A A Buzdin

Summary

Affiliation: Russian Academy of Sciences
Country: Russia

Publications

  1. ncbi Mouse retinal progenitor cell (RPC) cocultivation with retinal pigment epithelial cell culture affects features of RPC differentiation
    I V Kholodenko
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 71:767-74. 2006
  2. ncbi Anti-apoptotic effect of retinoic acid on retinal progenitor cells mediated by a protein kinase A-dependent mechanism
    Roman Kholodenko
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, Moscow 117997, Russia
    Cell Res 17:151-62. 2007
  3. ncbi Human-specific endogenous retroviruses
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
    ScientificWorldJournal 7:1848-68. 2007
  4. ncbi Chimeric retrogenes suggest a role for the nucleolus in LINE amplification
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
    FEBS Lett 581:2877-82. 2007
  5. pmc At least 50% of human-specific HERV-K (HML-2) long terminal repeats serve in vivo as active promoters for host nonrepetitive DNA transcription
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, Moscow 117997, Russia
    J Virol 80:10752-62. 2006
  6. pmc GREM, a technique for genome-wide isolation and quantitative analysis of promoter active repeats
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, Moscow 117997, Russia
    Nucleic Acids Res 34:e67. 2006
  7. ncbi Retroelements and formation of chimeric retrogenes
    A A Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, 117997, Moscow, Russia
    Cell Mol Life Sci 61:2046-59. 2004
  8. pmc The human genome contains many types of chimeric retrogenes generated through in vivo RNA recombination
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
    Nucleic Acids Res 31:4385-90. 2003
  9. ncbi Human-specific subfamilies of HERV-K (HML-2) long terminal repeats: three master genes were active simultaneously during branching of hominoid lineages
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, 117997 Moscow, Russia
    Genomics 81:149-56. 2003
  10. ncbi Genome-wide targeted search for human specific and polymorphic L1 integrations
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, 117997 Moscow, Russia
    Hum Genet 112:527-33. 2003

Collaborators

  • Elena Gogvadze
  • Alexey Fushan
  • Zoltan Ivics
  • Ilgar Mamedov
  • E D Sverdlov
  • M V Mityaev
  • Roman Kholodenko
  • Elena Kovalskaya
  • Denis Kuzmin
  • O B Bantysh
  • Tatyana Vinogradova
  • I V Kholodenko
  • Tatyana Chalaya
  • Dawid P Grzela
  • Galina Malakhova
  • Dmitry Sokov
  • Eugene Kopantzev
  • Maria Suntsova
  • I V Krieger
  • Viktor Sorokin
  • Irina Kholodenko
  • Anna Tolmazova
  • Olga Sazonova
  • V N Yarygin
  • V F Sorokin
  • R V Kholodenko
  • J A Baibikova
  • L P Revina
  • G G Chestukhina
  • V M Stepanov
  • I A Zalunin
  • L I Kostina

