Nickolai A Tchurikov


Affiliation: Engelhardt Institute of Molecular Biology
Country: Russia


  1. Tchurikov N, Kretova O. Suffix-specific RNAi leads to silencing of F element in Drosophila melanogaster. PLoS ONE. 2007;2:e476 pubmed
    ..These data also suggest that double stranded RNAs possessing suffix are processed by both RNAi and an additional silencing mechanism. ..
  2. Tchurikov N, Kravatsky Y, Kretova O. Link Between Double-Strand DNA Break Hotspots and Transcription Regulation: Forum Domains - 50-250 kb Chromosome Regions Containing Coordinately Expressed Genes. Biochemistry (Mosc). 2018;83:437-449 pubmed publisher
    ..The need to revise the available data on DNase I-hypersensitive sites in various genomes, including endogenous DNA breaks of different nature, is discussed. ..
  3. Tchurikov N, Fedoseeva D, Sosin D, Snezhkina A, Melnikova N, Kudryavtseva A, et al. Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation. J Mol Cell Biol. 2015;7:366-82 pubmed publisher
    ..The data suggest a strong link between chromosome breakage and several different mechanisms of epigenetic regulation of gene expression. ..
  4. Tchurikov N, Fedoseeva D, Gashnikova N, Sosin D, Gorbacheva M, Alembekov I, et al. Conserved sequences in the current strains of HIV-1 subtype A in Russia are effectively targeted by artificial RNAi in vitro. Gene. 2016;583:78-83 pubmed publisher
  5. request reprint
    Tchurikov N, Kretova O, Chernov B, Golova Y, Zhimulev I, Zykov I. SuUR protein binds to the boundary regions separating forum domains in Drosophila melanogaster. J Biol Chem. 2004;279:11705-10 pubmed
    ..These results suggest that the regular distribution of boundary regions in chromosomes may represent the dispersion of sites designed for chromosomal silencing. ..
  6. Tchurikov N, Kretova O, Moiseeva E, Sosin D. Evidence for RNA synthesis in the intergenic region between enhancer and promoter and its inhibition by insulators in Drosophila melanogaster. Nucleic Acids Res. 2009;37:111-22 pubmed publisher
    ..These results highlight the involvement of RNA-tracking mechanisms in the communications between enhancers and promoters, which are inhibited by insulators...
  7. Tchurikov N, Kretova O, Sosin D, Zykov I, Zhimulev I, Kravatsky Y. Genome-wide profiling of forum domains in Drosophila melanogaster. Nucleic Acids Res. 2011;39:3667-85 pubmed publisher
    ..The data on the global mapping of forum domains revealed a strong correlation between fragmentation sites in chromosomes, particular sets of mobile elements and regions of intercalary heterochromatin. ..
  8. Tchurikov N, Kretova O, Fedoseeva D, Sosin D, Grachev S, Serebraykova M, et al. DNA double-strand breaks coupled with PARP1 and HNRNPA2B1 binding sites flank coordinately expressed domains in human chromosomes. PLoS Genet. 2013;9:e1003429 pubmed publisher
    ..Thus, our data suggest a novel type of gene regulation: a coordinated transcription or silencing of gene clusters delimited by DSB hot spots as well as PARP1 and HNRNPa2B1 binding sites. ..
  9. Kretova O, Fedoseeva D, Gorbacheva M, Gashnikova N, Gashnikova M, Melnikova N, et al. Six Highly Conserved Targets of RNAi Revealed in HIV-1-Infected Patients from Russia Are Also Present in Many HIV-1 Strains Worldwide. Mol Ther Nucleic Acids. 2017;8:330-344 pubmed publisher
    ..The data are important for both the understanding of the patterns of HIV-1 mutability and properties of RT and for the development of gene therapy approaches using RNAi for the treatment of HIV/AIDS. ..

More Information


  1. Fedoseeva D, Kretova O, Gorbacheva M, Tchurikov N. Individual effects of the copia and gypsy enhancer and insulator on chromatin marks, eRNA synthesis, and binding of insulator proteins in transfected genetic constructs. Gene. 2018;641:151-160 pubmed publisher
    ..Our results suggest the formation of chromatin loops that are shaped by the enhancer and the insulator...
  2. Kravatsky Y, Chechetkin V, Fedoseeva D, Gorbacheva M, Kravatskaya G, Kretova O, et al. A Bioinformatic Pipeline for Monitoring of the Mutational Stability of Viral Drug Targets with Deep-Sequencing Technology. Viruses. 2017;9: pubmed publisher
    ..The developed pipeline is freely available to download at the website Brief comments and comparisons between VirMut and other pipelines are also presented. ..