Andrey Korshunov

Summary

Affiliation: Neurosurgical NN Burdenko Institute
Country: Russia

Publications

  1. pmc Prognostic value of tumour associated antigen immunoreactivity and apoptosis in cerebral glioblastomas: an analysis of 168 cases
    A Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    J Clin Pathol 52:574-80. 1999
  2. ncbi DNA topoisomerase II-alpha and cyclin A immunoexpression in meningiomas and its prognostic significance: an analysis of 263 cases
    Andrey Korshunov
    Department of Neuropathology, Burdenko Neurosurgical Institute, Moscow, Russia
    Arch Pathol Lab Med 126:1079-86. 2002
  3. ncbi Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome
    Andrey Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    Int J Cancer 104:728-34. 2003
  4. ncbi The histologic grade is a main prognostic factor for patients with intracranial ependymomas treated in the microneurosurgical era: an analysis of 258 patients
    Andrey Korshunov
    Department of Neuropathology, Burdenko Neurosurgical Institute, Moscow, Russia
    Cancer 100:1230-7. 2004
  5. ncbi Molecular stratification of diagnostically challenging high-grade gliomas composed of small cells: the utility of fluorescence in situ hybridization
    Andrey Korshunov
    Department of Neuropathology, NN Burdenko Neurosurgical Institute, Fadeeva Str 5, Moscow, 125047, Russia
    Clin Cancer Res 10:7820-6. 2004
  6. ncbi Clinical utility of fluorescence in situ hybridization (FISH) in nonbrainstem glioblastomas of childhood
    Andrey Korshunov
    Department of Neuropathology, NN Burdenko Neurosurgical Institute, Moscow, Russia
    Mod Pathol 18:1258-63. 2005
  7. ncbi The prognostic relevance of molecular alterations in glioblastomas for patients age < 50 years
    Andrey Korshunov
    Department of Neuropathology, N N Burdenko Neurosurgical Institute, Moscow, Russia
    Cancer 104:825-32. 2005
  8. ncbi Genetically distinct and clinically relevant subtypes of glioblastoma defined by array-based comparative genomic hybridization (array-CGH)
    Andrey Korshunov
    Department of Neuropathology, NN Burdenko Neurosurgical Institute, Fadeeva Str 5, 125047, Moscow, Russia
    Acta Neuropathol 111:465-74. 2006
  9. ncbi Recurrent cytogenetic aberrations in histologically benign, invasive meningiomas of the sphenoid region
    Andrey Korshunov
    Department of Neuropathology, N N Burdenko Neurosurgical Institute, 4 th Tverskaya Yamskaya str 16, Fadeeva Str 5, Moscow, 125047, Russia
    J Neurooncol 81:131-7. 2007
  10. ncbi Recurrent cytogenetic aberrations in central neurocytomas and their biological relevance
    Andrey Korshunov
    Department of Neuropathology, NN Burdenko Neurosurgical Institute, Fadeeva Str 5, Moscow, 125047, Russia
    Acta Neuropathol 113:303-12. 2007

