V P Skulachev

Summary

Affiliation: Lomonosov Moscow State University
Country: Russia

Publications

  1. ncbi request reprint Cations SkQ1 and MitoQ accumulated in mitochondria delay opening of ascorbate/FeSO4-induced nonspecific pore in the inner mitochondrial membrane
    L S Khailova
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia
    Biochemistry (Mosc) 73:1121-4. 2008
  2. ncbi request reprint Cytochrome c in the apoptotic and antioxidant cascades
    V P Skulachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    FEBS Lett 423:275-80. 1998
  3. ncbi request reprint Anion carriers in fatty acid-mediated physiological uncoupling
    V P Skulachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    J Bioenerg Biomembr 31:431-45. 1999
  4. ncbi request reprint Phenoptosis: programmed death of an organism
    V P Skulachev
    Department of Bioenergetics, Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 64:1418-26. 1999
  5. ncbi request reprint Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms
    V P Skulachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russian Federation
    Mol Aspects Med 20:139-84. 1999
  6. ncbi request reprint Possible role of reactive oxygen species in antiviral defense
    V P Skulachev
    Department of Bioenergetics, Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 63:1438-40. 1998
  7. ncbi request reprint Biochemical mechanisms of evolution and the role of oxygen
    V P Skulachev
    Department of Bioenergetics, Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 63:1335-43. 1998
  8. ncbi request reprint Aging is a specific biological function rather than the result of a disorder in complex living systems: biochemical evidence in support of Weismann's hypothesis
    V P Skulachev
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Russia
    Biochemistry (Mosc) 62:1191-5. 1997
  9. ncbi request reprint Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell
    V P Skulachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russian Federation
    FEBS Lett 397:7-10. 1996
  10. ncbi request reprint Mild uncoupling of respiration and phosphorylation as a mechanism providing nephro- and neuroprotective effects of penetrating cations of the SkQ family
    E Y Plotnikov
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia
    Biochemistry (Mosc) 77:1029-37. 2012

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Cations SkQ1 and MitoQ accumulated in mitochondria delay opening of ascorbate/FeSO4-induced nonspecific pore in the inner mitochondrial membrane
    L S Khailova
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia
    Biochemistry (Mosc) 73:1121-4. 2008
    ..These results suggest that under the conditions used SkQ1 protects mitochondria from oxidative damage as an antioxidant when added at extremely low concentrations...
  2. ncbi request reprint Cytochrome c in the apoptotic and antioxidant cascades
    V P Skulachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    FEBS Lett 423:275-80. 1998
    ..3) The main respiratory chain losing its cytochrome c is inhibited in such a fashion that antimycin-like agents fail to stimulate ROS production...
  3. ncbi request reprint Anion carriers in fatty acid-mediated physiological uncoupling
    V P Skulachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    J Bioenerg Biomembr 31:431-45. 1999
    ..e., formation of useful substances, decomposition of unwanted substances, and antioxidant defense. Moreover, partial uncoupling might take part in optimization of the rate of ATP synthesis in aerobic cells...
  4. ncbi request reprint Phenoptosis: programmed death of an organism
    V P Skulachev
    Department of Bioenergetics, Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 64:1418-26. 1999
    ..In line with this logic, some cases are already described when inhibition of apoptosis strongly improves the postischemic state of the organism...
  5. ncbi request reprint Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms
    V P Skulachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russian Federation
    Mol Aspects Med 20:139-84. 1999
    ....
  6. ncbi request reprint Possible role of reactive oxygen species in antiviral defense
    V P Skulachev
    Department of Bioenergetics, Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 63:1438-40. 1998
    ..So, the infected cell and its neighbors (which are the most likely to be infected) are eliminated, thus blocking the spreading of the viral infection...
