Research Topics
Genomes and GenesSpecies | L P OvchinnikovSummaryCountry: Russia Publications
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Detail Information
Publications
Y-box-binding protein 1 (YB-1) and its functionsI A Eliseeva
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
Biochemistry (Mosc) 76:1402-33. 2011..Both the oncogenic and antioncogenic activities of YB-1 are reviewed. The potential use of YB-1 in diagnostics and therapy as an early cancer marker and a molecular target is discussed...
YB-1 promotes microtubule assembly in vitro through interaction with tubulin and microtubulesKonstantin G Chernov
Laboratoire Structure Activité des Biomolécules Normales et Pathologiques, INSERM UEVE U829 Evry, 91025 France
BMC Biochem 9:23. 2008..YB-1 is a major regulator of gene expression in eukaryotic cells. In addition to its role in transcription, YB-1 plays a key role in translation and stabilization of mRNAs...
[Major mRNP proteins in the structural organization and function of mRNA in eukaryotic cells]L P Ovchinnikov
Mol Biol (Mosk) 35:548-58. 2001..The parts these mRNP proteins play in translation regulation, stability, and localization of mRNA are described, and the the possible mechanisms of their function are discussed...
Interaction of the universal mRNA-binding protein, p50, with actin: a possible link between mRNA and microfilamentsP V Ruzanov
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russian Federation
J Cell Sci 112:3487-96. 1999..Together, these findings support the view that p50 may play an important role in mRNA transport, anchoring, and localization on actin filaments in the cell...
P50/YB-1, a major protein of cytoplasmic mRNPs, regulates its own synthesisO V Skabkina
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142290 Russia
Dokl Biochem Biophys 395:93-5. 2004
The major messenger ribonucleoprotein particle protein p50 (YB-1) promotes nucleic acid strand annealingM A Skabkin
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia
J Biol Chem 276:44841-7. 2001..Our results suggest that the alteration of nucleic acid conformation is a basic mechanism of the p50-dependent regulation of gene expression...
YB-1 is capable of forming extended nanofibrilsO M Selivanova
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia
Biochemistry (Mosc) 75:115-20. 2010..They possess polarity and tend to associate with one another to give structures of a higher order, like ribbons or bundles. The YB-1 fibrillar architecture has a distinct periodicity with a repeat unit of about 52 nm...
Interaction of eukaryotic threonyl-tRNA synthetase with high-Mr RNAs and tRNA(Thr)A N Fedorov
Institute of Protein Research, Academy of Sciences of the USSR, Pushchino
Eur J Biochem 169:185-91. 1987..In the extract of rabbit reticulocytes about one-third of the threonyl-tRNA synthetase molecules are in association with cognate tRNA(Thr) and thus are unable to interact with high-Mr RNAs...
Proteasome system of protein degradation and processingA V Sorokin
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia
Biochemistry (Mosc) 74:1411-42. 2009..Data on damages of the proteasome system that lead to the development of different diseases are given separately...
Nucleocytoplasmic transport of proteinsA V Sorokin
Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia
Biochemistry (Mosc) 72:1439-57. 2007....
The major protein of messenger ribonucleoprotein particles in somatic cells is a member of the Y-box binding transcription factor familyV M Evdokimova
Institute of Protein Research, Russian Academy of Sciences, Puschino, Moscow Region
J Biol Chem 270:3186-92. 1995..Highly purified p50 forms large 18 S homomultimeric complexes with a molecular mass of about 800 kilodaltons and melts RNA secondary structure. This suggests that p50 may affect translation by changing the overall structure of the mRNA...
