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Zhanar R Shaimerdenova
Affiliation: Palladin Institute of Biochemistry
Khlebnikov A, Schepetkin I, Kishkentaeva A, Shaimerdenova Z, Atazhanova G, Adekenov S, et al. Inhibition of T Cell Receptor Activation by Semi-Synthetic Sesquiterpene Lactone Derivatives and Molecular Modeling of Their Interaction with Glutathione and Tyrosine Kinase ZAP-70. Molecules. 2019;24: pubmed publisher
..We suggest that natural and/or semi-synthetic SLs with an α -methylene- γ -lactone moiety can specifically target GSH and the kinase site of ZAP-70 and inhibit the initial phases of TCR activation. ..