Research Topics
| A M OlovnikovSummaryCountry: Russia Publications
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Detail Information
Publications
Telomeres, telomerase, and aging: origin of the theoryA M Olovnikov
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia
Exp Gerontol 31:443-8. 1996..the DNA sequences that shorten in dividing normal cells are telomeres and the enzyme that maintains telomere length constant in immortal cell populations is telomerase...
Towards the quantitative traits regulation: fountain theory implications in comparative and developmental biologyA M Olovnikov
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow
Int J Dev Biol 41:923-31. 1997..The pivotal evolutionary function of transposons could reside in their ability to contain and relocate fDNA along the chromosomes...
Pseudoprimers cause somatic hypermutation of Ig genesA M Olovnikov
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 125319, Russia
Biochemistry (Mosc) 63:1447-8. 1998..The MP is a product of the cleavage of the nascent transcript. Each MP has an erroneous base on its 3; terminus. Wobbling of the unpaired 3; end of the MP forces the DNA polymerase to make an error...
Notes on a "printomere" mechanism of cellular memory and ion regulation of chromatin configurationsA M Olovnikov
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 125319, Russia
Biochemistry (Mosc) 64:1427-35. 1999..Owing to printomeres, cellular memory about the proper structure of chromatin decompactions is created, kept, and can be carried through the succession of doublings of differentiated cells...
[Redusome aging: commentaries]A M Olovnikov
Institute of Biochemical Physics of RAS, ul Chernyakhovskogo, 5 94, Moscow, 125319, Russia
Adv Gerontol 12:28-45. 2003..Telomere attrition is only a bystander process of aging, while the genuine cause of the cell and organism aging is the redusome DNA shortening...
Hypothesis: lifespan is regulated by chronomere DNA of the hypothalamusA M Olovnikov
Institute of Biochemical Physics, Russian Academy of Sciences, Chernyakhovskogo, 5 94, Moscow, 125319 Russia
J Alzheimers Dis 11:241-52. 2007..Calorie restriction increases lifespan by preserving mitochondrial and other organismal functions owing to the decreased chronomere shortening...
The redusome hypothesis of aging and the control of biological time during individual developmentA M Olovnikov
Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 125319, Russia
Biochemistry (Mosc) 68:2-33. 2003..Processing of certain redusomes in terminally differentiating cells is a cause of a proliferation arrest. Linkage of genes in a eukaryotic chromosome is determined by the distances between genes and redusomes...
Biological evolution based on nonrandom variability regulated by the organismA M Olovnikov
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119334, Russia
Biochemistry (Mosc) 74:1404-8. 2009..It is highly probable that some of these phenotypes are adaptive and lay the basis for the origin of the next biological species. The proposed mechanism can serve as a basis for a new theory of the origin of species...
