Affiliation: Institute of Molecular Genetics
Radion E, Sokolova O, Ryazansky S, Komarov P, Abramov Y, Kalmykova A. The Integrity of piRNA Clusters is Abolished by Insulators in the Drosophila Germline. Genes (Basel). 2019;10: pubmed publisher
..A genome-wide analysis revealed that Su(Hw)-binding sites are depleted in endogenous germline piRNA clusters, suggesting that their functional integrity is under strict evolutionary constraints. ..
Radion E, Morgunova V, Ryazansky S, Akulenko N, Lavrov S, Abramov Y, et al
. Key role of piRNAs in telomeric chromatin maintenance and telomere nuclear positioning in Drosophila germline. Epigenetics Chromatin. 2018;11:40 pubmed publisher
..Telomeric chromatin is highly sensitive to piRNA loss, implying the existence of a novel developmental checkpoint that depends on telomere integrity in the germline. ..
Kordyukova M, Olovnikov I, Kalmykova A. Transposon control mechanisms in telomere biology. Curr Opin Genet Dev. 2018;49:56-62 pubmed publisher
Olovnikov I, Morgunova V, Mironova A, Kordyukova M, Radion E, Olenkina O, et al
. Interaction of Telomeric Retroelement HeT-A Transcripts and Their Protein Product Gag in Early Embryogenesis of Drosophila. Biochemistry (Mosc). 2016;81:1023-30 pubmed publisher
..The specific localization of HeT-A RNA is dependent on microtubules since disruption of microtubules caused delocalization of HeT-A transcripts. This transgenic system is a valuable model for the study of telomeric RNA biogenesis. ..
Radion E, Ryazansky S, Akulenko N, Rozovsky Y, Kwon D, Morgunova V, et al
. Telomeric Retrotransposon HeT-A Contains a Bidirectional Promoter that Initiates Divergent Transcription of piRNA Precursors in Drosophila Germline. J Mol Biol. 2017;429:3280-3289 pubmed publisher
..These data indicate that Drosophila telomeres share properties of unistrand and dual-strand piRNA clusters. ..
Akulenko N, Ryazansky S, Morgunova V, Komarov P, Olovnikov I, Vaury C, et al
. Transcriptional and chromatin changes accompanying de novo formation of transgenic piRNA clusters. RNA. 2018;: pubmed publisher
..As a result, genomic copies of a weak piRNA transgenic cluster show a mosaic association with Rhino foci, while the majority of strong transgene copies associate with Rhino and are hence involved in piRNA production. ..
Morgunova V, Akulenko N, Radion E, Olovnikov I, Abramov Y, Olenina L, et al
. Telomeric repeat silencing in germ cells is essential for early development in Drosophila. Nucleic Acids Res. 2015;43:8762-73 pubmed publisher
..Our data demonstrate that Ccr4-Not, Woc, Trf2 and Ars2, components of different regulatory pathways, are required for telomere protection in the germline in order to guarantee normal development. ..