Detail Information

Publications32

  1. pmc Prognostic value of tumour associated antigen immunoreactivity and apoptosis in cerebral glioblastomas: an analysis of 168 cases
    A Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    J Clin Pathol 52:574-80. 1999
    ..To evaluate a possible association between clinical outcome in patients with glioblastoma and expression of some immunohistochemical variables and apoptosis...
  2. ncbi DNA topoisomerase II-alpha and cyclin A immunoexpression in meningiomas and its prognostic significance: an analysis of 263 cases
    Andrey Korshunov
    Department of Neuropathology, Burdenko Neurosurgical Institute, Moscow, Russia
    Arch Pathol Lab Med 126:1079-86. 2002
    ..Therefore, numerous efforts have been made to evaluate the meningioma growth fraction and its prognostic value. However, a universally applicable proliferative marker for meningioma outcome is not yet a reality...
  3. ncbi Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome
    Andrey Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    Int J Cancer 104:728-34. 2003
    ..Further studies are needed to identify more reliable prognostic markers and to address in more detail the role of cell cycle aberrations in these tumors...
  4. ncbi The histologic grade is a main prognostic factor for patients with intracranial ependymomas treated in the microneurosurgical era: an analysis of 258 patients
    Andrey Korshunov
    Department of Neuropathology, Burdenko Neurosurgical Institute, Moscow, Russia
    Cancer 100:1230-7. 2004
    ..It has been shown that the histologic classification of ependymoma is a significant predictor of clinical outcome in patients with ependymoma...
  5. ncbi Molecular stratification of diagnostically challenging high-grade gliomas composed of small cells: the utility of fluorescence in situ hybridization
    Andrey Korshunov
    Department of Neuropathology, NN Burdenko Neurosurgical Institute, Fadeeva Str 5, Moscow, 125047, Russia
    Clin Cancer Res 10:7820-6. 2004
    ..The aim of this study was molecular stratification of morphologically ambiguous high-grade gliomas composed from small cells. Fluorescence in situ hybridization (FISH) with commercially available probes was used for this purpose...
  6. ncbi Clinical utility of fluorescence in situ hybridization (FISH) in nonbrainstem glioblastomas of childhood
    Andrey Korshunov
    Department of Neuropathology, NN Burdenko Neurosurgical Institute, Moscow, Russia
    Mod Pathol 18:1258-63. 2005
    ..In conclusion, a FISH analysis of 10q23 dosage should be recommended as an ancillary laboratory method that allows further clinical subdivision of pediatric glioblastomas...
  7. ncbi The prognostic relevance of molecular alterations in glioblastomas for patients age < 50 years
    Andrey Korshunov
    Department of Neuropathology, N N Burdenko Neurosurgical Institute, Moscow, Russia
    Cancer 104:825-32. 2005
    ..The objective of the current study was the molecular analysis of glioblastomas from adult patients age < 50 years ("young adults")...
  8. ncbi Genetically distinct and clinically relevant subtypes of glioblastoma defined by array-based comparative genomic hybridization (array-CGH)
    Andrey Korshunov
    Department of Neuropathology, NN Burdenko Neurosurgical Institute, Fadeeva Str 5, 125047, Moscow, Russia
    Acta Neuropathol 111:465-74. 2006
    ..Therefore, array-CGH screening of glioblastomas could provide clinically useful information and, perhaps, potentially improve the quality of treatment...
  9. ncbi Recurrent cytogenetic aberrations in histologically benign, invasive meningiomas of the sphenoid region
    Andrey Korshunov
    Department of Neuropathology, N N Burdenko Neurosurgical Institute, 4 th Tverskaya Yamskaya str 16, Fadeeva Str 5, Moscow, 125047, Russia
    J Neurooncol 81:131-7. 2007
    ..Inasmuch as no reliable adjuvant therapy for recurrent meningiomas is available thus far, revealed genomic aberrations can provide a potential targets for drug discovery and therapeutic intervention in a future...
  10. ncbi Recurrent cytogenetic aberrations in central neurocytomas and their biological relevance
    Andrey Korshunov
    Department of Neuropathology, NN Burdenko Neurosurgical Institute, Fadeeva Str 5, Moscow, 125047, Russia
    Acta Neuropathol 113:303-12. 2007
    ..Thus these data support that MYCN oncogene gain/overexpression accompanied by reduced expression of BIN1 tumor suppressor may contribute to central neurocytoma tumorigenesis...
  11. ncbi Immunohistochemical markers for prognosis of average-risk pediatric medulloblastomas. The effect of apoptotic index, TrkC, and c-myc expression
    Andrey Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    J Neurooncol 58:271-9. 2002
    ....
  12. ncbi Immunohistochemical markers for prognosis of ependymal neoplasms
    Andrey Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    J Neurooncol 58:255-70. 2002
    ....
  13. ncbi Immunohistochemical markers for prognosis of oligodendroglial neoplasms
    Andrey Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    J Neurooncol 58:237-53. 2002
    ....
  14. ncbi Prognostic value of immunoexpression of the chemoresistance-related proteins in ependymomas: an analysis of 76 cases
    A Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    J Neurooncol 45:219-27. 1999
    ..02; P = 0.02). The obtained results allow one to conclude that ChRPs expression is closely associated with low-grade ependymomas and immunohistochemical findings may be estimated as a predictor for local tumor progression...
  15. ncbi The prognostic significance of vascular endothelial growth factor (VEGF C-1) immunoexpression in oligodendroglioma. An analysis of 91 cases
    A Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    J Neurooncol 48:13-9. 2000
    ....
  16. ncbi The prognostic significance of DNA topoisomerase II-alpha (Ki-S1), p21/Cip-1, and p27/Kip-1 protein immunoexpression in oligodendrogliomas
    A Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    Arch Pathol Lab Med 125:892-8. 2001
    ....
  17. ncbi Pleomorphic xanthoastrocytomas: immunohistochemistry, grading and clinico-pathologic correlations. An analysis of 34 cases from a single Institute
    A Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    J Neurooncol 52:63-72. 2001