  7. ncbi request reprint Biochemical mechanisms of evolution and the role of oxygen
    V P Skulachev
    Department of Bioenergetics, Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 63:1335-43. 1998
    ..On the other hand, a decrease in the life activity and a considerable increase in life span occurring in a nematode upon mutations inhibiting the CoQ biosynthesis (S. Hekimi) might serve as an example of a K --> r transition...
  8. ncbi request reprint Aging is a specific biological function rather than the result of a disorder in complex living systems: biochemical evidence in support of Weismann's hypothesis
    V P Skulachev
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Russia
    Biochemistry (Mosc) 62:1191-5. 1997
    ....
  9. ncbi request reprint Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell
    V P Skulachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russian Federation
    FEBS Lett 397:7-10. 1996
    ..Another result of the long-lived pores is mitochondrial swelling. This disrupts the outer mitochondrial membrane and releases the apoptosis-inducing protein. Apoptosis eliminates ROS-producing cells (cell selection)...
  10. ncbi request reprint Mild uncoupling of respiration and phosphorylation as a mechanism providing nephro- and neuroprotective effects of penetrating cations of the SkQ family
    E Y Plotnikov
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia
    Biochemistry (Mosc) 77:1029-37. 2012
    ..We conclude that beneficial effects of penetrating cation derivatives of rhodamine 19 in renal pathologies and brain ischemia may be at least partially explained by uncoupling of oxidation and phosphorylation...
  11. ncbi request reprint Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: synthesis and in vitro studies
    Y N Antonenko
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
    Biochemistry (Mosc) 73:1273-87. 2008
    ..Therefore, they might be used to effectively prevent ROS-induced oxidation of lipids and proteins in the inner mitochondrial membrane in vivo...
  12. ncbi request reprint Effect of oxidative stress on dynamics of mitochondrial reticulum
    O Yu Pletjushkina
    A N Belozersky Institute, Moscow State University, 119992 Moscow, Russia
    Biochim Biophys Acta 1757:518-24. 2006
    ....
  13. ncbi request reprint Thermoregulatory uncoupling in heart muscle mitochondria: involvement of the ATP/ADP antiporter and uncoupling protein
    R A Simonyan
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    FEBS Lett 436:81-4. 1998
    ....
  14. doi request reprint Mechanisms of nephroprotective effect of mitochondria-targeted antioxidants under rhabdomyolysis and ischemia/reperfusion
    E Y Plotnikov
    Laboratory of Mitochondrial Structure and Functions, AN Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, 119991 Russia
    Biochim Biophys Acta 1812:77-86. 2011
    ..SkQR1 also normalized renal erythropoietin level lowered after kidney ischemia/reperfusion and injection of a well-known nephrotoxic agent gentamicin...
  15. doi request reprint Mitochondria-targeted antioxidant SkQR1 ameliorates gentamycin-induced renal failure and hearing loss
    S S Jankauskas
    Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia
    Biochemistry (Mosc) 77:666-70. 2012
    ..Treatment with SkQR1 also decreases gentamycin-induced hearing loss. Mitochondria-targeted antioxidants, such as SkQR1, are new promising agents for preventing negative consequences of therapy with antibiotics...
  16. ncbi request reprint Substitution of ether linkage for ester bond in phospholipids increases permeability of bilayer lipid membrane for SkQ1-type penetrating cations
    T M Il'yasova
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia
    Biochemistry (Mosc) 77:1038-43. 2012
    ..In the latter case, suppression of SkQ1-mediated proton conductivity of the BLM was also observed...
  17. doi request reprint Protective effects of mitochondria-targeted antioxidant SkQ in aqueous and lipid membrane environments
    Y N Antonenko
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, 119991, Moscow, Russian Federation
    J Membr Biol 222:141-9. 2008
    ..It is concluded that SkQ1H(2) operates as a ROS scavenger in both aqueous and lipid environments, being effective at preventing ROS-induced damage to membrane lipids as well as membrane-embedded peptides...
  18. ncbi request reprint Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke)
    L E Bakeeva
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
    Biochemistry (Mosc) 73:1288-99. 2008
    ..SkQ1 was ineffective, most probably due to lower permeability of the blood-brain barrier to this compound...
