule under the action of HP-beta-CD. This is evidenced by the data on thermal inactivation of GAPDH and differential scanning calorimetry...
  16. doi request reprint Thermal inactivation, denaturation and aggregation of mitochondrial aspartate aminotransferase
    Nikolay V Golub
    Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    Biophys Chem 135:125-31. 2008
    ..The size of the protein aggregates formed at heating of mAAT at a constant rate (1 degrees C min(- 1)) has been characterized by dynamic light scattering...
  17. pmc Quantification of anti-aggregation activity of chaperones: a test-system based on dithiothreitol-induced aggregation of bovine serum albumin
    Vera A Borzova
    Department of Molecular Organization of Biological Structures, Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia
    PLoS ONE 8:e74367. 2013
    ..5 was used. Among the chemical chaperones studied, arginine ethyl ester and arginine amide reveal the highest anti-aggregation activity ([L]0.5 = 53 and 58 mM, respectively). ..