Affiliation: Institute of Cytology
- In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress toleranceI Guzhova
Laboratory of Cell Protection Mechanisms, Institute of Cytology Russian Academy of Science Tikhoretsky 4, 194064, St Petersburg, Russia
Brain Res 914:66-73. 2001..These results suggest that extracellular Hsp70 may provide a means by which glia can affect neuronal function, perhaps enhancing neuronal stress tolerance...
- Downstream caspases are novel targets for the antiapoptotic activity of the molecular chaperone hsp70Elena Yu Komarova
Institute of Cytology RAS, Tikhoretsky pr 4, St Petersburg 194064, Russia
Cell Stress Chaperones 9:265-75. 2004..Thus, Hsp70 may act to suppress caspase-dependent apoptotic signaling through binding the precursor forms of both caspase-3 and caspase-7 and preventing their maturation...
- [Induction and accumulation of HSP70 leads to formation of its complexes with other cell proteins]I V Guzhova
Institute of Cytology RAS, St Petersburg
Tsitologiia 42:647-52. 2000..The data demonstrate that besides its traditional target, i.e. newly synthesized or abnormal polypeptides, Hsp70 is able to bind mature, active proteins...
- [Effect of heat shock on cell differentiation and apoptosis in U-937 cells]I V Guzhova
Institute of Cytology RAS, St Petersburg, Russia
Tsitologiia 42:653-8. 2000..It is concluded that Hsp70 accumulating in higher amounts is able to transiently protect cells of TNF-mediated cytotoxic effect by physical association with the proteins that serve as modulators of apoptosis...