  19. ncbi request reprint Barbara Cannon's data on the UCP1-ablated mice: "non-cannonical" point of view
    V P Skulachev
    Department of Bioenergetics, A N Berlozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    Biosci Rep 21:189-94. 2001
    ..In the UCP1-ablated mice, activity of UCP2 and 3 appears to be insufficient to induce CoQH2 oxidation in resting brown fat mitochondria, which results in hypothermia...
  20. ncbi request reprint Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies
    M V Skulachev
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Russia
    Curr Drug Targets 12:800-26. 2011
    ....
  21. ncbi request reprint Mitochondria-targeted plastoquinone antioxidant SkQR1 decreases trauma-induced neurological deficit in rat
    N K Isaev
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia
    Biochemistry (Mosc) 77:996-9. 2012
    ..Our results suggest that SkQR1 exhibits profound neuroprotective effect, which may be explained by its antioxidative activity...
  22. ncbi request reprint Hydrogen peroxide produced inside mitochondria takes part in cell-to-cell transmission of apoptotic signal
    O Yu Pletjushkina
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
    Biochemistry (Mosc) 71:60-7. 2006
    ..e. disappearance of organs during ontogenesis...
  23. ncbi request reprint Cold-induced changes in the energy coupling and the UCP3 level in rodent skeletal muscles
    R A Simonyan
    Department of Bioenergetics, AN Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia
    Biochim Biophys Acta 1505:271-9. 2001
    ..Cold exposure does not affect energy coupling in liver mitochondria. The possible involvement of UCP3 isoforms in nucleotide-sensitive and -insensitive uncoupling is discussed...
  24. ncbi request reprint Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells
    L S Agapova
    Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia
    Biochemistry (Mosc) 73:1300-16. 2008
    ..Extremely high efficiency of SkQ1, related to its accumulation in the mitochondrial membrane, indicates that mitochondrial ROS production is critical for tumorigenesis at least in some animal models...
  25. ncbi request reprint Marginal blebbing during the early stages of TNF-induced apoptosis indicates alteration in actomyosin contractility
    L V Domnina
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow 119992, Russia
    Cell Biol Int 28:471-5. 2004
    ..Localization of marginal blebs at the active edge may be associated with special organization of cortex in that zone...
  26. pmc Noncoupled NADH:ubiquinone oxidoreductase of Azotobacter vinelandii is required for diazotrophic growth at high oxygen concentrations
    Y V Bertsova
    Department of Bioenergetics, A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow 119899, Russia
    J Bacteriol 183:6869-74. 2001
    ..vinelandii. It was also found that the oxidation of NADPH in the A. vinelandii respiratory chain is catalyzed solely by NDH II...
  27. ncbi request reprint Reactive oxygen species produced in mitochondria are involved in age-dependent changes of hematopoietic and mesenchymal progenitor cells in mice. A study with the novel mitochondria-targeted antioxidant SkQ1
    I N Shipounova
    National Hematological Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation
    Mech Ageing Dev 131:415-21. 2010
    ..The anti-aging effects of SkQ1 described here are in perfect agreement with the inhibitory effects of this antioxidant on aging observed in the other models...
  28. ncbi request reprint Mitochondria in the programmed death phenomena; a principle of biology: "it is better to die than to be wrong"
    V P Skulachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    IUBMB Life 49:365-73. 2000
    ..It is hypothesized that aging represents a slow ROS-linked phenoptosis that eliminates individuals with damaged genomes and gives reproductive advantage to those who succeeded in a better preservation of their genomes from damage...
  29. doi request reprint In vivo injected mitochondria-targeted plastoquinone antioxidant SkQR1 prevents β-amyloid-induced decay of long-term potentiation in rat hippocampal slices
    N A Kapay
    Department of Brain Research, Research Center of Neurology, Russian Academy of Medical Sciences, Pereulok Obukha 5, 105064 Moscow, Russia
    Biochemistry (Mosc) 76:1367-70. 2011
    ....
