Research Topics
Species | A A BuzdinSummaryAffiliation: Russian Academy of Sciences Country: Russia Publications
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Detail Information
Publications
GREM, a technique for genome-wide isolation and quantitative analysis of promoter active repeatsAnton Buzdin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, Moscow 117997, Russia
Nucleic Acids Res 34:e67. 2006..Importantly, GREM tag frequencies linearly correlated with the corresponding LTR-driven transcript levels found using RT-PCR. The GREM technique enabled us to identify 54 new functional human promoters created by retroviral LTRs...- At least 50% of human-specific HERV-K (HML-2) long terminal repeats serve in vivo as active promoters for host nonrepetitive DNA transcriptionAnton Buzdin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, Moscow 117997, Russia
J Virol 80:10752-62. 2006..Our data also suggest a selective suppression of transcription for LTRs located in gene introns... 
Human-specific endogenous retrovirusesAnton Buzdin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
ScientificWorldJournal 7:1848-68. 2007....- Retroelements and formation of chimeric retrogenesA A Buzdin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya, 117997, Moscow, Russia
Cell Mol Life Sci 61:2046-59. 2004..The abovementioned events are also able to give rise to new RE families. These mechanisms are reviewed here along with the description of major RE groups... - The human genome contains many types of chimeric retrogenes generated through in vivo RNA recombinationAnton Buzdin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
Nucleic Acids Res 31:4385-90. 2003..These findings suggest that RNA-RNA recombination during L1 reverse transcription followed by the integration of the recombinants into the host genome is a general event in genome evolution... - Human-specific subfamilies of HERV-K (HML-2) long terminal repeats: three master genes were active simultaneously during branching of hominoid lineagesAnton Buzdin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, 117997 Moscow, Russia
Genomics 81:149-56. 2003..We also found hs HERV-K (HML-2) LTRs integrations in introns of 12 human genes and identified 13 new hs HERV-K (HML-2) LTRs... - Genome-wide targeted search for human specific and polymorphic L1 integrationsAnton Buzdin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, 117997 Moscow, Russia
Hum Genet 112:527-33. 2003..The results suggest that TGDA is a universal method that can be successfully used for the detection of evolutionary and polymorphic markers in any closely related genomes... - A new family of chimeric retrotranscripts formed by a full copy of U6 small nuclear RNA fused to the 3' terminus of l1Anton Buzdin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
Genomics 80:402-6. 2002..The integrations of such fused retrotranscripts into the human genome took place until recently. Here we report one U6-L1 insertion that is polymorphic in humans. We also propose a mechanism used to generate chimeric retrotranscripts... - A technique for genome-wide identification of differences in the interspersed repeats integrations between closely related genomes and its application to detection of human-specific integrations of HERV-K LTRsAnton Buzdin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya, Moscow, 117997, Russia
Genomics 79:413-22. 2002..No deletion/insertion polymorphism was detected for the LTR HSIs for 25 unrelated caucasoid individuals. We also discuss the possible research applications for TGDA research... - Chimeric retrogenes suggest a role for the nucleolus in LINE amplificationAnton Buzdin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
FEBS Lett 581:2877-82. 2007..These hypotheses will be discussed in this review... 
Retroelements and their impact on genome evolution and functioningElena Gogvadze
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, 16 10 Miklukho Maklaya St, 117997 Moscow, Russia
Cell Mol Life Sci 66:3727-42. 2009....- Functional significance of a putative sp1 transcription factor binding site in the survivin gene promoterM V Mityaev
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
Biochemistry (Mosc) 73:1183-91. 2008..Mutation within this sequence led to a sharp decrease of promoter activity. The functional architecture of the survivin promoter is discussed based on results known from the literature and those obtained here... - [A functional analysis of retroviral endogenous inserts in view of human genome evolution.]A A Buzdin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, Moscow, 117997 Russia
Bioorg Khim 36:38-46. 2010..hsERV viruses regulate the activity of known protein-encoding genes by means of RNA interference, function as enhancers, and provide new polyadenylation signals for mRNA... - Genome-wide comparison of differences in the integration sites of interspersed repeats between closely related genomesIlgar Mamedov
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16 10 Miklukho Maklaya Street, 117997 Moscow, Russia
Nucleic Acids Res 30:e71. 2002.... - Enhancer element potentially involved in human survivin gene promoter regulation in lung cancer cell linesM V Mityaev
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
Biochemistry (Mosc) 75:182-91. 2010..The data provide another possibility to increase survivin promoter activity without changing its cancer specificity for application in cancer (in particular, lung cancer) gene therapy... - Novel family of human transposable elements formed due to fusion of the first exon of gene MAST2 with retrotransposon SVAO B Bantysh
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia
Biochemistry (Mosc) 74:1393-9. 2009..Also, we show that human L1 reverse transcriptase adds an extra cytosine residue to the 3' terminus of the nascent first strand of cDNA... - Tripartite chimeric pseudogene from the genome of rice blast fungus Magnaporthe grisea suggests double template jumps during long interspersed nuclear element (LINE) reverse transcriptionElena Gogvadze
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
BMC Genomics 8:360. 2007..Chimeric retroelements with a similar structure were recently found in three mammalian genomes. All these chimeras are likely formed by RNA template switches during the reverse transcription of diverse LINE elements... - Human-specific modulation of transcriptional activity provided by endogenous retroviral insertionsElena Gogvadze
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
J Virol 83:6098-105. 2009..The antisense transcripts formed from LTR promoter were shown to decrease the mRNA level of the corresponding genes. The human-specific regulation of these genes suggests their involvement in the evolutionary process... - Improving specificity of DNA hybridization-based methodsTatyana Chalaya
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117871, Russia
Nucleic Acids Res 32:e130. 2004..MDR is also useful for the genome-wide recovery of highly conserved DNA sequences, as we demonstrate by comparing human and pygmy marmoset genomes... - Functional human endogenous retroviral LTR transcription start sites are located between the R and U5 regionsElena Kovalskaya
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho-Maklaya, Moscow 117997, Russia
Virology 346:373-8. 2006..Surprisingly, the transcription was initiated predominantly from the very 3' termini of the LTR R regions. The data presented here may shed light on adaptive coevolution of human endogenous retroviruses with their host cells... - Membrane proteins of Aedes aegypti larvae bind toxins Cry4B and Cry11A of Bacillus thuringiensis ssp. israelensisI V Krieger
Institute of Genetics and Selection of Industrial Microorganisms, Moscow, 113545, Russia
Biochemistry (Mosc) 64:1163-8. 1999..These proteins are likely to be Cry4B and Cry11A toxin receptors in gut epithelial cells of Aedes aegypti larvae... - Interaction of 65- and 62-kD proteins from the apical membranes of the Aedes aegypti larvae midgut epithelium with Cry4B and Cry11A endotoxins of Bacillus thuringiensisA A Buzdin
Institute of Genetics and Selection of Industrial Microorganisms, Moscow, 113545, Russia
Biochemistry (Mosc) 67:540-6. 2002..Monosaccharide residues are not involved in the binding of the 65- and 62-kD proteins with Cry4B, Cry11A, and Cry9A... - Novel strong tissue specific promoter for gene expression in human germ cellsDenis Kuzmin
Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
BMC Biotechnol 10:58. 2010..We report a novel, tissue-specific promoter that was identified and engineered from the native upstream regulatory region of the human gene NDUFV1 containing an endogenous retroviral sequence...