Genomes and Genes
A E Berman
Affiliation: Institute of Biomedical Chemistry
- Integrins: structure and functionsA E Berman
Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow
Membr Cell Biol 13:207-44. 2000..Biochemical mechanisms, by which the signal functions of integrins are realized, are discussed. The data on the participation of integrins in oncogenic cell transformation, metastasis, and apoptosis are analyzed...
- Role of integrin alphavbeta3 in substrate-dependent apoptosis of human intestinal carcinoma cellsG E Morozevich
Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, 119992, Russia
Biochemistry (Mosc) 68:416-23. 2003..The data provide the first evidence that alphavbeta3 integrin can generate apoptosis-stimulating signals...
- Integrins: structure and signalingA E Berman
Orekchovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow 119121, Russia
Biochemistry (Mosc) 68:1284-99. 2003..This review summarizes current views on the structure of integrins, integrin associated proteins, and biochemical mechanisms underlying their signaling functions...
- Expression and role of integrins in invasive activity of oncotransformed fibroblasts differing in spontaneous metastasizingG E Morozevich
Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow 119121, Russia
Biochemistry (Mosc) 69:665-73. 2004..The role of specific properties of the extracellular matrix surrounding tumor cells and of specific surface integrins expressed in these cells in developing of the malignant phenotype is discussed...
- Implication of alpha5beta1 integrin in invasion of drug-resistant MCF-7/ADR breast carcinoma cells: a role for MMP-2 collagenaseG E Morozevich
Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, 119121, Russia
Biochemistry (Mosc) 73:791-6. 2008..These data suggest that alpha5beta1 controls invasion ability of these cells by regulating expression of MMP-2, which involves PI-3K and Erk1/2 protein kinase signaling...
- The role of beta1 integrin subfamily in anchorage-dependent apoptosis of breast carcinoma cells differing in multidrug resistanceG E Morozevich
Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow, Russia
Biochemistry (Mosc) 71:489-95. 2006..These data show that activation of beta1-integrin signaling markedly upregulated anoikis of the adenocarcinoma cells...
- Integrin alphavbeta3 promotes anchorage-dependent apoptosis in human intestinal carcinoma cellsN I Kozlova
Institute of Biomedical Chemistry RAMS, Pogodinskaya str. 10, 119832 Moscow, Russia
Oncogene 20:4710-7. 2001..Thus, for the first time, our data prove that alphavbeta3 integrin can be an active transducer of apoptosis-stimulating signals generated in response to disruption of the cell-matrix contacts...
- [The role of alphavbeta3 integrin in changes of the invasive phenotype in CP-transformed fibroblasts with multiple drug resistance]G E Morozevich
Institute of Biomedical Chemistry by V N Orekchovich, RAMS, Moscow
Vopr Med Khim 48:111-20. 2002..The role of integrin alpha v beta 3 in malignant phenotype and multiple drug resistance of tumor cells is discussed...
- C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cellsD Zhuang
Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Oncogene 27:6623-34. 2008..Our data suggest that one of the major functions of C-MYC overexpression in melanoma progression is to continuous suppress BRAF(V600E)- or NRAS(Q61R)-dependent senescence programs...