  30. ncbi request reprint Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals
    V V Neroev
    Helmholtz Moscow Research Institute of Eye Diseases, Moscow, 105062, Russia
    Biochemistry (Mosc) 73:1317-28. 2008
    ..It is concluded that low concentrations of SkQ1 are promising in treating retinopathies, cataract, uveitis, glaucoma, and some other ocular diseases...
  31. doi request reprint SkBQ - prooxidant addressed to mitochondria
    M Y Vyssokikh
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia
    Biochemistry (Mosc) 78:1366-70. 2013
    ..The possibility of using SkBQ as an anticancer drug for the treatment of cancers such as prostate cancer whose cells are sensitive to mitochondrial reactive oxygen species is discussed. ..
  32. ncbi request reprint A biochemical approach to the problem of aging: "megaproject" on membrane-penetrating ions. The first results and prospects
    V P Skulachev
    Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119991, Russia
    Biochemistry (Mosc) 72:1385-96. 2007
    ..Thus, it seems reasonable to perform clinical testing of SkQ preparations as promising drugs for treatment of age-related and some other severe diseases of human and animals...
  33. ncbi request reprint Bioenergetic aspects of apoptosis, necrosis and mitoptosis
    V P Skulachev
    Department of Bioenergetics, Belozersky Institute of Physico Chemical Biology and School of Bioengineering and Bioinformatics, Moscow State University, Moscow, 119992, Russia
    Apoptosis 11:473-85. 2006
    ..Massive mitoptosis can result in cell death due to release to cytosol of the cell death proteins normally hidden in the mitochondrial intermembrane space...
  34. ncbi request reprint The p66shc protein: a mediator of the programmed death of an organism?
    V P Skulachev
    Department of Bioenergetics, Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    IUBMB Life 49:177-80. 2000
    ..Serine-phosphorylated p66shc there is proposed to block mitosis and initiate apoptosis. The large-scale apoptosis leads to phenoptosis and, hence, shortens the life span of the organism...
  35. ncbi request reprint Cytochrome d induction in Escherichia coli growing under unfavorable conditions
    A V Bogachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russian Federation
    FEBS Lett 336:75-8. 1993
    ..It is suggested (i) that it is delta mu H+ decrease rather than reduction of the respiratory chain that is the signal for the induction of cytochrome d, and (ii) the Arc system is involved in this type of metabolic regulation...
  36. ncbi request reprint H2O2 sensors of lungs and blood vessels and their role in the antioxidant defense of the body
    V P Skulachev
    Department of Bioenergetics, Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 66:1153-6. 2001
    ..The possible roles of such systems under normal conditions (e.g., the effect of O2*- in air) and in some pathologies (e.g., pneumonia) is discussed...
  37. doi request reprint What is "phenoptosis" and how to fight it?
    V P Skulachev
    Lomonosov Moscow State University, Belozersky Institute of Physico Chemical Biology and Faculty of Bioengineering and Bioinformatics, Moscow, 119991, Russia
    Biochemistry (Mosc) 77:689-706. 2012
    ..These drops are already available in drugstores. Thus, SkQ1 is the first mitochondria-targeted drug employed in medical practice...
  38. ncbi request reprint New data on biochemical mechanism of programmed senescence of organisms and antioxidant defense of mitochondria
    V P Skulachev
    Belozersky Institute of Physico Chemical Biology and Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119991, Russia
    Biochemistry (Mosc) 74:1400-3. 2009
    ..Methionine quenches ROS, being converted to methionine sulfoxide, which is re-reduced to the initial methionine by NADPH...
  39. ncbi request reprint Effects of the inhibitors of dynamics of cytoskeletal structures on the development of apoptosis induced by the tumor necrosis factor
    L V Domnina
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Russia
    Biochemistry (Mosc) 67:737-46. 2002
    ..It is suggested that the stimulation of apoptosis by cytoskeletal inhibitors may be attributed to the altered distribution of cell organelles, especially, mitochondria...