    ..No one from immunohistochemical variables reached significant value. In summary, the three-tiered PXAs subdivision proposed by us is carrying some element of rationality but, undoubtedly, requires further prospective studies...
  18. ncbi p14ARF protein (FL-132) immunoreactivity in intracranial ependymomas and its prognostic significance: an analysis of 103 cases
    A Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    Acta Neuropathol 102:271-7. 2001
    ..56; P=0.0003); and (4) most beneficial information for evaluation of malignant ependymoma outcome should be elicited from simultaneous immunohistochemical investigation of p14 ARF and p53 in tumor specimen...
  19. ncbi Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome
    Andrey Korshunov
    Department of Neuropathology, Burdenko Neurosurgical Institute, Moscow, Russia
    Arch Pathol Lab Med 126:42-8. 2002
    ..To investigate immunoexpression of 2 cyclin-dependent kinase inhibitors, p18INK4C (p18) and p14ARF (p14), in oligodendrogliomas and to evaluate the possible association with tumor grade and clinical outcome...
  20. ncbi Immunohistochemical markers for prognosis of anaplastic astrocytomas
    Andrey Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    J Neurooncol 58:203-15. 2002
    ..Thus, the results obtained reveal the advantage of combined approach including evaluation of routine histological parameters and immunohistochemical variables for further clinical subdivision of anaplastic astrocytomas...
  21. ncbi Immunohistochemical markers for prognosis of cerebral glioblastomas
    Andrey Korshunov
    Department of Neuropathology, Neurosurgical NN Burdenko Institute, Moscow, Russia
    J Neurooncol 58:217-36. 2002
    ..Therefore, the glioblastoma subdivision on three cytological subsets proposed by us is carrying some element of rationality but, undoubtedly, requires further prospective studies...
  22. ncbi Immunohistochemical markers for intracranial ependymoma recurrence. An analysis of 88 cases
    A Korshunov
    Department of Neuropathology Surgery, Neurosurgical NN Burdenko Institute, Moscow, Russia
    J Neurol Sci 177:72-82. 2000
    ..So, the immunohistochemical variables were found to be strongest predictors of ependymoma recurrence and they seem to be useful for assessing individual tumor prognosis in routinely processed biopsy specimen...
  23. ncbi Gains at the 1p36 chromosomal region are associated with symptomatic leptomeningeal dissemination of supratentorial glioblastomas
    Andrey Korshunov
    The Department of Neuropathology, Burdenko Neurosurgical Institute, Moscow, Russia
    Am J Clin Pathol 127:585-90. 2007
    ..1 locus involving at least 3 DNA clones from this chromosomal region. Consequently, an analysis of 1p copy number status might be kept in mind as an additional tool for further predicting the clinical course of glioblastoma...
  24. pmc Gene expression patterns in ependymomas correlate with tumor location, grade, and patient age
    Andrey Korshunov
    Department of Neuropathology, Neurosurgical Nikolai Nilovich Burdenko Institute, Moscow, Russia
    Am J Pathol 163:1721-7. 2003
    ..In summary, our results provide new insight in the biochemical pathways particularly intriguing in the pathomechanism of ependymomas and suggest that this entity comprises molecularly distinct diseases...
  25. doi Fast detection of MYCN copy number alterations in brain neuronal tumors by real-time PCR
    S G Malakho
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    J Clin Lab Anal 22:123-30. 2008
    ..01) between qPCR and FISH/array-CGH. Absolute qPCR assays possess high precision compared to other conventional methods and can be used for accurate and quickness detection of MYCN status (low-level gene gain and amplification)...
  26. ncbi Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas
    Stefan Pfister
    Division Molecular Genetics, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Genes Chromosomes Cancer 46:839-51. 2007
    ..02) were confirmed to be more frequent in medulloblastomas. These data further support the hypothesis of two different tumor entities of embryonal neuroepithelial tumors with characteristic genetic aberrations. (c) 2007 Wiley-Liss, Inc...
  27. ncbi Chromosomal imbalances in clear cell ependymomas
    Christian H Rickert
    Department of Anatomical Pathology, Royal Children s Hospital Melbourne, Melbourne, Australia, and Institute of Neuropathology, University Hospital Munster, Munster, Germany
    Mod Pathol 19:958-62. 2006
    ....
  28. ncbi Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma
    Frank Mendrzyk
    Division of Molecular Genetics and Central Unit Biostatistics, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 12:2070-9. 2006
    ..Pathogenesis of ependymomas is still poorly understood and molecular markers for risk-adapted patient stratification are not available. Our aim was to screen for novel genomic imbalances and prognostic markers in ependymal tumors...
  29. ncbi Isochromosome breakpoints on 17p in medulloblastoma are flanked by different classes of DNA sequence repeats
    Frank Mendrzyk
    Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany
    Genes Chromosomes Cancer 45:401-10. 2006
    ..Furthermore, we identified artifacts introduced in DNA copy number data by cross-hybridization of low-copy repeat sequences and discuss the challenge these can pose in the interpretation of diagnostic microarrays...
  30. ncbi Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma
    Frank Mendrzyk
    Division of Molecular Genetics B060, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    J Clin Oncol 23:8853-62. 2005
    ..Identification of molecular markers for prognosis and development of novel pathogenesis-based therapies depends crucially on a better understanding of medulloblastoma pathomechanisms...
  31. ncbi Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival
    Kai Neben
    Division of Molecular Genetics B060, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 64:3103-11. 2004
    ....
  32. pmc BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas
    Stefan Pfister
    Division Molecular Genetics, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Clin Invest 118:1739-49. 2008
    ....