- Rapamycin induces pluripotent genes associated with avoidance of replicative senescenceTatiana V Pospelova
Institute of Cytology Russian Academy of Sciences St Petersburg, Russia St Petersburg State University St Petersburg, Russia
Cell Cycle 12:3841-51. 2013..We conclude that suppression mTORC1 activity may prevent replicative senescence without transformation of rodent cells. ..
- Suppression of replicative senescence by rapamycin in rodent embryonic cellsTatiana V Pospelova
Institute of Cytology, St Petersburg, Russia
Cell Cycle 11:2402-7. 2012..Following rapamycin treatment and removal, a fraction of proliferating REFs gradually increased and senescent phenotype disappeared completely by passage 24...
- Pseudo-DNA damage response in senescent cellsTatyana V Pospelova
Institute of Cytology, Russian Academy of Sciences, St Petersburg, Russia
Cell Cycle 8:4112-8. 2009..Thus, cellular senescence leads to activation of atypical DDR without detectable DNA damage. Pseudo-DDR may be a marker of general over-activation of senescent cells...