  40. ncbi request reprint Interrelations of mitochondrial fragmentation and cell death under ischemia/reoxygenation and UV-irradiation: protective effects of SkQ1, lithium ions and insulin
    E Y Plotnikov
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
    FEBS Lett 582:3117-24. 2008
    ..This means that mitochondrial fission is not essential for apoptotic cascade progression...
  41. ncbi request reprint Selective elimination of mitochondria from living cells induced by inhibitors of bioenergetic functions
    K G Lyamzaev
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, 119899 Moscow, Russia
    Biochem Soc Trans 32:1070-1. 2004
    ..The fraction of mitochondria-depleted cells remained viable...
  42. ncbi request reprint Uncoupling effect of lauryl sulfate on mitochondria can be mediated by release of bound endogenous fatty acids
    R A Simonian
    Belozersky Institute of Physico Chemical Biology and Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, 119992, Russia
    Biochemistry (Mosc) 71:1365-9. 2006
    ..As to high LS, it causes a nonspecific (CAtr-insensitive) damage to the mitochondrial membrane...
  43. ncbi request reprint Analysis of HI0220 protein from Haemophilus influenzae, a novel structural and functional analog of ArcB protein from Escherichia coli
    I V Manukhov
    Department of Bioenergetics, Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 65:1321-6. 2000
    ..influenzae revealed conserved amino acid regions. Transmembrane helix II was shown to be highly homologous in all the ArcB-type proteins. The involvement of this region in ArcB-mediated oxygen-dependent regulation is suggested...
  44. ncbi request reprint Mitochondrial filaments and clusters as intracellular power-transmitting cables
    V P Skulachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, 119899, Moscow, Russia
    Trends Biochem Sci 26:23-9. 2001
    ..As to small mitochondria, they might represent a transportable form of these organelles...
  45. ncbi request reprint The programmed death phenomena, aging, and the Samurai law of biology
    V P Skulachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119899, Russia
    Exp Gerontol 36:995-1024. 2001
    ..It is stressed that for humans these cruel regulations look like an atavism that should be overcome to prolong the human life span...
  46. ncbi request reprint Mitochondria enter the nucleus (one further problem in chronic alcoholism)
    L E Bakeeva
    Department of Bioenergetics, Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119899 Russia
    Biochemistry (Mosc) 66:1335-41. 2001
    ..It is suggested that the entrance of mitochondria into the nucleus promotes both the attack of mitochondria by nuclear proteins and the attack of nuclear DNA and proteins by proteins of the mitochondrial intermembrane space...
  47. ncbi request reprint Comparative analysis of proapoptotic activity of cytochrome c mutants in living cells
    G V Sharonov
    Shemyakin Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul Miklukho Maklaya 16 10, 117997, Moscow, Russia
    Apoptosis 10:797-808. 2005
    ..This mutant is competent as a respiratory-chain electron carrier and well suited for knock-in studies of cytochrome c-mediated apoptosis...
  48. doi request reprint Functions of mitochondria: from intracellular power stations to mediators of a senescence program
    V P Skulachev
    Belozersky Institute of Physico Chemical Biology, Moscow State University, Vorobyevy Gory, Bldg 40, Moscow, 119991, Russia
    Cell Mol Life Sci 66:1785-93. 2009
    ..My present task is a "megaproject" with an ambitious goal of minimizing the damaging effect of O(2)(-.) and stopping senescence...
  49. ncbi request reprint If cancer is a special case of phenoptosis, how can we conquer it?
    V P Skulachev
    Faculty of Bioengineering and Bioinformatics, Department of Bioenergetics, Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
    Biochemistry (Mosc) 71:930-1. 2006
  50. ncbi request reprint Cytochrome c, an ideal antioxidant
    M O Pereverzev
    Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow 119992, Russia
    Biochem Soc Trans 31:1312-5. 2003
    ..It is important that cytochrome c is not damaged during the antioxidant reaction, in contrast with many other antioxidants...