Detail Information

Publications25

  1. ncbi Mouse retinal progenitor cell (RPC) cocultivation with retinal pigment epithelial cell culture affects features of RPC differentiation
    I V Kholodenko
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 71:767-74. 2006
    ..6-1.7-fold increase in rod photoreceptor cell rhodopsin marker immunoreactivity. The data suggest the influence of the intercellular interaction networks on RPC differentiation...
  2. ncbi Anti-apoptotic effect of retinoic acid on retinal progenitor cells mediated by a protein kinase A-dependent mechanism
    Roman Kholodenko
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, Moscow 117997, Russia
    Cell Res 17:151-62. 2007
    ....
  3. ncbi Human-specific endogenous retroviruses
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
    ScientificWorldJournal 7:1848-68. 2007
    ....
  4. ncbi Chimeric retrogenes suggest a role for the nucleolus in LINE amplification
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
    FEBS Lett 581:2877-82. 2007
    ..These hypotheses will be discussed in this review...
  5. pmc At least 50% of human-specific HERV-K (HML-2) long terminal repeats serve in vivo as active promoters for host nonrepetitive DNA transcription
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, Moscow 117997, Russia
    J Virol 80:10752-62. 2006
    ..Our data also suggest a selective suppression of transcription for LTRs located in gene introns...
  6. pmc GREM, a technique for genome-wide isolation and quantitative analysis of promoter active repeats
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, Moscow 117997, Russia
    Nucleic Acids Res 34:e67. 2006
    ..Importantly, GREM tag frequencies linearly correlated with the corresponding LTR-driven transcript levels found using RT-PCR. The GREM technique enabled us to identify 54 new functional human promoters created by retroviral LTRs...
  7. ncbi Retroelements and formation of chimeric retrogenes
    A A Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, 117997, Moscow, Russia
    Cell Mol Life Sci 61:2046-59. 2004
    ..The abovementioned events are also able to give rise to new RE families. These mechanisms are reviewed here along with the description of major RE groups...
  8. pmc The human genome contains many types of chimeric retrogenes generated through in vivo RNA recombination
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
    Nucleic Acids Res 31:4385-90. 2003
    ..These findings suggest that RNA-RNA recombination during L1 reverse transcription followed by the integration of the recombinants into the host genome is a general event in genome evolution...
  9. ncbi Human-specific subfamilies of HERV-K (HML-2) long terminal repeats: three master genes were active simultaneously during branching of hominoid lineages
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, 117997 Moscow, Russia
    Genomics 81:149-56. 2003
    ..We also found hs HERV-K (HML-2) LTRs integrations in introns of 12 human genes and identified 13 new hs HERV-K (HML-2) LTRs...
  10. ncbi Genome-wide targeted search for human specific and polymorphic L1 integrations
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, 117997 Moscow, Russia
    Hum Genet 112:527-33. 2003
    ..The results suggest that TGDA is a universal method that can be successfully used for the detection of evolutionary and polymorphic markers in any closely related genomes...
  11. ncbi A technique for genome-wide identification of differences in the interspersed repeats integrations between closely related genomes and its application to detection of human-specific integrations of HERV-K LTRs
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, Moscow, 117997, Russia
    Genomics 79:413-22. 2002
    ..No deletion/insertion polymorphism was detected for the LTR HSIs for 25 unrelated caucasoid individuals. We also discuss the possible research applications for TGDA research...
  12. ncbi A new family of chimeric retrotranscripts formed by a full copy of U6 small nuclear RNA fused to the 3' terminus of l1
    Anton Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
    Genomics 80:402-6. 2002
    ..The integrations of such fused retrotranscripts into the human genome took place until recently. Here we report one U6-L1 insertion that is polymorphic in humans. We also propose a mechanism used to generate chimeric retrotranscripts...
  13. doi Retroelements and their impact on genome evolution and functioning
    Elena Gogvadze
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya St, 117997 Moscow, Russia
    Cell Mol Life Sci 66:3727-42. 2009
    ....
  14. ncbi Functional significance of a putative sp1 transcription factor binding site in the survivin gene promoter
    M V Mityaev
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 73:1183-91. 2008
    ..Mutation within this sequence led to a sharp decrease of promoter activity. The functional architecture of the survivin promoter is discussed based on results known from the literature and those obtained here...
  15. ncbi [A functional analysis of retroviral endogenous inserts in view of human genome evolution.]
    A A Buzdin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, Moscow, 117997 Russia
    Bioorg Khim 36:38-46. 2010
    ..hsERV viruses regulate the activity of known protein-encoding genes by means of RNA interference, function as enhancers, and provide new polyadenylation signals for mRNA...
  16. pmc Genome-wide comparison of differences in the integration sites of interspersed repeats between closely related genomes
    Ilgar Mamedov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya Street, 117997 Moscow, Russia
    Nucleic Acids Res 30:e71. 2002
    ....
  17. ncbi Enhancer element potentially involved in human survivin gene promoter regulation in lung cancer cell lines
    M V Mityaev
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 75:182-91. 2010
    ..The data provide another possibility to increase survivin promoter activity without changing its cancer specificity for application in cancer (in particular, lung cancer) gene therapy...
  18. ncbi Novel family of human transposable elements formed due to fusion of the first exon of gene MAST2 with retrotransposon SVA
    O B Bantysh
    Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
    Biochemistry (Mosc) 74:1393-9. 2009
    ..Also, we show that human L1 reverse transcriptase adds an extra cytosine residue to the 3' terminus of the nascent first strand of cDNA...
  19. pmc Tripartite chimeric pseudogene from the genome of rice blast fungus Magnaporthe grisea suggests double template jumps during long interspersed nuclear element (LINE) reverse transcription
    Elena Gogvadze
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
    BMC Genomics 8:360. 2007
    ..Chimeric retroelements with a similar structure were recently found in three mammalian genomes. All these chimeras are likely formed by RNA template switches during the reverse transcription of diverse LINE elements...
  20. ncbi Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regions
    Elena Kovalskaya
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, Moscow 117997, Russia
    Virology 346:373-8. 2006
    ..Surprisingly, the transcription was initiated predominantly from the very 3' termini of the LTR R regions. The data presented here may shed light on adaptive coevolution of human endogenous retroviruses with their host cells...
  21. pmc Human-specific modulation of transcriptional activity provided by endogenous retroviral insertions
    Elena Gogvadze
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
    J Virol 83:6098-105. 2009
    ..The antisense transcripts formed from LTR promoter were shown to decrease the mRNA level of the corresponding genes. The human-specific regulation of these genes suggests their involvement in the evolutionary process...
  22. pmc Improving specificity of DNA hybridization-based methods
    Tatyana Chalaya
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
    Nucleic Acids Res 32:e130. 2004
    ..MDR is also useful for the genome-wide recovery of highly conserved DNA sequences, as we demonstrate by comparing human and pygmy marmoset genomes...
  23. ncbi Membrane proteins of Aedes aegypti larvae bind toxins Cry4B and Cry11A of Bacillus thuringiensis ssp. israelensis
    I V Krieger
    Institute of Genetics and Selection of Industrial Microorganisms, Moscow, 113545, Russia
    Biochemistry (Mosc) 64:1163-8. 1999
    ..These proteins are likely to be Cry4B and Cry11A toxin receptors in gut epithelial cells of Aedes aegypti larvae...
  24. ncbi Interaction of 65- and 62-kD proteins from the apical membranes of the Aedes aegypti larvae midgut epithelium with Cry4B and Cry11A endotoxins of Bacillus thuringiensis
    A A Buzdin
    Institute of Genetics and Selection of Industrial Microorganisms, Moscow, 113545, Russia
    Biochemistry (Mosc) 67:540-6. 2002
    ..Monosaccharide residues are not involved in the binding of the 65- and 62-kD proteins with Cry4B, Cry11A, and Cry9A...
  25. pmc Novel strong tissue specific promoter for gene expression in human germ cells
    Denis Kuzmin
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
    BMC Biotechnol 10:58. 2010
    ..We report a novel, tissue-specific promoter that was identified and engineered from the native upstream regulatory region of the human gene NDUFV1 containing an endogenous retroviral sequence...