  51. ncbi request reprint Transfer of cationic antibacterial agents berberine, palmatine, and benzalkonium through bimolecular planar phospholipid film and Staphylococcus aureus membrane
    I I Severina
    Department of Bioenergetics, A. N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia
    IUBMB Life 52:321-4. 2001
    ..The berberine accumulation was prevented by protonophore CCCP and was stimulated by mutation in the MDR pump NorA. It is concluded that the plant alkaloids and benzalkonium are penetrating cations and substrates of an MDR pump...
  52. ncbi request reprint Advanced glycation of cellular proteins as a possible basic component of the "master biological clock"
    F F Severin
    Lomonosov Moscow State University, Belozersky Institute of Physico Chemical Biology, Moscow, 119991, Russia
    Biochemistry (Mosc) 78:1043-7. 2013
    ..This could result in the age-dependent decrease in the level of this hormone leading to aging of the organism. ..
  53. pmc H+/e- stoichiometry for NADH dehydrogenase I and dimethyl sulfoxide reductase in anaerobically grown Escherichia coli cells
    A V Bogachev
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russia
    J Bacteriol 178:6233-7. 1996
    ..These data suggest that (i) the H+/e- stoichiometry for E. coli NDH-I is at least 1.5 and (ii) the DMSO reductase does not generate a proton motive force...
  54. ncbi request reprint Ion permeability induced in artificial membranes by the ATP/ADP antiporter
    I M Tikhonova
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Russian Federation
    FEBS Lett 337:231-4. 1994
    ..Thus the obtained data are consistent with the assumption that native and modified ANT might function as an H(+)-specific conductor and as a permeability transition pore, respectively...
  55. ncbi request reprint Induction of the Escherichia coli cytochrome d by low delta mu H+ and by sodium ions
    A V Bogachev
    Department of Bioenergetics, A N Belozersky Institute of Phisico Chemical Biology, Moscow State University, Russia
    Eur J Biochem 232:304-8. 1995
    ..It is assumed that in the control of the cytochrome d synthesis, the Arc system is involved in the delta mu H+ sensing whereas sensing of delta mu Na+ (or of the Na+ concentration) is mediated by some other receptor system...
  56. ncbi request reprint Stress-induced changes in ubiquinone concentration and alternative oxidase in plant mitochondria
    V N Popov
    Department of Plant Physiology and Biochemistry, Voronezh State University, Russia
    Biosci Rep 21:369-79. 2001
    ..The role of reduced Q accumulation and AOX induction in the defense against oxidative damage is discussed...
  57. ncbi request reprint Long-distance apoptotic killing of cells is mediated by hydrogen peroxide in a mitochondrial ROS-dependent fashion
    O Yu Pletjushkina
    Cell Death Differ 12:1442-4. 2005
  58. ncbi request reprint Effects of cold exposure in vivo and uncouplers and recouplers in vitro on potato tuber mitochondria
    V N Popov
    Department of Plant Physiology and Biochemistry, Voronezh State University, Voronezh 394693, Russia
    Biochim Biophys Acta 1553:232-7. 2002
    ..As to the plant uncoupling protein, its contribution to the uncoupling in tuber is negligible or, under the conditions used, somehow desensitized to nucleotides...
  59. ncbi request reprint The F1-ATPase of Vibrio alginolyticus. Purification and N-terminal sequence of major subunits
    - Dmitriev OYu
    A N Belozersky Laboratory for Molecular Biology and Bioorganic Chemistry, Moscow State University, USSR
    FEBS Lett 258:219-22. 1989
    ..Amino acid sequences of N-terminal regions of the major subunits revealed close homology with those of E. coli H+-ATPase and of Propionigenium modestum Na+-ATPase...